MA49127B1 - Dérivés d'indole n-substitués - Google Patents
Dérivés d'indole n-substituésInfo
- Publication number
- MA49127B1 MA49127B1 MA49127A MA49127A MA49127B1 MA 49127 B1 MA49127 B1 MA 49127B1 MA 49127 A MA49127 A MA 49127A MA 49127 A MA49127 A MA 49127A MA 49127 B1 MA49127 B1 MA 49127B1
- Authority
- MA
- Morocco
- Prior art keywords
- indole derivatives
- substituted indole
- formula
- derivatives
- pharmaceuticals
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne des dérivés de formule (i), dans laquelle, r1 et r2 sont tels que définis dans la description, leur préparation, des sels pharmaceutiquement acceptables de ceux-ci et leur utilisation en tant que produits pharmaceutiques, ainsi que des compositions pharmaceutiques contenant un ou plusieurs composés de formule (i), et en particulier leur utilisation en tant que modulateurs du récepteur ep2 de prostaglandine 2.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2017062008 | 2017-05-18 | ||
| PCT/EP2018/062865 WO2018210995A1 (fr) | 2017-05-18 | 2018-05-17 | Dérivés d'indole n-substitués |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA49127A MA49127A (fr) | 2021-05-26 |
| MA49127B1 true MA49127B1 (fr) | 2022-05-31 |
Family
ID=62186481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA49127A MA49127B1 (fr) | 2017-05-18 | 2018-05-17 | Dérivés d'indole n-substitués |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US20200069686A1 (fr) |
| EP (1) | EP3625224B1 (fr) |
| JP (1) | JP7065117B2 (fr) |
| KR (1) | KR102650756B1 (fr) |
| CN (1) | CN110621666A (fr) |
| AR (1) | AR111806A1 (fr) |
| AU (1) | AU2018269667B2 (fr) |
| BR (1) | BR112019024114A2 (fr) |
| CA (1) | CA3063637A1 (fr) |
| CL (1) | CL2019003257A1 (fr) |
| CO (1) | CO2019010804A2 (fr) |
| CR (1) | CR20190567A (fr) |
| CY (1) | CY1124528T1 (fr) |
| DK (1) | DK3625224T3 (fr) |
| EA (1) | EA039630B1 (fr) |
| ES (1) | ES2894124T3 (fr) |
| HR (1) | HRP20211532T1 (fr) |
| HU (1) | HUE056406T2 (fr) |
| IL (1) | IL270616B (fr) |
| LT (1) | LT3625224T (fr) |
| MA (1) | MA49127B1 (fr) |
| MX (1) | MX394108B (fr) |
| PE (1) | PE20191787A1 (fr) |
| PH (1) | PH12019502562B1 (fr) |
| PL (1) | PL3625224T3 (fr) |
| PT (1) | PT3625224T (fr) |
| RS (1) | RS62441B1 (fr) |
| SG (1) | SG11201908660RA (fr) |
| SI (1) | SI3625224T1 (fr) |
| TW (1) | TWI768043B (fr) |
| UA (1) | UA124748C2 (fr) |
| WO (1) | WO2018210995A1 (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
| KR102612140B1 (ko) | 2017-05-18 | 2023-12-08 | 이도르시아 파마슈티컬스 리미티드 | 피리미딘 유도체 |
| AR111808A1 (es) | 2017-05-18 | 2019-08-21 | Idorsia Pharmaceuticals Ltd | Derivados de pirimidina como moduladores del receptor de pge2 |
| EA201992676A1 (ru) | 2017-05-18 | 2020-05-06 | Идорсия Фармасьютиклз Лтд | Фенильные производные в качестве модуляторов pge2 рецепторов |
| US11325899B2 (en) | 2017-05-18 | 2022-05-10 | Idorsia Pharmaceuticals Ltd | Benzofurane and benzothiophene derivatives as PGE2 receptor modulators |
| WO2021060281A1 (fr) * | 2019-09-24 | 2021-04-01 | Agc株式会社 | Antagoniste double des récepteurs ep2/ep4 de la prostaglandine e2 |
| WO2021205367A1 (fr) * | 2020-04-08 | 2021-10-14 | Askat Inc. | Utilisation d'antagonistes du récepteur ep4 pour le traitement du cancer du foie, d'un mélanome, d'un lymphome et de la leucémie |
| JP7816164B2 (ja) | 2020-11-13 | 2026-02-18 | 小野薬品工業株式会社 | Ep4拮抗薬と免疫チェックポイント阻害物質との併用によるがん治療 |
| TW202604507A (zh) | 2024-05-02 | 2026-02-01 | 瑞士商愛杜西亞製藥有限公司 | 經n-取代之吲哚衍生物的結晶形式 |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2000234451B2 (en) | 2000-03-24 | 2005-09-29 | Asterand Uk Acquisition Limited | Use of prostanoid ep4 receptor antagonists for the treatment of headache and assays for such antagonists |
| HN2001000224A (es) | 2000-10-19 | 2002-06-13 | Pfizer | Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos. |
| GB0031302D0 (en) | 2000-12-21 | 2001-01-31 | Glaxo Group Ltd | Napthalene derivatives |
| GB0031295D0 (en) | 2000-12-21 | 2001-01-31 | Glaxo Group Ltd | Naphthalene derivatives |
| GB0103269D0 (en) | 2001-02-09 | 2001-03-28 | Glaxo Group Ltd | Napthalene derivatives |
| MXPA04009961A (es) | 2002-04-12 | 2004-12-13 | Pfizer | Compuestos de imidazol como agentes anti-inflamatorios y analgesicos. |
| JP2005532291A (ja) | 2002-04-12 | 2005-10-27 | ファイザー株式会社 | 抗炎症薬および鎮痛薬としてのピラゾール化合物 |
| CA2485485A1 (fr) | 2002-05-23 | 2003-12-04 | Theratechnologies Inc. | Peptides antagonistes du soustype ep4 des recepteurs de la prostaglandine e2 |
| CN100408570C (zh) | 2003-01-29 | 2008-08-06 | 阿斯特兰德英国有限公司 | Ep4受体拮抗剂 |
| CN1871240B (zh) * | 2003-08-26 | 2012-11-07 | 帝人制药株式会社 | 吡咯并嘧啶酮衍生物 |
| CA2536870C (fr) | 2003-09-03 | 2009-10-27 | Pfizer Inc. | Composes de phenyle ou de pyridyle amide utiles comme antagonistes de la prostaglandine e2 |
| GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| KR20070006890A (ko) | 2004-05-04 | 2007-01-11 | 화이자 인코포레이티드 | 오르토 치환된 아릴 또는 헤테로아릴 아마이드 화합물 |
| AU2005238291A1 (en) | 2004-05-04 | 2005-11-10 | Pfizer Inc. | Substituted methyl aryl or heteroaryl amide compounds |
| HN2005000795A (es) | 2004-10-15 | 2010-08-19 | Aventis Pharma Inc | Pirimidinas como antagonistas del receptor de prostaglandina d2 |
| ATE533766T1 (de) | 2005-05-19 | 2011-12-15 | Merck Canada Inc | Chinolinderivate als ep4-antagonisten |
| WO2006128129A2 (fr) | 2005-05-26 | 2006-11-30 | Synta Pharmaceuticals Corp. | Traitement anticancereux |
| JP5244091B2 (ja) | 2006-04-24 | 2013-07-24 | メルク カナダ インコーポレイテッド | Ep4受容体アンタゴニストとしてのインドールアミド誘導体 |
| CA2654811A1 (fr) | 2006-06-12 | 2007-12-21 | Merck Frosst Canada Ltd. | Derives amide de l'indoline en tant que ligands du recepteur ep4 |
| WO2008008059A1 (fr) | 2006-07-12 | 2008-01-17 | Locus Pharmaceuticals, Inc. | Agents anti-cancer et leurs utilisations |
| CA2657227A1 (fr) | 2006-07-14 | 2008-01-17 | Novartis Ag | Derives de la pyrimidine en tant qu'inhibiteurs d'alk-5 |
| AU2007283404B2 (en) | 2006-08-11 | 2013-04-18 | Merck Canada Inc. | Thiophenecarboxamide derivatives as EP4 receptor ligands |
| WO2008039882A1 (fr) | 2006-09-30 | 2008-04-03 | Sanofi-Aventis U.S. Llc | Combinaison de niacine et d'un antagoniste du récepteur de prostaglandine d2 |
| CA2679175C (fr) | 2007-02-26 | 2015-01-13 | Merck Frosst Canada Ltd. | Derives d'indole et indoline cyclopropyl amide comme antagonistes du recepteur ep4 |
| CN101636385B (zh) | 2007-03-26 | 2012-09-05 | 默克弗罗斯特加拿大有限公司 | 作为ep4受体拮抗剂的萘和喹啉磺酰脲衍生物 |
| KR20090122931A (ko) | 2007-03-26 | 2009-12-01 | 아스테라스 세이야쿠 가부시키가이샤 | 오르니틴 유도체 |
| EP2014657A1 (fr) | 2007-06-21 | 2009-01-14 | Bayer Schering Pharma Aktiengesellschaft | Diaminopyrimidine en tant que modulateurs du récepteur EP2 |
| EP2172447A4 (fr) | 2007-07-03 | 2011-08-24 | Astellas Pharma Inc | Composé amide |
| ES2518919T3 (es) | 2008-05-14 | 2014-11-05 | Astellas Pharma Inc. | Derivados del ácido 4-(Indol-7-ilcarbonilaminometil)ciclohexanocarboxílico como antagonistas del receptor EP4 útiles para el tratamiento de la insuficiencia renal crónica o la nefropatía diabética |
| CN102149384B (zh) | 2008-08-14 | 2014-08-20 | 南京奥昭生物科技有限公司 | 作为ep4受体拮抗剂的杂环酰胺衍生物 |
| CN102164942B (zh) | 2008-09-19 | 2017-02-15 | 生物科技研究有限公司 | 三萜系化合物及其使用的方法 |
| MX2011003166A (es) | 2008-09-25 | 2011-04-27 | Merck Frosst Canada Ltd | Derivados de sulfonilurea beta-carbolina como antagonistas del receptor ep4. |
| BR112012029647A2 (pt) | 2010-05-21 | 2016-08-02 | Chemilia Ab | novos derivados de pirimidinas |
| WO2012039972A1 (fr) | 2010-09-21 | 2012-03-29 | Eisai R&D Management Co., Ltd. | Composition pharmaceutique |
| ES2537017T3 (es) | 2010-09-29 | 2015-06-01 | Nb Health Laboratory Co. Ltd. | Anticuerpo dirigido contra el receptor EP4 de la prostaglandina E2 humano |
| WO2012076063A1 (fr) | 2010-12-10 | 2012-06-14 | Rottapharm S.P.A. | Dérivés de pyridinamide en tant qu'antagonistes de récepteur ep4 |
| WO2012103071A2 (fr) | 2011-01-25 | 2012-08-02 | Eisai R&D Management Co., Ltd. | Composés et compositions |
| MX2013010898A (es) * | 2011-03-24 | 2013-12-06 | Chemilia Ab | Novedoso derivados de la pirimidina. |
| PL2729445T3 (pl) | 2011-07-04 | 2016-04-29 | Rottapharm Biotech Srl | Cykliczne pochodne aminowe jako antagoniści receptora EP4 |
| EP2554662A1 (fr) | 2011-08-05 | 2013-02-06 | M Maria Pia Cosma | Procédés pour le traitement de maladies rétiniennes dégénératives |
| WO2013090552A1 (fr) | 2011-12-13 | 2013-06-20 | Yale University | Compositions et procédés pour la réduction de l'épuisement de ctl |
| SG11201406584TA (en) | 2012-04-24 | 2014-11-27 | Vertex Pharma | Dna-pk inhibitors |
| TWI572597B (zh) | 2012-06-29 | 2017-03-01 | 美國禮來大藥廠 | 二甲基-苯甲酸化合物 |
| AR091429A1 (es) | 2012-06-29 | 2015-02-04 | Lilly Co Eli | Compuestos de fenoxietil piperidina |
| UA115576C2 (uk) | 2012-12-06 | 2017-11-27 | Байєр Фарма Акцієнгезелльшафт | Похідні бензимідазолу як антагоністи ер4 |
| EP2765128A1 (fr) | 2013-02-07 | 2014-08-13 | Almirall, S.A. | Benzamides substitués présentant une activité vis-à-vis de récepteurs EP4 |
| TW201443004A (zh) | 2013-02-15 | 2014-11-16 | Lilly Co Eli | 苯氧基乙氧基化合物 |
| TWI636046B (zh) | 2013-05-17 | 2018-09-21 | 美國禮來大藥廠 | 苯氧基乙基二氫-1h-異喹啉化合物 |
| CN105431416B (zh) | 2013-06-12 | 2019-01-08 | 科研制药株式会社 | 4-炔基咪唑衍生物和含有其作为有效成分的药物 |
| MX2016002544A (es) | 2013-09-04 | 2016-06-17 | Squibb Bristol Myers Co | Compuestos utiles como inmunomoduladores. |
| RS57508B1 (sr) | 2013-09-06 | 2018-10-31 | Aurigene Discovery Tech Ltd | 1,2,4-derivati oksadiazola kao imunomodulatori |
| WO2015044900A1 (fr) | 2013-09-27 | 2015-04-02 | Aurigene Discovery Technologies Limited | Composés immunomodulateurs thérapeutiques |
| SI3057959T1 (en) | 2013-10-17 | 2018-07-31 | Vertex Pharmaceuticals Incorporated | DNA-PK INHIBITORS |
| JP6200596B2 (ja) | 2013-12-17 | 2017-09-20 | イーライ リリー アンド カンパニー | ジメチル安息香酸化合物 |
| HUE035698T2 (en) | 2013-12-17 | 2018-05-28 | Lilly Co Eli | Phenoxyethyl ring amine derivatives and their activity as EP4 receptor modulator |
| TW201607943A (zh) | 2013-12-19 | 2016-03-01 | 拜耳製藥公司 | 作為ep4配體之新穎苯并咪唑衍生物 |
| TW201623277A (zh) | 2014-03-26 | 2016-07-01 | 安斯泰來製藥股份有限公司 | 醯胺化合物 |
| SG11201609770TA (en) | 2014-05-23 | 2016-12-29 | Eisai R&D Man Co Ltd | Combination therapies for the treatment of cancer |
| WO2016021742A1 (fr) | 2014-08-07 | 2016-02-11 | Takeda Pharmaceutical Company Limited | Composés hétérocycliques utilisés en tant qu'antagonistes des récepteurs ccr4 |
| WO2016054807A1 (fr) * | 2014-10-10 | 2016-04-14 | Merck Sharp & Dohme Corp. | Inhibiteurs de la kinase trka, compositions en contenant et méthodes associées |
| HUE052969T2 (hu) | 2015-01-09 | 2021-05-28 | Ono Pharmaceutical Co | Triciklusos spiro vegyület |
| JP6689297B2 (ja) | 2015-07-23 | 2020-04-28 | 武田薬品工業株式会社 | 複素環化合物 |
| CA3002144C (fr) | 2015-10-16 | 2024-01-23 | Eisai R&D Management Co., Ltd. | Antagonistes d'ep4 |
-
2018
- 2018-05-17 PE PE2019002413A patent/PE20191787A1/es unknown
- 2018-05-17 LT LTEPPCT/EP2018/062865T patent/LT3625224T/lt unknown
- 2018-05-17 SI SI201830413T patent/SI3625224T1/sl unknown
- 2018-05-17 WO PCT/EP2018/062865 patent/WO2018210995A1/fr not_active Ceased
- 2018-05-17 BR BR112019024114-0A patent/BR112019024114A2/pt not_active Application Discontinuation
- 2018-05-17 CN CN201880031869.9A patent/CN110621666A/zh active Pending
- 2018-05-17 PL PL18725223T patent/PL3625224T3/pl unknown
- 2018-05-17 MX MX2019013639A patent/MX394108B/es unknown
- 2018-05-17 RS RS20211259A patent/RS62441B1/sr unknown
- 2018-05-17 CA CA3063637A patent/CA3063637A1/fr active Pending
- 2018-05-17 PT PT18725223T patent/PT3625224T/pt unknown
- 2018-05-17 AR ARP180101311A patent/AR111806A1/es not_active Application Discontinuation
- 2018-05-17 EP EP18725223.4A patent/EP3625224B1/fr active Active
- 2018-05-17 CR CR20190567A patent/CR20190567A/es unknown
- 2018-05-17 HR HRP20211532TT patent/HRP20211532T1/hr unknown
- 2018-05-17 UA UAA201911973A patent/UA124748C2/uk unknown
- 2018-05-17 DK DK18725223.4T patent/DK3625224T3/da active
- 2018-05-17 EA EA201992679A patent/EA039630B1/ru unknown
- 2018-05-17 MA MA49127A patent/MA49127B1/fr unknown
- 2018-05-17 HU HUE18725223A patent/HUE056406T2/hu unknown
- 2018-05-17 JP JP2019563494A patent/JP7065117B2/ja not_active Expired - Fee Related
- 2018-05-17 PH PH1/2019/502562A patent/PH12019502562B1/en unknown
- 2018-05-17 KR KR1020197037058A patent/KR102650756B1/ko active Active
- 2018-05-17 US US16/614,268 patent/US20200069686A1/en not_active Abandoned
- 2018-05-17 SG SG11201908660R patent/SG11201908660RA/en unknown
- 2018-05-17 AU AU2018269667A patent/AU2018269667B2/en not_active Ceased
- 2018-05-17 ES ES18725223T patent/ES2894124T3/es active Active
- 2018-05-17 TW TW107116708A patent/TWI768043B/zh not_active IP Right Cessation
-
2019
- 2019-09-30 CO CONC2019/0010804A patent/CO2019010804A2/es unknown
- 2019-11-13 IL IL270616A patent/IL270616B/en unknown
- 2019-11-14 CL CL2019003257A patent/CL2019003257A1/es unknown
-
2021
- 2021-09-27 CY CY20211100841T patent/CY1124528T1/el unknown
-
2022
- 2022-11-27 US US18/058,873 patent/US20230165859A1/en not_active Abandoned
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