MA44965A - Dérivés de pyridinyle, compositions pharmaceutiques et utilisations de ceux-ci en tant qu'inhibiteurs d'aoc3 - Google Patents
Dérivés de pyridinyle, compositions pharmaceutiques et utilisations de ceux-ci en tant qu'inhibiteurs d'aoc3Info
- Publication number
- MA44965A MA44965A MA044965A MA44965A MA44965A MA 44965 A MA44965 A MA 44965A MA 044965 A MA044965 A MA 044965A MA 44965 A MA44965 A MA 44965A MA 44965 A MA44965 A MA 44965A
- Authority
- MA
- Morocco
- Prior art keywords
- pharmaceutical compositions
- pyridinyl derivatives
- aoc3 inhibitors
- aoc3
- inhibitors
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 101000694615 Homo sapiens Membrane primary amine oxidase Proteins 0.000 title 1
- 102100027159 Membrane primary amine oxidase Human genes 0.000 title 1
- FIULGFJIHJJXMT-UHFFFAOYSA-N [C]1[N]C=CC=C1 Chemical class [C]1[N]C=CC=C1 FIULGFJIHJJXMT-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La présente invention concerne de nouveaux dérivés de pyridinyle de formule (i) dans laquelle r1 et a sont tels que définis dans la description et les revendications, leur utilisation en tant que médicaments, des procédés pour leur utilisation thérapeutique et des compositions pharmaceutiques les contenant.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16169356 | 2016-05-12 | ||
| PCT/EP2017/060890 WO2017194453A1 (fr) | 2016-05-12 | 2017-05-08 | Dérivés de pyridinyle, compositions pharmaceutiques et utilisations de ceux-ci en tant qu'inhibiteurs d'aoc3 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA44965A true MA44965A (fr) | 2019-03-20 |
| MA44965B1 MA44965B1 (fr) | 2021-02-26 |
Family
ID=55967162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA44965A MA44965B1 (fr) | 2016-05-12 | 2017-05-08 | Dérivés de pyridinyle, compositions pharmaceutiques et utilisations de ceux-ci en tant qu'inhibiteurs d'aoc3 |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US9926292B2 (fr) |
| EP (1) | EP3455216B1 (fr) |
| JP (1) | JP6639702B2 (fr) |
| KR (1) | KR20190003995A (fr) |
| CN (1) | CN109153664B (fr) |
| AR (1) | AR108462A1 (fr) |
| AU (1) | AU2017262707B2 (fr) |
| CA (1) | CA3023805A1 (fr) |
| CL (1) | CL2018003158A1 (fr) |
| CO (1) | CO2018012020A2 (fr) |
| CY (1) | CY1123744T1 (fr) |
| DK (1) | DK3455216T3 (fr) |
| EA (1) | EA037188B1 (fr) |
| ES (1) | ES2844926T3 (fr) |
| HR (1) | HRP20202078T1 (fr) |
| HU (1) | HUE053312T2 (fr) |
| IL (1) | IL262662B (fr) |
| JO (1) | JOP20170115B1 (fr) |
| LT (1) | LT3455216T (fr) |
| MA (1) | MA44965B1 (fr) |
| MX (1) | MX379327B (fr) |
| PE (1) | PE20190151A1 (fr) |
| PH (1) | PH12018502376B1 (fr) |
| PL (1) | PL3455216T3 (fr) |
| PT (1) | PT3455216T (fr) |
| RS (1) | RS61256B1 (fr) |
| SA (1) | SA518400393B1 (fr) |
| SG (1) | SG11201809687TA (fr) |
| SI (1) | SI3455216T1 (fr) |
| TW (1) | TWI746551B (fr) |
| UA (1) | UA121930C2 (fr) |
| WO (1) | WO2017194453A1 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210113561A1 (en) * | 2018-04-17 | 2021-04-22 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| CN112789277B (zh) * | 2018-10-22 | 2022-11-04 | 广东东阳光药业有限公司 | 胍类衍生物及其用途 |
| JP7425793B2 (ja) | 2018-10-29 | 2024-01-31 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ピリジニルスルホンアミド誘導体、医薬組成物およびそれらの使用 |
| CA3112510A1 (fr) * | 2018-10-29 | 2020-05-07 | Boehringer Ingelheim International Gmbh | Derives de pyridinyl sulfonamide, compositions pharmaceutiques et leurs utilisations |
| MX2022005199A (es) | 2019-10-29 | 2022-08-04 | Eccogene Shanghai Co Ltd | Inhibidores de ssao y uso de los mismos. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19518073A1 (de) * | 1995-05-17 | 1996-11-21 | Hoechst Ag | Substituierte Benzyloxycarbonylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| WO2005020921A2 (fr) * | 2003-08-29 | 2005-03-10 | Exelixis, Inc. | Modulateurs c-kit et leurs procedes d'utilisation |
| DE602005013793D1 (de) * | 2004-07-27 | 2009-05-20 | Astellas Pharma Inc | Thiazolderivate mit vap-1-hemmender wirkung |
| EP2479165B1 (fr) * | 2009-09-16 | 2017-10-25 | Astellas Pharma Inc. | Composé de glycine |
| KR101879011B1 (ko) * | 2011-03-15 | 2018-07-16 | 아스테라스 세이야쿠 가부시키가이샤 | 구아니딘 화합물 |
| EP3333163A4 (fr) | 2015-08-06 | 2019-01-09 | UBE Industries, Ltd. | Dérivé de guanidine substitué |
-
2017
- 2017-05-08 SI SI201730584T patent/SI3455216T1/sl unknown
- 2017-05-08 DK DK17721706.4T patent/DK3455216T3/da active
- 2017-05-08 WO PCT/EP2017/060890 patent/WO2017194453A1/fr not_active Ceased
- 2017-05-08 EP EP17721706.4A patent/EP3455216B1/fr active Active
- 2017-05-08 EA EA201892539A patent/EA037188B1/ru not_active IP Right Cessation
- 2017-05-08 LT LTEP17721706.4T patent/LT3455216T/lt unknown
- 2017-05-08 HU HUE17721706A patent/HUE053312T2/hu unknown
- 2017-05-08 RS RS20201583A patent/RS61256B1/sr unknown
- 2017-05-08 CN CN201780027576.9A patent/CN109153664B/zh active Active
- 2017-05-08 PL PL17721706T patent/PL3455216T3/pl unknown
- 2017-05-08 US US15/588,739 patent/US9926292B2/en active Active
- 2017-05-08 PT PT177217064T patent/PT3455216T/pt unknown
- 2017-05-08 MA MA44965A patent/MA44965B1/fr unknown
- 2017-05-08 AU AU2017262707A patent/AU2017262707B2/en not_active Ceased
- 2017-05-08 HR HRP20202078TT patent/HRP20202078T1/hr unknown
- 2017-05-08 CA CA3023805A patent/CA3023805A1/fr active Pending
- 2017-05-08 UA UAA201812102A patent/UA121930C2/uk unknown
- 2017-05-08 PE PE2018002340A patent/PE20190151A1/es unknown
- 2017-05-08 KR KR1020187035976A patent/KR20190003995A/ko not_active Abandoned
- 2017-05-08 JP JP2018559351A patent/JP6639702B2/ja active Active
- 2017-05-08 SG SG11201809687TA patent/SG11201809687TA/en unknown
- 2017-05-08 ES ES17721706T patent/ES2844926T3/es active Active
- 2017-05-08 MX MX2018013701A patent/MX379327B/es unknown
- 2017-05-11 JO JOP/2017/0115A patent/JOP20170115B1/ar active
- 2017-05-11 AR ARP170101262A patent/AR108462A1/es not_active Application Discontinuation
- 2017-05-11 TW TW106115558A patent/TWI746551B/zh not_active IP Right Cessation
-
2018
- 2018-10-29 IL IL262662A patent/IL262662B/en unknown
- 2018-11-06 CO CONC2018/0012020A patent/CO2018012020A2/es unknown
- 2018-11-07 SA SA518400393A patent/SA518400393B1/ar unknown
- 2018-11-08 CL CL2018003158A patent/CL2018003158A1/es unknown
- 2018-11-12 PH PH12018502376A patent/PH12018502376B1/en unknown
-
2021
- 2021-01-19 CY CY20211100039T patent/CY1123744T1/el unknown
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