MA49514A - Particules virales recombinantes avec tropisme modifié, et leurs utilisations pour l'introduction ciblée de matériel génétique dans des cellules humaines - Google Patents

Particules virales recombinantes avec tropisme modifié, et leurs utilisations pour l'introduction ciblée de matériel génétique dans des cellules humaines

Info

Publication number
MA49514A
MA49514A MA049514A MA49514A MA49514A MA 49514 A MA49514 A MA 49514A MA 049514 A MA049514 A MA 049514A MA 49514 A MA49514 A MA 49514A MA 49514 A MA49514 A MA 49514A
Authority
MA
Morocco
Prior art keywords
human cells
genetic material
viral particles
recombinant viral
targeted introduction
Prior art date
Application number
MA049514A
Other languages
English (en)
Other versions
MA49514B1 (fr
Inventor
Aris N Economides
Christos Kyratsous
Andrew J Murphy
Leah Sabin
Christopher Schoenherr
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=63080488&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA49514(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MA49514A publication Critical patent/MA49514A/fr
Publication of MA49514B1 publication Critical patent/MA49514B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14123—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14145—Special targeting system for viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151—Methods of production or purification of viral material
    • C12N2750/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MA49514A 2017-06-27 2018-06-27 Particules virales recombinantes avec tropisme modifié, et leurs utilisations pour l'introduction ciblée de matériel génétique dans des cellules humaines MA49514B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762525708P 2017-06-27 2017-06-27
PCT/US2018/039878 WO2019006046A2 (fr) 2017-06-27 2018-06-27 Particules virales recombinées à tropisme modifié et utilisations associées pour l'introduction ciblée de matériel génétique dans des cellules humaines

Publications (2)

Publication Number Publication Date
MA49514A true MA49514A (fr) 2020-05-06
MA49514B1 MA49514B1 (fr) 2023-06-28

Family

ID=63080488

Family Applications (1)

Application Number Title Priority Date Filing Date
MA49514A MA49514B1 (fr) 2017-06-27 2018-06-27 Particules virales recombinantes avec tropisme modifié, et leurs utilisations pour l'introduction ciblée de matériel génétique dans des cellules humaines

Country Status (30)

Country Link
US (1) US20200140492A1 (fr)
EP (4) EP4706687A3 (fr)
JP (5) JP2020525020A (fr)
KR (3) KR20200021987A (fr)
CN (2) CN116891534A (fr)
AU (4) AU2018290885B2 (fr)
BR (1) BR112019027866A2 (fr)
CA (1) CA3066950A1 (fr)
CL (3) CL2019003843A1 (fr)
CO (1) CO2019014684A2 (fr)
CY (1) CY1126149T1 (fr)
DK (1) DK3645553T5 (fr)
ES (1) ES2943020T3 (fr)
FI (1) FI3645553T3 (fr)
HR (1) HRP20230538T1 (fr)
HU (1) HUE061908T2 (fr)
IL (2) IL318395A (fr)
LT (1) LT3645553T (fr)
MA (1) MA49514B1 (fr)
MD (1) MD3645553T2 (fr)
MX (2) MX2020000246A (fr)
PE (2) PE20251541A1 (fr)
PH (1) PH12019550269B1 (fr)
PL (1) PL3645553T3 (fr)
PT (1) PT3645553T (fr)
RS (1) RS64233B1 (fr)
SG (1) SG11201911614XA (fr)
SI (1) SI3645553T1 (fr)
SM (1) SMT202300168T1 (fr)
WO (1) WO2019006046A2 (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10577627B2 (en) 2014-06-09 2020-03-03 Voyager Therapeutics, Inc. Chimeric capsids
US12421525B2 (en) 2018-02-28 2025-09-23 University of Pittsburgh—of the Commonwealth System of Higher Education Conjugates comprising AAVs and CAS9 polypeptides
EP3774926A1 (fr) 2018-04-05 2021-02-17 Bio-Rad ABD Serotec GmbH Systèmes d'affichage pour protéines d'intérêt
GB201903479D0 (en) * 2019-03-14 2019-05-01 Univ Oxford Innovation Ltd Polypeptide with enchanced rate of spontaneous isopeptide bond formation with it's peptide tag partner and uses thereof
CN113874518B (zh) * 2019-03-18 2025-04-25 生物辐射Abd瑟罗泰克有限公司 保护含SpyTag的周质融合蛋白免于蛋白酶Tsp和OmpT降解
AU2020283537A1 (en) * 2019-05-24 2021-12-16 Regeneron Pharmaceuticals, Inc. Modified viral particles and uses thereof
US12215288B2 (en) * 2019-06-11 2025-02-04 Chevron U.S.A. Inc. Membranes for contaminant removal from natural gas and methods for use thereof
BR112021026309A2 (pt) * 2019-06-26 2022-06-07 Ap Biosciences Inc Anticorpos para ativação de células t
GB201915905D0 (en) * 2019-11-01 2019-12-18 Spybiotech Ltd Viruses with modified capsid proteins
EP4055030A4 (fr) 2019-11-08 2024-05-22 President And Fellows Of Harvard College Polypeptides de capside virale
EP4055034A4 (fr) 2019-11-08 2024-05-29 President And Fellows Of Harvard College Polypeptides de capside virale
CN114632148B (zh) * 2020-12-15 2024-08-09 榕森生物科技(北京)有限公司 病原样抗原疫苗及其制备方法
CN114634578B (zh) * 2020-12-15 2024-04-02 榕森生物科技(北京)有限公司 针对新型冠状病毒感染的疫苗组合物
MX2024005314A (es) 2021-11-04 2024-05-17 Regeneron Pharma Particulas virales redirigidas a musculo esqueletico.
CN114213505B (zh) * 2021-12-10 2022-09-20 和元生物技术（上海）股份有限公司 一种适用于特异感染u87-mg细胞的腺相关病毒突变体
US12584145B2 (en) 2022-04-15 2026-03-24 Washington University Conjugate systems and methods of use thereof
AU2023269134A1 (en) 2022-05-09 2024-12-12 Regeneron Pharmaceuticals, Inc. Vectors and methods for in vivo antibody production
WO2023240124A1 (fr) 2022-06-07 2023-12-14 Regeneron Pharmaceuticals, Inc. Particules virales pseudotypées pour le ciblage de cellules exprimant un tcr
MA71631A (fr) 2022-07-29 2025-05-30 Regeneron Pharmaceuticals, Inc. Particules virales reciblées vers le récepteur 1 de transferrine
AU2023379457A1 (en) 2022-11-14 2025-05-15 Regeneron Pharmaceuticals, Inc. Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
US20240168018A1 (en) 2022-11-18 2024-05-23 Regeneron Pharmaceuticals, Inc. Methods for detecting and evaluating viruses and virus-like particles
WO2024124019A2 (fr) * 2022-12-07 2024-06-13 Ginkgo Bioworks, Inc. Vecteurs aav ciblant des cellules souches hématopoïétiques
CN115819628B (zh) * 2022-12-28 2026-07-28 河南赛诺特生物技术有限公司 一种高免疫原性与反应性的cd47膜蛋白及其制备方法和应用
WO2024173248A1 (fr) 2023-02-13 2024-08-22 Regeneron Pharmaceuticals, Inc. Traitement de troubles musculaires avec des anticorps anti-cacng1 humains
CN121039163A (zh) 2023-05-02 2025-11-28 瑞泽恩制药公司 抗人m-钙粘蛋白（cdh15）抗体、缀合物及其用于将遗传有效负载递送至肌肉细胞的用途
WO2024263705A2 (fr) 2023-06-20 2024-12-26 Regeneron Pharmaceuticals, Inc. Procédés de purification de capsides de virus adéno-associé remplies
JPWO2025018388A1 (fr) * 2023-07-20 2025-01-23
CN119552829A (zh) * 2023-09-01 2025-03-04 北京昌平实验室 靶向性基因编辑酶工程化的腺相关病毒及其药物组合物
CN121794393A (zh) 2023-09-07 2026-04-03 里珍纳龙药品有限公司 经共价表面修饰的腺相关病毒的生产和纯化
WO2025084336A1 (fr) 2023-10-17 2025-04-24 国立大学法人大阪大学 Molécule pouvant se lier simultanément à une capside de vaa et à un récepteur cible
WO2025097030A1 (fr) * 2023-11-02 2025-05-08 Oregon State University Particules pseudo-virales présentant des antigènes de neisseria gonorrhoeae et leur utilisation pour l'immunisation contre la gonorrhée
WO2025111473A1 (fr) 2023-11-21 2025-05-30 Regeneron Pharmaceuticals, Inc. Production de virus adéno-associés modifiés en surface de manière covalente par conjugaison in vitro et purification de virus adéno-associés modifiés en surface de manière covalente
AU2025207849A1 (en) 2024-01-11 2026-07-16 Regeneron Pharmaceuticals, Inc. Viral particles retargeted to nervous system tissues
WO2025155923A1 (fr) 2024-01-17 2025-07-24 The Broad Institute, Inc. Modifications de capsides de vaa permettant une administration améliorée de gènes à l'échelle du snc par l'intermédiaire d'interactions avec le récepteur de la transferrine
WO2025160340A2 (fr) 2024-01-26 2025-07-31 Regeneron Pharmaceuticals, Inc. Immunosuppression combinée pour inhiber une réponse immunitaire et pour permettre une administration et une réadministration d'immunogène
CN117723749B (zh) * 2024-02-07 2024-06-04 南昌大学 基于分子粘合剂的动态光散射免疫传感检测方法
US20250277048A1 (en) 2024-03-01 2025-09-04 Regeneron Pharmaceuticals, Inc. The use of cd40 inhibitors for inhibiting an immune response and enabling immunogen administration and re-administration
WO2025217174A1 (fr) 2024-04-08 2025-10-16 The Broad Institute, Inc. Modifications de capside d'aav qui permettent une délivrance améliorée de gènes à l'échelle du snc par l'intermédiaire d'interactions avec l'anhydrase carbonique iv
WO2025217163A2 (fr) 2024-04-08 2025-10-16 The Broad Institute, Inc. Nouveaux capsides aav se liant à cd59 humain
WO2026025058A1 (fr) 2024-07-25 2026-01-29 Regeneron Pharmaceuticals, Inc. Particules virales d'aav reciblées sur des cellules cancéreuses exprimant le r-egf
WO2026039325A2 (fr) 2024-08-12 2026-02-19 Regeneron Pharmaceuticals, Inc. Gènes mtm1 modifiés et utilisations associées
WO2026050618A1 (fr) 2024-08-29 2026-03-05 Regeneron Pharmaceuticals, Inc. Constructions polynucléotidiques et lignées cellulaires de production d'aav recombinants
WO2026112457A2 (fr) 2024-11-21 2026-05-28 Regeneron Pharmaceuticals, Inc. Molécules de liaison à l'antigène hétérodimères qui se lient à des particules virales et leurs utilisations
CN119529113A (zh) * 2024-11-28 2025-02-28 浙江大学 一种基于PCV2 VLPs的纳米抗原展示平台及制备方法和应用
CN120519522B (zh) * 2025-07-23 2025-11-18 南昌大学第一附属医院 基于双向负载模块的通用工程外泌体构建方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1286981C (zh) * 2004-11-30 2006-11-29 华中科技大学同济医学院附属同济医院 表达人类cyp2j2反义基因的重组腺相关病毒及其制备方法
EP2158211B1 (fr) 2007-05-31 2016-08-10 Medigene AG Protéine structurale mutée d'un parvovirus
WO2011072204A1 (fr) 2009-12-10 2011-06-16 Regeneron Pharmaceuticals, Inc. Souris fabriquant des anticorps à chaînes lourdes
GB201002362D0 (en) 2010-02-11 2010-03-31 Isis Innovation Peptide tag systems that spontaneously form an irreversible link to protein partners via isopeptide bonds
AR094403A1 (es) 2013-01-11 2015-07-29 Hoffmann La Roche Terapia de combinación de anticuerpos anti-her3
AU2015230938C1 (en) 2014-03-21 2021-10-14 Regeneron Pharmaceuticals, Inc. Non-human animals that make single domain binding proteins
US20160018835A1 (en) * 2014-07-18 2016-01-21 Retroficiency, Inc. System and method for virtual energy assessment of facilities
AU2016207099C1 (en) * 2015-01-15 2021-02-04 University Of Copenhagen Virus-like particle with efficient epitope display
CN107438625A (zh) 2015-02-26 2017-12-05 Var2制药有限公司 使用嵌合抗原受体（cars）的胎盘样硫酸软骨素的免疫治疗靶向和使用具有分割蛋白结合系统的cars的癌症的免疫治疗靶向
EP3141600A1 (fr) 2015-09-11 2017-03-15 Institut National de la Recherche Agronomique Polypeptides de fusion de la proteine d'enveloppe de nepovirus et leurs utilisations
CA3034089A1 (fr) * 2016-08-18 2018-02-22 The Regents Of The University Of California Ingenierie genomique de crispr-cas par l'intermediaire d'un systeme d'administration d'aav modulaire
US12421525B2 (en) 2018-02-28 2025-09-23 University of Pittsburgh—of the Commonwealth System of Higher Education Conjugates comprising AAVs and CAS9 polypeptides

Also Published As

Publication number Publication date
CA3066950A1 (fr) 2019-01-03
CO2019014684A2 (es) 2020-01-17
ES2943020T3 (es) 2023-06-08
EP4706687A3 (fr) 2026-07-15
PT3645553T (pt) 2023-05-08
EP4706687A2 (fr) 2026-03-11
MD3645553T2 (ro) 2023-07-31
CY1126149T1 (el) 2023-11-15
DK3645553T5 (da) 2024-08-26
PH12019550269B1 (en) 2024-05-22
AU2018290885A1 (en) 2020-01-16
SG11201911614XA (en) 2020-01-30
CL2020003438A1 (es) 2021-07-23
AU2023204611A1 (en) 2023-08-03
HUE061908T2 (hu) 2023-09-28
MX2020000246A (es) 2020-08-10
CL2019003843A1 (es) 2020-07-24
SMT202300168T1 (it) 2023-07-20
JP2024071769A (ja) 2024-05-24
JP2022186991A (ja) 2022-12-15
RU2020101596A (ru) 2021-07-27
PH12019550269A1 (en) 2021-01-11
JP2025129257A (ja) 2025-09-04
IL318395A (en) 2025-03-01
AU2018290885B2 (en) 2023-07-27
SI3645553T1 (sl) 2023-06-30
PE20251541A1 (es) 2025-06-05
IL271570B1 (en) 2026-01-01
JP2020525020A (ja) 2020-08-27
EP4706688A2 (fr) 2026-03-11
MA49514B1 (fr) 2023-06-28
US20200140492A1 (en) 2020-05-07
MX2023009051A (es) 2023-08-10
KR20200021987A (ko) 2020-03-02
CN116891534A (zh) 2023-10-17
EP4706688A3 (fr) 2026-05-27
WO2019006046A2 (fr) 2019-01-03
AU2026200716A1 (en) 2026-02-19
PE20200895A1 (es) 2020-09-08
CN110997699A (zh) 2020-04-10
RU2020101596A3 (fr) 2022-03-22
DK3645553T3 (da) 2023-05-22
CL2025002293A1 (es) 2025-11-14
IL271570A (en) 2020-02-27
EP4219529A1 (fr) 2023-08-02
BR112019027866A2 (pt) 2020-07-07
IL271570B2 (en) 2026-05-01
HRP20230538T1 (hr) 2023-08-04
LT3645553T (lt) 2023-04-25
KR20250091321A (ko) 2025-06-20
EP3645553A2 (fr) 2020-05-06
PL3645553T3 (pl) 2023-07-17
RS64233B1 (sr) 2023-06-30
JP2026127663A (ja) 2026-08-06
AU2026200717A1 (en) 2026-02-19
KR20260039813A (ko) 2026-03-20
WO2019006046A3 (fr) 2019-02-14
AU2023204611B2 (en) 2025-10-30
EP3645553B1 (fr) 2023-03-15
FI3645553T3 (fi) 2023-05-22

Similar Documents

Publication Publication Date Title
MA49513A (fr) Vecteurs viraux recombinés à tropisme modifié et utilisations associées pour l'introduction ciblée de matériel génétique dans des cellules humaines
IL271570A (en) Recombinant viral particles that have undergone a tropism change and their uses for the targeted introduction of genetic material into human cells
EP3638317A4 (fr) Insertions ciblées d'adn non viral
EP3634486A4 (fr) Anticorps multispécifiques modifiés et autres protéines multimères avec des mutations de région ch2-ch3 asymétriques
GB2578802B8 (en) Programmable DNA binding proteins that increase efficiency and/or specificity of genome targeting in eukaryotic cells for use in therapy
MA51842A (fr) Vecteurs d'adn non viraux et utilisations associées pour la production d'anticorps et de protéines de fusion
EP3642353A4 (fr) Évaluation du risque de complication d'une greffe avec l'adn acellulaire total
EP3414787A4 (fr) Matériaux d'électrode prélithiés et cellules les comprenant
EP3452055A4 (fr) Procédés perfectionnés d'édition de génome avec et sans nucléases programmables
MX2018004121A (es) Receptores de antigeno y usos de los mismos.
EP3518971A4 (fr) Formulations thérapeutiques d'anticorps et de protéines et leurs utilisations
ZA201905070B (en) Tumor selective tata-box and caat-box mutants
MA45790A (fr) Particules de type viral avec revêtement haute densité pour induire l'expression d'anticorps
EP3463299A4 (fr) Compositions de nanoémulsion de médicaments taxoïdes, et leurs procédés d'utilisation pour cibler des cellules cancéreuses et des cellules souches cancéreuses
MY202113A (en) Enterovirus 71 animal model
EP3363427A4 (fr) Composition cosmétique comprenant des particules de gommage solubles dans l'eau contenant un polypeptide et/ou une culture cellulaire
MX376266B (es) Particulas no replicantes derivadas de virus y sus usos.
EP3870718A4 (fr) Procédés et utilisations de l'introduction de mutations dans un matériel génétique pour l'assemblage du génome
EP3455360A4 (fr) Constructions d'adn pour la fabrication de polypeptides biothérapeutiques pour utilisation dans des vaccins et des agents thérapeutiques pour animaux
HUE057861T2 (hu) Eljárás genetikai kezelésre az AAV-XBP1S/GFP vírus alkalmazásával és annak alkalmazása amiotrófiás laterálszklerózis megelõzésében és kezelésében
EP3677668A4 (fr) Construction génétique et biocapteur pour la détection rapide de molécules ahls et les bactéries pathogènes qui les produisent
EP3810895A4 (fr) Levage hydraulique de potasse et autres minerais d'évaporite
TH1701000216A (th) ไซโตเมกาโลไวรัสมนุษย์ที่ประกอบรวมด้วยแอนติเจนจากภายนอก