MA49716A - Incorporation de nucléotides non naturels et procédés d'utilisationin vivo - Google Patents

Incorporation de nucléotides non naturels et procédés d'utilisationin vivo

Info

Publication number
MA49716A
MA49716A MA049716A MA49716A MA49716A MA 49716 A MA49716 A MA 49716A MA 049716 A MA049716 A MA 049716A MA 49716 A MA49716 A MA 49716A MA 49716 A MA49716 A MA 49716A
Authority
MA
Morocco
Prior art keywords
incorporation
vivo
procedures
natural nucleotides
nucleotides
Prior art date
Application number
MA049716A
Other languages
English (en)
Inventor
Vivian T Dien
Aaron W Feldman
Floyd E Romesberg
Yorke Zhang
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Publication of MA49716A publication Critical patent/MA49716A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07007—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA049716A 2017-07-11 2018-07-10 Incorporation de nucléotides non naturels et procédés d'utilisationin vivo MA49716A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762531329P 2017-07-11 2017-07-11

Publications (1)

Publication Number Publication Date
MA49716A true MA49716A (fr) 2021-04-07

Family

ID=65002437

Family Applications (1)

Application Number Title Priority Date Filing Date
MA049716A MA49716A (fr) 2017-07-11 2018-07-10 Incorporation de nucléotides non naturels et procédés d'utilisationin vivo

Country Status (4)

Country Link
US (1) US12497642B2 (fr)
EP (1) EP3651774A4 (fr)
MA (1) MA49716A (fr)
WO (1) WO2019014262A1 (fr)

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EP3129493B1 (fr) 2014-04-09 2021-07-07 The Scripps Research Institute Importation de triphosphates de nucléosides non naturels ou modifiés dans des cellules par l'intermédiaire de transporteurs de triphosphates d'acide nucléique
WO2017106767A1 (fr) 2015-12-18 2017-06-22 The Scripps Research Institute Production de nucléotides non naturels par l'utilisation d'un système crispr/cas9
ES2929047T3 (es) 2016-06-24 2022-11-24 Scripps Research Inst Transportador de nucleósido trifosfato novedoso y usos del mismo
MA49716A (fr) 2017-07-11 2021-04-07 Scripps Research Inst Incorporation de nucléotides non naturels et procédés d'utilisationin vivo
TW202426655A (zh) 2017-07-11 2024-07-01 美商新索思股份有限公司 非天然核苷酸之導入及其方法
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CN113260374A (zh) 2018-11-08 2021-08-13 新索思股份有限公司 白介素10缀合物及其用途
CA3127689A1 (fr) 2019-02-06 2020-08-13 Synthorx, Inc. Conjugues d'il-2 et methodes d'utilisation de ceux-ci
IL288941B2 (en) 2019-06-14 2025-10-01 Scripps Research Inst Reagents and methods for replication, transcription, and translation in semisynthetic organisms
WO2021030706A1 (fr) 2019-08-15 2021-02-18 Synthorx, Inc. Polythérapies immuno-oncologiques avec des conjugués d'il-2
US12344648B2 (en) 2019-08-23 2025-07-01 Synthrox, Inc. IL-15 conjugates and uses thereof
AU2020347154A1 (en) 2019-09-10 2022-03-03 Synthorx, Inc. IL-2 conjugates and methods of use to treat autoimmune diseases
EP4041247A4 (fr) * 2019-09-30 2024-03-06 The Scripps Research Institute Organismes eucaryotes semi-synthétiques
TW202128996A (zh) * 2019-10-10 2021-08-01 美商史基普研究協會 用於活體內合成非天然多肽的組合物及方法
EP4054644A1 (fr) 2019-11-04 2022-09-14 Synthorx, Inc. Conjugués d'interleukine 10 et leurs utilisations
CN115038789A (zh) 2019-12-02 2022-09-09 塑造治疗公司 治疗性编辑
KR20230027235A (ko) 2020-06-25 2023-02-27 신톡스, 인크. Il-2 콘쥬게이트 및 항-egfr 항체를 사용한 면역 종양학 병용 요법
MX2023004029A (es) 2020-10-09 2023-04-27 Synthorx Inc Terapia de combinacion de inmunoncologia con conjugados de il-2 y pembrolizumab.
CA3194880A1 (fr) 2020-10-09 2022-04-14 Carolina E. CAFFARO Therapies immuno-oncologiques avec des conjugues d'il-2
WO2022174102A1 (fr) 2021-02-12 2022-08-18 Synthorx, Inc. Polythérapie contre le cancer du poumon avec des conjugués d'il-2 et un anticorps anti-pd-1 ou un fragment de liaison à l'antigène de ce dernier
WO2022174101A1 (fr) 2021-02-12 2022-08-18 Synthorx, Inc. Polythérapie contre le cancer de la peau à l'aide de conjugués il-2 et de cemiplimab
TW202313679A (zh) 2021-06-03 2023-04-01 美商欣爍克斯公司 包含il-2接合物及pd-1拮抗劑之頭頸癌組合療法
JP2024525866A (ja) 2021-07-16 2024-07-12 アプター バイオ，インク． 遺伝子発現を調節するためのポリヌクレオチド組成物および方法
EP4452327A1 (fr) 2021-12-20 2024-10-30 Synthorx, Inc. Polythérapie contre le cancer de la tête et du cou comprenant un conjugué d'il-2 et du pembrolizumab
WO2023122750A1 (fr) 2021-12-23 2023-06-29 Synthorx, Inc. Polythérapie contre le cancer avec des conjugués d'il-2 et du cétuximab
WO2024136899A1 (fr) 2022-12-21 2024-06-27 Synthorx, Inc. Thérapie anticancéreuse avec des conjugués d'il-2 et des thérapies par récepteur antigénique chimérique
WO2024196937A1 (fr) 2023-03-20 2024-09-26 Synthorx, Inc. Thérapie anticancéreuse avec des conjugués de peg il-2
WO2025158385A1 (fr) 2024-01-25 2025-07-31 Genzyme Corporation Il-2 pégylé pour supprimer une réponse immunitaire adaptative à une thérapie génique
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US12497642B2 (en) 2025-12-16

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