MA49986A - Procédés de préparation d'oligomères morpholino phosphorodiamidate par l'intermédiaire d'une synthèse à flux rapide - Google Patents
Procédés de préparation d'oligomères morpholino phosphorodiamidate par l'intermédiaire d'une synthèse à flux rapideInfo
- Publication number
- MA49986A MA49986A MA049986A MA49986A MA49986A MA 49986 A MA49986 A MA 49986A MA 049986 A MA049986 A MA 049986A MA 49986 A MA49986 A MA 49986A MA 49986 A MA49986 A MA 49986A
- Authority
- MA
- Morocco
- Prior art keywords
- processes
- rapid flow
- via rapid
- flow synthesis
- oligomers via
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G79/00—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule
- C08G79/02—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule a linkage containing phosphorus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/314—Phosphoramidates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3233—Morpholino-type ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/30—Production chemically synthesised
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Luminescent Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762562741P | 2017-09-25 | 2017-09-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA49986A true MA49986A (fr) | 2020-07-01 |
Family
ID=65810587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA049986A MA49986A (fr) | 2017-09-25 | 2018-09-25 | Procédés de préparation d'oligomères morpholino phosphorodiamidate par l'intermédiaire d'une synthèse à flux rapide |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20200362339A1 (fr) |
| EP (1) | EP3672601B1 (fr) |
| JP (1) | JP7218361B2 (fr) |
| ES (1) | ES2963336T3 (fr) |
| MA (1) | MA49986A (fr) |
| TW (1) | TWI812647B (fr) |
| WO (1) | WO2019060862A1 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019060862A1 (fr) | 2017-09-25 | 2019-03-28 | Sarepta Therapeutics, Inc. | Procédés de préparation d'oligomères morpholino phosphorodiamidate par l'intermédiaire d'une synthèse à flux rapide |
| KR20220098217A (ko) * | 2019-11-13 | 2022-07-11 | 니뽄 신야쿠 가부시키가이샤 | 올리고 핵산 화합물의 제조 방법 |
| KR102934598B1 (ko) | 2020-06-05 | 2026-03-05 | 넥스올리고(주) | 신규한 몰포리노 올리고뉴클레오티드 유도체 |
| US12378267B2 (en) | 2021-06-17 | 2025-08-05 | Entrada Therapeutics, Inc. | Synthesis of FMOC-protected morpholino monomers and oligomers |
| CN119156395A (zh) | 2022-04-22 | 2024-12-17 | 恩特拉达治疗学股份有限公司 | 用于递送治疗剂的环肽 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5217866A (en) | 1985-03-15 | 1993-06-08 | Anti-Gene Development Group | Polynucleotide assay reagent and method |
| WO1986005519A1 (fr) | 1985-03-15 | 1986-09-25 | James Summerton | Reactif et procede d'analyse de polynucleotides |
| US5185444A (en) | 1985-03-15 | 1993-02-09 | Anti-Gene Deveopment Group | Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages |
| US5506337A (en) | 1985-03-15 | 1996-04-09 | Antivirals Inc. | Morpholino-subunit combinatorial library and method |
| US5521063A (en) | 1985-03-15 | 1996-05-28 | Antivirals Inc. | Polynucleotide reagent containing chiral subunits and methods of use |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5166315A (en) | 1989-12-20 | 1992-11-24 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| WO1990002749A1 (fr) | 1988-09-01 | 1990-03-22 | Forskningscenter Risø | Procede de synthese de peptides et support solide de realisation dudit procede |
| US8067571B2 (en) | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
| PL2735568T3 (pl) * | 2006-05-10 | 2018-02-28 | Sarepta Therapeutics, Inc. | Analogi oligonukleotydowe mające kationowe połączenia pomiędzy podjednostkami |
| US8076476B2 (en) | 2007-11-15 | 2011-12-13 | Avi Biopharma, Inc. | Synthesis of morpholino oligomers using doubly protected guanine morpholino subunits |
| US8299206B2 (en) | 2007-11-15 | 2012-10-30 | Avi Biopharma, Inc. | Method of synthesis of morpholino oligomers |
| RU2606627C2 (ru) * | 2007-11-15 | 2017-01-10 | Серепта Терапьютикс,Инк. | Способ синтеза морфолиновых олигомеров |
| EP2499248B1 (fr) * | 2009-11-13 | 2017-01-04 | Sarepta Therapeutics, Inc. | Composé antiviral antisens et méthode de traitement d'une infection par le virus grippal |
| ES2607603T3 (es) | 2010-09-30 | 2017-04-03 | Nippon Shinyaku Co., Ltd. | Derivado de ácido morfolino nucleico |
| JP6496549B2 (ja) | 2011-11-30 | 2019-04-03 | サレプタ セラピューティクス, インコーポレイテッド | 脊髄性筋萎縮症における誘発されたエクソン包含 |
| US20140315977A1 (en) * | 2013-03-14 | 2014-10-23 | Sarepta Therapeutics, Inc. | Exon skipping compositions for treating muscular dystrophy |
| DK3015467T3 (da) * | 2013-05-24 | 2025-02-10 | Ajinomoto Kk | Morpholino-oligonukleotidfremstillingsfremgangsmåde |
| US11236338B2 (en) * | 2013-09-05 | 2022-02-01 | Sarepta Therapeutics, Inc. | Antisense-induced exon2 inclusion in acid alpha-glucosidase |
| DK3118311T3 (en) * | 2014-03-12 | 2019-03-11 | Nippon Shinyaku Co Ltd | Antisense nucleic acid |
| EP3858993A1 (fr) * | 2015-10-09 | 2021-08-04 | Sarepta Therapeutics, Inc. | Compositions et procédés pour le traitement de la dystrophie musculaire de duchenne et de troubles apparentés |
| MD3464306T2 (ro) * | 2016-05-24 | 2024-08-31 | Sarepta Therapeutics Inc | Procedee de preparare a oligomerilor morfolino fosforodiamidați |
| BR112018074346B1 (pt) * | 2016-05-24 | 2023-01-03 | Sarepta Therapeutics, Inc. | Composto oligomérico e processo para preparar um composto oligomérico |
| KR102523527B1 (ko) * | 2016-06-30 | 2023-04-20 | 사렙타 쎄러퓨틱스 인코퍼레이티드 | 포스포로디아미데이트 모르폴리노 올리고머의 제조 방법 |
| WO2019060862A1 (fr) | 2017-09-25 | 2019-03-28 | Sarepta Therapeutics, Inc. | Procédés de préparation d'oligomères morpholino phosphorodiamidate par l'intermédiaire d'une synthèse à flux rapide |
-
2018
- 2018-09-25 WO PCT/US2018/052524 patent/WO2019060862A1/fr not_active Ceased
- 2018-09-25 JP JP2020516835A patent/JP7218361B2/ja active Active
- 2018-09-25 MA MA049986A patent/MA49986A/fr unknown
- 2018-09-25 TW TW107133695A patent/TWI812647B/zh active
- 2018-09-25 US US16/650,305 patent/US20200362339A1/en not_active Abandoned
- 2018-09-25 EP EP18859106.9A patent/EP3672601B1/fr active Active
- 2018-09-25 ES ES18859106T patent/ES2963336T3/es active Active
-
2024
- 2024-06-20 US US18/749,007 patent/US12590306B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP7218361B2 (ja) | 2023-02-06 |
| EP3672601B1 (fr) | 2023-09-13 |
| ES2963336T3 (es) | 2024-03-26 |
| TWI812647B (zh) | 2023-08-21 |
| US12590306B2 (en) | 2026-03-31 |
| EP3672601A4 (fr) | 2021-05-12 |
| US20250043283A1 (en) | 2025-02-06 |
| WO2019060862A1 (fr) | 2019-03-28 |
| EP3672601A1 (fr) | 2020-07-01 |
| US20200362339A1 (en) | 2020-11-19 |
| JP2020535141A (ja) | 2020-12-03 |
| TW201919659A (zh) | 2019-06-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3672601A4 (fr) | Procédés de préparation d'oligomères morpholino phosphorodiamidate par l'intermédiaire d'une synthèse à flux rapide | |
| MA45155A (fr) | Procédés de préparation d'oligomères morpholino de phosphorodiamidate | |
| MA45183A (fr) | Procédés de préparation d'oligomères morpholino de phosphorodiamidate | |
| MA49775A (fr) | Procédés de préparation d'oligomères morpholino de phosphorodiamidate | |
| EP3980073A4 (fr) | Procédés de préparation de complexes protéine-oligonucléotide | |
| GB2567754B (en) | Flow path sensing for flow therapy apparatus | |
| EP3307266A4 (fr) | Nouvelles polythérapies à base de cannabinoïdes pour le myélome multiple (mm) | |
| EP3302507A4 (fr) | Procédés de diagnostic pour thérapie par lymphocytes t | |
| EP3387189A4 (fr) | Système pour coordonner des machines de fraisage et de pavage | |
| EP3353278A4 (fr) | Préparation d'échantillons pour des types d'échantillons compliqués | |
| MA41962A (fr) | Récepteur antigénique chimérique ciblant le cd5 pour une thérapie adoptive à base de cellules t | |
| DK3609540T5 (da) | Fremgangsmåde til immunkonjugatsyntese | |
| EP3509982A4 (fr) | Distributeur proactif pour système d'alerte mobile d'opérateur | |
| EP3631564A4 (fr) | Système à réalité augmentée à fixation amovible pour lunettes | |
| EP3367890A4 (fr) | Procédés de radiothérapie pour déclencher des médicaments à photoactivation | |
| MA45362A (fr) | Procédés de préparation d'oligomères morpholino de phosphorodiamidate | |
| EP3360893A4 (fr) | Molécule de pdl-1 soluble à forte affinité | |
| EP3500286A4 (fr) | Synthèse d'échelle d'elamipretide à base de n-carboxyanhydride | |
| EP3334464A4 (fr) | Conjugués chélatés à base de manganèse pour l'imagerie par résonance magnétique moléculaire | |
| EP3837113A4 (fr) | Système de positionnement intégré à une machine | |
| PL3609789T3 (pl) | Układ pakowania do wytwarzania torebek | |
| EP3766869A4 (fr) | Procédé simple de préparation d'avibactam | |
| EP3681697A4 (fr) | Supports thermiques pour éléments 3d formés à partir de particules | |
| EP2817473A4 (fr) | Appareil pour régler l'alignement de machines à forer | |
| EP3317004A4 (fr) | Appareil de préparation d'une solution, et procédés associés |