MA50096A - Formulations de nanoparticules lipidiques de vecteurs d'adn exempts de capside non viraux - Google Patents
Formulations de nanoparticules lipidiques de vecteurs d'adn exempts de capside non virauxInfo
- Publication number
- MA50096A MA50096A MA050096A MA50096A MA50096A MA 50096 A MA50096 A MA 50096A MA 050096 A MA050096 A MA 050096A MA 50096 A MA50096 A MA 50096A MA 50096 A MA50096 A MA 50096A
- Authority
- MA
- Morocco
- Prior art keywords
- free dna
- lipid nanoparticle
- dna vectors
- nanoparticle formulations
- viral capside
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5176—Compounds of unknown constitution, e.g. material from plants or animals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
- C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
- C12N2710/14144—Chimeric viral vector comprising heterologous viral elements for production of another viral vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Optics & Photonics (AREA)
- Nanotechnology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Dispersion Chemistry (AREA)
- Botany (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762556333P | 2017-09-08 | 2017-09-08 | |
| US201762556334P | 2017-09-08 | 2017-09-08 | |
| US201762556381P | 2017-09-09 | 2017-09-09 | |
| US201862675317P | 2018-05-23 | 2018-05-23 | |
| US201862675322P | 2018-05-23 | 2018-05-23 | |
| US201862675324P | 2018-05-23 | 2018-05-23 | |
| US201862675327P | 2018-05-23 | 2018-05-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA50096A true MA50096A (fr) | 2020-07-15 |
Family
ID=65635269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA050096A MA50096A (fr) | 2017-09-08 | 2018-09-07 | Formulations de nanoparticules lipidiques de vecteurs d'adn exempts de capside non viraux |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20210059953A1 (fr) |
| EP (1) | EP3679148A4 (fr) |
| JP (3) | JP2020537493A (fr) |
| KR (1) | KR102696307B1 (fr) |
| CN (1) | CN111295448A (fr) |
| AU (1) | AU2018330208B2 (fr) |
| BR (1) | BR112020004219A2 (fr) |
| CA (1) | CA3075180A1 (fr) |
| CO (1) | CO2020002262A2 (fr) |
| IL (1) | IL272799B2 (fr) |
| MA (1) | MA50096A (fr) |
| MX (1) | MX2020002501A (fr) |
| MY (1) | MY209906A (fr) |
| PH (1) | PH12020500466A1 (fr) |
| SG (1) | SG11202000765PA (fr) |
| WO (1) | WO2019051289A1 (fr) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ762100A (en) | 2017-08-09 | 2025-12-19 | Bioverativ Therapeutics Inc | Nucleic acid molecules and uses thereof |
| KR20200120649A (ko) * | 2018-02-14 | 2020-10-21 | 제너레이션 바이오 컴퍼니 | 비-바이러스 dna 벡터 및 항체 및 융합 단백질 생산을 위한 이의 용도 |
| WO2019226650A1 (fr) * | 2018-05-23 | 2019-11-28 | Modernatx, Inc. | Administration d'adn |
| EP3833766A1 (fr) | 2018-08-09 | 2021-06-16 | Bioverativ Therapeutics Inc. | Molécules d'acide nucléique et leurs utilisations pour une thérapie génique non virale |
| JP7759311B2 (ja) | 2019-07-19 | 2025-10-23 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | リコンビナーゼ組成物及び使用方法 |
| US20220288231A1 (en) * | 2019-08-12 | 2022-09-15 | Generation Bio Co. | Methods and compositions for reducing gene or nucleic acid therapy-related immune responses |
| WO2021046265A1 (fr) | 2019-09-06 | 2021-03-11 | Generation Bio Co. | Compositions de nanoparticules lipidiques comprenant de l'adn à extrémités fermées et des lipides clivables et leurs procédés d'utilisation |
| JP2023502576A (ja) * | 2019-11-22 | 2023-01-25 | ジェネレーション バイオ カンパニー | イオン化可能な脂質およびそれらのナノ粒子組成物 |
| CN110974954B (zh) * | 2019-12-24 | 2021-03-16 | 珠海丽凡达生物技术有限公司 | 一种用于增强核酸疫苗免疫效果的脂质纳米颗粒及其制备方法 |
| DE102020111571A1 (de) | 2020-03-11 | 2021-09-16 | Immatics US, Inc. | Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren |
| EP4153223A1 (fr) | 2020-05-20 | 2023-03-29 | Flagship Pioneering Innovations VI, LLC | Compositions immunogènes et leurs utilisations |
| IL298362A (en) | 2020-05-20 | 2023-01-01 | Flagship Pioneering Innovations Vi Llc | Coronavirus antigen compositions and their uses |
| KR20230029685A (ko) | 2020-05-29 | 2023-03-03 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | Trem 조성물 및 이에 관련된 방법 |
| WO2021243301A2 (fr) | 2020-05-29 | 2021-12-02 | Flagship Pioneering Innovations Vi, Llc. | Compositions à base de trem et procédés associés |
| AU2021307952A1 (en) * | 2020-07-17 | 2023-03-02 | Generation Bio Co. | Methods for encapsulating polynucleotides into reduced sizes of Lipid nanoparticles and novel formulation thereof |
| JP2023535632A (ja) | 2020-07-27 | 2023-08-18 | アンジャリウム バイオサイエンシズ エージー | Ｄｎａ分子の組成物、その作製方法、及びその使用方法 |
| AU2021336976A1 (en) | 2020-09-03 | 2023-03-23 | Flagship Pioneering Innovations Vi, Llc | Immunogenic compositions and uses thereof |
| GB202014751D0 (en) | 2020-09-18 | 2020-11-04 | Lightbio Ltd | Targeting vector |
| CZ310613B6 (cs) | 2020-09-23 | 2026-01-28 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Lipidoidy pro transfekci nukleových kyselin a jejich použití |
| WO2022115645A1 (fr) | 2020-11-25 | 2022-06-02 | Akagera Medicines, Inc. | Nanoparticules lipidiques utilisées pour l'administration d'acides nucléiques, et méthodes d'utilisation associées |
| IL303886A (en) | 2020-12-23 | 2023-08-01 | Flagship Pioneering Inc | Compositions of modified trems and uses thereof |
| WO2022155195A1 (fr) * | 2021-01-12 | 2022-07-21 | Peranteau William | Nanoparticules de lipide ionisables destinées à l'administration in utéro d'arnm |
| EP4313109A1 (fr) | 2021-03-31 | 2024-02-07 | Flagship Pioneering Innovations V, Inc. | Polypeptides de thanotransmission et leur utilisation dans le traitement du cancer |
| CA3218126A1 (fr) * | 2021-05-07 | 2022-11-10 | Matthew MANGANIELLO | Compositions de vecteurs d'adn non viraux lyophilisees et leurs utilisations |
| CZ310443B6 (cs) | 2021-07-19 | 2025-06-25 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Cyklohexanové lipidoidy pro transfekci nukleových kyselin a jejich použití |
| EP4377457A1 (fr) | 2021-07-26 | 2024-06-05 | Flagship Pioneering Innovations VI, LLC | Compositions de trem et leurs utilisations |
| EP4124348A1 (fr) * | 2021-07-30 | 2023-02-01 | 4basebio UK Ltd | Nanoparticules pour l'administration de cellules |
| CN116179605B (zh) * | 2021-08-12 | 2025-11-11 | 蓝图生物医药(广州)有限公司 | 一种重组腺相关病毒载体及其应用 |
| MX2024003262A (es) | 2021-09-17 | 2024-06-19 | Flagship Pioneering Innovations Vi Llc | Composiciones y metodos para producir poliribonucleotidos circulares. |
| CA3235625A1 (fr) | 2021-10-18 | 2023-04-27 | Flagship Pioneering Innovations Vi, Llc | Compositions et procedes de purification de polyribonucleotides |
| EP4436984A1 (fr) | 2021-11-24 | 2024-10-02 | Flagship Pioneering Innovations VI, LLC | Compositions immunogènes de coronavirus et leurs utilisations |
| CN118401544A (zh) | 2021-11-24 | 2024-07-26 | 旗舰创业创新六公司 | 水痘-带状疱疹病毒免疫原组合物及其用途 |
| IL312965A (en) | 2021-11-24 | 2024-07-01 | Flagship Pioneering Innovations Vi Llc | Immunogenic compositions and their uses |
| KR20240118174A (ko) | 2021-12-17 | 2024-08-02 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 변성 조건 하에서의 원형 rna의 풍부화를 위한 방법 |
| EP4453201A1 (fr) | 2021-12-22 | 2024-10-30 | Flagship Pioneering Innovations VI, LLC | Compositions et procédés de purification de polyribonucléotides |
| KR20240118881A (ko) | 2021-12-23 | 2024-08-05 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 항푸소제닉 폴리펩티드를 인코딩하는 원형 폴리리보뉴클레오티드 |
| WO2023148303A1 (fr) * | 2022-02-02 | 2023-08-10 | Mslsolutions Gmbh | Procédé de production de médicaments et de vaccins |
| CN119072330A (zh) * | 2022-03-14 | 2024-12-03 | 世代生物公司 | 异源初免加强疫苗组合物和使用方法 |
| KR20240166554A (ko) | 2022-03-25 | 2024-11-26 | 세일 바이오메디슨스, 인크. | 신규한 이온화 가능 지질 및 지질 나노입자, 및 이를 사용하는 방법 |
| US20250228928A1 (en) * | 2022-04-04 | 2025-07-17 | Spark Therapeutics, Inc. | Immune enhancement and infectious disease treatment |
| WO2023196634A2 (fr) | 2022-04-08 | 2023-10-12 | Flagship Pioneering Innovations Vii, Llc | Vaccins et procédés associés |
| CA3257006A1 (fr) | 2022-05-09 | 2023-11-16 | Flagship Pioneering Innovations Vi, Llc | Compositions de trem et procédés d'utilisation pour traiter des troubles prolifératifs |
| TW202409283A (zh) | 2022-05-13 | 2024-03-01 | 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 | 雙股ｄｎａ組合物及相關方法 |
| CA3256897A1 (fr) | 2022-05-25 | 2023-11-30 | Akagera Medicines, Inc. | Nanoparticules lipidiques pour l'administration d'acides nucléiques et leurs procédés d'utilisation |
| US20250179492A1 (en) | 2022-06-22 | 2025-06-05 | Flagship Pioneering Innovations Vi, Llc | Compositions of modified trems and uses thereof |
| WO2024015428A1 (fr) * | 2022-07-12 | 2024-01-18 | Trustees Of Boston University | Voies de signalisation cellulaire synthétiques et leurs utilisations |
| EP4565604A2 (fr) | 2022-08-01 | 2025-06-11 | Flagship Pioneering Innovations VII, LLC | Protéines immunomodulatrices et méthodes associées |
| KR102544632B1 (ko) * | 2022-08-05 | 2023-06-16 | 주식회사 무진메디 | 장쇄 세라마이드가 포함된 지질 나노입자 및 이를 포함하는 세포 사멸용 조성물 |
| WO2024035952A1 (fr) | 2022-08-12 | 2024-02-15 | Remix Therapeutics Inc. | Procédés et compositions pour moduler l'épissage au niveau de sites d'épissage alternatifs |
| US20260060926A1 (en) | 2022-08-31 | 2026-03-05 | Sail Biomedicines, Inc. | Novel ionizable lipids and lipid nanoparticles and methods of using the same |
| US20240174732A1 (en) | 2022-10-05 | 2024-05-30 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additional polypeptides and their use in treating cancer |
| EP4612296A1 (fr) | 2022-10-31 | 2025-09-10 | Flagship Pioneering Innovations VI, LLC | Compositions et procédés de purification de polyribonucléotides |
| TW202434728A (zh) | 2022-11-08 | 2024-09-01 | 美商旗艦先鋒創新有限責任公司 | 用於產生環狀多核糖核苷酸的組成物和方法 |
| TW202430215A (zh) | 2022-12-14 | 2024-08-01 | 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 | 用於將治療劑遞送至骨之組成物和方法 |
| US20240252520A1 (en) | 2023-01-09 | 2024-08-01 | Beth Israel Deaconess Medical Center, Inc. | Therapeutic agents and their use for treating chronic wounds |
| WO2024151687A1 (fr) | 2023-01-09 | 2024-07-18 | Flagship Pioneering Innovations V, Inc. | Commutateurs génétiques et leur utilisation dans le traitement du cancer |
| WO2024151583A2 (fr) | 2023-01-09 | 2024-07-18 | Flagship Pioneering Innovations Vii, Llc | Vaccins et procédés associés |
| WO2024151673A2 (fr) | 2023-01-09 | 2024-07-18 | President And Fellows Of Harvard College | Molécules d'acide nucléique recombinant et leur utilisation dans la cicatrisation de plaies |
| WO2024167885A1 (fr) | 2023-02-06 | 2024-08-15 | Flagship Pioneering Innovations Vii, Llc | Compositions immunomodulatrices et procédés associés |
| CN121263425A (zh) | 2023-02-13 | 2026-01-02 | 旗舰创业创新第七有限责任公司 | 含可裂解接头的可电离脂质和用于治疗性组合物的脂质载体 |
| IL322378A (en) | 2023-02-17 | 2025-09-01 | Flagship Pioneering Innovations Vii Llc | DNA compositions containing modified cytosine |
| EP4665405A1 (fr) | 2023-02-17 | 2025-12-24 | Flagship Pioneering Innovations VII, LLC | Compositions d'adn comprenant un uracile modifié |
| AU2024229184A1 (en) | 2023-03-02 | 2025-08-28 | Krystal Biotech, Inc. | Interleukin-2 and interleukin-12 for cancer therapy |
| EP4680750A1 (fr) | 2023-03-15 | 2026-01-21 | Flagship Pioneering Innovations VI, LLC | Compositions comprenant des polyribonucléotides et leurs utilisations |
| CN121358494A (zh) | 2023-03-15 | 2026-01-16 | 旗舰创业创新第六有限责任公司 | 免疫原性组合物及其用途 |
| KR102938591B1 (ko) * | 2023-04-06 | 2026-03-12 | 주식회사 무진메디 | 수분산성이 우수한 고함량 세라마이드 조성물 |
| EP4695393A1 (fr) | 2023-04-12 | 2026-02-18 | Flagship Pioneering Innovations VI, LLC | Trem modifiées, compositions et procédés associés |
| EP4695391A1 (fr) | 2023-04-12 | 2026-02-18 | Flagship Pioneering Innovations VI, LLC | Trems destinés à être utilisés dans la correction de mutations faux-sens |
| WO2024220746A2 (fr) | 2023-04-21 | 2024-10-24 | Flagship Pioneering Innovations Vii, Llc | Agents d'arni ciblant la synthase d'acides gras et procédés associés |
| WO2024258829A1 (fr) | 2023-06-12 | 2024-12-19 | Flagship Pioneering Innovations Vii, Llc | Compositions de vaccin contre le sars-cov-2 et procédés associés |
| WO2025006684A1 (fr) | 2023-06-28 | 2025-01-02 | Flagship Pioneering Innovations Vi, Llc | Polyribonucléotides circulaires codant pour des polypeptides antifusogènes |
| KR20260044217A (ko) | 2023-07-25 | 2026-04-01 | 플래그쉽 파이어니어링 이노베이션스 Vii, 엘엘씨 | Cas 엔도뉴클레아제 및 관련 방법 |
| WO2025042786A1 (fr) | 2023-08-18 | 2025-02-27 | Flagship Pioneering Innovations Vi, Llc | Compositions comprenant des polyribonucléotides circulaires et leurs utilisations |
| WO2025049632A1 (fr) * | 2023-08-29 | 2025-03-06 | Rejuvenation Technologies Inc. | Compositions et méthodes pour l'administration large d'arn dans un tissu |
| WO2025054236A2 (fr) | 2023-09-06 | 2025-03-13 | Flagship Pioneering Innovations Vii, Llc | Compositions de vaccin contre le sars-cov-2 et procédés associés |
| WO2025052180A2 (fr) | 2023-09-07 | 2025-03-13 | Axelyf ehf. | Lipides et nanoparticules lipidiques |
| WO2025064475A2 (fr) | 2023-09-18 | 2025-03-27 | Flagship Pioneering Innovations Vii, Llc | Compositions lipidoïdes ionisables et leurs utilisations thérapeutiques |
| WO2025072331A1 (fr) | 2023-09-26 | 2025-04-03 | Flagship Pioneering Innovations Vii, Llc | Nucléases cas et procédés ou méthodes associés |
| WO2025096807A2 (fr) | 2023-10-31 | 2025-05-08 | Flagship Pioneering Innovations Vii, Llc | Nouvelles formes d'adn thérapeutique |
| WO2025106670A1 (fr) | 2023-11-14 | 2025-05-22 | Flagship Pioneering Innovations Vii, Llc | Compositions lipidoïdes ionisables et leurs utilisations thérapeutiques |
| US20250161347A1 (en) | 2023-11-22 | 2025-05-22 | Flagship Pioneering Innovations Vii, Llc | Methods and compositions for treating non-alcoholic fatty liver disease |
| TW202545974A (zh) | 2024-01-26 | 2025-12-01 | 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 | 免疫受體抑制蛋白及相關方法 |
| WO2025194019A1 (fr) | 2024-03-14 | 2025-09-18 | Flagship Pioneering Innovations Vii, Llc | Méthodes de traitement de la fibrose hépatique et de la stéatose hépatique non alcoolique |
| WO2025217275A2 (fr) | 2024-04-10 | 2025-10-16 | Flagship Pioneering Innovations Vii, Llc | Compositions ciblées sur des cellules immunitaires et procédés associés |
| US20250353881A1 (en) | 2024-05-16 | 2025-11-20 | Flagship Pioneering Innovations Vii, Llc | Immunoreceptor inhibitory proteins and related methods |
| WO2025245188A2 (fr) | 2024-05-21 | 2025-11-27 | Flagship Pioneering Innovations Vii, Llc | Méthodes de traitement de la stéatose hépatique et d'une stéatose hépatique non alcoolique |
| WO2025245111A1 (fr) | 2024-05-22 | 2025-11-27 | Flagship Pioneering Innovations Vii, Llc | Protéines de ciblage d'immunorécepteurs et procédés associés |
| US20260000702A1 (en) | 2024-06-26 | 2026-01-01 | Flagship Pioneering Innovations Vii, Llc | Therapeutic circular dna forms |
| WO2026003582A2 (fr) | 2024-06-27 | 2026-01-02 | Axelyf ehf. | Lipides et nanoparticules lipidiques |
| WO2026055543A1 (fr) | 2024-09-06 | 2026-03-12 | Flagship Pioneering Innovations Vii, Llc | Compositions d'adn modifiées et procédés associés |
| WO2026055547A1 (fr) | 2024-09-06 | 2026-03-12 | Flagship Pioneering Innovations Vii, Llc | Compositions d'adn et procédés associés |
| WO2026064313A1 (fr) | 2024-09-17 | 2026-03-26 | Flagship Pioneering Innovations Vii, Llc | Compositions d'arn et procédés associés |
| WO2026085300A1 (fr) | 2024-10-16 | 2026-04-23 | Flagship Pioneering Innovations Vii, Llc | Procédés et compositions |
| WO2026085495A1 (fr) | 2024-10-18 | 2026-04-23 | Generation Bio Co. | Compositions d'acides nucléiques synthétiques partiellement simples brin, utilisations et procédés associés |
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| US5869305A (en) * | 1992-12-04 | 1999-02-09 | The University Of Pittsburgh | Recombinant viral vector system |
| US5478745A (en) * | 1992-12-04 | 1995-12-26 | University Of Pittsburgh | Recombinant viral vector system |
| DE10044384A1 (de) * | 2000-09-08 | 2002-04-18 | Medigene Ag | Wirtszellen zur Verpackung von rekombinantem Adeno-assoziiertem Virus (rAAV), Verfahren zu ihrer Herstellung und deren Verwendung |
| US20090023671A1 (en) * | 2005-01-06 | 2009-01-22 | Brashears Sarah J | Rnai Agents for Maintenance of Stem Cells |
| HUE041875T2 (hu) * | 2005-05-31 | 2019-06-28 | Univ Colorado Regents | Eljárás génbejuttatásra |
| WO2008016391A2 (fr) * | 2006-01-31 | 2008-02-07 | The Board Of Trustees Of The Leland Stanford Junior University | Vecteurs parvoviraux auto-complémentaires et leurs procédés de fabrication et d'utilisation |
| AU2016203992A1 (en) * | 2009-05-11 | 2016-06-30 | Berg Llc | Methods for the diagnosis of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers |
| EP2500434A1 (fr) * | 2011-03-12 | 2012-09-19 | Association Institut de Myologie | Vecteurs AAV sans capside, compositions et procédés pour la production des vecteurs et la thérapie génique |
| US9943574B2 (en) * | 2012-06-27 | 2018-04-17 | Arthrogen B.V. | Combination for treating an inflammatory disorder |
| WO2014089239A1 (fr) * | 2012-12-07 | 2014-06-12 | Alnylam Pharmaceuticals, Inc. | Formulations de particules lipidiques d'acide nucléique améliorées |
| RS57739B1 (sr) * | 2013-03-14 | 2018-12-31 | Translate Bio Inc | Kompozicije cftr irnk i postupci i upotrebe u vezi sa njima |
| EP3492597A3 (fr) * | 2013-05-21 | 2019-08-28 | University of Florida Research Foundation, Inc. | Compositions de vecteur aav3 recombinant à capside modifiée et procédés d'utilisation dans la thérapie génétique du cancer du foie chez l'homme |
| US10426737B2 (en) * | 2013-12-19 | 2019-10-01 | Novartis Ag | Lipids and lipid compositions for the delivery of active agents |
| US11033638B2 (en) * | 2015-01-07 | 2021-06-15 | Universität Autonoma De Barcelona | Single-vector gene construct comprising insulin and glucokinase genes |
| US11046955B2 (en) * | 2015-04-24 | 2021-06-29 | University Of Massachusetts | Modified AAV constructs and uses thereof |
| LT3394030T (lt) * | 2015-12-22 | 2022-04-11 | Modernatx, Inc. | Junginiai ir kompozicijos terapinei medžiagai teikti intraceliuliniu būdu |
| MX2018010633A (es) * | 2016-03-03 | 2019-06-13 | Univ Massachusetts | Acido desoxirribonucleico (adn) lineal duplex de extremos cerrados para transferencia genica no viral. |
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2018
- 2018-09-07 KR KR1020207009733A patent/KR102696307B1/ko active Active
- 2018-09-07 CA CA3075180A patent/CA3075180A1/fr active Pending
- 2018-09-07 US US16/644,574 patent/US20210059953A1/en not_active Abandoned
- 2018-09-07 MX MX2020002501A patent/MX2020002501A/es unknown
- 2018-09-07 CN CN201880057740.5A patent/CN111295448A/zh active Pending
- 2018-09-07 MA MA050096A patent/MA50096A/fr unknown
- 2018-09-07 IL IL272799A patent/IL272799B2/en unknown
- 2018-09-07 SG SG11202000765PA patent/SG11202000765PA/en unknown
- 2018-09-07 EP EP18853914.2A patent/EP3679148A4/fr active Pending
- 2018-09-07 AU AU2018330208A patent/AU2018330208B2/en active Active
- 2018-09-07 BR BR112020004219-6A patent/BR112020004219A2/pt unknown
- 2018-09-07 WO PCT/US2018/050042 patent/WO2019051289A1/fr not_active Ceased
- 2018-09-07 JP JP2020512808A patent/JP2020537493A/ja active Pending
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- 2020-03-06 PH PH12020500466A patent/PH12020500466A1/en unknown
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2022
- 2022-11-02 JP JP2022176366A patent/JP2023002828A/ja active Pending
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2024
- 2024-10-28 JP JP2024189114A patent/JP2025016593A/ja active Pending
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| Publication number | Publication date |
|---|---|
| US20210059953A1 (en) | 2021-03-04 |
| KR20200051708A (ko) | 2020-05-13 |
| MX2020002501A (es) | 2020-09-17 |
| JP2023002828A (ja) | 2023-01-10 |
| RU2020110805A3 (fr) | 2022-01-19 |
| MY209906A (en) | 2025-08-11 |
| PH12020500466A1 (en) | 2021-01-25 |
| NZ761412A (en) | 2024-07-05 |
| IL272799B2 (en) | 2025-11-01 |
| EP3679148A1 (fr) | 2020-07-15 |
| AU2018330208A1 (en) | 2020-02-27 |
| BR112020004219A2 (pt) | 2020-09-08 |
| JP2025016593A (ja) | 2025-02-04 |
| CO2020002262A2 (es) | 2020-05-29 |
| KR102696307B1 (ko) | 2024-08-16 |
| WO2019051289A1 (fr) | 2019-03-14 |
| CN111295448A (zh) | 2020-06-16 |
| EP3679148A4 (fr) | 2021-06-09 |
| JP2020537493A (ja) | 2020-12-24 |
| IL272799B1 (en) | 2025-07-01 |
| CA3075180A1 (fr) | 2019-03-14 |
| SG11202000765PA (en) | 2020-03-30 |
| RU2020110805A (ru) | 2021-10-11 |
| AU2018330208B2 (en) | 2025-04-17 |
| IL272799A (en) | 2020-04-30 |
| WO2019051289A9 (fr) | 2019-05-23 |
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