MA50149B1 - Procedé pour la préparation de l'anneau de pipérazine pour la synthèse de pyrazinocarbazole - Google Patents
Procedé pour la préparation de l'anneau de pipérazine pour la synthèse de pyrazinocarbazoleInfo
- Publication number
- MA50149B1 MA50149B1 MA50149A MA50149A MA50149B1 MA 50149 B1 MA50149 B1 MA 50149B1 MA 50149 A MA50149 A MA 50149A MA 50149 A MA50149 A MA 50149A MA 50149 B1 MA50149 B1 MA 50149B1
- Authority
- MA
- Morocco
- Prior art keywords
- synthesis
- preparation
- piperazine ring
- pyrazinocarbazole
- pirlindole
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 238000003786 synthesis reaction Methods 0.000 title abstract 3
- NSZFLMNSYSRWSJ-UHFFFAOYSA-N 11h-pyrazino[2,3-a]carbazole Chemical compound C1=CC2=NC=CN=C2C2=C1C1=CC=CC=C1N2 NSZFLMNSYSRWSJ-UHFFFAOYSA-N 0.000 title abstract 2
- 125000004193 piperazinyl group Chemical group 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- IWVRVEIKCBFZNF-UHFFFAOYSA-N LSM-1636 Chemical compound C1CNC2CCCC3=C2N1C1=CC=C(C)C=C13 IWVRVEIKCBFZNF-UHFFFAOYSA-N 0.000 abstract 2
- 229950002220 pirlindole Drugs 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
La présente invention concerne un procédé amélioré pour la synthèse d'un cycle pipérazine, en particulier pour la préparation de composés hétérocycliques utiles en tant qu'intermédiaires dans la synthèse de pyrazinocarbazoles tels que le pirlindole antidépresseur. Le procédé de l'invention est utile pour préparer des énantiomères de pirlindole, ou un sel pharmaceutiquement acceptable de ceux-ci.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT11003717 | 2017-04-21 | ||
| EP17167851.9A EP3392250A1 (fr) | 2017-04-21 | 2017-04-24 | Procedé pour la préparation de l'anneau de pipérazine pour la synthèse de pyrazinocarbazole |
| PCT/IB2018/052753 WO2018193414A1 (fr) | 2017-04-21 | 2018-04-20 | Procédé de préparation d'un cycle pipérazine pour la synthèse de dérivés de pyrazinocarbazole |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA50149A MA50149A (fr) | 2021-05-26 |
| MA50149B1 true MA50149B1 (fr) | 2022-03-31 |
Family
ID=58632260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA50149A MA50149B1 (fr) | 2017-04-21 | 2018-04-20 | Procedé pour la préparation de l'anneau de pipérazine pour la synthèse de pyrazinocarbazole |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US11008327B2 (fr) |
| EP (2) | EP3392250A1 (fr) |
| JP (1) | JP7121750B2 (fr) |
| KR (1) | KR102525824B1 (fr) |
| CN (1) | CN110831943B (fr) |
| AU (1) | AU2018254238B2 (fr) |
| CL (1) | CL2019002967A1 (fr) |
| CO (1) | CO2019012592A2 (fr) |
| CY (1) | CY1125139T1 (fr) |
| EA (1) | EA038552B1 (fr) |
| EC (1) | ECSP19076875A (fr) |
| IL (1) | IL270048B (fr) |
| MA (1) | MA50149B1 (fr) |
| MX (1) | MX387253B (fr) |
| PE (1) | PE20191739A1 (fr) |
| PH (1) | PH12019550211B1 (fr) |
| PT (1) | PT3612534T (fr) |
| SA (1) | SA519410309B1 (fr) |
| UA (1) | UA123692C2 (fr) |
| WO (1) | WO2018193414A1 (fr) |
| ZA (1) | ZA201907517B (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111620882B (zh) * | 2020-06-12 | 2021-08-31 | 欧洛德(武汉)光电科技有限公司 | 新型用于有机电致发光器件的化合物及应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3288860A (en) | 1965-03-30 | 1966-11-29 | Procter & Gamble | Alkali metal salts of sulfinyl carbanions and alkali metal alkanesulfenates, processes for their preparation and reactions thereof with alkyl halides |
| IT1312539B1 (it) * | 1999-04-16 | 2002-04-22 | Erregierre Spa | Processo per la preparazione del pirlindolo cloridrato. |
| SMT202400359T1 (it) * | 2014-05-09 | 2024-11-15 | Tecnimede Sociedade Tecnico Medicinal S | Sali mandelati degli enantiomeri del pirlindolo per l'uso in medicina |
| JP6516769B2 (ja) | 2014-05-09 | 2019-05-22 | テクニメデ ソシエダーデ テクニコ−メディシナル エス．アー． | 光学活性ピルリンドールエナンチオマーおよびその塩を得るための方法 |
| KR102298676B1 (ko) | 2014-05-09 | 2021-09-07 | 테크니메데 소시에다데 테크니코-메디시날 에스.에이. | 의약으로서 사용되기 위한 (s)-펄린돌 및 약학적으로 허용 가능한 그의 염 |
| CN104774208A (zh) * | 2015-04-24 | 2015-07-15 | 南京靖龙药物研发有限公司 | 一种氘标记吡吲哚盐酸盐的制备方法 |
-
2017
- 2017-04-24 EP EP17167851.9A patent/EP3392250A1/fr not_active Withdrawn
-
2018
- 2018-04-20 CN CN201880028465.4A patent/CN110831943B/zh active Active
- 2018-04-20 IL IL270048A patent/IL270048B/en unknown
- 2018-04-20 MA MA50149A patent/MA50149B1/fr unknown
- 2018-04-20 AU AU2018254238A patent/AU2018254238B2/en active Active
- 2018-04-20 MX MX2019012511A patent/MX387253B/es unknown
- 2018-04-20 JP JP2019557487A patent/JP7121750B2/ja active Active
- 2018-04-20 WO PCT/IB2018/052753 patent/WO2018193414A1/fr not_active Ceased
- 2018-04-20 PT PT187256425T patent/PT3612534T/pt unknown
- 2018-04-20 EA EA201992384A patent/EA038552B1/ru unknown
- 2018-04-20 PH PH1/2019/550211A patent/PH12019550211B1/en unknown
- 2018-04-20 KR KR1020197033652A patent/KR102525824B1/ko active Active
- 2018-04-20 UA UAA201910930A patent/UA123692C2/uk unknown
- 2018-04-20 EP EP18725642.5A patent/EP3612534B1/fr active Active
- 2018-04-20 US US16/607,046 patent/US11008327B2/en active Active
- 2018-04-20 PE PE2019002065A patent/PE20191739A1/es unknown
-
2019
- 2019-10-16 SA SA519410309A patent/SA519410309B1/ar unknown
- 2019-10-17 CL CL2019002967A patent/CL2019002967A1/es unknown
- 2019-10-30 EC ECSENADI201976875A patent/ECSP19076875A/es unknown
- 2019-11-12 CO CONC2019/0012592A patent/CO2019012592A2/es unknown
- 2019-11-13 ZA ZA201907517A patent/ZA201907517B/en unknown
-
2022
- 2022-03-04 CY CY20221100187T patent/CY1125139T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3060592A1 (fr) | 2018-10-25 |
| JP7121750B2 (ja) | 2022-08-18 |
| JP2020517664A (ja) | 2020-06-18 |
| EP3612534A1 (fr) | 2020-02-26 |
| MA50149A (fr) | 2021-05-26 |
| BR112019022073A2 (pt) | 2020-08-18 |
| NZ758426A (en) | 2024-10-25 |
| CY1125139T1 (el) | 2023-06-09 |
| WO2018193414A1 (fr) | 2018-10-25 |
| ECSP19076875A (es) | 2020-02-28 |
| PH12019550211A1 (en) | 2020-10-26 |
| CO2019012592A2 (es) | 2020-01-17 |
| EA201992384A1 (ru) | 2020-02-19 |
| KR102525824B1 (ko) | 2023-04-25 |
| SA519410309B1 (ar) | 2021-11-17 |
| EP3612534B1 (fr) | 2021-12-22 |
| CN110831943A (zh) | 2020-02-21 |
| PE20191739A1 (es) | 2019-12-12 |
| PH12019550211B1 (en) | 2023-11-15 |
| PT3612534T (pt) | 2022-03-22 |
| MX387253B (es) | 2025-03-18 |
| UA123692C2 (uk) | 2021-05-12 |
| CL2019002967A1 (es) | 2020-04-13 |
| KR20200006544A (ko) | 2020-01-20 |
| CN110831943B (zh) | 2022-05-03 |
| EA038552B1 (ru) | 2021-09-14 |
| AU2018254238A1 (en) | 2019-10-31 |
| ZA201907517B (en) | 2020-11-25 |
| AU2018254238B2 (en) | 2022-02-24 |
| US20200131186A1 (en) | 2020-04-30 |
| IL270048B (en) | 2022-06-01 |
| EP3392250A1 (fr) | 2018-10-24 |
| US11008327B2 (en) | 2021-05-18 |
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