MA33127B1 - Composition liposomique - Google Patents
Composition liposomiqueInfo
- Publication number
- MA33127B1 MA33127B1 MA34174A MA34174A MA33127B1 MA 33127 B1 MA33127 B1 MA 33127B1 MA 34174 A MA34174 A MA 34174A MA 34174 A MA34174 A MA 34174A MA 33127 B1 MA33127 B1 MA 33127B1
- Authority
- MA
- Morocco
- Prior art keywords
- liposomes
- combination
- relates
- liposomal composition
- eribuline
- Prior art date
Links
- 239000002502 liposome Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A61K9/1278—Post-loading, e.g. by ion or pH gradient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'INVENTION CONCERNE UNE NOUVELLE COMPOSITION LIPOSOMIQUE QUI CONTIENT DE L'ERIBULINE OU UN SEL DE QUALITÉ PHARMACEUTIQUE DE CELUI-CI. L'INVENTION CONCERNE ÉGALEMENT UN PROCÉDÉ DE MISE AU POINT DE CETTE COMPOSITION LIPOSOMIQUE.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16465309P | 2009-03-30 | 2009-03-30 | |
| JP2009082521 | 2009-03-30 | ||
| PCT/JP2010/055770 WO2010113984A1 (fr) | 2009-03-30 | 2010-03-30 | Composition liposomique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA33127B1 true MA33127B1 (fr) | 2012-03-01 |
Family
ID=42828273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA34174A MA33127B1 (fr) | 2009-03-30 | 2010-03-30 | Composition liposomique |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US20120058178A1 (fr) |
| EP (1) | EP2415470B1 (fr) |
| JP (1) | JP5551683B2 (fr) |
| KR (1) | KR101495951B1 (fr) |
| CN (1) | CN102369008B (fr) |
| AU (1) | AU2010232347A1 (fr) |
| BR (1) | BRPI1014527B8 (fr) |
| CA (1) | CA2756811C (fr) |
| CO (1) | CO6430500A2 (fr) |
| CY (1) | CY1118231T1 (fr) |
| DK (1) | DK2415470T3 (fr) |
| ES (1) | ES2593027T3 (fr) |
| HR (1) | HRP20161157T1 (fr) |
| HU (1) | HUE029577T2 (fr) |
| IL (1) | IL215059A (fr) |
| LT (1) | LT2415470T (fr) |
| MA (1) | MA33127B1 (fr) |
| ME (1) | ME02518B (fr) |
| MX (1) | MX2011009632A (fr) |
| MY (1) | MY160203A (fr) |
| NZ (1) | NZ595212A (fr) |
| PE (2) | PE20151519A1 (fr) |
| PL (1) | PL2415470T3 (fr) |
| PT (1) | PT2415470T (fr) |
| RS (1) | RS55148B1 (fr) |
| SG (1) | SG174255A1 (fr) |
| SI (1) | SI2415470T1 (fr) |
| SM (1) | SMT201600307B (fr) |
| TW (1) | TWI392519B (fr) |
| UA (1) | UA103794C2 (fr) |
| WO (1) | WO2010113984A1 (fr) |
| ZA (1) | ZA201106535B (fr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8097648B2 (en) | 1998-06-17 | 2012-01-17 | Eisai R&D Management Co., Ltd. | Methods and compositions for use in treating cancer |
| CN101209243B (zh) | 2006-12-29 | 2010-12-08 | 石药集团中奇制药技术(石家庄)有限公司 | 一种脂质体药物及其制备方法 |
| CN102369008B (zh) | 2009-03-30 | 2014-10-29 | 卫材R&D管理有限公司 | 脂质体组合物 |
| WO2010113983A1 (fr) | 2009-03-30 | 2010-10-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Procédé de mise au point d'une composition liposomique |
| RU2561582C2 (ru) * | 2010-11-19 | 2015-08-27 | Российская Федерация в лице Министерства промышленности и торговли Российской Федерации | Инъекционная лекарственная форма олигопептидного препарата для лечения рассеянного склероза и способ ее получения |
| JP2014508165A (ja) | 2011-03-02 | 2014-04-03 | モルフォテック、インク. | 乳癌の治療のためのエリブリンおよびファーレツズマブの共投与 |
| WO2014121211A2 (fr) * | 2013-02-01 | 2014-08-07 | Zoneone Pharma, Inc. | Chargement à distance de médicaments médiocrement solubles dans l'eau dans des liposomes |
| CN106999419A (zh) | 2014-08-04 | 2017-08-01 | 佐尼奥尼制药股份有限公司 | 远程装载略微水溶性药物至脂质膜泡 |
| EP3265063A4 (fr) | 2015-03-03 | 2018-11-07 | Cureport, Inc. | Formulations pharmaceutiques liposomales à double charge |
| SI3350222T1 (sl) | 2015-09-18 | 2022-01-31 | Technische Universitaet Muenchen | Ligandi za integrin avbeta6, sinteza in uporaba le-teh |
| EP3372223B1 (fr) | 2015-11-02 | 2024-04-17 | FUJIFILM Corporation | Composition liposomale et son procédé de production |
| WO2017188350A1 (fr) | 2016-04-28 | 2017-11-02 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Procédé d'inhibition de croissance tumorale |
| US11331272B2 (en) | 2017-01-18 | 2022-05-17 | Temasek Life Sciences Laboratory Limited | Hyperstabilized liposomes increase targeting of mitotic cells |
| US11332498B2 (en) | 2017-03-17 | 2022-05-17 | Technische Universitat Munchen | Ligands for integrin αVβ8, synthesis and uses thereof |
| RU2734900C1 (ru) * | 2017-03-31 | 2020-10-26 | Фуджифилм Корпорэйшн | Липосомальная композиция и фармацевтическая композиция |
| WO2019097073A1 (fr) | 2017-11-20 | 2019-05-23 | Basilea Pharmaceutica International AG | Associations pharmaceutiques destinées à être utilisées dans le traitement du cancer |
| MA51514A (fr) * | 2018-01-02 | 2021-04-07 | Scynexis Inc | Compositions injectables d'antifongiques triterpénoïdes encapsulées dans des liposomes |
| PL3811931T3 (pl) | 2018-06-20 | 2024-11-18 | Fujifilm Corporation | Skojarzony środek leczniczy zawierający kompozycję liposomową z kapsułkowanym lekiem i inhibitor punktu kontroli immunologicznej |
| TWI837189B (zh) | 2018-10-01 | 2024-04-01 | 日商富士軟片股份有限公司 | 包含內含藥物之脂質體組成物及鉑製劑之組合醫藥 |
| US12036204B2 (en) | 2019-07-26 | 2024-07-16 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating tumor |
| US11083705B2 (en) | 2019-07-26 | 2021-08-10 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating tumor |
| US20230201119A1 (en) * | 2020-05-29 | 2023-06-29 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Liposome containing ethylenediamine tetraacetic acid or salt thereof and eribulin or pharmaceutically acceptable salt thereof |
| GB2626483A (en) * | 2021-10-14 | 2024-07-24 | Pacira Pharmaceuticals Inc | Multivesicular liposome formulations of dexamethasone |
| CN115957351B (zh) * | 2022-11-15 | 2023-06-27 | 中国人民解放军海军第九七一医院 | 一种碘海醇注射液及其制备方法 |
| CN121001745A (zh) * | 2023-03-30 | 2025-11-21 | 上海济昀生物科技有限公司 | 一种磷脂组合物及其制备方法及含氮化合物的应用 |
Family Cites Families (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5736155A (en) * | 1984-08-08 | 1998-04-07 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| IL91664A (en) | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
| GB9126209D0 (en) | 1991-12-10 | 1992-02-12 | Orion Yhtymae Oy | Drug formulations for parenteral use |
| PT695169E (pt) | 1993-04-22 | 2003-04-30 | Skyepharma Inc | Lipossomas multivesiculares de ciclodextrina encapsulando compostos farmacologicos e metodos para a sua utilizacao |
| FR2736056B1 (fr) | 1995-06-29 | 1997-08-08 | Commissariat Energie Atomique | Derives de cyclodextrines, leur preparation et leur utilisation pour incorporer des molecules hydrophobes dans des systemes de tensioactifs organises |
| US6051251A (en) | 1997-11-20 | 2000-04-18 | Alza Corporation | Liposome loading method using a boronic acid compound |
| US8097648B2 (en) | 1998-06-17 | 2012-01-17 | Eisai R&D Management Co., Ltd. | Methods and compositions for use in treating cancer |
| US6653341B1 (en) | 1998-06-17 | 2003-11-25 | Eisai Co., Ltd. | Methods and compositions for use in treating cancer |
| JP4454151B2 (ja) | 1998-06-17 | 2010-04-21 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 大環状類似体及びそれらの使用並びに調製方法 |
| US6593308B2 (en) | 1999-12-03 | 2003-07-15 | The Regents Of The University Of California | Targeted drug delivery with a hyaluronan ligand |
| CN1116875C (zh) | 2000-10-19 | 2003-08-06 | 南京振中生物工程有限公司 | 紫杉醇脂质组合物及其制备方法 |
| ES2387886T3 (es) | 2001-11-13 | 2012-10-03 | Celator Pharmaceuticals, Inc. | Composiciones que transportan lípidos con una mejor estabilidad sanguínea |
| AU2002340670A1 (en) | 2001-11-13 | 2003-05-26 | Celator Technologies, Inc. | Lipid carrier compositions and methods for improved drug retention |
| AU2003281200A1 (en) | 2002-07-03 | 2004-01-23 | Tasuku Honjo | Immunopotentiating compositions |
| DE10255106A1 (de) | 2002-11-24 | 2004-06-09 | Novosom Ag | Liposomale Glucocorticoide |
| AU2003298738A1 (en) * | 2002-11-26 | 2004-06-18 | Su-Ming Chiang | Liposomal formulations |
| CN101899114A (zh) | 2002-12-23 | 2010-12-01 | 惠氏公司 | 抗pd-1抗体及其用途 |
| BR0317882A (pt) | 2002-12-31 | 2005-12-13 | Bharat Serums & Vaccines Ltd | Processo para fabricação de lipossomas de longa circulação não tratados com peg; lipossoma; composição de doxorrubicina lipossomal de longa duração não tratada com peg; e método |
| US7563869B2 (en) | 2003-01-23 | 2009-07-21 | Ono Pharmaceutical Co., Ltd. | Substance specific to human PD-1 |
| EP1618897A4 (fr) * | 2003-04-04 | 2010-09-29 | Eisai R&D Man Co Ltd | Structure de membrane lipidique comportant un anticorps monoclonal anti-mt-mmp |
| US6747011B1 (en) | 2003-06-04 | 2004-06-08 | A.P. Group, Inc. | Antitumor drugs and methods |
| US20050129753A1 (en) | 2003-11-14 | 2005-06-16 | Gabizon Alberto A. | Method for drug loading in liposomes |
| CA2553573A1 (fr) | 2004-01-29 | 2005-08-11 | Eisai R & D Management Co., Ltd. | Methode de stabilisation d'un compose de macrolide |
| LT3173073T (lt) * | 2004-05-03 | 2025-01-10 | Ipsen Biopharm Ltd. | Liposomos, skirtos vaistų pristatymui |
| EP1750673B1 (fr) | 2004-05-17 | 2009-12-02 | Tekmira Pharmaceuticals Corporation | Formulations liposomales comprenant de la dihydrosphingomyéline, et procedés d'utilisation correspondants |
| SI2522663T1 (sl) | 2004-06-03 | 2015-08-31 | Eisai R&D Management Co., Ltd. | Vmesne spojine za pripravo halihondrina B |
| WO2006037230A1 (fr) | 2004-10-06 | 2006-04-13 | Bc Cancer Agency | Liposomes permettant une meilleure retention du medicament, destines au traitement du cancer |
| US9707302B2 (en) | 2013-07-23 | 2017-07-18 | Immunomedics, Inc. | Combining anti-HLA-DR or anti-Trop-2 antibodies with microtubule inhibitors, PARP inhibitors, bruton kinase inhibitors or phosphoinositide 3-kinase inhibitors significantly improves therapeutic outcome in cancer |
| DK2439273T3 (da) | 2005-05-09 | 2019-06-03 | Ono Pharmaceutical Co | Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika |
| PT1907424E (pt) | 2005-07-01 | 2015-10-09 | Squibb & Sons Llc | Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1) |
| TWI373473B (en) | 2005-09-02 | 2012-10-01 | Otsuka Pharma Co Ltd | Anticancer agent |
| CN101209243B (zh) | 2006-12-29 | 2010-12-08 | 石药集团中奇制药技术(石家庄)有限公司 | 一种脂质体药物及其制备方法 |
| US20090196913A1 (en) | 2007-05-11 | 2009-08-06 | Ken Shi Kun Huang | Anti-Alpha-V Immunoliposome Composition, Methods, and Uses |
| BR122017025062B8 (pt) | 2007-06-18 | 2021-07-27 | Merck Sharp & Dohme | anticorpo monoclonal ou fragmento de anticorpo para o receptor de morte programada humano pd-1, polinucleotídeo e composição compreendendo o referido anticorpo ou fragmento |
| BRPI0817909B1 (pt) | 2007-10-03 | 2022-06-21 | Eisai R&D Management Co., Ltd | Métodos de obtenção e de preparação de uma composição diastereomericamente pura, compostos, e método para produzir os referidos compostos |
| US20090196917A1 (en) | 2008-02-01 | 2009-08-06 | University Of Kentucky Research Foundation | Liposomal Formulations of Hydrophobic Lactone Drugs in the Presence of Metal Ions |
| EP2262837A4 (fr) | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | Protéines de liaison avec pd-1 |
| JP2012500855A (ja) | 2008-08-25 | 2012-01-12 | アンプリミューン、インコーポレーテッド | Pd−1アンタゴニストおよび感染性疾患を処置するための方法 |
| US8552154B2 (en) | 2008-09-26 | 2013-10-08 | Emory University | Anti-PD-L1 antibodies and uses therefor |
| EP3255060A1 (fr) | 2008-12-09 | 2017-12-13 | F. Hoffmann-La Roche AG | Anticorps anti-pd-l1 et leur utilisation pour améliorer la fonction des lymphocytes t |
| WO2010113983A1 (fr) | 2009-03-30 | 2010-10-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Procédé de mise au point d'une composition liposomique |
| RU2476216C1 (ru) | 2009-03-30 | 2013-02-27 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Липосомальная композиция |
| CN102369008B (zh) | 2009-03-30 | 2014-10-29 | 卫材R&D管理有限公司 | 脂质体组合物 |
| RU2405601C1 (ru) | 2009-05-19 | 2010-12-10 | Федеральное государственное учреждение "Московский научно-исследовательский онкологический институт им. П.А. Герцена Федерального агентства по высокотехнологичной медицинской помощи" | Способ лечения злокачественных опухолей мочевого пузыря |
| JP5388735B2 (ja) | 2009-07-21 | 2014-01-15 | 浜松ホトニクス株式会社 | マイクロチャンネルプレート |
| WO2011066342A2 (fr) | 2009-11-24 | 2011-06-03 | Amplimmune, Inc. | Inhibition simultanée de pd-l1/pd-l2 |
| RU2579511C2 (ru) | 2010-01-26 | 2016-04-10 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Производные фуро[3,2-в]пирана, применимые в синтезе аналогов |
| JP2014508165A (ja) | 2011-03-02 | 2014-04-03 | モルフォテック、インク. | 乳癌の治療のためのエリブリンおよびファーレツズマブの共投与 |
| EP2686441B1 (fr) | 2011-03-18 | 2019-05-08 | Eisai R&D Management Co., Ltd. | Procédé et utilisation pour prédire la réponse à l'éribuline |
| PT2691112T (pt) | 2011-03-31 | 2018-07-10 | Merck Sharp & Dohme | Formulações estáveis de anticorpos para o recetor pd-1 humano de morte programada e tratamentos relacionados |
| EP2693875A4 (fr) | 2011-04-08 | 2014-10-22 | British Columbia Cancer Agency | Composés de bisphénol et leurs procédés d'utilisation |
| AU2012284147A1 (en) | 2011-07-19 | 2014-02-27 | Stc. Unm | Intraperitoneally-administered nanocarriers that release their therapeutic load based on the inflammatory environment of cancers |
| MX368257B (es) | 2011-08-01 | 2019-09-26 | Genentech Inc | Antagonistas de unión al eje pd-1e inhibidores de mek y sus usos en el tratamiento de cáncer. |
| RU2689977C2 (ru) | 2012-12-04 | 2019-05-30 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Применение эрибулина для лечения рака молочной железы |
| WO2014159562A1 (fr) | 2013-03-14 | 2014-10-02 | Bristol-Myers Squibb Company | Combinaison d'agoniste de dr5 et d'antagoniste anti-pd-1 et méthodes d'utilisation associées |
| ES2822665T3 (es) | 2013-05-31 | 2021-05-04 | Merck Sharp & Dohme | Terapias de combinación para el cáncer |
| CA2912346A1 (fr) | 2013-06-11 | 2014-12-18 | Novartis Ag | Combinaisons pharmaceutiques d'un inhibiteur de pi3k et d'un destabilisateur de microtubule |
| BR112015029386B1 (pt) | 2013-06-26 | 2023-11-14 | Eisai R&D Management Co., Ltd. | Uso de eribulina e lenvatinibe como terapia de combinação e kit |
| WO2015042279A1 (fr) | 2013-09-18 | 2015-03-26 | Stc. Unm | Nanoparticules de silice mésoporeuse toroïdales (tmsnp) et proto-cellules associées |
| US9457019B2 (en) | 2013-11-07 | 2016-10-04 | Deciphera Pharmaceuticals, Llc | Methods for inhibiting tie-2 kinase useful in the treatment of cancer |
| US20170020817A1 (en) | 2013-12-19 | 2017-01-26 | Luminus Biosciences, Inc. | Solid nanoparticle formulation of microtuble inhibitors with reduced ostwald repening for oral administration |
| PE20170255A1 (es) | 2014-01-24 | 2017-03-22 | Dana Farber Cancer Inst Inc | Moleculas de anticuerpo que se unen a pd-1 y usos de las mismas |
| CA2940983A1 (fr) | 2014-03-03 | 2015-09-11 | Eisai R&D Management Co., Ltd. | Utilisation d'eribuline et d'inhibiteurs de mtor en tant que polytherapie pour le traitement du cancer |
| KR20240144452A (ko) | 2014-03-05 | 2024-10-02 | 브리스톨-마이어스 스큅 컴퍼니 | 항-pd-1 항체 및 또 다른 항암제의 조합물을 이용한 신장암의 치료 |
| US20170100367A1 (en) | 2014-05-28 | 2017-04-13 | Eisai R&D Management Co., Ltd. | Use of eribulin in the treatment of cancer |
| WO2015184145A1 (fr) | 2014-05-28 | 2015-12-03 | Eisai R&D Management Co., Ltd. | Utilisation de l'éribuline et des inhibiteurs de la poly(adp-ribose) polymérase (parp) en tant que que polythérapie pour le traitement du cancer |
| MA40921A (fr) | 2014-11-05 | 2017-09-12 | Abbvie Stemcentrx Llc | Récepteurs antigéniques chimériques anti-cldn et procédés d'utilisation |
| CN105640935A (zh) | 2014-11-12 | 2016-06-08 | 天津市汉康医药生物技术有限公司 | 供注射用甲磺酸艾日布林药物组合物 |
| JP2016133331A (ja) | 2015-01-16 | 2016-07-25 | ソニー株式会社 | 電気的測定用カートリッジ、生体試料用電気的測定装置及び生体試料用電気的測定方法 |
| CN117100753A (zh) | 2015-02-12 | 2023-11-24 | 大连万春布林医药有限公司 | 普那布林联合免疫检查点抑制剂的用途 |
| AU2016226157B2 (en) | 2015-03-04 | 2022-01-27 | Eisai R&D Management Co., Ltd. | Combination of a PD-1 antagonist and eribulin for treating cancer |
| WO2017188350A1 (fr) | 2016-04-28 | 2017-11-02 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Procédé d'inhibition de croissance tumorale |
| WO2018071792A1 (fr) | 2016-10-14 | 2018-04-19 | Merck Sharp & Dohme Corp. | Combinaison d'un antagoniste de pd-1 et d'éribuline dans le traitement du cancer urothélial |
| AR112603A1 (es) | 2017-07-10 | 2019-11-20 | Lilly Co Eli | Anticuerpos biespecíficos inhibidores de punto de control |
| US12036204B2 (en) | 2019-07-26 | 2024-07-16 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating tumor |
| US11083705B2 (en) | 2019-07-26 | 2021-08-10 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating tumor |
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