MA50256A - Composés de pyrazolopyrimidinone et leurs utilisations - Google Patents

Composés de pyrazolopyrimidinone et leurs utilisations

Info

Publication number
MA50256A
MA50256A MA050256A MA50256A MA50256A MA 50256 A MA50256 A MA 50256A MA 050256 A MA050256 A MA 050256A MA 50256 A MA50256 A MA 50256A MA 50256 A MA50256 A MA 50256A
Authority
MA
Morocco
Prior art keywords
pyrazolopyrimidinone compounds
pyrazolopyrimidinone
compounds
Prior art date
Application number
MA050256A
Other languages
English (en)
Inventor
Stephane Ciblat
Laura Gillard
Hossein Ismaili
George Edwin Katibah
Vu Linh Ly
Chudi Obioma Ndubaku
Franck Raeppel
Yeeman K Ramtohul
Tucker Curran Roberts
Taras Rybak
Leonard Sung
Mariam Zaky
Original Assignee
Aduro Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aduro Biotech Inc filed Critical Aduro Biotech Inc
Publication of MA50256A publication Critical patent/MA50256A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA050256A 2017-09-15 2018-09-14 Composés de pyrazolopyrimidinone et leurs utilisations MA50256A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762559482P 2017-09-15 2017-09-15
US201862633248P 2018-02-21 2018-02-21
US201862687769P 2018-06-20 2018-06-20

Publications (1)

Publication Number Publication Date
MA50256A true MA50256A (fr) 2020-07-22

Family

ID=65723108

Family Applications (1)

Application Number Title Priority Date Filing Date
MA050256A MA50256A (fr) 2017-09-15 2018-09-14 Composés de pyrazolopyrimidinone et leurs utilisations

Country Status (22)

Country Link
US (1) US10738056B2 (fr)
EP (1) EP3681888A4 (fr)
JP (1) JP2020533376A (fr)
KR (1) KR20200032751A (fr)
CN (1) CN111212839A (fr)
AU (1) AU2018331456B2 (fr)
BR (1) BR112020003676A2 (fr)
CA (1) CA3075751A1 (fr)
CL (1) CL2020000544A1 (fr)
CO (1) CO2020002107A2 (fr)
CR (1) CR20200114A (fr)
DO (1) DOP2020000051A (fr)
EC (1) ECSP20018586A (fr)
IL (1) IL273236A (fr)
JO (1) JOP20200055A1 (fr)
MA (1) MA50256A (fr)
MX (1) MX2020002869A (fr)
PE (1) PE20210340A1 (fr)
PH (1) PH12020500500A1 (fr)
SG (1) SG11202002218VA (fr)
TW (1) TW201920185A (fr)
WO (1) WO2019055750A1 (fr)

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US11203610B2 (en) 2017-12-20 2021-12-21 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 2′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
TWI833744B (zh) 2018-04-06 2024-03-01 捷克科學院有機化學與生物化學研究所 3'3'-環二核苷酸
TWI818007B (zh) 2018-04-06 2023-10-11 捷克科學院有機化學與生物化學研究所 2'3'-環二核苷酸
MA55805A (fr) 2019-05-03 2022-03-09 Flagship Pioneering Innovations V Inc Métodes de modulation de l'activité immunitaire
CA3151850A1 (fr) * 2019-08-21 2021-02-25 The Scripps Research Institute Agonistes bicycliques du simulateur de genes d'interferon (sting)
CN110724143B (zh) * 2019-10-09 2021-03-23 清华大学 一种靶向btk蛋白降解化合物的制备及其在治疗自身免疫系统疾病与肿瘤中的应用
CN110627725B (zh) * 2019-10-14 2022-10-18 遵义医科大学 一种4-取代5-二氟甲基-3-硝基-1h-吡唑类化合物及其制备方法与应用
JP7254246B2 (ja) * 2019-11-25 2023-04-07 アムジエン・インコーポレーテツド デルタ－５デサチュラーゼ阻害剤としての複素環式化合物及び使用方法
CN113248491B (zh) * 2020-02-11 2022-02-25 中国科学院上海药物研究所 一类取代的吲哚脲衍生物、合成方法及其用途
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EP4153304A1 (fr) * 2020-05-20 2023-03-29 F. Hoffmann-La Roche AG Nouveaux dérivés de malonitrile
CA3194351A1 (fr) * 2020-10-14 2022-04-21 Christopher G. Nasveschuk Composes tricycliques pour degrader des neo-substrats pour une therapie medicale
JP7397996B2 (ja) 2020-11-09 2023-12-13 武田薬品工業株式会社 抗体薬物コンジュゲート
CN114644633B (zh) * 2020-12-18 2026-02-03 北京诺诚健华医药科技有限公司 杂环类jak抑制剂
WO2022137082A1 (fr) * 2020-12-22 2022-06-30 Novartis Ag Dérivés de pyrrolo[3,2-b]pyridine utiles dans le traitement d'états associés à la cgas
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US20240252598A1 (en) * 2021-04-13 2024-08-01 University Of Washington Designed constitutively active cyclic gmp-amp synthase as a genetically encoded stimulant of interferons
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Also Published As

Publication number Publication date
EP3681888A4 (fr) 2021-07-07
IL273236A (en) 2020-04-30
JOP20200055A1 (ar) 2020-03-10
PE20210340A1 (es) 2021-02-22
CN111212839A (zh) 2020-05-29
SG11202002218VA (en) 2020-04-29
CO2020002107A2 (es) 2020-05-29
CR20200114A (es) 2020-06-01
CA3075751A1 (fr) 2019-03-21
PH12020500500A1 (en) 2021-03-01
AU2018331456B2 (en) 2020-10-08
DOP2020000051A (es) 2020-08-15
JP2020533376A (ja) 2020-11-19
EP3681888A1 (fr) 2020-07-22
WO2019055750A1 (fr) 2019-03-21
ECSP20018586A (es) 2020-06-30
AU2018331456A1 (en) 2020-03-05
CL2020000544A1 (es) 2020-10-02
US10738056B2 (en) 2020-08-11
TW201920185A (zh) 2019-06-01
KR20200032751A (ko) 2020-03-26
MX2020002869A (es) 2020-07-24
US20190119285A1 (en) 2019-04-25
BR112020003676A2 (pt) 2020-09-01

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