MA50430B1 - Composés d'imidazo[4,5-d]pyrrolo[2,3-b]pyridine comme inhibiteurs de janus kinases - Google Patents

Composés d'imidazo[4,5-d]pyrrolo[2,3-b]pyridine comme inhibiteurs de janus kinases

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Publication number
MA50430B1
MA50430B1 MA50430A MA50430A MA50430B1 MA 50430 B1 MA50430 B1 MA 50430B1 MA 50430 A MA50430 A MA 50430A MA 50430 A MA50430 A MA 50430A MA 50430 B1 MA50430 B1 MA 50430B1
Authority
MA
Morocco
Prior art keywords
pyrrolo
imidazo
kinase inhibitors
pyridine compounds
janus kinase
Prior art date
Application number
MA50430A
Other languages
English (en)
Other versions
MA50430A (fr
Inventor
Aihua Wang
Mark S Tichenor
Kevin D Kreutter
Tatiana Koudriakova
Kristi Leonard
Michele C Rizzolio
Russell C Smith
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Priority claimed from PCT/US2017/066744 external-priority patent/WO2018112379A1/fr
Publication of MA50430A publication Critical patent/MA50430A/fr
Publication of MA50430B1 publication Critical patent/MA50430B1/fr

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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  • Health & Medical Sciences (AREA)
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Abstract

La présente invention concerne des composés acétonitrile 2-((1r,4r)-4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)cyclohexyl), des compositions pharmaceutiques les contenant, des procédés de fabrication de ceux-ci, et des procédés d'utilisation de ceux-ci comprenant des méthodes de traitement d'états pathologiques, de troubles et d'états médiés par jak, tels que la maladie intestinale inflammatoire.
MA50430A 2016-12-16 2017-12-15 Composés d'imidazo[4,5-d]pyrrolo[2,3-b]pyridine comme inhibiteurs de janus kinases MA50430B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662435609P 2016-12-16 2016-12-16
PCT/US2017/066744 WO2018112379A1 (fr) 2016-12-16 2017-12-15 Inhibiteurs à petites molécules de la famille jak des kinases

Publications (2)

Publication Number Publication Date
MA50430A MA50430A (fr) 2020-09-02
MA50430B1 true MA50430B1 (fr) 2022-06-30

Family

ID=65895700

Family Applications (1)

Application Number Title Priority Date Filing Date
MA50430A MA50430B1 (fr) 2016-12-16 2017-12-15 Composés d'imidazo[4,5-d]pyrrolo[2,3-b]pyridine comme inhibiteurs de janus kinases

Country Status (2)

Country Link
AR (1) AR110382A1 (fr)
MA (1) MA50430B1 (fr)

Also Published As

Publication number Publication date
AR110382A1 (es) 2019-03-20
MA50430A (fr) 2020-09-02

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