MA51331A - COMPOSÉS CYCLIQUES CONDENSÉS 6,5 À SUBSTITUTION DIARYLE, UTILISÉS EN TANT QU'INHIBITEURS DU C5aR - Google Patents
COMPOSÉS CYCLIQUES CONDENSÉS 6,5 À SUBSTITUTION DIARYLE, UTILISÉS EN TANT QU'INHIBITEURS DU C5aRInfo
- Publication number
- MA51331A MA51331A MA051331A MA51331A MA51331A MA 51331 A MA51331 A MA 51331A MA 051331 A MA051331 A MA 051331A MA 51331 A MA51331 A MA 51331A MA 51331 A MA51331 A MA 51331A
- Authority
- MA
- Morocco
- Prior art keywords
- compounds used
- cyclic compounds
- condensed cyclic
- c5ar inhibitors
- diaryl substitution
- Prior art date
Links
- 102100032957 C5a anaphylatoxin chemotactic receptor 1 Human genes 0.000 title 1
- 101710098483 C5a anaphylatoxin chemotactic receptor 1 Proteins 0.000 title 1
- 150000001923 cyclic compounds Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- YCWSUKQGVSGXJO-NTUHNPAUSA-N nifuroxazide Chemical group C1=CC(O)=CC=C1C(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 YCWSUKQGVSGXJO-NTUHNPAUSA-N 0.000 title 1
- 238000006467 substitution reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762609834P | 2017-12-22 | 2017-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA51331A true MA51331A (fr) | 2020-10-28 |
Family
ID=66949183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA051331A MA51331A (fr) | 2017-12-22 | 2018-12-20 | COMPOSÉS CYCLIQUES CONDENSÉS 6,5 À SUBSTITUTION DIARYLE, UTILISÉS EN TANT QU'INHIBITEURS DU C5aR |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10828285B2 (fr) |
| EP (1) | EP3728203B1 (fr) |
| JP (1) | JP7254082B2 (fr) |
| KR (1) | KR102736360B1 (fr) |
| CN (1) | CN111788185B (fr) |
| AU (1) | AU2018388655C1 (fr) |
| CA (1) | CA3085946A1 (fr) |
| ES (1) | ES2980175T3 (fr) |
| IL (1) | IL275500B2 (fr) |
| MA (1) | MA51331A (fr) |
| MX (1) | MX2020006459A (fr) |
| SG (1) | SG11202005791QA (fr) |
| TW (1) | TWI789470B (fr) |
| WO (1) | WO2019126424A1 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10562896B2 (en) | 2017-05-31 | 2020-02-18 | Chemocentryx, Inc. | 6-5 fused rings as C5a inhibitors |
| WO2018222601A1 (fr) | 2017-05-31 | 2018-12-06 | Chemocentryx, Inc. | Cycles 5-5 fusionnés utilisés en tant qu'inhibiteurs de c5a |
| JP2020532551A (ja) | 2017-09-03 | 2020-11-12 | アンジオン バイオメディカ コーポレーション | Ｒｈｏ関連コイルドコイルキナーゼ（ＲＯＣＫ）阻害剤としてのビニルヘテロ環 |
| MX2020006460A (es) * | 2017-12-22 | 2020-11-06 | Chemocentryx Inc | Compuestos de anillo 5,5 fusionado sustituido con diarilo como inhibidores de c5ar. |
| WO2019126424A1 (fr) | 2017-12-22 | 2019-06-27 | Chemocentryx, Inc. | Composés cycliques condensés 6,5 à substitution diaryle, utilisés en tant qu'inhibiteurs du c5ar |
| BR112020019822A2 (pt) | 2018-04-02 | 2021-03-16 | Chemocentryx, Inc. | Profármacos de antagonistas bicíclicos fundidos de c5ar |
| KR20220118419A (ko) | 2019-12-19 | 2022-08-25 | 액티브 바이오테크 에이비 | 과도한 혈관신생과 관련된 안구 질병의 치료를 위한 화합물 |
| HRP20241159T1 (hr) | 2020-02-07 | 2024-12-06 | Gasherbrum Bio, Inc. | Heterociklički agonisti za glp-1 |
| EP3868368A1 (fr) * | 2020-02-21 | 2021-08-25 | Dompe' Farmaceutici S.P.A. | Inhibiteur de l'activité de cxcl8 (interleukine-8), combinaison d'un corticostéroïde et composition pharmaceutique et son utilisation |
| CN116368140A (zh) | 2020-09-10 | 2023-06-30 | 加舒布鲁姆生物公司 | 杂环glp-1激动剂 |
| JP7839157B2 (ja) | 2020-10-28 | 2026-04-01 | ケモセントリックス， インコーポレイテッド | 化膿性汗腺炎を処置する方法 |
| WO2022140258A1 (fr) * | 2020-12-21 | 2022-06-30 | Chemocentryx, Inc. | Traitement de la glomérulopathie à c3 à l'aide d'un inhibiteur de c5a |
| CN113143920B (zh) * | 2021-05-25 | 2023-04-25 | 湖北工业大学 | Ponesimod化合物在制备抗EV71病毒药物中的应用 |
| CN120957993A (zh) | 2023-02-16 | 2025-11-14 | 加舒布鲁姆生物公司 | 杂环glp-1激动剂 |
| CN116983264B (zh) * | 2023-09-28 | 2023-12-22 | 中国农业科学院农产品加工研究所 | 一种二氢大麻二酚二苯甲酸酯的包埋体系及其制备方法和应用 |
Family Cites Families (44)
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|---|---|---|---|---|
| US1268002A (en) | 1917-09-12 | 1918-05-28 | William M Goodwin | Measuring instrument. |
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| DK27383A (da) * | 1982-02-17 | 1983-08-18 | Lepetit Spa | Fremgangsmaade til fremstilling af pyrazol(4,3-c)pyridiner |
| GB8613591D0 (en) | 1986-06-04 | 1986-07-09 | Roussel Lab Ltd | Chemical compounds |
| FR2761266B1 (fr) | 1997-03-28 | 1999-07-02 | Sanofi Sa | Composition pharmaceutique formee par granulation humide pour l'administration orale d'un derive du n-piperidino-3- pyrazolecarboxamide, de ses sels et de leurs solvates |
| DK1320531T3 (da) * | 2000-08-10 | 2011-01-03 | Pfizer Italia Srl | Bicyclo-pyrazoler, der er aktive som kinase inhibitorer, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger, der indeholder disse |
| JP5260818B2 (ja) | 2000-09-29 | 2013-08-14 | ノバルティス・インターナショナル・ファーマシューティカル・リミテッド | 高親和性低分子Ｃ５ａ受容体調節物質 |
| SE524438C2 (sv) | 2000-10-05 | 2004-08-10 | Magnus Georg Goertz | Fjärrstyrt dörrelaterat låsarrangemang, första och andra datorpogramprodukt, bärande medium och ett datorlösbart medium |
| US7902179B2 (en) | 2001-04-26 | 2011-03-08 | Ajinomoto Co., Inc. | Heterocyclic compounds |
| DE10231789A1 (de) | 2001-07-19 | 2003-02-06 | Luk Lamellen & Kupplungsbau | Verfahren, Vorrichtung und deren Verwendung zum Betrieb eines Kraftfahrzeuges |
| ITMI20012025A1 (it) | 2001-09-28 | 2003-03-28 | Dompe Spa | Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono |
| EP1487796A4 (fr) | 2002-03-28 | 2005-11-16 | Neurogen Corp | Biarylamides substitues en tant que modulateurs du recepteur c5a |
| CA2479930A1 (fr) | 2002-03-28 | 2003-10-09 | Neurogen Corporation | Tetrahydroisoquinoleines substituees servant de modulateurs du recepteur c5a |
| CA2480082A1 (fr) | 2002-03-29 | 2003-10-16 | Neurogen Corporation | Therapie combinatoire pour le traitement de maladies faisant intervenir des composants inflammatoires |
| AU2003265395A1 (en) | 2002-08-14 | 2004-03-03 | Ppd Discovery, Inc. | Prenylation inhibitors and methods of their synthesis and use |
| US7169775B2 (en) | 2002-08-21 | 2007-01-30 | Neurogen Corporation | Amino methyl imidazoles as C5a receptor modulators |
| AU2003291403A1 (en) | 2002-11-08 | 2004-06-03 | Neurogen Corporation | 3-substituted-6-aryl pyridined as ligands of c5a receptors |
| US20040214856A1 (en) | 2003-04-23 | 2004-10-28 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
| US7145012B2 (en) | 2003-04-23 | 2006-12-05 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
| AU2003902354A0 (en) | 2003-05-15 | 2003-05-29 | Harkin, Denis W. | Treatment of haemorrhagic shock |
| WO2005007087A2 (fr) | 2003-07-03 | 2005-01-27 | Neurogen Corporation | Derives (heterocycloalkyl)methyle substitues de type azole utilises comme modulateurs des recepteurs c5a |
| WO2006042102A2 (fr) | 2004-10-05 | 2006-04-20 | Neurogen Corporation | Composes de pyrrolo-pyridine, de pyrrolo-pyrimidine et composes heterocycliques apparentes |
| WO2007019083A1 (fr) * | 2005-08-04 | 2007-02-15 | Janssen Pharmaceutica N.V. | Composes de pyrimidine utiles comme modulateurs des recepteurs de la serotonine |
| US7598255B2 (en) * | 2005-08-04 | 2009-10-06 | Janssen Pharmaceutica Nv | Pyrimidine compounds as serotonin receptor modulators |
| WO2007051062A2 (fr) | 2005-10-28 | 2007-05-03 | Chemocentryx, Inc. | Dihydropyridines substituees et leurs methodes d'utilisation |
| WO2008024978A2 (fr) * | 2006-08-24 | 2008-02-28 | Serenex, Inc. | Dérivés de benzène, de pyridine et de pyridazine |
| WO2009155565A1 (fr) | 2008-06-20 | 2009-12-23 | Genentech, Inc. | Composés triazolopyridine inhibiteurs de jak kinase et procédés |
| RS54998B1 (sr) | 2008-12-22 | 2016-11-30 | Chemocentryx Inc | Antagonisti c5ar |
| US20110275639A1 (en) | 2008-12-22 | 2011-11-10 | Chemocentryx, Inc. | C5aR ANTAGONISTS |
| BR112012004335A8 (pt) | 2009-09-02 | 2016-06-21 | Merck Sharp & Dohme | Composto, composição farmacêutica, e, uso do composto. |
| RS56332B1 (sr) | 2010-06-24 | 2017-12-29 | Chemocentryx Inc | Antagonisti c5ar |
| US8846656B2 (en) * | 2011-07-22 | 2014-09-30 | Novartis Ag | Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5a receptor modulators |
| KR20150042271A (ko) | 2012-08-16 | 2015-04-20 | 얀센 파마슈티카 엔.브이. | N형 칼슘 채널 차단제로서의 치환된 피롤로피라졸 |
| CN103421006B (zh) | 2013-08-18 | 2016-06-22 | 上海师范大学 | 2,3,5,7-四取代二氢吡唑并六氢吡啶衍生物及其制备方法和应用 |
| GB201321746D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| EP3439658B1 (fr) | 2016-04-04 | 2021-11-24 | ChemoCentryx, Inc. | Antagonistes de c5ar solubles |
| US10562896B2 (en) * | 2017-05-31 | 2020-02-18 | Chemocentryx, Inc. | 6-5 fused rings as C5a inhibitors |
| WO2018222601A1 (fr) | 2017-05-31 | 2018-12-06 | Chemocentryx, Inc. | Cycles 5-5 fusionnés utilisés en tant qu'inhibiteurs de c5a |
| US10589871B2 (en) | 2017-09-25 | 2020-03-17 | Hamilton Sundstrand Corporation | Prognostic health monitoring and jam detection for use with an aircraft |
| WO2019126424A1 (fr) | 2017-12-22 | 2019-06-27 | Chemocentryx, Inc. | Composés cycliques condensés 6,5 à substitution diaryle, utilisés en tant qu'inhibiteurs du c5ar |
| MX2020006460A (es) * | 2017-12-22 | 2020-11-06 | Chemocentryx Inc | Compuestos de anillo 5,5 fusionado sustituido con diarilo como inhibidores de c5ar. |
| BR112020019822A2 (pt) * | 2018-04-02 | 2021-03-16 | Chemocentryx, Inc. | Profármacos de antagonistas bicíclicos fundidos de c5ar |
-
2018
- 2018-12-20 WO PCT/US2018/066667 patent/WO2019126424A1/fr not_active Ceased
- 2018-12-20 CA CA3085946A patent/CA3085946A1/fr active Pending
- 2018-12-20 JP JP2020534237A patent/JP7254082B2/ja active Active
- 2018-12-20 MX MX2020006459A patent/MX2020006459A/es unknown
- 2018-12-20 CN CN201880083299.8A patent/CN111788185B/zh active Active
- 2018-12-20 SG SG11202005791QA patent/SG11202005791QA/en unknown
- 2018-12-20 KR KR1020207020939A patent/KR102736360B1/ko active Active
- 2018-12-20 MA MA051331A patent/MA51331A/fr unknown
- 2018-12-20 ES ES18890906T patent/ES2980175T3/es active Active
- 2018-12-20 AU AU2018388655A patent/AU2018388655C1/en active Active
- 2018-12-20 US US16/226,865 patent/US10828285B2/en active Active
- 2018-12-20 EP EP18890906.3A patent/EP3728203B1/fr active Active
- 2018-12-21 TW TW107146332A patent/TWI789470B/zh active
-
2020
- 2020-06-18 IL IL275500A patent/IL275500B2/en unknown
- 2020-09-25 US US17/033,124 patent/US11478460B2/en active Active
-
2022
- 2022-09-13 US US17/931,801 patent/US12268675B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2021506893A (ja) | 2021-02-22 |
| KR102736360B1 (ko) | 2024-11-28 |
| US12268675B2 (en) | 2025-04-08 |
| EP3728203B1 (fr) | 2024-03-13 |
| US20230115912A1 (en) | 2023-04-13 |
| MX2020006459A (es) | 2020-11-06 |
| AU2018388655C1 (en) | 2023-03-23 |
| CN111788185A (zh) | 2020-10-16 |
| EP3728203A4 (fr) | 2021-06-16 |
| ES2980175T3 (es) | 2024-09-30 |
| AU2018388655B2 (en) | 2022-11-24 |
| KR20200109316A (ko) | 2020-09-22 |
| TW201927782A (zh) | 2019-07-16 |
| EP3728203A1 (fr) | 2020-10-28 |
| US11478460B2 (en) | 2022-10-25 |
| IL275500A (en) | 2020-08-31 |
| BR112020012270A2 (pt) | 2020-11-24 |
| IL275500B1 (en) | 2023-01-01 |
| US20190192491A1 (en) | 2019-06-27 |
| NZ765589A (en) | 2024-04-26 |
| RU2020124093A (ru) | 2022-01-25 |
| SG11202005791QA (en) | 2020-07-29 |
| AU2018388655A1 (en) | 2020-07-09 |
| US10828285B2 (en) | 2020-11-10 |
| TWI789470B (zh) | 2023-01-11 |
| CN111788185B (zh) | 2024-12-13 |
| JP7254082B2 (ja) | 2023-04-07 |
| CA3085946A1 (fr) | 2019-06-27 |
| IL275500B2 (en) | 2023-05-01 |
| WO2019126424A1 (fr) | 2019-06-27 |
| US20210106568A1 (en) | 2021-04-15 |
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