MA56398A - Composés 2,3-dihydroquinazoline en tant qu'inhibiteurs de nav1.8 - Google Patents
Composés 2,3-dihydroquinazoline en tant qu'inhibiteurs de nav1.8Info
- Publication number
- MA56398A MA56398A MA056398A MA56398A MA56398A MA 56398 A MA56398 A MA 56398A MA 056398 A MA056398 A MA 056398A MA 56398 A MA56398 A MA 56398A MA 56398 A MA56398 A MA 56398A
- Authority
- MA
- Morocco
- Prior art keywords
- inhibitors
- dihydroquinazoline compounds
- dihydroquinazoline
- compounds
- Prior art date
Links
- GZLYSDJGEXGQDO-UHFFFAOYSA-N C1=CC=CC2=NCNC=C21 Chemical class C1=CC=CC2=NCNC=C21 GZLYSDJGEXGQDO-UHFFFAOYSA-N 0.000 title 1
- 101000654356 Homo sapiens Sodium channel protein type 10 subunit alpha Proteins 0.000 title 1
- 102100031374 Sodium channel protein type 10 subunit alpha Human genes 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/93—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962867714P | 2019-06-27 | 2019-06-27 | |
| US201962896698P | 2019-09-06 | 2019-09-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA56398A true MA56398A (fr) | 2022-05-04 |
Family
ID=71738221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA056398A MA56398A (fr) | 2019-06-27 | 2020-06-23 | Composés 2,3-dihydroquinazoline en tant qu'inhibiteurs de nav1.8 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20230103791A1 (fr) |
| EP (1) | EP3990436A1 (fr) |
| JP (1) | JP7701880B2 (fr) |
| KR (1) | KR20220030257A (fr) |
| CN (1) | CN114040911B (fr) |
| AU (2) | AU2020302338A1 (fr) |
| BR (1) | BR112021026395A2 (fr) |
| CA (1) | CA3142902A1 (fr) |
| CL (1) | CL2021003477A1 (fr) |
| CO (1) | CO2022000480A2 (fr) |
| IL (1) | IL288236B2 (fr) |
| MA (1) | MA56398A (fr) |
| MX (1) | MX2021015605A (fr) |
| PH (1) | PH12021500049A1 (fr) |
| TW (1) | TWI877177B (fr) |
| WO (1) | WO2020261114A1 (fr) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4262978A1 (fr) * | 2020-12-18 | 2023-10-25 | GlaxoSmithKline Intellectual Property Development Limited | Composés chimiques utiles pour inhiber les canaux sodiques sensibles à la tension nav1.8 et traiter les maladies médiées par nav1.8 |
| CN116601153B (zh) * | 2020-12-18 | 2025-10-28 | 葛兰素史密斯克莱知识产权发展有限公司 | 作为nav1.8抑制剂的含氮2,3-二氢喹唑啉酮化合物 |
| JP2024513688A (ja) | 2021-03-12 | 2024-03-27 | アンバー セラピューティクス リミテッド | 失禁制御のためのデバイス、システム、および方法 |
| WO2022256842A1 (fr) | 2021-06-04 | 2022-12-08 | Vertex Pharmaceuticals Incorporated | Tétrahydrofuranes à substitution hydroxy et (halo)alkoxy utiles en tant que modulateurs de canaux sodiques |
| CA3221938A1 (fr) | 2021-06-04 | 2022-12-08 | Vertex Pharmaceuticals Incorporated | Analogues de tetrahydrofurane substitues utiles en tant que modulateurs de canaux sodiques |
| AU2022283934A1 (en) | 2021-06-04 | 2023-11-30 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofuran-2-carboxamides as modulators of sodium channels |
| US20240400544A1 (en) | 2021-06-04 | 2024-12-05 | Vertex Pharmaceuticals Incorporated | N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamide analogs as modulators of sodium channels |
| SMT202500481T1 (it) | 2021-06-04 | 2026-01-12 | Vertex Pharma | N-(idrossialchil(etero)aril)tetraidrofuran carbossammidi come modulatori di canali del sodio |
| HRP20260068T1 (hr) | 2021-06-04 | 2026-02-27 | Vertex Pharmaceuticals Incorporated | Čvrsti farmaceutski oblici i režimi doziranja koji obuhvaćaju (2r,3s,4s,5r)-4-[[3-(3,4-difluor-2-metoksifenil)-4,5-dimetil-5-(trifluormetil)tetrahidrofuran-2-karbonil]amino]piridin-2-karboksamid |
| AR126669A1 (es) | 2021-08-02 | 2023-11-01 | Eurofarma Laboratorios S A | COMPUESTOS N-ACILIDRAZÓNICOS INHIBIDORES DE Nav 1.7 Y/O Nav 1.8, SUS PROCESOS DE OBTENCIÓN, COMPOSICIONES, USOS, MÉTODOS DE TRATAMIENTO DE ESTOS Y KITS |
| UY39882A (es) | 2021-08-02 | 2023-06-15 | Eurofarma Laboratorios S A | COMPUESTOS NACILHIDRAZÓNICOS INHIBIDORES DE Nav 1.7 Y/O Nav 1.8, SUS PROCESOS DE OBTENCIÓN, COMPOSICIONES, USOS, MÉTODOS DE TRATAMIENTO DE ESTOS Y KITS |
| AU2023225036A1 (en) * | 2022-02-25 | 2024-07-11 | Katholieke Universiteit Leuven | Dihydroquinazolinones and related analogs for inhibiting yap/taz-tead |
| CN114605408B (zh) * | 2022-03-30 | 2023-06-16 | 沈阳药科大学 | 5-羟基-1,3-二取代苯基吡啶并[2,3-d]嘧啶类化合物及其制法和应用 |
| US20230382910A1 (en) | 2022-04-22 | 2023-11-30 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| CA3256248A1 (fr) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | Composés hétéroaryles pour le traitement de la douleur |
| WO2023205463A1 (fr) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | Composés hétéroaryles pour le traitement de la douleur |
| CA3257285A1 (fr) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | Composés hétéroaryles pour le traitement de la douleur |
| JP2025516005A (ja) | 2022-04-25 | 2025-05-23 | サイトワン セラピューティクス インコーポレイテッド | 疼痛の処置のためのｎａｖ１．８の二環式複素環アミド阻害剤 |
| TW202400560A (zh) * | 2022-04-28 | 2024-01-01 | 南韓商愛思開生物製藥股份有限公司 | Ｎ－氧化物化合物及其用途 |
| CA3258570A1 (fr) * | 2022-06-09 | 2023-12-14 | Glaxosmithkline Intellectual Property Development Limited | Composés chimiques |
| US20250368647A1 (en) * | 2022-06-09 | 2025-12-04 | Glaxosmithkline Intellectual Property Development Limited | Nitrogen containing condensed 2,3-dihydroquinazolinone compounds as nav1.8 inhibitors |
| WO2024123815A1 (fr) | 2022-12-06 | 2024-06-13 | Vertex Pharmaceuticals Incorporated | Procédé de synthèse de modulateurs de tétrahydrofurane substitués de canaux sodiques |
| EP4660182A1 (fr) | 2023-01-30 | 2025-12-10 | Eurofarma Laboratórios S.A. | Composés aryle pyridines inhibiteurs de nav 1.7 et/ou de nav 1.8, leurs procédés d'obtention, compositions, utilisations, méthodes de traitement et trousses |
| PY2405420A (es) | 2023-01-30 | 2024-11-14 | Eurofarma Laboratorios S A | Amidas bloqueadoras de nav 1.7 y/o nav 1.8, sus procesos de obtención, composiciones, usos, métodos de tratamiento de los mismos y kits |
| WO2024159287A1 (fr) | 2023-01-30 | 2024-08-08 | Eurofarma Laboratórios S.A. | Hydoxymates inhibiteurs de nav 1.7 et/ou de nav 1.8, leurs procédés d'obtention, compositions, utilisations, méthodes de traitement et trousses |
| PY2404093A (es) | 2023-01-30 | 2024-10-03 | Eurofarma Laboratorios S A | Hidrazidas bloqueadoras de nav 1.7 y/o nav 1.8, sus procesos de obtención, composiciones, usos, métodos de tratamiento de los mismos y kits |
| PY2404641A (es) | 2023-01-30 | 2024-10-03 | Eurofarma Laboratorios S A | COMPUESTOS FENÓLICOS BLOQUEADORES DE Nav 1.7 Y/O Nav 1.8, SUS PROCESOS DE OBTENCIÓN, SUS COMPOSICIONES, SUS USOS, LOS MÉTODOS DE TRATAMIENTO DE LOS MISMOS Y SUS KITS |
| WO2025054260A1 (fr) * | 2023-09-07 | 2025-03-13 | Kinnate Biopharma Inc. | Inhibiteurs de la kinase mek |
| WO2025090480A1 (fr) | 2023-10-23 | 2025-05-01 | Vertex Pharmaceuticals Incorporated | Composés hétéroaryles pour le traitement de la douleur |
| WO2025090516A1 (fr) | 2023-10-23 | 2025-05-01 | Vertex Pharmaceuticals Incorporated | Procédés de préparation de composés pour le traitement de la douleur et de formes solides de ceux-ci |
| WO2025090511A1 (fr) | 2023-10-23 | 2025-05-01 | Vertex Pharmaceuticals Incorporated | Procédés de préparation de modulateurs de canaux sodiques et formes solides de ceux-ci pour le traitement de la douleur |
| WO2025090465A1 (fr) | 2023-10-23 | 2025-05-01 | Vertex Pharmaceuticals Incorporated | Composés hétéroaryle pour le traitement de la douleur |
| US20250186419A1 (en) | 2023-12-07 | 2025-06-12 | Vertex Pharmaceuticals Incorporated | Dosing regimens for treating pain |
| WO2025160286A1 (fr) | 2024-01-24 | 2025-07-31 | Siteone Therapeutics, Inc. | 2-aryl cycloalkyle et inhibiteurs d'hétérocycloalkyle de nav1.8 pour le traitement de la douleur |
| WO2025240895A1 (fr) * | 2024-05-17 | 2025-11-20 | Siteone Therapeutics, Inc. | Inhibiteurs cycloalkyle et hétérocycloalkyle substitués de nav1.8 pour le traitement de la douleur |
| US20260001877A1 (en) | 2024-06-28 | 2026-01-01 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| WO2026013449A2 (fr) | 2024-07-11 | 2026-01-15 | Sea4Us - Biotecnologia E Recursos Marinhos, Sa | Composés dérivés d'oxazolidone et leur utilisation dans le traitement de la douleur chronique et aiguë |
| WO2026030525A1 (fr) | 2024-07-31 | 2026-02-05 | Vertex Pharmaceuticals Incorporated | Formes galéniques et schémas posologiques de zilvétrigine pour le traitement de la douleur |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3761480A (en) * | 1968-07-10 | 1973-09-25 | Pennwalt Corp | Process for the preparation of 3-aryl-6-sulfamyl-7-halo-1,2,3,4-tetrahydro-4-quinazolinones |
| JPS5518713B2 (fr) * | 1972-09-09 | 1980-05-21 | ||
| ZA200507979B (en) * | 2003-03-03 | 2007-03-28 | Vertex Pharma Inc | Quinazolines useful as modulators of ion channels |
| US7713983B2 (en) * | 2003-03-03 | 2010-05-11 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
| US7767680B2 (en) * | 2004-11-03 | 2010-08-03 | Vertex Pharmaceuticals Incorporated | Ion channel modulators and methods of use |
| US7893260B2 (en) * | 2005-11-04 | 2011-02-22 | Hydra Biosciences, Inc. | Substituted quinazolin-4-one compounds for antagonizing TRPV3 function |
| ES2377988T3 (es) * | 2005-11-14 | 2012-04-03 | Vertex Pharmaceuticals, Inc. | Quinazolinas útiles como moduladores de canales iónicos controlados por voltaje |
| WO2008004716A1 (fr) * | 2006-07-05 | 2008-01-10 | Korea Reserach Institute Of Chemical Technology | Nouveaux dérivés substitués de 1h-quinazoline-2,4-dione, procédé de préparation de ces derniers et composition pharmaceutique contenant lesdits dérivés |
| AR065081A1 (es) * | 2007-01-29 | 2009-05-13 | Xenon Pharmaceuticals Inc | Compuestos de quinazolinona y pirimidona fusionados y composicion farmaceutica |
| RU2683788C2 (ru) * | 2013-01-31 | 2019-04-02 | Вертекс Фармасьютикалз Инкорпорейтед | Амиды хинолина и хиназолина, полезные в качестве модуляторов натриевых каналов |
| US20190134056A1 (en) * | 2017-03-10 | 2019-05-09 | The Trustees Of The Stevens Institute Of Technolog | K-ras mutations and antagonists |
-
2020
- 2020-06-23 MX MX2021015605A patent/MX2021015605A/es unknown
- 2020-06-23 MA MA056398A patent/MA56398A/fr unknown
- 2020-06-23 IL IL288236A patent/IL288236B2/en unknown
- 2020-06-23 EP EP20743811.0A patent/EP3990436A1/fr active Pending
- 2020-06-23 KR KR1020227002579A patent/KR20220030257A/ko not_active Ceased
- 2020-06-23 AU AU2020302338A patent/AU2020302338A1/en not_active Abandoned
- 2020-06-23 PH PH1/2021/500049A patent/PH12021500049A1/en unknown
- 2020-06-23 CA CA3142902A patent/CA3142902A1/fr active Pending
- 2020-06-23 US US17/617,479 patent/US20230103791A1/en active Pending
- 2020-06-23 WO PCT/IB2020/055921 patent/WO2020261114A1/fr not_active Ceased
- 2020-06-23 CN CN202080047250.4A patent/CN114040911B/zh active Active
- 2020-06-23 JP JP2021577097A patent/JP7701880B2/ja active Active
- 2020-06-23 BR BR112021026395A patent/BR112021026395A2/pt unknown
- 2020-06-24 TW TW109121445A patent/TWI877177B/zh active
-
2021
- 2021-12-24 CL CL2021003477A patent/CL2021003477A1/es unknown
-
2022
- 2022-01-20 CO CONC2022/0000480A patent/CO2022000480A2/es unknown
-
2023
- 2023-11-20 AU AU2023270195A patent/AU2023270195B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL288236B2 (en) | 2026-02-01 |
| CO2022000480A2 (es) | 2022-01-28 |
| JP7701880B2 (ja) | 2025-07-02 |
| IL288236A (en) | 2022-01-01 |
| CN114040911A (zh) | 2022-02-11 |
| JP2022538588A (ja) | 2022-09-05 |
| PH12021500049A1 (en) | 2022-06-27 |
| MX2021015605A (es) | 2022-02-16 |
| CN114040911B (zh) | 2024-10-22 |
| KR20220030257A (ko) | 2022-03-10 |
| US20230103791A1 (en) | 2023-04-06 |
| AU2023270195B2 (en) | 2025-12-18 |
| IL288236B1 (en) | 2025-10-01 |
| CA3142902A1 (fr) | 2020-12-30 |
| WO2020261114A1 (fr) | 2020-12-30 |
| CL2021003477A1 (es) | 2023-04-21 |
| BR112021026395A2 (pt) | 2022-02-08 |
| AU2023270195A1 (en) | 2023-12-14 |
| EP3990436A1 (fr) | 2022-05-04 |
| TWI877177B (zh) | 2025-03-21 |
| AU2020302338A1 (en) | 2022-01-27 |
| TW202114995A (zh) | 2021-04-16 |
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