MA51418A - Inhibiteurs de glycolate oxydase pour le traitement de maladies - Google Patents

Inhibiteurs de glycolate oxydase pour le traitement de maladies

Info

Publication number
MA51418A
MA51418A MA051418A MA51418A MA51418A MA 51418 A MA51418 A MA 51418A MA 051418 A MA051418 A MA 051418A MA 51418 A MA51418 A MA 51418A MA 51418 A MA51418 A MA 51418A
Authority
MA
Morocco
Prior art keywords
diseases
treatment
oxidase inhibitors
glycolate oxidase
glycolate
Prior art date
Application number
MA051418A
Other languages
English (en)
Inventor
Qi Chao
Bing Wang
Original Assignee
Biomarin Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomarin Pharm Inc filed Critical Biomarin Pharm Inc
Publication of MA51418A publication Critical patent/MA51418A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
MA051418A 2017-12-29 2018-12-28 Inhibiteurs de glycolate oxydase pour le traitement de maladies MA51418A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762611995P 2017-12-29 2017-12-29
US201862765313P 2018-08-20 2018-08-20

Publications (1)

Publication Number Publication Date
MA51418A true MA51418A (fr) 2020-11-04

Family

ID=65234672

Family Applications (1)

Application Number Title Priority Date Filing Date
MA051418A MA51418A (fr) 2017-12-29 2018-12-28 Inhibiteurs de glycolate oxydase pour le traitement de maladies

Country Status (17)

Country Link
US (3) US11384055B2 (fr)
EP (1) EP3732167A2 (fr)
JP (2) JP7344878B2 (fr)
KR (1) KR20200112860A (fr)
CN (6) CN117069712A (fr)
AR (1) AR114070A1 (fr)
AU (1) AU2018395275A1 (fr)
BR (1) BR112020013073A2 (fr)
CA (1) CA3086401A1 (fr)
CL (1) CL2020001742A1 (fr)
IL (3) IL297802A (fr)
MA (1) MA51418A (fr)
MX (6) MX2020006414A (fr)
PE (1) PE20201500A1 (fr)
SG (1) SG11202005807QA (fr)
TW (2) TWI811282B (fr)
WO (1) WO2019133770A2 (fr)

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IL297802A (en) * 2017-12-29 2022-12-01 Biomarin Pharm Inc Glycolate oxidase inhibitors to treat the disease
WO2019165159A1 (fr) 2018-02-23 2019-08-29 Oxalurx, Inc. Composés et méthodes de traitement de maladies liées à l'oxalate
KR102865323B1 (ko) * 2018-07-06 2025-09-26 칸테로 테라퓨틱스, 인코포레이티드 트리아졸 글리콜레이트 옥시다아제 억제제
BR112022003358A2 (pt) * 2019-08-22 2022-05-17 Oxalurx Inc Composto, composição farmacêutica, método para inibir atividade de glicolato oxidase (gox) em uma amostra biológica, método para tratar uma doença relacionada ao oxalato em um indivíduo que necessita do mesmo, e uso de um composto
WO2021086874A1 (fr) 2019-11-01 2021-05-06 GyanRx Sciences, Inc. Carboxylates hétérocycles en tant qu'inhibiteurs de glycolate oxydase
US20230129160A1 (en) * 2020-01-08 2023-04-27 Cantero Therapeutics, Inc. Processes for preparing triazole glycolate oxidase inhibitors
WO2022002131A1 (fr) * 2020-06-30 2022-01-06 苏州恩华生物医药科技有限公司 Dérivé de 5-((1,2,3,4-tétrahydroisoquinoline-7-yl)amino)pyridin-2(1h)-one et son utilisation
KR20230106582A (ko) 2020-08-04 2023-07-13 캘시리틱스 테라퓨틱스, 인코포레이티드 트리페닐 칼실리틱 화합물의 제형
WO2022066933A1 (fr) * 2020-09-24 2022-03-31 Chinook Therapeutics Canada, Inc. Composés triazolyl substitués de pentafluoro-sulfanyl et procédés d'utilisation associés
CN114478210A (zh) * 2022-02-26 2022-05-13 江苏壹药新材料有限公司 一种7-氯萘-2-甲醛的合成方法
WO2023170024A1 (fr) * 2022-03-11 2023-09-14 University Of Copenhagen Modulateurs de camk2 et leur utilisation en médecine
GB202213162D0 (en) 2022-09-08 2022-10-26 Cambridge Entpr Ltd Prodrugs
CN120225507A (zh) * 2022-11-25 2025-06-27 海思科医药集团股份有限公司 一种三唑衍生物及其在医药上的应用
WO2024212137A1 (fr) * 2023-04-12 2024-10-17 Cantero Therapeutics, Inc. Formes cristallines d'un composé d'acide 1h-1, 2, 3-triazole-4-carboxylique
WO2025206002A1 (fr) * 2024-03-28 2025-10-02 日本曹達株式会社 Composé de triazole et microbicide pour une utilisation agricole ou horticole

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JP2017095366A (ja) * 2015-11-18 2017-06-01 持田製薬株式会社 新規ビアリールアミド誘導体
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WO2017100266A1 (fr) * 2015-12-07 2017-06-15 Wake Forest University Health Sciences Inhibiteurs de glycolate oxydase et méthodes d'utilisation pour le traitement des calculs rénaux
CN105541796B (zh) * 2016-03-03 2017-11-14 武汉工程大学 一种nh‑1,2,3‑三唑联吡啶化合物的合成方法
CN105669569B (zh) * 2016-03-03 2017-12-12 武汉工程大学 一种nh‑1,2,3‑三唑化合物的合成方法
IL297802A (en) * 2017-12-29 2022-12-01 Biomarin Pharm Inc Glycolate oxidase inhibitors to treat the disease
BR112021025781A2 (pt) * 2019-06-19 2022-03-03 Biomarin Pharm Inc Composto, composição farmacêutica, método de tratamento de uma doença ou transtorno associado com um defeito no metabolismo de glioxilato, método de tratamento de uma doença ou transtorno associado com a enzima glicolato oxidase (go) ou alterações no metabolismo de oxalato e método para inibição da enzima go

Also Published As

Publication number Publication date
JP7344878B2 (ja) 2023-09-14
IL275496A (en) 2020-08-31
WO2019133770A2 (fr) 2019-07-04
CN117024420A (zh) 2023-11-10
KR20200112860A (ko) 2020-10-05
US20210171474A1 (en) 2021-06-10
IL297802A (en) 2022-12-01
TW202340155A (zh) 2023-10-16
AR114070A1 (es) 2020-07-15
TW201930272A (zh) 2019-08-01
PE20201500A1 (es) 2020-12-29
US20230089374A1 (en) 2023-03-23
CN117126151A (zh) 2023-11-28
US20230079913A1 (en) 2023-03-16
MX2022016434A (es) 2023-01-30
MX2022016427A (es) 2023-01-30
MX2020006414A (es) 2020-09-17
MX2022016415A (es) 2023-01-30
RU2020120974A (ru) 2022-01-31
CN117069713A (zh) 2023-11-17
SG11202005807QA (en) 2020-07-29
JP2023159181A (ja) 2023-10-31
CA3086401A1 (fr) 2019-07-04
WO2019133770A3 (fr) 2019-08-15
EP3732167A2 (fr) 2020-11-04
CN117126152A (zh) 2023-11-28
JP2021509401A (ja) 2021-03-25
AU2018395275A1 (en) 2020-07-16
US11384055B2 (en) 2022-07-12
BR112020013073A2 (pt) 2020-12-01
MX2022016463A (es) 2023-02-01
CN111788187A (zh) 2020-10-16
MX2022016422A (es) 2023-01-30
RU2020120974A3 (fr) 2022-01-31
CN117069712A (zh) 2023-11-17
TWI811282B (zh) 2023-08-11
IL297788A (en) 2022-12-01
CL2020001742A1 (es) 2021-01-29

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