MA51620A - Analogues de dihydrobenzofurane et d'inden en tant qu'inhibiteurs de sarcomes cardiaques - Google Patents

Analogues de dihydrobenzofurane et d'inden en tant qu'inhibiteurs de sarcomes cardiaques

Info

Publication number
MA51620A
MA51620A MA051620A MA51620A MA51620A MA 51620 A MA51620 A MA 51620A MA 051620 A MA051620 A MA 051620A MA 51620 A MA51620 A MA 51620A MA 51620 A MA51620 A MA 51620A
Authority
MA
Morocco
Prior art keywords
dihydrobenzofurane
inden
sarcomas
analogues
cardiac
Prior art date
Application number
MA051620A
Other languages
English (en)
Other versions
MA51620B1 (fr
Inventor
Luke W Ashcraft
Chihyuan Chuang
Bradley P Morgan
Mark Vanderwal
Wenyue Wang
Original Assignee
Cytokinetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=65324663&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA51620(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cytokinetics Inc filed Critical Cytokinetics Inc
Publication of MA51620A publication Critical patent/MA51620A/fr
Publication of MA51620B1 publication Critical patent/MA51620B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/027—Organoboranes and organoborohydrides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
MA51620A 2018-01-19 2019-01-18 Analogues de dihydrobenzofurane et d'inden en tant qu'inhibiteurs de sarcomes cardiaques MA51620B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862619643P 2018-01-19 2018-01-19
US201862745724P 2018-10-15 2018-10-15
EP19703917.5A EP3740481B9 (fr) 2018-01-19 2019-01-18 Analogues de dihydrobenzofurane et d'inden en tant qu'inhibiteurs de sarcomes cardiaques
PCT/US2019/014344 WO2019144041A1 (fr) 2018-01-19 2019-01-18 Analogues de dihydrobenzofurane et d'inden en tant qu'inhibiteurs de sarcomes cardiaques

Publications (2)

Publication Number Publication Date
MA51620A true MA51620A (fr) 2020-11-25
MA51620B1 MA51620B1 (fr) 2024-10-31

Family

ID=65324663

Family Applications (1)

Application Number Title Priority Date Filing Date
MA51620A MA51620B1 (fr) 2018-01-19 2019-01-18 Analogues de dihydrobenzofurane et d'inden en tant qu'inhibiteurs de sarcomes cardiaques

Country Status (33)

Country Link
US (4) US10836755B2 (fr)
EP (2) EP4491622A3 (fr)
JP (3) JP7401439B2 (fr)
KR (1) KR102797441B1 (fr)
CN (3) CN117924208A (fr)
AU (2) AU2019208331C1 (fr)
BR (1) BR112020014428A2 (fr)
CA (2) CA3252332A1 (fr)
CL (2) CL2020001871A1 (fr)
CO (1) CO2020009225A2 (fr)
DK (1) DK3740481T5 (fr)
EC (1) ECSP20044709A (fr)
ES (1) ES2986630T3 (fr)
FI (1) FI3740481T3 (fr)
HR (1) HRP20241014T2 (fr)
HU (1) HUE067913T2 (fr)
IL (1) IL276094B2 (fr)
LT (1) LT3740481T (fr)
MA (1) MA51620B1 (fr)
MD (1) MD3740481T3 (fr)
MX (2) MX2020007532A (fr)
MY (1) MY203855A (fr)
NZ (1) NZ765795A (fr)
PH (1) PH12020551090A1 (fr)
PL (1) PL3740481T3 (fr)
PT (1) PT3740481T (fr)
RS (1) RS66042B9 (fr)
SG (1) SG11202006296YA (fr)
SI (1) SI3740481T1 (fr)
SM (1) SMT202400329T1 (fr)
TW (2) TWI835770B (fr)
UY (1) UY38057A (fr)
WO (1) WO2019144041A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD3740481T3 (ro) 2018-01-19 2025-06-30 Cytokinetics Inc Analogi de dihidrobenzofuran și inden în calitate de inhibitori ai sarcomerului cardiac
JP7610985B2 (ja) * 2018-06-26 2025-01-09 サイトキネティックス， インコーポレイテッド 心臓サルコメア阻害剤
JP7438148B2 (ja) * 2018-06-26 2024-02-26 サイトキネティックス， インコーポレイテッド 心臓サルコメア阻害剤
CA3110237A1 (fr) 2018-08-31 2020-03-05 Cytokinetics, Inc. Inhibiteurs de sarcomes cardiaques
MX2021013422A (es) * 2019-05-03 2022-02-11 Praxis Prec Medicines Inc Inhibidores de kcnt1 y metodos de uso.
IL289884B2 (en) * 2019-07-17 2026-01-01 Cytokinetics Inc Oral formulations of cardiac sarcomere inhibitors
SMT202400224T1 (it) * 2019-07-17 2024-07-09 Cytokinetics Inc Polimorfi di (r)-n-(5-(5-etil-1,2,4-ossadiazol-3-il)-2,3-diidro-1h-inden-1-il)-1-metil-1h-pirazolo-4-carbossammide
NZ784931A (en) * 2019-07-17 2025-03-28 Cytokinetics Inc Polymorphs of (r)-n-(5-(5-isopropyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)-2-methyl-2h-tetrazole-5-carboxamide
CA3190060A1 (fr) 2020-08-28 2022-03-03 MyoKardia, Inc. Methodes de traitement par modulateur de myosine
CN112094253B (zh) * 2020-09-10 2023-01-10 株式会社大熊制药 用于制备sglt抑制剂中间体的合成方法
JP2024508526A (ja) 2021-03-04 2024-02-27 サイトキネティックス， インコーポレイテッド 心筋サルコメア阻害剤
ES3014965T3 (en) 2021-07-16 2025-04-28 Cytokinetics Inc Aficamten dosage regimens for treating obstructive hypertrophic cardiomyopathy
HRP20251575T1 (hr) 2021-08-03 2026-01-30 Cytokinetics, Inc. Postupak pripreme afikamtena
CN120549937A (zh) 2022-04-26 2025-08-29 迈奥卡迪亚公司 施用肌球蛋白抑制剂的方法
TW202423423A (zh) 2022-07-20 2024-06-16 美商胞質動力學公司 治療非阻塞性肥厚性心肌病之方法
CA3262959A1 (fr) 2022-08-04 2024-02-08 Cytokinetics, Incorporated Méthodes de traitement de la cardiomyopathie hypertrophique obstructive
WO2024040190A1 (fr) 2022-08-18 2024-02-22 Cytokinetics, Incorporated Dérivés d'indane et de coumarane utilisés en tant qu'inhibiteurs de myosine du muscle squelettique rapide
WO2024134498A1 (fr) 2022-12-22 2024-06-27 Assia Chemical Industries Ltd. Formes à l'état solide d'aficamten et leur procédé de préparation
CN115894361A (zh) * 2022-12-28 2023-04-04 上海合全药业股份有限公司 一种钯催化合成1-乙酰基-6-氰基-四氢喹啉的方法
WO2024179422A1 (fr) * 2023-03-02 2024-09-06 苏州科睿思制药有限公司 Co-cristal d'afimten, son procédé de préparation et son utilisation
WO2025096779A2 (fr) 2023-11-01 2025-05-08 Bristol Myers Squibb Company Procédés de traitement avec un inhibiteur de myosine à l'aide de niveaux de protéine
WO2025175141A1 (fr) * 2024-02-16 2025-08-21 Cytokinetics, Incorporated Inhibiteurs de la myosine rapide des muscles squelettiques
US20250295639A1 (en) 2024-03-20 2025-09-25 Cytokinetics, Incorporated Methods for treating heart diseases

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US633499A (en) 1899-06-29 1899-09-19 Oil Well Supply Co Coupling for pipes, tubes, or casings.
US6334997B1 (en) 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
ES2293638T3 (es) 1994-03-25 2008-03-16 Isotechnika, Inc. Mejora de la eficacia de farmacos por deuteracion.
US5919785A (en) 1996-04-03 1999-07-06 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU2002365057A1 (en) 2001-12-21 2003-07-30 Cytokinetics, Inc. Compositions and methods for treating heart failure
AU2002367023A1 (en) 2001-12-21 2003-07-30 Cytokinetics, Inc. Compositions and methods for treating heart failure
WO2004000764A2 (fr) * 2002-06-24 2003-12-31 Vivoquest, Inc. Dimeres de benzo(b)furane
US7399866B2 (en) 2003-01-14 2008-07-15 Cytokinetics, Inc. Compounds, compositions, and methods
AU2004206955A1 (en) 2003-01-21 2004-08-05 Archemix Corp. Aptamer therapeutics useful in ocular pharmacotherapy
EP1605752B1 (fr) 2003-03-27 2011-09-14 Cytokinetics, Inc. Sulfonamides pour le traitment de l' insuffisance cardiaque congestive, leur compositions et utilisations.
MXPA05013469A (es) 2003-06-20 2006-03-09 Amgen Inc Derivados de piperazina y metodos de uso.
MXPA06014495A (es) 2004-06-17 2007-03-01 Cytokinetics Inc Compuestos, composiciones y metodos.
US20060173183A1 (en) * 2004-12-31 2006-08-03 Alantos Pharmaceuticals, Inc., Multicyclic bis-amide MMP inhibitors
CN101137414A (zh) * 2004-12-31 2008-03-05 欧兰拓制药股份有限公司 多环双酰胺mmp抑制剂
PE20061298A1 (es) 2005-04-22 2006-12-24 Wyeth Corp Compuestos derivados de dihidrobenzofurano como agonistas del receptor de serotonina 5-ht2c
EA013525B1 (ru) * 2005-05-20 2010-06-30 Алантос-Фармасьютикалз Холдинг, Инк. Гетеробициклические ингибиторы металлопротеазы и их применение
EP1959962A2 (fr) 2005-12-16 2008-08-27 Cytokinetics, Inc. Entites chimiques, compositions et methodes
RU2318818C1 (ru) 2006-04-12 2008-03-10 Общество С Ограниченной Ответственностью "Исследовательский Институт Химического Разнообразия" Азагетероциклы, комбинаторная библиотека, фокусированная библиотека, фармацевтическая композиция и способ получения (варианты)
SA08290245B1 (ar) 2007-04-23 2012-02-12 استرازينيكا ايه بي مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم
US20090192168A1 (en) 2008-01-04 2009-07-30 Alex Muci Compounds, Compositions and Methods
WO2010033701A2 (fr) * 2008-09-19 2010-03-25 Genzyme Corporation Inhibiteurs de la sphingosine kinase 1
JP5659224B2 (ja) 2009-05-15 2015-01-28 ノバルティス アーゲー アルドステロンシンターゼ阻害剤としてのアリールピリジン
US8592426B2 (en) 2011-01-24 2013-11-26 Hoffmann—La Roche Inc. Aryl-benzocycloalkyl amide derivatives
US8759380B2 (en) 2011-04-22 2014-06-24 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use
WO2013048928A1 (fr) * 2011-09-27 2013-04-04 Bristol-Myers Squibb Company Composés pyrrolinone carboxamide utiles comme inhibiteurs de lipase endothéliale
MX336247B (es) 2012-01-20 2016-01-13 Actelion Pharmaceuticals Ltd Derivados de amida heterociclicos como antagonistas del receptor p2x7.
WO2014205234A1 (fr) 2013-06-21 2014-12-24 MyoKardia, Inc. Composés de pyrimidinedione substitués par cycloalkyle
SMT202000071T1 (it) 2013-06-21 2020-03-13 Myokardia Inc Composti di pirimidinadione contro le condizioni cardiache
SG11201604595VA (en) 2013-12-11 2016-07-28 Biogen Ma Inc Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology
WO2015142001A2 (fr) 2014-03-21 2015-09-24 충남대학교산학협력단 Composé doté d'une action cardiotonique et composition pharmaceutique permettant de prévenir ou de traiter l'insuffisance cardiaque et contenant ledit composé
US9663516B2 (en) 2014-12-18 2017-05-30 MyoKardia, Inc. Bicyclic-pyrimidinedione compounds
MX2017009445A (es) * 2015-01-20 2017-11-08 Merck Sharp & Dohme Inhibidores del factor xia.
KR102585550B1 (ko) 2015-01-22 2023-10-10 미요카디아, 인크. 확장성 심근병증 (dcm)의 치료를 위한 4-메틸술포닐-치환된 피페리딘 우레아 화합물
CN105884752B (zh) * 2015-02-13 2018-08-31 山东轩竹医药科技有限公司 并环类回旋酶和拓扑异构酶iv抑制剂
MX2018003845A (es) 2015-10-02 2018-06-18 Syngenta Participations Ag Derivados de oxadiazol microbicidas.
CN108430997B (zh) 2015-12-17 2021-06-04 先正达参股股份有限公司 杀微生物的噁二唑衍生物
BR112018012378B1 (pt) 2015-12-18 2022-12-20 Syngenta Participations Ag Composto da fórmula (i) e seu uso, composição agroquímica e método de controle ou prevenção de infestação de plantas úteis por microrganismos fitopatogênicos
WO2017190107A1 (fr) 2016-04-29 2017-11-02 Board Of Regents, The University Of Texas System Liants de récepteur sigma
US11066396B2 (en) 2016-06-23 2021-07-20 Merck Sharp & Dohme Corp. 3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitors
EP3519416B1 (fr) 2016-09-27 2021-03-31 Merck Sharp & Dohme Corp. Dérivés de chromane, d'isochromane et de dihydroisobenzofurane en tant que modulateurs allostériques négatifs de mglur2, compositions et leur utilisation
WO2018089433A1 (fr) 2016-11-08 2018-05-17 Navitor Pharmaceuticals, Inc. Inhibiteurs de mtorc phényle et leurs utilisations
JP2020023442A (ja) 2016-12-19 2020-02-13 住友化学株式会社 オキサジアゾール化合物及び植物病害防除方法
US20200000822A1 (en) 2017-02-23 2020-01-02 Board Of Regents, The University Of Texas System Methods of treatment for cancer, sterol homeostasis, and neurological diseases
US10981900B2 (en) 2017-02-28 2021-04-20 Medshine Discovery Inc. Spiro compound and use thereof
KR20250116181A (ko) 2017-08-04 2025-07-31 미요카디아, 인크. 비대성 심근병증의 치료에서 사용하기 위한 마바캄텐
MD3740481T3 (ro) 2018-01-19 2025-06-30 Cytokinetics Inc Analogi de dihidrobenzofuran și inden în calitate de inhibitori ai sarcomerului cardiac
TWI903299B (zh) 2018-03-08 2025-11-01 美商英塞特公司 作為PI3K-γ抑制劑之胺基吡嗪二醇化合物
US10710994B2 (en) 2018-03-19 2020-07-14 Genentech, Inc. Oxadiazole transient receptor potential channel inhibitors
JP7438148B2 (ja) 2018-06-26 2024-02-26 サイトキネティックス， インコーポレイテッド 心臓サルコメア阻害剤
JP7610985B2 (ja) 2018-06-26 2025-01-09 サイトキネティックス， インコーポレイテッド 心臓サルコメア阻害剤
CA3110237A1 (fr) 2018-08-31 2020-03-05 Cytokinetics, Inc. Inhibiteurs de sarcomes cardiaques
IL279810B2 (en) 2018-08-31 2025-03-01 Xenon Pharmaceuticals Inc Heteroaryl-modified sulfonamide compounds and their use as medicinal agents
NZ784931A (en) 2019-07-17 2025-03-28 Cytokinetics Inc Polymorphs of (r)-n-(5-(5-isopropyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)-2-methyl-2h-tetrazole-5-carboxamide
SMT202400224T1 (it) 2019-07-17 2024-07-09 Cytokinetics Inc Polimorfi di (r)-n-(5-(5-etil-1,2,4-ossadiazol-3-il)-2,3-diidro-1h-inden-1-il)-1-metil-1h-pirazolo-4-carbossammide
IL289884B2 (en) 2019-07-17 2026-01-01 Cytokinetics Inc Oral formulations of cardiac sarcomere inhibitors
CA3190060A1 (fr) 2020-08-28 2022-03-03 MyoKardia, Inc. Methodes de traitement par modulateur de myosine
JP2024508526A (ja) 2021-03-04 2024-02-27 サイトキネティックス， インコーポレイテッド 心筋サルコメア阻害剤
ES3014965T3 (en) 2021-07-16 2025-04-28 Cytokinetics Inc Aficamten dosage regimens for treating obstructive hypertrophic cardiomyopathy
HRP20251575T1 (hr) 2021-08-03 2026-01-30 Cytokinetics, Inc. Postupak pripreme afikamtena
CN120549937A (zh) 2022-04-26 2025-08-29 迈奥卡迪亚公司 施用肌球蛋白抑制剂的方法

Also Published As

Publication number Publication date
HUE067913T2 (hu) 2024-11-28
CN111757875B (zh) 2024-01-09
ES2986630T3 (es) 2024-11-12
EP3740481B9 (fr) 2025-01-15
US20230119665A1 (en) 2023-04-20
IL276094A (en) 2020-08-31
EP4491622A2 (fr) 2025-01-15
SG11202006296YA (en) 2020-08-28
AU2019208331C1 (en) 2024-11-14
MA51620B1 (fr) 2024-10-31
PH12020551090A1 (en) 2021-09-01
NZ765795A (en) 2026-01-30
US20210147399A1 (en) 2021-05-20
EP3740481A1 (fr) 2020-11-25
FI3740481T3 (fi) 2024-07-30
CA3087283C (fr) 2026-01-27
RS66042B9 (sr) 2025-05-30
US11472796B2 (en) 2022-10-18
AU2019208331A1 (en) 2020-07-16
MY203855A (en) 2024-07-22
CA3087283A1 (fr) 2019-07-25
US10836755B2 (en) 2020-11-17
CN117964573A (zh) 2024-05-03
TW202436291A (zh) 2024-09-16
IL276094B2 (en) 2023-08-01
LT3740481T (lt) 2024-08-26
UY38057A (es) 2019-08-30
CA3252332A1 (fr) 2025-06-04
MD3740481T2 (ro) 2024-12-31
US20250059173A1 (en) 2025-02-20
US20190256504A1 (en) 2019-08-22
DK3740481T5 (da) 2025-05-05
WO2019144041A1 (fr) 2019-07-25
EP3740481B1 (fr) 2024-06-26
CO2020009225A2 (es) 2020-08-10
MX2022014312A (es) 2022-12-07
JP7401439B2 (ja) 2023-12-19
RS66042B1 (sr) 2024-11-29
JP2025106500A (ja) 2025-07-15
PL3740481T3 (pl) 2024-11-04
SMT202400329T1 (it) 2024-09-16
PT3740481T (pt) 2024-09-13
MD3740481T3 (ro) 2025-06-30
EP4491622A3 (fr) 2025-04-30
TWI835770B (zh) 2024-03-21
AU2024204859A1 (en) 2024-08-01
US12065436B2 (en) 2024-08-20
KR20200112895A (ko) 2020-10-05
HRP20241014T1 (hr) 2024-11-08
JP2023169374A (ja) 2023-11-29
IL276094B1 (en) 2023-04-01
HRP20241014T2 (hr) 2025-05-23
SI3740481T1 (sl) 2024-09-30
TW201940471A (zh) 2019-10-16
DK3740481T3 (da) 2024-07-08
CN111757875A (zh) 2020-10-09
KR102797441B1 (ko) 2025-04-22
CL2022001091A1 (es) 2023-01-20
CN117924208A (zh) 2024-04-26
TWI898447B (zh) 2025-09-21
BR112020014428A2 (pt) 2020-12-01
FI3740481T9 (fi) 2025-05-07
MX2020007532A (es) 2020-09-09
AU2019208331B2 (en) 2024-05-02
CL2020001871A1 (es) 2020-10-23
JP2021511331A (ja) 2021-05-06
ECSP20044709A (es) 2020-10-30

Similar Documents

Publication Publication Date Title
MA51620A (fr) Analogues de dihydrobenzofurane et d'inden en tant qu'inhibiteurs de sarcomes cardiaques
MA49903A (fr) Sulfonylureés et sulfonylthioureés en tant qu'inhibiteurs de nlrp3
EP4069212A4 (fr) Inhibiteurs de hif-2 alpha
MA52486A (fr) Pyridazinones utilisés en tant qu'inhibiteurs de parp7
PL3638666T3 (pl) Chwastobójczo skuteczne 3-fenyloizoksazolino-5-karboksyamidy amidów kwasu tetrahydro- i dihydrofuranokarboksylowego
EP3860449A4 (fr) Agencement d'électrodes
EP3773563C0 (fr) Promédicaments d'antagonistes de c5ar bicycliques fusionnés
EP3768854A4 (fr) Modulation de l'expression de hsd17b13
EP3906029A4 (fr) Inhibiteurs de l'interaction ménine-mll
MA46180A (fr) Analogues de l'amyline
EP3454844A4 (fr) Polythérapies d'inhibiteurs de hdac et d'inhibiteurs de pd-1
EP3801500A4 (fr) Inhibiteurs de sarm1
EP3716830C0 (fr) Détection de l'usage de l'équipement d'hygiène
MA52004A (fr) Inhibiteurs d'o-glycoprotéine-2-acétamido-2-désoxy-3-d-glycopyranosidase
MA51337A (fr) Inhibiteurs spiro exo-aza de l'interaction ménine-mll
MA49006A (fr) Inhibiteurs d'ip6k
IL268905B (en) Phage therapy
EP3752001A4 (fr) Dérivés de sobétirome
EP3983360C0 (fr) Décomposition de struvite
MA53648A (fr) Inhibiteurs d'o-glycoprotéine-2-acétamido-2-désoxy-3-d-glucopyranosidase
EP3612133A4 (fr) Échafaudages implantables pour le traitement de la sinusite
EP3697763A4 (fr) Inhibiteurs de la d-amino-acide oxydase et applications thérapeutiques associées
EP3759680A4 (fr) Modification de flux de travaux sur le terrain
EP3952930C0 (fr) Vaporisateur d'agents de décontamination
EP3793980A4 (fr) Forme cristalline de s-apomorphine