MA51627A - Benzofurane, benzopyrrole, benzothiophène substitués et inhibiteurs du complément structurellement apparentés - Google Patents

Benzofurane, benzopyrrole, benzothiophène substitués et inhibiteurs du complément structurellement apparentés

Info

Publication number: MA51627A
Authority: MA; Morocco
Prior art keywords: benzofurane; benzopyrrole; benzothiophene; substitutes; structurally related
Prior art date: 2018-04-06

Application number

MA051627A

Other languages

English (en)

Other versions

MA51627B1 (fr

Inventor

Yarlagadda S Babu

Venkat R Chintareddy

zhao Dang

Pravin L Kotian

V Satish Kumar

peng-cheng Lu

Wei Lv

Trung Xuan Nguyen

Krishnan Raman

Minwan Wu

Weihe Zhang

Original Assignee

Biocryst Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2018-04-06

Filing date

2019-04-05

Publication date

2021-06-02

2019-04-05 Application filed by Biocryst Pharm Inc filed Critical Biocryst Pharm Inc

2021-06-02 Publication of MA51627A publication Critical patent/MA51627A/fr

2021-10-29 Publication of MA51627B1 publication Critical patent/MA51627B1/fr

Links

FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 title 2
SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 2
IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 title 1
239000004074 complement inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Ophthalmology & Optometry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Furan Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Quinoline Compounds (AREA)
Indole Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

MA51627A 2018-04-06 2019-04-05 Benzofurane, benzopyrrole, benzothiophène substitués et inhibiteurs du complément structurellement apparentés MA51627B1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201862654108P	2018-04-06	2018-04-06
PCT/US2019/026054 WO2019195720A1 (fr)	2018-04-06	2019-04-05	Benzofurane, benzopyrrole, benzothiophène substitués et inhibiteurs du complément structurellement apparentés

Publications (2)

Publication Number	Publication Date
MA51627A true MA51627A (fr)	2021-06-02
MA51627B1 MA51627B1 (fr)	2021-10-29

Family

ID=68101457

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
MA51627A MA51627B1 (fr)	2018-04-06	2019-04-05	Benzofurane, benzopyrrole, benzothiophène substitués et inhibiteurs du complément structurellement apparentés
MA57412A MA57412B1 (fr)	2018-04-06	2019-04-05	Benzopyrrole substitués et inhibiteurs du complément structurellement apparentés

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
MA57412A MA57412B1 (fr)	2018-04-06	2019-04-05	Benzopyrrole substitués et inhibiteurs du complément structurellement apparentés

Country Status (34)

Country	Link
US (6)	US11021458B2 (fr)
EP (3)	EP3939658B1 (fr)
JP (2)	JP7383635B2 (fr)
KR (1)	KR102936604B1 (fr)
CN (2)	CN117164499A (fr)
AR (1)	AR115033A1 (fr)
AU (2)	AU2019247471B2 (fr)
BR (1)	BR112020019183A2 (fr)
CL (2)	CL2020002578A1 (fr)
CO (1)	CO2020013840A2 (fr)
CY (1)	CY1124510T1 (fr)
DK (2)	DK3687506T3 (fr)
EA (1)	EA202092383A1 (fr)
ES (2)	ES3000732T3 (fr)
FI (1)	FI3939658T3 (fr)
HR (2)	HRP20211405T1 (fr)
HU (2)	HUE055307T2 (fr)
IL (2)	IL277787B2 (fr)
LT (2)	LT3687506T (fr)
MA (2)	MA51627B1 (fr)
MD (2)	MD3939658T2 (fr)
MX (2)	MX2020010508A (fr)
PE (1)	PE20210398A1 (fr)
PH (1)	PH12020551589A1 (fr)
PL (2)	PL3939658T3 (fr)
PT (2)	PT3687506T (fr)
PY (1)	PY1927283A (fr)
RS (2)	RS62370B1 (fr)
SG (1)	SG11202008972WA (fr)
SI (2)	SI3687506T1 (fr)
SM (2)	SMT202100579T1 (fr)
TW (2)	TWI873092B (fr)
UY (1)	UY38174A (fr)
WO (1)	WO2019195720A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI873092B (zh)	2018-04-06	2025-02-21	美商百歐克斯製藥公司	取代的苯并呋喃、苯并吡咯、苯并噻吩及結構相關的補體抑制劑
CA3148119A1 (fr) *	2019-07-31	2021-02-04	Biocryst Pharmaceuticals, Inc.	Schemas posologiques pour inhibiteurs oraux du facteur d du complement
UY38909A (es) *	2019-10-09	2021-05-31	Biocryst Pharm Inc	Inhibidores del factor d del complemento para administración oral
UY38912A (es)	2019-10-09	2021-05-31	Biocryst Pharm Inc	Inhibidores del factor d del complemento para administración oral
CN115362162A (zh)	2020-02-20	2022-11-18	艾其林医药公司	用于治疗补体因子d介导的障碍的杂芳基化合物
AR121715A1 (es) *	2020-04-03	2022-06-29	Biocryst Pharm Inc	Pirrolopirimidinaminas como inhibidores del sistema del complemento
WO2022060764A1 (fr) *	2020-09-18	2022-03-24	Merck Sharp & Dohme Corp.	Benzofuran-carboxamides modifiés comme inhibiteurs du glucosylcéramide synthase
TW202304890A (zh) *	2021-04-14	2023-02-01	美商百歐克斯製藥公司	Klk5雙環雜芳香族抑制劑
CN118176187A (zh) *	2021-10-21	2024-06-11	江苏恒瑞医药股份有限公司	稠合环类化合物、其制备方法及其在医药上的应用
AR129422A1 (es) *	2022-05-25	2024-08-21	Univ Leuven Kath	Nuevos derivados para tratar trastornos mediados por trpm3
WO2024112831A1 (fr) *	2022-11-22	2024-05-30	Maze Therapeutics, Inc.	Inhibiteurs d'élément 19 de la famille 6a des transporteurs de solutés (slc6a19) et leurs procédés d'utilisation
WO2024148269A2 (fr) *	2023-01-06	2024-07-11	Biocryst Pharmaceuticals, Inc.	Formes posologiques orales et régimes posologiques oraux pour le traitement de maladies médiées par le complément
KR102925481B1 (ko) *	2023-09-05	2026-02-10	광주과학기술원	신규 화합물 및 이의 건선 치료 용도
US20250129371A1 (en)	2023-10-11	2025-04-24	Regeneron Pharmaceuticals, Inc.	Treatment Of Macular Degeneration With Complement Factor D (CFD) Inhibitors
CN119504834B (zh) *	2024-11-21	2025-10-17	南开大学	一种以含硅基团为疏水标签的pd-l1蛋白降解剂及其制备方法、药物组合物和应用

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3377387A (en)	1966-12-01	1968-04-09	Purdue Research Foundation	Process for preparing nitro compounds by reacting organic amines with ozone
US4559157A (en)	1983-04-21	1985-12-17	Creative Products Resource Associates, Ltd.	Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr)	1983-08-30	1985-04-24	Oreal	Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
LU86084A1 (fr)	1985-09-20	1987-04-02	Faco Sa	Apparei de massage electrique
US5102417A (en)	1985-11-07	1992-04-07	Expandable Grafts Partnership	Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US4800882A (en)	1987-03-13	1989-01-31	Cook Incorporated	Endovascular stent and delivery system
US4820508A (en)	1987-06-23	1989-04-11	Neutrogena Corporation	Skin protective composition
US4886062A (en)	1987-10-19	1989-12-12	Medtronic, Inc.	Intravascular radially expandable stent and method of implant
US4992478A (en)	1988-04-04	1991-02-12	Warner-Lambert Company	Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en)	1988-09-12	1990-07-03	University Of New York	Treatment of damaged bone marrow and dosage units therefor
WO1990013332A1 (fr)	1989-05-11	1990-11-15	Cedars-Sinai Medical Center	Support pour medicaments a liberation progressive
WO1991012779A1 (fr)	1990-02-28	1991-09-05	Medtronic, Inc.	Prothese pour l'elution intraluminale d'un medicament
US5419760A (en)	1993-01-08	1995-05-30	Pdt Systems, Inc.	Medicament dispensing stent for prevention of restenosis of a blood vessel
US5429634A (en)	1993-09-09	1995-07-04	Pdt Systems	Biogenic implant for drug delivery and method
US6774278B1 (en)	1995-06-07	2004-08-10	Cook Incorporated	Coated implantable medical device
AU3127900A (en)	1998-12-23	2000-07-31	Du Pont Pharmaceuticals Company	Thrombin or factor xa inhibitors
US6472393B1 (en)	1999-01-13	2002-10-29	Genentech, Inc.	Serine protease inhibitors
GB0016454D0 (en)	2000-07-04	2000-08-23	Hoffmann La Roche	Thienopyrrolidinones
US6770729B2 (en)	2002-09-30	2004-08-03	Medtronic Minimed, Inc.	Polymer compositions containing bioactive agents and methods for their use
WO2007136572A2 (fr) *	2006-05-15	2007-11-29	Merck & Co., Inc.	Composés bicycliques antidiabétiques
JP2010502618A (ja) *	2006-08-31	2010-01-28	アリーナファーマシューティカルズ，インコーポレイテッド	セロトニン５−ｈｔ２ａ受容体のモジュレータとしてのベンゾフラン誘導体
US9056874B2 (en) *	2012-05-04	2015-06-16	Novartis Ag	Complement pathway modulators and uses thereof
PT2855456T (pt) *	2012-05-04	2017-07-10	Novartis Ag	Moduladores da via do complemento e usos dos mesmos
CN105555766A (zh) *	2013-07-18	2016-05-04	诺华股份有限公司	作为补体因子d抑制剂的氨基甲基-联芳基衍生物及其应用
JP2016531127A (ja)	2013-08-22	2016-10-06	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	アルキニルアルコール及び使用方法
EA201691727A1 (ru) *	2014-02-25	2017-01-30	Ачиллион Фармасьютикалс, Инк.	Фосфонатные соединения для лечения опосредованных комплементом нарушений
WO2016088082A1 (fr) *	2014-12-05	2016-06-09	Novartis Ag	Dérivés d'aminométhyl-biaryle en tant qu'inhibiteurs du facteur d du complément et leurs utilisations
WO2017035415A1 (fr)	2015-08-26	2017-03-02	Achillion Pharmaceuticals, Inc.	Composés alcyne pour le traitement de troubles immunitaires et inflammatoires
TWI854164B (zh) *	2016-02-01	2024-09-01	美商百歐克斯製藥公司	苯并吡唑化合物及其類似物
WO2019057946A1 (fr) *	2017-09-25	2019-03-28	F. Hoffmann-La Roche Ag	Composés aromatiques multi-cycliques utilisés en tant qu'inhibiteurs du facteur d
TWI873092B (zh)	2018-04-06	2025-02-21	美商百歐克斯製藥公司	取代的苯并呋喃、苯并吡咯、苯并噻吩及結構相關的補體抑制劑
CA3148119A1 (fr)	2019-07-31	2021-02-04	Biocryst Pharmaceuticals, Inc.	Schemas posologiques pour inhibiteurs oraux du facteur d du complement

2019
- 2019-04-03 TW TW108111855A patent/TWI873092B/zh active
- 2019-04-03 TW TW114101929A patent/TW202535858A/zh unknown
- 2019-04-05 KR KR1020207031889A patent/KR102936604B1/ko active Active
- 2019-04-05 IL IL277787A patent/IL277787B2/en unknown
- 2019-04-05 BR BR112020019183-3A patent/BR112020019183A2/pt unknown
- 2019-04-05 ES ES21183553T patent/ES3000732T3/es active Active
- 2019-04-05 FI FIEP21183553.3T patent/FI3939658T3/fi active
- 2019-04-05 ES ES19780738T patent/ES2891123T3/es active Active
- 2019-04-05 AU AU2019247471A patent/AU2019247471B2/en active Active
- 2019-04-05 WO PCT/US2019/026054 patent/WO2019195720A1/fr not_active Ceased
- 2019-04-05 MD MDE20220940T patent/MD3939658T2/ro unknown
- 2019-04-05 EP EP21183553.3A patent/EP3939658B1/fr active Active
- 2019-04-05 HR HRP20211405TT patent/HRP20211405T1/hr unknown
- 2019-04-05 EA EA202092383A patent/EA202092383A1/ru unknown
- 2019-04-05 HU HUE19780738A patent/HUE055307T2/hu unknown
- 2019-04-05 PT PT197807381T patent/PT3687506T/pt unknown
- 2019-04-05 SG SG11202008972WA patent/SG11202008972WA/en unknown
- 2019-04-05 DK DK19780738.1T patent/DK3687506T3/da active
- 2019-04-05 UY UY0001038174A patent/UY38174A/es active IP Right Grant
- 2019-04-05 SI SI201930099T patent/SI3687506T1/sl unknown
- 2019-04-05 PY PY201901927283A patent/PY1927283A/es unknown
- 2019-04-05 SM SM20210579T patent/SMT202100579T1/it unknown
- 2019-04-05 PE PE2020001534A patent/PE20210398A1/es unknown
- 2019-04-05 DK DK21183553.3T patent/DK3939658T3/da active
- 2019-04-05 RS RS20211179A patent/RS62370B1/sr unknown
- 2019-04-05 JP JP2020554437A patent/JP7383635B2/ja active Active
- 2019-04-05 HR HRP20241536TT patent/HRP20241536T1/hr unknown
- 2019-04-05 PL PL21183553.3T patent/PL3939658T3/pl unknown
- 2019-04-05 IL IL305879A patent/IL305879B2/en unknown
- 2019-04-05 EP EP24203044.3A patent/EP4524133A3/fr active Pending
- 2019-04-05 MD MDE20201202T patent/MD3687506T2/ro unknown
- 2019-04-05 MA MA51627A patent/MA51627B1/fr unknown
- 2019-04-05 EP EP19780738.1A patent/EP3687506B1/fr active Active
- 2019-04-05 RS RS20241292A patent/RS66185B1/sr unknown
- 2019-04-05 LT LTEPPCT/US2019/026054T patent/LT3687506T/lt unknown
- 2019-04-05 HU HUE21183553A patent/HUE069167T2/hu unknown
- 2019-04-05 MX MX2020010508A patent/MX2020010508A/es unknown
- 2019-04-05 SM SM20240528T patent/SMT202400528T1/it unknown
- 2019-04-05 PT PT211835533T patent/PT3939658T/pt unknown
- 2019-04-05 CN CN202311113144.3A patent/CN117164499A/zh active Pending
- 2019-04-05 SI SI201930860T patent/SI3939658T1/sl unknown
- 2019-04-05 PL PL19780738T patent/PL3687506T3/pl unknown
- 2019-04-05 MA MA57412A patent/MA57412B1/fr unknown
- 2019-04-05 CN CN201980037403.4A patent/CN112272553B/zh active Active
- 2019-04-05 LT LTEP21183553.3T patent/LT3939658T/lt unknown
- 2019-04-05 AR ARP190100905A patent/AR115033A1/es unknown
- 2019-07-15 US US16/511,642 patent/US11021458B2/en active Active
2020
- 2020-09-29 PH PH12020551589A patent/PH12020551589A1/en unknown
- 2020-10-05 CL CL2020002578A patent/CL2020002578A1/es unknown
- 2020-10-05 MX MX2022014817A patent/MX2022014817A/es unknown
- 2020-11-05 CO CONC2020/0013840A patent/CO2020013840A2/es unknown
2021
- 2021-02-05 US US17/168,574 patent/US11708347B2/en active Active
- 2021-03-16 US US17/202,965 patent/US11370774B2/en active Active
- 2021-09-21 CY CY20211100826T patent/CY1124510T1/el unknown
2022
- 2022-04-27 US US17/730,438 patent/US11866418B2/en active Active
- 2022-04-27 US US17/730,463 patent/US12043610B2/en active Active
- 2022-11-29 CL CL2022003360A patent/CL2022003360A1/es unknown
2023
- 2023-11-08 JP JP2023190466A patent/JP7720376B2/ja active Active
2024
- 2024-01-08 US US18/407,053 patent/US20240294494A1/en active Pending
- 2024-09-17 AU AU2024219811A patent/AU2024219811A1/en active Pending

Also Published As

Publication number	Publication date
LT3687506T (lt)	2021-09-10
JP7383635B2 (ja)	2023-11-20
IL277787B1 (en)	2023-10-01
RS62370B1 (sr)	2021-10-29
SMT202100579T1 (it)	2021-11-12
MA51627B1 (fr)	2021-10-29
DK3687506T3 (da)	2021-08-30
PH12020551589A1 (en)	2021-09-13
IL277787A (en)	2020-11-30
CN112272553A (zh)	2021-01-26
US11866418B2 (en)	2024-01-09
US12043610B2 (en)	2024-07-23
ES3000732T3 (en)	2025-03-03
WO2019195720A8 (fr)	2020-10-29
US20230072867A1 (en)	2023-03-09
IL305879A (en)	2023-11-01
MX2020010508A (es)	2020-11-12
EA202092383A1 (ru)	2021-02-10
HRP20211405T1 (hr)	2021-12-10
US20230099716A1 (en)	2023-03-30
TW202535858A (zh)	2025-09-16
IL305879B1 (en)	2024-08-01
EP3687506A1 (fr)	2020-08-05
MX2022014817A (es)	2023-01-18
JP7720376B2 (ja)	2025-08-07
KR20210005619A (ko)	2021-01-14
US20240294494A1 (en)	2024-09-05
US20220356166A1 (en)	2022-11-10
PY1927283A (es)	2019-10-16
MD3687506T2 (ro)	2021-12-31
PL3939658T3 (pl)	2025-01-20
CY1124510T1 (el)	2022-07-22
SI3687506T1 (sl)	2021-12-31
AU2019247471A1 (en)	2020-11-19
IL305879B2 (en)	2024-12-01
BR112020019183A2 (pt)	2021-01-05
CO2020013840A2 (es)	2021-01-29
EP4524133A2 (fr)	2025-03-19
US11370774B2 (en)	2022-06-28
JP2024028266A (ja)	2024-03-04
FI3939658T3 (fi)	2024-11-27
SG11202008972WA (en)	2020-10-29
JP2021521104A (ja)	2021-08-26
CL2020002578A1 (es)	2021-03-12
DK3939658T3 (da)	2024-12-02
EP3939658A1 (fr)	2022-01-19
HUE069167T2 (hu)	2025-02-28
WO2019195720A1 (fr)	2019-10-10
EP3687506B1 (fr)	2021-07-07
UY38174A (es)	2019-11-29
KR102936604B1 (ko)	2026-03-09
IL277787B2 (en)	2024-02-01
US20210221786A1 (en)	2021-07-22
TWI873092B (zh)	2025-02-21
US11021458B2 (en)	2021-06-01
PE20210398A1 (es)	2021-03-02
CL2022003360A1 (es)	2023-07-21
MD3939658T2 (ro)	2025-02-28
PT3687506T (pt)	2021-09-24
LT3939658T (lt)	2024-12-10
AR115033A1 (es)	2020-11-18
AU2024219811A1 (en)	2024-10-10
EP3687506A4 (fr)	2020-10-28
CN117164499A (zh)	2023-12-05
MA57412B1 (fr)	2024-10-31
CN112272553B (zh)	2023-09-22
US11708347B2 (en)	2023-07-25
EP4524133A3 (fr)	2025-06-11
PT3939658T (pt)	2024-11-27
ES2891123T3 (es)	2022-01-26
US20190345135A1 (en)	2019-11-14
EP3939658B1 (fr)	2024-10-02
AU2019247471B2 (en)	2024-07-18
HRP20241536T1 (hr)	2025-01-03
SI3939658T1 (sl)	2025-03-31
RS66185B1 (sr)	2024-12-31
TW202010742A (zh)	2020-03-16
HUE055307T2 (hu)	2021-11-29
SMT202400528T1 (it)	2025-01-14
PL3687506T3 (pl)	2021-12-20
CA3095628A1 (fr)	2019-10-10

Publication	Publication Date	Title
MA51627A (fr)	2021-06-02	Benzofurane, benzopyrrole, benzothiophène substitués et inhibiteurs du complément structurellement apparentés
IL284921A (en)	2021-09-30	Meat analogues and methods of producing the same
EP3818843A4 (fr)	2021-12-08	Cigarette
IL270494B (en)	2022-04-01	Thienopyridines and benzothiophenes useful as irak4 inhibitors
JP1680417S (ja)	2021-03-08	電子たばこ
JP1650479S (ja)	2023-01-11	電子タバコ
EP3818842A4 (fr)	2022-01-26	Cigarette
EP3818840A4 (fr)	2022-01-05	Cigarette
JP1662025S (ja)	2020-06-22	電子タバコ
PL4064886T3 (pl)	2025-02-24	Papieros elektroniczny
EP3765619C0 (fr)	2024-10-09	Inhibiteurs de micro-arn 22
PL4183271T3 (pl)	2025-02-10	Wyrób do palenia
JP1675821S (ja)	2021-01-04	電子タバコ
IL283054A (en)	2021-06-30	Methods of treating myelodysplastic syndrome
EP3793760A4 (fr)	2022-01-19	Profileur de fendeuse
EP3930510C0 (fr)	2024-08-14	Appareil de substitution du tabac
DK4004288T3 (da)	2024-02-12	Tørringsanlæg
JP1655838S (ja)	2020-03-23	電子たばこ
EP3920740C0 (fr)	2024-06-12	Dispositif de substitution du tabac
ES1231385Y (es)	2019-09-11	Aparato reposapies
EP3977260A4 (fr)	2023-01-25	Duplicata numérique
ES1220991Y (es)	2019-02-20	Ahumador
DE112019007904A5 (de)	2023-03-02	Vorrichtung zum trocknen feuchter, rieselfähiger produkte
UA41531S (uk)	2020-05-12	Електронна сигарета
JP1667426S (ja)	2020-08-31	電子たばこ