MA51998B1 - Nouveaux polymorphes de sel de calcium en tant qu'agents anti-inflammatoires, immunomodulateurs et anti-prolifératifs - Google Patents
Nouveaux polymorphes de sel de calcium en tant qu'agents anti-inflammatoires, immunomodulateurs et anti-prolifératifsInfo
- Publication number
- MA51998B1 MA51998B1 MA51998A MA51998A MA51998B1 MA 51998 B1 MA51998 B1 MA 51998B1 MA 51998 A MA51998 A MA 51998A MA 51998 A MA51998 A MA 51998A MA 51998 B1 MA51998 B1 MA 51998B1
- Authority
- MA
- Morocco
- Prior art keywords
- solvate
- hydrate
- compound
- formula
- calcium salt
- Prior art date
Links
- 159000000007 calcium salts Chemical class 0.000 title abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 230000001028 anti-proliverative effect Effects 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 title 1
- 239000002955 immunomodulating agent Substances 0.000 title 1
- 229940121354 immunomodulator Drugs 0.000 title 1
- 230000002584 immunomodulator Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000012453 solvate Substances 0.000 abstract 4
- 101150102768 Dhodh gene Proteins 0.000 abstract 2
- 108010052167 Dihydroorotate Dehydrogenase Proteins 0.000 abstract 2
- 102100032823 Dihydroorotate dehydrogenase (quinone), mitochondrial Human genes 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La présente invention concerne un polymorphe cristallin blanc a du sel de ca d'un composé de formule i ou un solvate et/ou un hydrate de celui-ci avec un rapport molaire d'un composé de formule i ou un solvate et/ou un hydrate de celui-ci à du calcium de l'ordre de 2 ± 0,3. L'invention concerne particulièrement un composé de formule i ou un solvate et/ou un hydrate de celui-ci qui est caractérisé par un motif de diffraction de rayons x sur poudre ayant des pics caractéristiques exprimés en degrés 2 thêta à ± 0,2 des valeurs indiquées ci-dessous : 2 thêta = 5,91°, 9,64°, 16,78°, 17,81°, 19,81°, 25,41°. L'invention concerne, plus particulièrement, de nouveaux polymorphes de sels de calcium du sel de ca d'un composé de formule i ou un solvate et/ou un hydrate de celui-ci qui inhibe la dihydroorotate déshydrogénase (dhodh), un procédé pour leur fabrication, des compositions pharmaceutiques les contenant et leur utilisation dans le traitement et la prévention de maladies, notamment leur utilisation dans des maladies présentant un avantage dans l'inhibition de la dihydroorotate déshydrogénase (dhodh).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18162244 | 2018-03-16 | ||
| PCT/EP2019/056560 WO2019175396A1 (fr) | 2018-03-16 | 2019-03-15 | Nouveaux polymorphes de sel de calcium en tant qu'agents anti-inflammatoires, immunomodulateurs et anti-prolifératifs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA51998A MA51998A (fr) | 2021-01-20 |
| MA51998B1 true MA51998B1 (fr) | 2024-05-31 |
Family
ID=61691328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA51998A MA51998B1 (fr) | 2018-03-16 | 2019-03-15 | Nouveaux polymorphes de sel de calcium en tant qu'agents anti-inflammatoires, immunomodulateurs et anti-prolifératifs |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US12037305B2 (fr) |
| EP (2) | EP3765439B1 (fr) |
| JP (2) | JP7358373B2 (fr) |
| KR (1) | KR102764121B1 (fr) |
| CN (1) | CN111836795B (fr) |
| AU (1) | AU2019233698B2 (fr) |
| BR (1) | BR112020017443A2 (fr) |
| DK (1) | DK3765439T3 (fr) |
| ES (1) | ES2980148T3 (fr) |
| FI (1) | FI3765439T3 (fr) |
| HR (1) | HRP20240695T1 (fr) |
| HU (1) | HUE067375T2 (fr) |
| IL (2) | IL307422B2 (fr) |
| LT (1) | LT3765439T (fr) |
| MA (1) | MA51998B1 (fr) |
| MD (1) | MD3765439T2 (fr) |
| MX (1) | MX2020009612A (fr) |
| MY (1) | MY204339A (fr) |
| PH (1) | PH12020551488A1 (fr) |
| PL (1) | PL3765439T3 (fr) |
| PT (1) | PT3765439T (fr) |
| RS (1) | RS65563B1 (fr) |
| SG (1) | SG11202008032YA (fr) |
| SI (1) | SI3765439T1 (fr) |
| SM (1) | SMT202400200T1 (fr) |
| UA (1) | UA128135C2 (fr) |
| WO (1) | WO2019175396A1 (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019175396A1 (fr) * | 2018-03-16 | 2019-09-19 | Immunic Ag | Nouveaux polymorphes de sel de calcium en tant qu'agents anti-inflammatoires, immunomodulateurs et anti-prolifératifs |
| WO2020081723A1 (fr) * | 2018-10-16 | 2020-04-23 | Georgia State University Research Foundation, Inc. | Promédicaments de monoxyde de carbone pour le traitement de troubles médicaux |
| JP2023522245A (ja) | 2020-04-21 | 2023-05-29 | イミュニック アクチェンゲゼルシャフト | ウイルス性疾患の治療又は予防において使用するためのビドフルジムス |
| WO2022200615A1 (fr) | 2021-03-26 | 2022-09-29 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Combinaison d'inhibiteur de la biosynthèse de la pyrimidine destinée à être utilisée dans le traitement d'infections virales |
| BR112023020806A2 (pt) | 2021-04-09 | 2023-12-12 | Immunic Ag | Inibidores de dhodh deuterados |
| US11877994B2 (en) * | 2021-08-02 | 2024-01-23 | Immunic Ag | Treatment of multiple sclerosis comprising DHODH inhibitors |
| UY40087A (es) | 2021-12-23 | 2023-06-30 | Immunic Ag | Inhibidores de DHODH que contienen un bioisóstero de ácido carboxílico. |
| WO2023232884A1 (fr) | 2022-06-01 | 2023-12-07 | Immunic Ag | Traitement de la colite ulcéreuse comprenant du vidofludimus ou un sel pharmaceutiquement acceptable de celui-ci |
| TW202506107A (zh) | 2023-06-28 | 2025-02-16 | 德商埃慕尼克股份公司 | 雜芳族dhodh抑制劑 |
| WO2025036941A1 (fr) | 2023-08-15 | 2025-02-20 | Immunic Ag | Forme posologique pharmaceutique à administrer par voie orale permettant une libération immédiate de vidofludimus |
| WO2025215126A1 (fr) | 2024-04-12 | 2025-10-16 | Immunic Ag | Synthèse de vidofludimus et de son sel de calcium |
| WO2026074007A1 (fr) | 2024-10-02 | 2026-04-09 | Immunic Ag | Agonistes de nurr1 avec remplacement de la fraction acide carboxylique ou carboxamide destinés à être utilisés dans le traitement de maladies neurodégénératives |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS50121428A (fr) | 1974-03-12 | 1975-09-23 | ||
| NL186239B (nl) | 1975-06-05 | Hoechst Ag | Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze. | |
| IL56012A (en) | 1977-11-29 | 1983-07-31 | Takeda Chemical Industries Ltd | N-(2-fluoro-4-bromo(or chloro)phenyl)-3,4,5,6-tetrahydrophthalamic acid derivatives,their preparation,and herbicidal compositions comprising them |
| JPS54154737A (en) | 1978-05-25 | 1979-12-06 | Mitsubishi Chem Ind Ltd | Cyclohexenedicarboxylic acid diamide and herbicide |
| JPS55157547A (en) | 1979-05-28 | 1980-12-08 | Takeda Chem Ind Ltd | Tetrahydrophthalamide derivative, its preparation and herbicide |
| AU1526483A (en) | 1982-06-14 | 1983-12-22 | Nippon Kayaku Kabushiki Kaisha | N-substituted-3,4,5,6-tetrahydrophthalamic acids |
| JPS59118750A (ja) | 1982-12-27 | 1984-07-09 | Eisai Co Ltd | カルボン酸アミド化合物およびその誘導体 |
| DE3534440A1 (de) | 1985-09-27 | 1987-04-02 | Hoechst Ag | Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes |
| GB9320299D0 (en) | 1993-10-01 | 1993-11-17 | Roussel Lab Ltd | Isoxazole derivatives |
| DE19547648A1 (de) | 1995-12-20 | 1997-06-26 | Hoechst Ag | Zubereitung, enthaltend High Density Lipoproteine und Crotonsäureamidderivate |
| DE19610955A1 (de) | 1996-03-20 | 1997-09-25 | Hoechst Ag | Kombinationspräparat, enthaltend 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)- anilid und N-(4-Trifluormethylphenyl)-2-cyan-3- hydroxycrotonsäureamid |
| AU2108099A (en) | 1998-01-30 | 1999-08-16 | Procept, Inc. | Immunosuppressive agents |
| GB9804343D0 (en) | 1998-02-27 | 1998-04-22 | Univ Cardiff | Chemical compounds |
| WO2003006424A1 (fr) | 2001-07-10 | 2003-01-23 | 4Sc Ag | Nouveaux composes utilises comme agents anti-inflammatoires, immunomodulateurs et anti-proliferatoires |
| DE60330391D1 (de) | 2002-12-23 | 2010-01-14 | 4Sc Ag | Cycloalken-dicarbonsäure-verbindungen als entzündungshemmende, immunmodulatorische und antiproliferative mittel |
| UA108760C2 (uk) | 2010-07-01 | 2015-06-10 | Кальцієві солі сполуки як протизапальні, імуномодулюючі та антипроліферативні засоби | |
| JP6629840B2 (ja) * | 2014-05-08 | 2020-01-15 | パノプテス・ファーマ・ゲーエムベーハー | 眼の疾患および障害を処置するための化合物 |
| JP6961879B2 (ja) * | 2015-12-30 | 2021-11-05 | レ ラボラトワール セルヴィエ ソシエテ・パール・アクシオンス・サンプリフィエ | 変異体イソクエン酸デヒドロゲナーゼを包含する腫瘍の処置 |
| WO2019175396A1 (fr) * | 2018-03-16 | 2019-09-19 | Immunic Ag | Nouveaux polymorphes de sel de calcium en tant qu'agents anti-inflammatoires, immunomodulateurs et anti-prolifératifs |
-
2019
- 2019-03-15 WO PCT/EP2019/056560 patent/WO2019175396A1/fr not_active Ceased
- 2019-03-15 MY MYPI2020004325A patent/MY204339A/en unknown
- 2019-03-15 HU HUE19711350A patent/HUE067375T2/hu unknown
- 2019-03-15 UA UAA202006622A patent/UA128135C2/uk unknown
- 2019-03-15 MA MA51998A patent/MA51998B1/fr unknown
- 2019-03-15 FI FIEP19711350.9T patent/FI3765439T3/fi active
- 2019-03-15 MD MDE20210073T patent/MD3765439T2/ro unknown
- 2019-03-15 LT LTEPPCT/EP2019/056560T patent/LT3765439T/lt unknown
- 2019-03-15 DK DK19711350.9T patent/DK3765439T3/da active
- 2019-03-15 SM SM20240200T patent/SMT202400200T1/it unknown
- 2019-03-15 CN CN201980018653.3A patent/CN111836795B/zh active Active
- 2019-03-15 SI SI201930751T patent/SI3765439T1/sl unknown
- 2019-03-15 ES ES19711350T patent/ES2980148T3/es active Active
- 2019-03-15 MX MX2020009612A patent/MX2020009612A/es unknown
- 2019-03-15 BR BR112020017443-2A patent/BR112020017443A2/pt active Search and Examination
- 2019-03-15 RS RS20240575A patent/RS65563B1/sr unknown
- 2019-03-15 SG SG11202008032YA patent/SG11202008032YA/en unknown
- 2019-03-15 PL PL19711350.9T patent/PL3765439T3/pl unknown
- 2019-03-15 JP JP2020549636A patent/JP7358373B2/ja active Active
- 2019-03-15 PT PT197113509T patent/PT3765439T/pt unknown
- 2019-03-15 HR HRP20240695TT patent/HRP20240695T1/hr unknown
- 2019-03-15 KR KR1020207026564A patent/KR102764121B1/ko active Active
- 2019-03-15 US US16/981,122 patent/US12037305B2/en active Active
- 2019-03-15 IL IL307422A patent/IL307422B2/en unknown
- 2019-03-15 EP EP19711350.9A patent/EP3765439B1/fr active Active
- 2019-03-15 EP EP24172742.9A patent/EP4438591A1/fr active Pending
- 2019-03-15 IL IL277326A patent/IL277326B2/en unknown
- 2019-03-15 AU AU2019233698A patent/AU2019233698B2/en active Active
-
2020
- 2020-09-16 PH PH12020551488A patent/PH12020551488A1/en unknown
-
2023
- 2023-09-25 JP JP2023159416A patent/JP2024001061A/ja active Pending
-
2024
- 2024-06-05 US US18/734,100 patent/US20250136542A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12020551488A1 (en) | Novel calcium salt polymorphs as anti-inflammatory, immunomodulatory and anti-proliferatory agents | |
| MX2022010795A (es) | Hidrato cristalino de un compuesto inhibidor de jak. | |
| JP7281822B2 (ja) | 細菌の排出ポンプ阻害剤 | |
| DK3218365T3 (en) | 2-AMINO-6- (DIFLUOROMETHYL) - 5,5-DIFLUORO-6-PHENYL-3,4,5,6-TETRAHYDROPYRIDINES AS BACE1 INHIBITORS | |
| US20170066741A1 (en) | 2-Amino-3,5,5-Trifluoro-3,4,5,6-Tetrahydropyridines as BACE1 Inhibitors for Treatment of Alzheimer's Disease | |
| PL148590B1 (en) | Method of obtaining novel derivatives of 2-amino-5-hydroxy-4-methylpyrimidine | |
| MA30704B1 (fr) | Compositions therapeutiques | |
| UA77454C2 (en) | N-substituted hydroxypyrimidinone carboxamide inhibitors of hiv integrase | |
| OA10745A (en) | Isothiazolones | |
| HK1212973A1 (zh) | 壞死性雕亡的小分子抑制劑 | |
| JP2003528853A (ja) | 酸化窒素シンターゼ阻害剤として有用なアミジノ化合物およびその塩 | |
| AU2014279113A1 (en) | 4-alkynyl imidazole derivative and medicine comprising same as active ingredient | |
| WO2006093801A1 (fr) | Derives de thiadiazine utiles en tant qu’agents anti-infectieux | |
| EP1524263A1 (fr) | prodrogues de derives de cycloalcenes | |
| MA40480B1 (fr) | Procédé de cristallisation de dérivés d'aripiprazole dans des formulations à libération prolongée pour le traitement de la schizophrénie | |
| WO2009042093A1 (fr) | Inhibiteurs de la protéase du vih | |
| WO2011002408A1 (fr) | Nouveaux composés pour le traitement de la neurodégénérescence associée à des maladies, telles que la maladie d'alzheimer ou la démence | |
| KR20020032548A (ko) | 치환 방향환 화합물, 그의 제조법 및 용도 | |
| MA30523B1 (fr) | Compose tricylique et utilisation pharmaceutique de celui-ci | |
| AU729453B2 (en) | Novel carbocyclic diarylmethylene derivatives, methods for preparing same, and therapeutical uses thereof | |
| WO2013190299A1 (fr) | Composés cyclohexane-1,2'-indene-1',2"-imidazol et leur utilisation en tant qu'inhibiteurs de bace | |
| WO2009042094A2 (fr) | Inhibiteurs de la protéase du vih | |
| MA64128B1 (fr) | Inhibiteurs de tead | |
| ZA202304537B (en) | Use of sphingosine-1-phosphate receptor agonist | |
| WO2007000392A3 (fr) | Guanidines a substitution chloro |