MA52569B1 - Méthodes pour améliorer la biodisponibilité et l'exposition d'un activateur de canal potassique voltage-dépendant - Google Patents
Méthodes pour améliorer la biodisponibilité et l'exposition d'un activateur de canal potassique voltage-dépendantInfo
- Publication number
- MA52569B1 MA52569B1 MA52569A MA52569A MA52569B1 MA 52569 B1 MA52569 B1 MA 52569B1 MA 52569 A MA52569 A MA 52569A MA 52569 A MA52569 A MA 52569A MA 52569 B1 MA52569 B1 MA 52569B1
- Authority
- MA
- Morocco
- Prior art keywords
- methods
- voltage
- potassium channel
- bioavailability
- exposure
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Selon certains modes de réalisation, la présente invention concerne des procédés et des utilisations pour traiter des troubles épileptiques chez un être humain, les procédés et les utilisations comprenant l'administration par voie orale d'une quantité thérapeutiquement efficace du modulateur allostérique du canal potassique sensible à la tension, n-[4-(6-fluoro-3,4-dihydro-1h-isoquinolin-2-yl)-2,6-diméthylphényl]-3,3- diméthylbutanamide (composé a), à l'homme en ayant besoin, par exemple, dans des conditions d'alimentation. La présente invention concerne en outre divers procédés améliorés de thérapie et d'administration du composé a.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862670253P | 2018-05-11 | 2018-05-11 | |
| PCT/US2019/031872 WO2019217924A1 (fr) | 2018-05-11 | 2019-05-10 | Procédés d'amélioration de la biodisponibilité et de l'exposition d'un dispositif d'ouverture de canal potassique sensible à la tension |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA52569A MA52569A (fr) | 2021-03-17 |
| MA52569B1 true MA52569B1 (fr) | 2023-11-30 |
Family
ID=66669101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA52569A MA52569B1 (fr) | 2018-05-11 | 2019-05-10 | Méthodes pour améliorer la biodisponibilité et l'exposition d'un activateur de canal potassique voltage-dépendant |
Country Status (34)
| Country | Link |
|---|---|
| US (6) | US11135214B2 (fr) |
| EP (2) | EP3790548B1 (fr) |
| JP (3) | JP7570924B2 (fr) |
| KR (1) | KR20210020892A (fr) |
| CN (3) | CN120549929A (fr) |
| AU (2) | AU2019265002C1 (fr) |
| BR (1) | BR112020022713A2 (fr) |
| CA (1) | CA3099292A1 (fr) |
| CL (1) | CL2020002932A1 (fr) |
| CO (1) | CO2020015476A2 (fr) |
| CR (1) | CR20200602A (fr) |
| DK (1) | DK3790548T3 (fr) |
| EA (1) | EA202092720A1 (fr) |
| ES (1) | ES2964409T3 (fr) |
| FI (1) | FI3790548T3 (fr) |
| GE (2) | GEAP202315508A (fr) |
| HR (1) | HRP20231447T1 (fr) |
| HU (1) | HUE064326T2 (fr) |
| IL (2) | IL319015A (fr) |
| LT (1) | LT3790548T (fr) |
| MA (1) | MA52569B1 (fr) |
| MD (1) | MD3790548T2 (fr) |
| MX (2) | MX2020012008A (fr) |
| MY (1) | MY204915A (fr) |
| PE (1) | PE20211211A1 (fr) |
| PH (1) | PH12020551898A1 (fr) |
| PL (1) | PL3790548T3 (fr) |
| PT (1) | PT3790548T (fr) |
| RS (1) | RS64922B1 (fr) |
| SG (1) | SG11202011102TA (fr) |
| SI (1) | SI3790548T1 (fr) |
| SM (1) | SMT202300399T1 (fr) |
| UA (1) | UA127229C2 (fr) |
| WO (1) | WO2019217924A1 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019217924A1 (fr) | 2018-05-11 | 2019-11-14 | Xenon Pharmaceuticals Inc. | Procédés d'amélioration de la biodisponibilité et de l'exposition d'un dispositif d'ouverture de canal potassique sensible à la tension |
| TWI886158B (zh) | 2019-10-10 | 2025-06-11 | 加拿大商再諾製藥公司 | 選擇性鉀通道調節劑之固態晶型 |
| MX2022005490A (es) | 2019-11-08 | 2022-08-10 | Xenon Pharmaceuticals Inc | Metodos para el tratamiento de trastornos depresivos. |
| CN114786658A (zh) * | 2019-12-06 | 2022-07-22 | 泽农医药公司 | Kv7钾离子通道开放剂治疗疼痛的用途 |
| US11957675B2 (en) * | 2021-02-09 | 2024-04-16 | Xenon Pharmaceuticals Inc. | Methods and uses for treating anhedonia |
| US20220288057A1 (en) * | 2021-02-09 | 2022-09-15 | Xenon Pharmaceuticals Inc. | Conjoint therapy for treating seizure disorders |
| CA3151863C (fr) | 2021-10-27 | 2024-01-02 | Shanghai Zhimeng Biopharma, Inc. | Compose comme regulateur de canal de potassium et preparation et utilisation connexes |
| CN113698345B (zh) * | 2021-10-27 | 2022-02-01 | 上海挚盟医药科技有限公司 | 作为钾通道调节剂的化合物及其制备和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8236861B2 (en) | 2004-02-13 | 2012-08-07 | Hormos Medical Corporation | Method for enhancing the bioavailablity of ospemifene |
| AU2006252519B2 (en) | 2005-06-02 | 2012-08-30 | Merck Sharp & Dohme Corp. | HCV protease inhibitors in combination with food |
| WO2007128462A1 (fr) | 2006-05-02 | 2007-11-15 | Chris Rundfeldt | Activateurs de canaux potassiques pour la prévention et le traitement de la dystonie et des systèmes assimilés à la dystonie |
| SG174095A1 (en) * | 2006-08-23 | 2011-09-29 | Valeant Pharmaceuticals Int | Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators |
| US8993593B2 (en) * | 2006-08-23 | 2015-03-31 | Valeant Pharmaceuticals International | N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators |
| US20100323016A1 (en) * | 2008-07-18 | 2010-12-23 | Biljana Nadjsombati | Modified release formulation and methods of use |
| JP2013517315A (ja) * | 2010-01-20 | 2013-05-16 | グラクソ グループ リミテッド | 新規組成物 |
| US10500216B2 (en) | 2011-11-18 | 2019-12-10 | Corcept Therapeutics, Inc. | Optimizing mifepristone absorption |
| WO2019217924A1 (fr) | 2018-05-11 | 2019-11-14 | Xenon Pharmaceuticals Inc. | Procédés d'amélioration de la biodisponibilité et de l'exposition d'un dispositif d'ouverture de canal potassique sensible à la tension |
-
2019
- 2019-05-10 WO PCT/US2019/031872 patent/WO2019217924A1/fr not_active Ceased
- 2019-05-10 HR HRP20231447TT patent/HRP20231447T1/hr unknown
- 2019-05-10 UA UAA202007781A patent/UA127229C2/uk unknown
- 2019-05-10 CR CR20200602A patent/CR20200602A/es unknown
- 2019-05-10 CN CN202510554824.1A patent/CN120549929A/zh active Pending
- 2019-05-10 EP EP19727216.4A patent/EP3790548B1/fr active Active
- 2019-05-10 CN CN201980046273.0A patent/CN112384216A/zh active Pending
- 2019-05-10 MY MYPI2020005869A patent/MY204915A/en unknown
- 2019-05-10 SG SG11202011102TA patent/SG11202011102TA/en unknown
- 2019-05-10 FI FIEP19727216.4T patent/FI3790548T3/fi active
- 2019-05-10 SM SM20230399T patent/SMT202300399T1/it unknown
- 2019-05-10 ES ES19727216T patent/ES2964409T3/es active Active
- 2019-05-10 MD MDE20210233T patent/MD3790548T2/ro unknown
- 2019-05-10 PL PL19727216.4T patent/PL3790548T3/pl unknown
- 2019-05-10 RS RS20231089A patent/RS64922B1/sr unknown
- 2019-05-10 SI SI201930665T patent/SI3790548T1/sl unknown
- 2019-05-10 JP JP2020562201A patent/JP7570924B2/ja active Active
- 2019-05-10 CN CN202510554905.1A patent/CN120549930A/zh active Pending
- 2019-05-10 DK DK19727216.4T patent/DK3790548T3/da active
- 2019-05-10 PT PT197272164T patent/PT3790548T/pt unknown
- 2019-05-10 AU AU2019265002A patent/AU2019265002C1/en active Active
- 2019-05-10 HU HUE19727216A patent/HUE064326T2/hu unknown
- 2019-05-10 MX MX2020012008A patent/MX2020012008A/es unknown
- 2019-05-10 CA CA3099292A patent/CA3099292A1/fr active Pending
- 2019-05-10 EP EP23185386.2A patent/EP4279133A3/fr active Pending
- 2019-05-10 BR BR112020022713-7A patent/BR112020022713A2/pt unknown
- 2019-05-10 MA MA52569A patent/MA52569B1/fr unknown
- 2019-05-10 KR KR1020207035334A patent/KR20210020892A/ko active Pending
- 2019-05-10 LT LTEPPCT/US2019/031872T patent/LT3790548T/lt unknown
- 2019-05-10 IL IL319015A patent/IL319015A/en unknown
- 2019-05-10 GE GEAP202315508A patent/GEAP202315508A/en unknown
- 2019-05-10 PE PE2020001843A patent/PE20211211A1/es unknown
- 2019-05-10 GE GEAP201915508A patent/GEP20237527B/en unknown
- 2019-05-10 IL IL278577A patent/IL278577B2/en unknown
- 2019-05-10 EA EA202092720A patent/EA202092720A1/ru unknown
- 2019-05-13 US US16/410,851 patent/US11135214B2/en active Active
-
2020
- 2020-11-09 PH PH12020551898A patent/PH12020551898A1/en unknown
- 2020-11-10 MX MX2023013247A patent/MX2023013247A/es unknown
- 2020-11-11 CL CL2020002932A patent/CL2020002932A1/es unknown
- 2020-12-11 CO CONC2020/0015476A patent/CO2020015476A2/es unknown
-
2021
- 2021-10-01 US US17/449,785 patent/US20220062266A1/en not_active Abandoned
-
2024
- 2024-04-26 US US18/648,049 patent/US20240316032A1/en active Pending
- 2024-05-30 US US18/679,045 patent/US20240316033A1/en active Pending
- 2024-09-17 AU AU2024219794A patent/AU2024219794A1/en active Pending
- 2024-10-09 JP JP2024177074A patent/JP7793016B2/ja active Active
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2025
- 2025-01-03 US US19/008,882 patent/US20250275957A1/en active Pending
- 2025-03-28 US US19/094,303 patent/US20250221980A1/en active Pending
- 2025-12-16 JP JP2025253235A patent/JP2026048849A/ja active Pending
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