MA56607A1 - Méthodes de traitement de troubles dépressifs - Google Patents

Méthodes de traitement de troubles dépressifs

Info

Publication number
MA56607A1
MA56607A1 MA56607A MA56607A MA56607A1 MA 56607 A1 MA56607 A1 MA 56607A1 MA 56607 A MA56607 A MA 56607A MA 56607 A MA56607 A MA 56607A MA 56607 A1 MA56607 A1 MA 56607A1
Authority
MA
Morocco
Prior art keywords
methods
depressive disorders
treating depressive
compound
present
Prior art date
Application number
MA56607A
Other languages
English (en)
Inventor
Gregory N Beatch
Cynthia Louise Harden
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Publication of MA56607A1 publication Critical patent/MA56607A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Selon certains modes de réalisation, la présente invention concerne des méthodes et des utilisations pour traiter des troubles dépressifs chez un être humain, les méthodes comprenant l'administration par voie orale d'une quantité thérapeutiquement efficace de n-[4-(6-fluoro-3,4-dihydro-1h-isoquinolin-2-yl)-2,6-diméthylphényl]-3,3-diméthylbutanamide (composé a), à la personne nécessitant un tel traitement. La présente invention concerne également diverses méthodes améliorées de thérapie et d'administration du composé a.
MA56607A 2019-11-08 2020-11-06 Méthodes de traitement de troubles dépressifs MA56607A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962932724P 2019-11-08 2019-11-08
PCT/US2020/059481 WO2021092439A1 (fr) 2019-11-08 2020-11-06 Méthodes de traitement de troubles dépressifs

Publications (1)

Publication Number Publication Date
MA56607A1 true MA56607A1 (fr) 2022-10-31

Family

ID=73643360

Family Applications (1)

Application Number Title Priority Date Filing Date
MA56607A MA56607A1 (fr) 2019-11-08 2020-11-06 Méthodes de traitement de troubles dépressifs

Country Status (19)

Country Link
US (2) US12178811B2 (fr)
EP (1) EP4054580A1 (fr)
JP (2) JP2022553569A (fr)
KR (1) KR20220098746A (fr)
CN (1) CN114667146A (fr)
AU (1) AU2020380961A1 (fr)
BR (1) BR112022008580A2 (fr)
CA (1) CA3155812A1 (fr)
CL (1) CL2022001102A1 (fr)
CO (1) CO2022008001A2 (fr)
CR (1) CR20220250A (fr)
GE (2) GEAP202415942A (fr)
IL (1) IL292678A (fr)
MA (1) MA56607A1 (fr)
MX (1) MX2022005490A (fr)
PE (1) PE20221766A1 (fr)
PH (1) PH12022551110A1 (fr)
TW (1) TW202128162A (fr)
WO (1) WO2021092439A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114667146A (zh) 2019-11-08 2022-06-24 泽农医药公司 治疗抑郁症的方法
US20230015539A1 (en) 2019-12-06 2023-01-19 Icahn School Of Medicine At Mount Sinai Method of treatment with kcnq channel openers
PE20231815A1 (es) * 2021-02-09 2023-11-16 Xenon Pharmaceuticals Inc Abridor de canales de potasio controlado por voltaje para uso en el tratamiento de la anhedonia
WO2022173853A1 (fr) * 2021-02-09 2022-08-18 Xenon Pharmaceuticals Inc. Thérapie conjointe pour le traitement de crises épileptiques
WO2023057977A1 (fr) * 2021-10-08 2023-04-13 Albert Ludwigs Universität Freiburg Traitement de troubles psychiatriques par stimulation cérébrale profonde

Family Cites Families (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3639385A (en) 1968-07-26 1972-02-01 Eastman Kodak Co Heterocyclic monoazo compounds from n n-diaralkyl anilines and polyester textile materials dyed therewith
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US4181803A (en) 1973-12-14 1980-01-01 Eisai Co., Ltd. Propiophenone derivatives and preparation thereof
US4326525A (en) 1980-10-14 1982-04-27 Alza Corporation Osmotic device that improves delivery properties of agent in situ
ATE25078T1 (de) 1982-10-27 1987-02-15 Degussa 2-amino-3-acylamino-6-benzylamino-pyridinderivate mit anti-epileptischer wirkung.
DE3337593A1 (de) 1982-10-27 1984-05-03 Degussa Ag, 6000 Frankfurt 2-amino-3-acylamino-6-benzylamino-pyridin-derivate mit antiepileptischer wirkung
EP0189788B1 (fr) 1985-01-23 1989-09-13 ASTA Pharma Aktiengesellschaft Combinaison synergétique de flupirtine et d'anti-phlogistiques non-stéroidaux
EP0193056B1 (fr) 1985-02-23 1989-06-07 ASTA Pharma Aktiengesellschaft Combinaison de la flupirtine avec des spasmolytiques à effet anticholinergique
DE3604575A1 (de) 1985-02-23 1986-08-28 Degussa Ag, 6000 Frankfurt Kombination von flupirtin und anticholinergisch wirkenden spasmolytika
JP2583067B2 (ja) 1987-08-04 1997-02-19 住友化学工業株式会社 モノアゾ化合物およびそれを用いて疎水性繊維材料を染色または捺染する方法
GB8800199D0 (en) 1988-01-06 1988-02-10 Beecham Group Plc Pharmaceutical preparation
MC2029A1 (fr) 1988-05-16 1990-04-25 Asta Pharma Ag (n-heterocyclyl)-3 diamino-2,6 pyridines substituees et leurs n-oxydes,preparation de ces composes et leur application comme medicaments
US5629307A (en) 1989-10-20 1997-05-13 Olney; John W. Use of ibogaine in reducing excitotoxic brain damage
US6004945A (en) 1990-05-10 1999-12-21 Fukunaga; Atsuo F. Use of adenosine compounds to relieve pain
IN172468B (fr) 1990-07-14 1993-08-14 Asta Medica Ag
US5643921A (en) 1990-09-26 1997-07-01 E.R. Squibb & Sons, Inc. Cardiopulmonary bypass and organ transplant using a potassium channel activator
US5234947A (en) 1991-11-07 1993-08-10 New York University Potassium channel activating compounds and methods of use thereof
DE4200259A1 (de) 1992-01-08 1993-07-15 Asta Medica Ag Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung
US5262419A (en) 1992-06-11 1993-11-16 E. R. Squibb & Sons, Inc. Method for the prophylaxis and/or treatment of ulcerative gastrointestinal conditions using a potassium channel activator
CA2115792C (fr) 1993-03-05 2005-11-01 David J. Mayer Methode de traitement de la douleur
US5428039A (en) 1994-02-20 1995-06-27 The Center For Innovative Technology Method for electively achieving reversible hyperpolarized cardiac arrest
JP4097285B2 (ja) 1994-09-22 2008-06-11 リチャード・アラン・スミス 種々の頑固な疾患の治療のための医薬の製造に有用な組成物
US5679706A (en) 1994-09-30 1997-10-21 Bristol-Myers Squibb Company Combination of a potassium channel activator and an antiarrhythmic agent
WO1996019233A2 (fr) 1994-12-12 1996-06-27 Omeros Medical Systems, Inc. Solution d'irrigation et procede d'inhibition de la douleur, de l'inflammation et des spasmes
DE19539861A1 (de) 1995-10-26 1997-04-30 Asta Medica Ag Verwendung von 4-Amino-4-(4-fluorbenzylamino)-1-ethoxy-carbonylaminobenzen zur Prophylaxe und Behandlung der Folgen der akuten und chronischen zerebralen Minderdurchblutung sowie neurodegenerativer Erkrankungen
DE19701694A1 (de) 1997-01-20 1998-07-23 Asta Medica Ag Neue Modifikationen des 2-Amino-4-(4-fluorbenzylamino)-l-ethoxycarbonyl-aminobenzen sowie Verfahren zu ihrer Herstellung
US5760007A (en) 1997-07-16 1998-06-02 Ortho Pharmaceutical Corporation Anticonvulsant derivatives useful in treating neuropathic pain
DE69832176T2 (de) 1997-08-08 2006-08-03 Chugai Seiyaku K.K. Arzneimittel gegen diabetes-komplikationen
US6265417B1 (en) 1997-12-18 2001-07-24 Abbott Laboratories Potassium channel openers
US6593335B1 (en) 1997-12-18 2003-07-15 Abbott Laboratories Potassium channel openers
US6211171B1 (en) 1998-05-19 2001-04-03 Dalhousie University Use of antidepressants for local analgesia
JP3441970B2 (ja) 1998-06-30 2003-09-02 株式会社サミー 豆腐の製造方法及び製造装置
WO2000035434A2 (fr) 1998-12-14 2000-06-22 Cellegy Pharmaceuticals, Inc. Compositions et techniques de traitement de troubles anorectaux
US6281211B1 (en) 1999-02-04 2001-08-28 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
GB9903476D0 (en) 1999-02-17 1999-04-07 Zeneca Ltd Therapeutic agents
JP2002538221A (ja) 1999-03-10 2002-11-12 ワーナー−ランバート・カンパニー 抗てんかん作用を有する化合物を包含する鎮痛組成物およびその使用方法
CA2367895A1 (fr) 1999-03-17 2000-09-21 Signal Pharmaceuticals, Inc. Composes et techniques de modulation des recepteurs des oestrogenes
AT409083B (de) 1999-04-01 2002-05-27 Sanochemia Pharmazeutika Ag Pharmazeutische, tolperison enthaltende zubereitung zur oralen verabreichung
US6610324B2 (en) 1999-04-07 2003-08-26 The Mclean Hospital Corporation Flupirtine in the treatment of fibromyalgia and related conditions
GB9915414D0 (en) 1999-07-01 1999-09-01 Glaxo Group Ltd Medical use
CN1230174C (zh) 1999-07-06 2005-12-07 伊莱利利公司 治疗偏头痛的选择性iGluR5受体拮抗剂
US6472165B1 (en) 1999-08-03 2002-10-29 Arzneimittelwerk Dresden Gmbh Modulatory binding site in potassium channels for screening and finding new active ingredients
US6495550B2 (en) 1999-08-04 2002-12-17 Icagen, Inc. Pyridine-substituted benzanilides as potassium ion channel openers
NZ527771A (en) 1999-08-04 2005-04-29 Icagen Inc Methods for treating or preventing anxiety
JP2003506387A (ja) 1999-08-04 2003-02-18 アイカゲン インコーポレイテッド カリウムチャンネルオープナーとしてのベンズアニリド
US6117900A (en) 1999-09-27 2000-09-12 Asta Medica Aktiengesellschaft Use of retigabine for the treatment of neuropathic pain
US6383511B1 (en) 1999-10-25 2002-05-07 Epicept Corporation Local prevention or amelioration of pain from surgically closed wounds
US6538004B2 (en) 2000-03-03 2003-03-25 Abbott Laboratories Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers
US20020015730A1 (en) 2000-03-09 2002-02-07 Torsten Hoffmann Pharmaceutical formulations and method for making
TWI287984B (en) 2000-10-17 2007-10-11 Wyeth Corp Pharmaceutical composition for modulating bladder function
US6589986B2 (en) 2000-12-20 2003-07-08 Wyeth Methods of treating anxiety disorders
US6469042B1 (en) 2001-02-20 2002-10-22 Bristol-Myers Squibb Company Fluoro oxindole derivatives as modulators if KCNQ potassium channels
AR033095A1 (es) 2001-04-04 2003-12-03 Wyeth Corp Metodos para el tratamiento de motilidad gastrica hiperactiva
GB0121214D0 (en) 2001-08-31 2001-10-24 Btg Int Ltd Synthetic method
AU2003202115A1 (en) 2002-02-12 2003-09-04 Pfizer Inc. Non-peptide compounds affecting the action of gonadotropin-releasing hormone (gnrh)
ATE533743T1 (de) 2002-05-17 2011-12-15 Janssen Pharmaceutica Nv Harnstoffderivate von aminotetralin als modulatoren des vanilloid-rezeptors vr1
WO2003106454A1 (fr) 2002-06-12 2003-12-24 Orchid Chemicals & Pharmaceuticals Ltd Derives de 1h-isoquinoline-oxazolidinone, et leur utilisation comme agents antibacteriens
AUPS312602A0 (en) 2002-06-21 2002-07-18 James Cook University Organ arrest, protection, preservation and recovery
US7419981B2 (en) 2002-08-15 2008-09-02 Pfizer Inc. Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor
AU2003294441A1 (en) 2002-11-22 2004-06-18 Bristol-Myers Squibb Company 1-aryl-2-hydroxyethyl amides as potassium channel openers
ATE488231T1 (de) 2002-12-23 2010-12-15 Icagen Inc Quinazolinone als kaliumkanalmodulatoren
WO2004058739A1 (fr) 2002-12-27 2004-07-15 H. Lundbeck A/S Dérivés de 1,2,4-triaminobenzène utiles pour traiter des troubles du système nerveux central
BRPI0408205A (pt) 2003-03-14 2006-02-14 Lundbeck & Co As H derivado de anilina substituìdo, composição farmacêutica, e, uso de uma composição farmacêutica
EP1613303A1 (fr) 2003-03-21 2006-01-11 H. Lundbeck A/S Derives de para-diaminobenzene substitues
AU2004233941A1 (en) 2003-04-25 2004-11-11 H. Lundbeck A/S Sustituted indoline and indole derivatives
US20060241134A1 (en) 2003-05-27 2006-10-26 Altana Pharma Ga Pharmaceutical combinations of a proton pump inhibitor and a compound which modifies gastrointestinal motility
US20050070570A1 (en) 2003-06-18 2005-03-31 4Sc Ag Novel potassium channels modulators
EP1663239A4 (fr) 2003-09-10 2008-07-23 Cedars Sinai Medical Center Administration assistee par les canaux potassiques d'agents a travers la barriere hemato-encephalique
US20050089559A1 (en) 2003-10-23 2005-04-28 Istvan Szelenyi Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
DE10359335A1 (de) 2003-10-23 2005-05-25 Viatris Gmbh & Co. Kg Kombinationen aus Kaliumkanalöffnern und Natriumkanalinhibitoren oder Natriumkanal beeinflussenden Wirkstoffen zur Behandlung von Schmerzzuständen
ES2235626B1 (es) 2003-11-10 2006-11-01 Almirall Prodesfarma, S.A. Formas de administracion masticables, no comprimidas dosificadas individualmente.
US8236861B2 (en) 2004-02-13 2012-08-07 Hormos Medical Corporation Method for enhancing the bioavailablity of ospemifene
TWI349666B (en) 2004-03-12 2011-10-01 Lundbeck & Co As H Substituted morpholine and thiomorpholine derivatives
AU2005233642A1 (en) 2004-04-13 2005-10-27 Astellas Pharma Inc. Polycyclic pyridines as potassium ion channel modulators
EP1748776A1 (fr) 2004-05-03 2007-02-07 Duke University Compositions influant sur la perte de poids
UA89503C2 (uk) 2004-09-13 2010-02-10 Х. Луннбек А/С Заміщені похідні аніліну
JPWO2006054513A1 (ja) 2004-11-19 2008-05-29 キッセイ薬品工業株式会社 神経因性疼痛の予防又は治療剤
EP1688141A1 (fr) 2005-01-31 2006-08-09 elbion AG Utilisation de flupirtine pour le traitement de la vessie hyperactive et des maladies associées et pour le traitement du syndrome du colon irritable
CA2599890C (fr) 2005-03-03 2011-05-03 H. Lundbeck A/S Derives de pyridine substitues
WO2006130686A2 (fr) 2005-06-02 2006-12-07 Schering Corporation Administration d'inhibiteurs de protease du vhc en combinaison avec des aliments pour ameliorer la biodisponibilite
US7683058B2 (en) 2005-09-09 2010-03-23 H. Lundbeck A/S Substituted pyrimidine derivatives
WO2007128462A1 (fr) 2006-05-02 2007-11-15 Chris Rundfeldt Activateurs de canaux potassiques pour la prévention et le traitement de la dystonie et des systèmes assimilés à la dystonie
US8993593B2 (en) * 2006-08-23 2015-03-31 Valeant Pharmaceuticals International N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
BRPI0716715B1 (pt) * 2006-08-23 2021-07-06 Xenon Pharmaceuticals, Inc Derivados de 4-(n-azacicloalquil) anilidas como moduladores de canal de potássio, seus usos, produto, composição, comprimido e cápsula
US8030518B2 (en) 2006-11-28 2011-10-04 Valeant Pharmaceuticals International 1,4 diamino bicyclic retigabine analogues as potassium channel modulators
WO2008144320A2 (fr) 2007-05-17 2008-11-27 Endo Pharmaceuticals, Inc. Opioïde et procédés de fabrication et d'utilisation de celui-ci
EP2185149A1 (fr) * 2007-08-01 2010-05-19 H. Lundbeck A/S Utilisation d'agents d'ouverture kncq des canaux potassiques pour réduire des symptomes ou traiter des troubles et des états dans lesquels le système dopaminergique est détruit
JP2011506391A (ja) * 2007-12-11 2011-03-03 ノイロサーチ アクティーゼルスカブ カリウムチャネル活性化因子として有用な、新規の２−エチル−メチル−アミノ−３−アミド−６−アミノ−ピリジン誘導体
US20100323016A1 (en) 2008-07-18 2010-12-23 Biljana Nadjsombati Modified release formulation and methods of use
EP2525788A2 (fr) 2010-01-20 2012-11-28 Glaxo Group Limited Nouvelle composition du retigabine
WO2013067591A1 (fr) 2011-11-10 2013-05-16 Relevare Australia Pty Ltd Formulations topiques pour gestion de la douleur
US10500216B2 (en) 2011-11-18 2019-12-10 Corcept Therapeutics, Inc. Optimizing mifepristone absorption
US9248122B2 (en) 2012-11-28 2016-02-02 Grünenthal GmbH Heteroquinoline-3-carboxamides as KCNQ2/3 modulators
JP7121144B2 (ja) * 2018-02-20 2022-08-17 ハー・ルンドベック・アクチエゼルスカベット Ｋｖ７カリウムチャネル開口薬としてのアルコール誘導体
RS64922B1 (sr) 2018-05-11 2023-12-29 Xenon Pharmaceuticals Inc Postupci za povećanje bioraspoloživosti i izloženosti otvaraču naponom kontrolisanih kalijumskih kanala
TWI886158B (zh) 2019-10-10 2025-06-11 加拿大商再諾製藥公司 選擇性鉀通道調節劑之固態晶型
CN114667146A (zh) 2019-11-08 2022-06-24 泽农医药公司 治疗抑郁症的方法
US20230015539A1 (en) 2019-12-06 2023-01-19 Icahn School Of Medicine At Mount Sinai Method of treatment with kcnq channel openers
US20210213009A1 (en) 2019-12-13 2021-07-15 Xenon Pharmaceuticals Inc. Methods of treating pain
PE20231815A1 (es) 2021-02-09 2023-11-16 Xenon Pharmaceuticals Inc Abridor de canales de potasio controlado por voltaje para uso en el tratamiento de la anhedonia
WO2022173853A1 (fr) 2021-02-09 2022-08-18 Xenon Pharmaceuticals Inc. Thérapie conjointe pour le traitement de crises épileptiques
KR102694996B1 (ko) 2021-10-27 2024-08-13 상하이 지멍 바이오파마 아이엔씨 칼륨 채널 조절제로 사용되는 화합물 및 이의 제조 및 응용

Also Published As

Publication number Publication date
US20210161886A1 (en) 2021-06-03
CL2022001102A1 (es) 2023-01-27
CR20220250A (es) 2022-08-19
TW202128162A (zh) 2021-08-01
PE20221766A1 (es) 2022-11-11
AU2020380961A1 (en) 2022-05-26
GEAP202415942A (en) 2024-10-28
GEP20257732B (en) 2025-02-10
JP2026001049A (ja) 2026-01-06
MX2022005490A (es) 2022-08-10
NZ787838A (en) 2025-08-29
US12178811B2 (en) 2024-12-31
CN114667146A (zh) 2022-06-24
KR20220098746A (ko) 2022-07-12
CO2022008001A2 (es) 2022-06-10
US20250108044A1 (en) 2025-04-03
BR112022008580A2 (pt) 2022-08-09
EP4054580A1 (fr) 2022-09-14
IL292678A (en) 2022-07-01
PH12022551110A1 (en) 2024-02-26
JP2022553569A (ja) 2022-12-23
WO2021092439A1 (fr) 2021-05-14
CA3155812A1 (fr) 2021-05-14

Similar Documents

Publication Publication Date Title
RU2498988C2 (ru) Ингибиторы активности протеинтирозинкиназы
DE60126980D1 (de) Therapeutische agentien und methoden ihrer verwendung zur behandlung von amyloidogenen erkrankungen
MA52569B1 (fr) Méthodes pour améliorer la biodisponibilité et l'exposition d'un activateur de canal potassique voltage-dépendant
MA25809A1 (fr) Derives d'arylmethylamine pour usage comme inhibiteurs de tryptase
MA44764A (fr) Méthodes de traitement de patients présentant une hypercholestérolémie familiale
MA51627B1 (fr) Benzofurane, benzopyrrole, benzothiophène substitués et inhibiteurs du complément structurellement apparentés
ATE119520T1 (de) Derivate von hydroxaminsäure und von n- hydroxyharnstoff sowie ihre verwendung.
EA199900669A1 (ru) Промежуточные соединения для получения замещенных n-[аминоиминометил или аминометил)фенил]пропиламидов
DE59810761D1 (de) Verwendung von vasopressin-antagonisten zur behandlung von störungen oder erkrankungen des innenohres
DE60140871D1 (de) Arylmethylamin-derivate zur verwendung als inhibitoren von tryptase
HUP9802971A1 (hu) Az MMP-inhibitorok alkalmazása a szemben történő érképződés kezelésére
ATE269865T1 (de) Pyrazolo(3,4-g)chinoxaline als pdgf-rezeptor protein tyrosin-kinase inhibitoren
NO20044530L (no) Fremgangsmate for behandling av kognitive forstyrrelser
WO2001091796A8 (fr) Methodes, composes et compositions permettant de traiter la goutte
MA68743B1 (fr) Composés et compositions pour le traitement d'états associés à l'activité du récepteur de lpa
DE69827295D1 (de) Kombination von einem den retinoinsäure metabolismus blockierenden arzneimittel und einem tocopherol
ATE499933T1 (de) Verwendung von betain zur behandlung von claudicatio intermittens
DE69512940D1 (de) N-hydroxy-harnstoff-derivate als entzündunghemmende mittel
MA53372B1 (fr) Pyridopyrimidinones comme inhibiteurs du récepteur h4 de l'histamine
DE69924979D1 (de) Behandlung von chronischen schmerzen
MA61730A1 (fr) Thérapie conjointe pour le traitement de crises épileptiques
EA200401295A1 (ru) Статиновая терапия для усиления поддержания когнитивной функции
MA56958A1 (fr) Utilisation d'un agent d'ouverture du canal potassique kv7 pour le traitement de la douleur
ATE190484T1 (de) Arzneimittel zur behandlung von durch babesia verursachten protozoeninfektionen
ATE320255T1 (de) Tie2 rezeptor-kinase-inhibitoren zur behandlung von angiogenen erkrankungen