MA52888A - Composés de benzènesulfonamide et leur utilisation en tant qu'agents thérapeutiques - Google Patents

Composés de benzènesulfonamide et leur utilisation en tant qu'agents thérapeutiques

Info

Publication number
MA52888A
MA52888A MA052888A MA52888A MA52888A MA 52888 A MA52888 A MA 52888A MA 052888 A MA052888 A MA 052888A MA 52888 A MA52888 A MA 52888A MA 52888 A MA52888 A MA 52888A
Authority
MA
Morocco
Prior art keywords
therapeutic agents
benzene sulfonamide
sulfonamide compounds
compounds
benzene
Prior art date
Application number
MA052888A
Other languages
English (en)
Inventor
Kristen Nicole Burford
Thilo Focken
Verner Alexander Lofstrand
Michael Scott Wilson
Alla Yurevna Zenova
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Publication of MA52888A publication Critical patent/MA52888A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/50—Nitrogen atoms bound to hetero atoms
    • C07D277/52—Nitrogen atoms bound to hetero atoms to sulfur atoms, e.g. sulfonamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
MA052888A 2018-06-13 2019-06-13 Composés de benzènesulfonamide et leur utilisation en tant qu'agents thérapeutiques MA52888A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862684436P 2018-06-13 2018-06-13

Publications (1)

Publication Number Publication Date
MA52888A true MA52888A (fr) 2021-04-21

Family

ID=67138087

Family Applications (1)

Application Number Title Priority Date Filing Date
MA052888A MA52888A (fr) 2018-06-13 2019-06-13 Composés de benzènesulfonamide et leur utilisation en tant qu'agents thérapeutiques

Country Status (23)

Country Link
US (2) US10745392B2 (fr)
EP (1) EP3807281A1 (fr)
JP (3) JP7371029B2 (fr)
KR (1) KR102833674B1 (fr)
CN (1) CN112262142B (fr)
AU (1) AU2019285184B2 (fr)
BR (1) BR112020024729A2 (fr)
CA (1) CA3103600A1 (fr)
CL (1) CL2020003197A1 (fr)
CR (1) CR20200613A (fr)
EA (1) EA202092719A1 (fr)
EC (1) ECSP20079861A (fr)
IL (1) IL278949B2 (fr)
JO (1) JOP20200304A1 (fr)
MA (1) MA52888A (fr)
MX (1) MX2020013317A (fr)
NI (1) NI202000098A (fr)
PE (1) PE20211389A1 (fr)
PH (1) PH12020552111A1 (fr)
SA (1) SA520420768B1 (fr)
SG (1) SG11202011862PA (fr)
UA (1) UA127024C2 (fr)
WO (1) WO2019241533A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES3022639T3 (en) * 2016-05-20 2025-05-28 Xenon Pharmaceuticals Inc Benzenesulfonamide compounds and their use as therapeutic agents
CN110325531B (zh) 2016-12-09 2022-05-27 泽农医药公司 苯磺酰胺及其作为治疗剂的用途
BR112020024729A2 (pt) * 2018-06-13 2021-03-23 Xenon Pharmaceuticals, Inc. compostos de benzenossulfonamida e seu uso como agentes terapêuticos
IL279810B2 (en) 2018-08-31 2025-03-01 Xenon Pharmaceuticals Inc Heteroaryl-modified sulfonamide compounds and their use as medicinal agents
WO2024158653A2 (fr) * 2023-01-26 2024-08-02 Merck Sharp & Dohme Llc Composés d'indazole sulfonamide n-substitués à activité sélective dans le contexte de canaux sodiques voltage-dépendants
CN117510431A (zh) * 2023-11-08 2024-02-06 浙江雅辰药物科技股份有限公司 一种异噻唑-3-酮及其衍生物、合成方法

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US4326525A (en) 1980-10-14 1982-04-27 Alza Corporation Osmotic device that improves delivery properties of agent in situ
US5877193A (en) 1996-07-19 1999-03-02 Hoffmann-La Roche Inc. Use of N-(4-aryl-thiazol-2-yl)-sulfonamides
US6416780B1 (en) 1997-05-07 2002-07-09 Galen (Chemicals) Limited Intravaginal drug delivery devices for the administration of testosterone and testosterone precursors
AU2201500A (en) 1999-01-13 2000-08-01 Warner-Lambert Company Benzenesulfonamide derivatives and their use as mek inhibitors
DE19907385A1 (de) 1999-02-20 2000-08-24 Boehringer Ingelheim Pharma Neue substituierte 3-Phenoxy- und 3-Phenylalkyloxy-2-phenyl-propylamine
CN1365277A (zh) 1999-07-16 2002-08-21 沃尼尔·朗伯公司 使用mek抑制剂治疗慢性疼痛的方法
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
FR2836917B1 (fr) 2002-03-11 2006-02-24 Lipha Derives nitroso de la diphenylamine, compositions pharmaceutiques les contenant en tant que medicaments utilisables dans le traitement des pathologies caracterisees par une situation de stress oxydatif
AU2003243921B2 (en) 2002-06-27 2009-05-07 Novo Nordisk A/S Aryl carbonyl derivatives as therapeutic agents
JP2005162726A (ja) 2003-01-24 2005-06-23 Tanabe Seiyaku Co Ltd ピラゾロピリミジン化合物およびその製法
WO2004092123A2 (fr) 2003-04-10 2004-10-28 Microbia, Inc. Inhibiteurs d'invasion fongique
WO2005000309A2 (fr) 2003-06-27 2005-01-06 Ionix Pharmaceuticals Limited Composes chimiques
CA2531418A1 (fr) 2003-07-08 2005-01-20 Novartis Ag Composes benzenesulfonylamino, et compositions pharmaceutiques contenant ces composes
KR20060073930A (ko) 2003-08-08 2006-06-29 버텍스 파마슈티칼스 인코포레이티드 통증 치료시 나트륨 또는 칼슘 채널 차단제로서 유용한헤테로아릴아미노설포닐페닐 유도체
HU227684B1 (en) 2003-08-29 2011-11-28 Sanofi Aventis Adamantane and azabicyclo-octane and nonane derivatives and their use as dpp-iv inhibitors
WO2006066109A2 (fr) 2004-12-17 2006-06-22 Takeda San Diego, Inc. Inhibiteurs des hydroxysteroides deshydrogenases
GB0510139D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B1
CA2624726A1 (fr) 2005-10-06 2007-04-12 Sanofi-Aventis 4-oxy-n-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, procedes pour leur preparation et leur utilisation en tant que substances pharmaceutiques
CN101365686A (zh) 2005-12-21 2009-02-11 沃泰克斯药物股份有限公司 作为离子通道调节剂的杂环衍生物
MX2009001498A (es) 2006-08-15 2009-02-18 Hoffmann La Roche Derivados de fenilo, piridina y quinolina.
MX2009004019A (es) 2006-10-19 2009-06-19 Signal Pharm Llc Compuestos heteroarilo, composiciones de los mismos, y uso de los mismos como inhibidores de proteina cinasa.
WO2009012242A2 (fr) 2007-07-13 2009-01-22 Icagen, Inc. Inhibiteurs des canaux sodiques
JP5463285B2 (ja) 2007-07-13 2014-04-09 アイカジェン， インコーポレイテッド ナトリウムチャネル阻害物質
WO2009013171A2 (fr) 2007-07-24 2009-01-29 F. Hoffmann-La Roche Ag Composés antiviraux hétérocycliques
WO2009099177A1 (fr) 2008-02-06 2009-08-13 Taisho Pharmaceutical Co., Ltd. Dérivé d'amino-imidazole
MX2010014571A (es) 2008-06-25 2011-03-25 Daiichi Sankyo Co Ltd Compuestos de acido carboxilico.
AU2009266979A1 (en) 2008-07-01 2010-01-07 Vertex Pharmaceuticals Incorporated Heterocyclic derivatives as modulators of ion channels
WO2010029300A1 (fr) 2008-09-12 2010-03-18 Biolipox Ab Composés bis-aromatiques pour utilisation dans le traitement de l’inflammation
EA020460B1 (ru) 2009-01-12 2014-11-28 Пфайзер Лимитед Производные сульфонамида
ES2533065T3 (es) 2010-07-09 2015-04-07 Pfizer Limited Bencenosulfonamidas útiles como inhibidores de los canales de sodio
MX2013001970A (es) 2010-08-20 2013-08-09 Hutchison Medipharma Ltd Compuestos de pirrolopirimidina y usos de los mismos.
US9079902B2 (en) 2011-08-17 2015-07-14 Amgen Inc. Heteroaryl sodium channel inhibitors
JP2014532660A (ja) 2011-10-28 2014-12-08 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 電位作動型ナトリウムチャネルにおける選択活性を有するベンゾオキサゾリノン化合物
WO2013064983A1 (fr) 2011-10-31 2013-05-10 Xenon Pharmaceuticals Inc. Composés de benzènesulfonamide et leur utilisation en tant qu'agents thérapeutiques
EP2773641B1 (fr) 2011-10-31 2017-09-27 Xenon Pharmaceuticals Inc. Biaryléthersulfonamides et leur utilisation en tant qu'agents thérapeutiques
US8889741B2 (en) 2012-02-09 2014-11-18 Daiichi Sankyo Company, Limited Cycloalkane derivatives
WO2013122897A1 (fr) 2012-02-13 2013-08-22 Amgen Inc. Inhibiteurs des canaux sodiques de type dihydrobenzoxazine et tétrahydroquinoxaline
SG11201408284VA (en) 2012-05-22 2015-02-27 Xenon Pharmaceuticals Inc N-substituted benzamides and their use in the treatment of pain
EP2906558B1 (fr) 2012-10-15 2020-09-02 Daewoong Pharmaceutical Co., Ltd. Bloqueurs de canal sodique, leur procédé de préparation et leur utilisation
EP2911668A4 (fr) 2012-10-26 2016-07-20 Merck Sharp & Dohme Composés benzoxazolinone ayant une activité sélective dans les canaux sodiques potentiel-dépendants
BR112015008987A2 (pt) 2012-10-26 2017-07-04 Merck Sharp & Dohme composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de uma composição farmacêutica
TW201512171A (zh) 2013-04-19 2015-04-01 Pfizer Ltd 化學化合物
TW201443025A (zh) 2013-04-19 2014-11-16 Pfizer Ltd 化學化合物
US9212182B2 (en) 2013-06-12 2015-12-15 Amgen Inc. Bicyclic sulfonamide compounds as sodium channel inhibitors
GB201310542D0 (en) 2013-06-13 2013-07-31 Antabio Sas Compounds
US9663469B2 (en) 2013-09-09 2017-05-30 Bristol-Myers Squibb Company RORγ modulators
AU2014318979B2 (en) 2013-09-10 2019-03-28 Chromocell Corporation Sodium channel modulators for the treatment of pain and diabetes
AU2014356967A1 (en) 2013-11-27 2016-07-07 Genentech, Inc. Substituted benzamides and methods of use thereof
WO2015077905A1 (fr) 2013-11-29 2015-06-04 Merck Sharp & Dohme Corp. Composés de benzènesulfonamide à substitution bicycloamine ayant une activité sélective dans les canaux sodiques sensibles à la tension
WO2015099841A1 (fr) 2013-12-23 2015-07-02 Purdue Pharma L.P. Indazoles et leur utilisation
WO2016177340A1 (fr) 2015-05-05 2016-11-10 上海海雁医药科技有限公司 Dérivé de benzènesulfonamide substitué bicyclique, et procédé de préparation et utilisation pharmaceutique de celui-ci
CA3008614A1 (fr) 2015-12-18 2017-06-22 Merck Sharp & Dohme Corp. Composes d'arylsulfonamide a liaisons diamino-alkylamino ayant une activite selective vis-a-vis des canaux sodiques voltage-dependants
US10442778B2 (en) 2016-03-22 2019-10-15 Merck Sharp & Dohme Corp. N1-phenylpropane-1,2-diamine compounds with selective activity in voltage-gated sodium channels
ES3022639T3 (en) * 2016-05-20 2025-05-28 Xenon Pharmaceuticals Inc Benzenesulfonamide compounds and their use as therapeutic agents
EP3532462B1 (fr) 2016-10-27 2021-10-13 Bristol-Myers Squibb Company Inhibiteurs de nav1.7 de type acyl-sulfonamide
US10968210B2 (en) * 2016-11-17 2021-04-06 Merck Sharp & Dohme Corp. Diamino-alkylamino-linked arylsulfonamide compounds with selective activity in voltage-gated sodium channels
CN110325531B (zh) 2016-12-09 2022-05-27 泽农医药公司 苯磺酰胺及其作为治疗剂的用途
BR112020024729A2 (pt) 2018-06-13 2021-03-23 Xenon Pharmaceuticals, Inc. compostos de benzenossulfonamida e seu uso como agentes terapêuticos
MA53488A (fr) 2018-08-31 2021-12-08 Xenon Pharmaceuticals Inc Composés de sulfonamide substitués par hétéroaryle et leur utilisation en tant qu'inhibiteurs de canaux sodiques
IL279810B2 (en) 2018-08-31 2025-03-01 Xenon Pharmaceuticals Inc Heteroaryl-modified sulfonamide compounds and their use as medicinal agents

Also Published As

Publication number Publication date
AU2019285184B2 (en) 2023-11-16
IL278949A (en) 2021-01-31
CN112262142A (zh) 2021-01-22
JP7371029B2 (ja) 2023-10-30
AU2019285184A1 (en) 2021-01-28
JP2021528387A (ja) 2021-10-21
NI202000098A (es) 2021-05-28
JP2023138672A (ja) 2023-10-02
IL278949B1 (en) 2024-04-01
CA3103600A1 (fr) 2019-12-19
JOP20200304A1 (ar) 2020-11-25
PE20211389A1 (es) 2021-07-27
IL278949B2 (en) 2024-08-01
SG11202011862PA (en) 2020-12-30
US20190382398A1 (en) 2019-12-19
ECSP20079861A (es) 2021-03-31
SA520420768B1 (ar) 2022-08-30
CR20200613A (es) 2021-06-10
KR20210019507A (ko) 2021-02-22
KR102833674B1 (ko) 2025-07-14
US11325902B2 (en) 2022-05-10
BR112020024729A2 (pt) 2021-03-23
CL2020003197A1 (es) 2021-04-30
JP2025128218A (ja) 2025-09-02
WO2019241533A1 (fr) 2019-12-19
EA202092719A1 (ru) 2021-03-16
MX2020013317A (es) 2021-04-13
PH12020552111A1 (en) 2021-08-02
CN112262142B (zh) 2023-11-14
EP3807281A1 (fr) 2021-04-21
US10745392B2 (en) 2020-08-18
UA127024C2 (uk) 2023-03-15
US20200361927A1 (en) 2020-11-19

Similar Documents

Publication Publication Date Title
MA48583A (fr) Composés de benzènesulfonamide et leur utilisation en tant qu'agents thérapeutiques
MA52888A (fr) Composés de benzènesulfonamide et leur utilisation en tant qu'agents thérapeutiques
MA53489A (fr) Composés de sulfonamide substitués par hétéroaryle et leur utilisation en tant qu'agents thérapeutiques
MA52486A (fr) Pyridazinones utilisés en tant qu'inhibiteurs de parp7
EP3814567A4 (fr) Appareil d'entretien de vêtements
EP3442973A4 (fr) Nouveaux composés utilisés en tant qu'inhibiteurs de l'autotaxine et compositions pharmaceutiques les comprenant
EP3883576A4 (fr) Composés amino-triazolopyrimidine et amino-triazolopyrazine substitués utilisés en tant qu'antagonistes de récepteur de l'adénosine, compositions pharmaceutiques et leur utilisation
MA51224A (fr) Composés de sulfonamide et leur utilisation
MA49017A (fr) Modulateurs du récepteur 7 de la 5-hydroxytryptamine et utilisation de ces derniers en tant qu'agents thérapeutiques
EP3886879A4 (fr) Plaquettes en tant qu'agents de livraison
MA55325A (fr) Composés pour le traitement de maladies pd-l1
EP3402490A4 (fr) Utilisation thérapeutique de mitochondries et d'agents mitochondriaux combinés
EP3860449A4 (fr) Agencement d'électrodes
MA48942A (fr) Composés thérapeutiques, compositions et procédés d'utilisation associés
EP3853365A4 (fr) Modulateurs de l'expression de pnpla3
EP3645039A4 (fr) Utilisation d'anticorps anti-fam19a5 pour le traitement de la fibrose
MA56183A (fr) Pyrazolo-pyridines hétéroaromatiques substituées et leur utilisation en tant que modulateurs du récepteur glun2b
EP3892621A4 (fr) Composés d'halogénoallylamine et leur utilisation
MA53488A (fr) Composés de sulfonamide substitués par hétéroaryle et leur utilisation en tant qu'inhibiteurs de canaux sodiques
MA53479A (fr) Composés hétérocycliques en tant q'inibiteurs de vanin
EP3773747A4 (fr) Utilisation d'exosomes pour l'administration ciblée d'agents thérapeutiques
EP3728194A4 (fr) Composés de quinoléine sulfonamide et leur utilisation en tant qu'agents antibactériens
EP3917380C0 (fr) Évaluation de la progression de la maladie de huntington
EP3823604A4 (fr) Composés utiles en tant qu'inhibiteurs de l'indoléamine 2,3-dioxygénase et/ou de la tryptophane dioxygénase
EP3824131A4 (fr) Appareil d'entretien de vêtements