MA53489A - Composés de sulfonamide substitués par hétéroaryle et leur utilisation en tant qu'agents thérapeutiques - Google Patents

Composés de sulfonamide substitués par hétéroaryle et leur utilisation en tant qu'agents thérapeutiques

Info

Publication number
MA53489A
MA53489A MA053489A MA53489A MA53489A MA 53489 A MA53489 A MA 53489A MA 053489 A MA053489 A MA 053489A MA 53489 A MA53489 A MA 53489A MA 53489 A MA53489 A MA 53489A
Authority
MA
Morocco
Prior art keywords
therapeutic agents
heteroaryl substituted
sulphonamide compounds
substituted sulphonamide
compounds
Prior art date
Application number
MA053489A
Other languages
English (en)
Inventor
Jean-Christophe Andrez
Kristen Nicole Burford
Christoph Martin Dehnhardt
Thilo Focken
Michael Edward Grimwood
Qi Jia
Verner Alexander Lofstrand
Shaoyi Sun
Steven Sigmund Wesolowski
Michael Scott Wilson
Alla Yurevna Zenova
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=67953876&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA53489(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Publication of MA53489A publication Critical patent/MA53489A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MA053489A 2018-08-31 2019-08-29 Composés de sulfonamide substitués par hétéroaryle et leur utilisation en tant qu'agents thérapeutiques MA53489A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862725956P 2018-08-31 2018-08-31

Publications (1)

Publication Number Publication Date
MA53489A true MA53489A (fr) 2021-12-08

Family

ID=67953876

Family Applications (1)

Application Number Title Priority Date Filing Date
MA053489A MA53489A (fr) 2018-08-31 2019-08-29 Composés de sulfonamide substitués par hétéroaryle et leur utilisation en tant qu'agents thérapeutiques

Country Status (26)

Country Link
US (2) US10981905B2 (fr)
EP (1) EP3844150A1 (fr)
JP (1) JP7450606B2 (fr)
KR (1) KR20210054510A (fr)
CN (1) CN112638879B (fr)
AU (1) AU2019331005B2 (fr)
BR (1) BR112021000209A2 (fr)
CA (1) CA3110853A1 (fr)
CL (1) CL2021000443A1 (fr)
CO (1) CO2021001433A2 (fr)
CR (1) CR20210099A (fr)
DO (1) DOP2021000031A (fr)
EA (1) EA202190395A1 (fr)
EC (1) ECSP21013035A (fr)
IL (1) IL279810B2 (fr)
JO (1) JOP20200337A1 (fr)
MA (1) MA53489A (fr)
MX (1) MX2021001380A (fr)
MY (1) MY207670A (fr)
NI (1) NI202100013A (fr)
PE (1) PE20211066A1 (fr)
PH (1) PH12021550381A1 (fr)
SG (1) SG11202100109TA (fr)
TW (1) TW202115018A (fr)
WO (1) WO2020047323A1 (fr)
ZA (1) ZA202100593B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190086772A (ko) 2016-12-09 2019-07-23 제논 파마슈티칼스 인크. 벤젠술폰아미드 화합물 및 치료제로서의 그의 용도
CN117964573B (zh) 2018-01-19 2026-04-14 赛特凯恩蒂克公司 作为心肌节抑制剂的二氢苯并呋喃和茚类似物
BR112020024729A2 (pt) 2018-06-13 2021-03-23 Xenon Pharmaceuticals, Inc. compostos de benzenossulfonamida e seu uso como agentes terapêuticos
WO2020005888A1 (fr) 2018-06-26 2020-01-02 Cytokinetics, Inc. Inhibiteurs de sarcomères cardiaques
EP3814342B1 (fr) 2018-06-26 2022-07-27 Cytokinetics, Inc. Inhibiteurs de sarcomères cardiaques
CN112867539B (zh) 2018-08-31 2024-08-06 赛特凯恩蒂克公司 心脏肌小节抑制剂
IL279810B2 (en) 2018-08-31 2025-03-01 Xenon Pharmaceuticals Inc Heteroaryl-modified sulfonamide compounds and their use as medicinal agents
TW202302594A (zh) 2021-03-04 2023-01-16 美商胞質動力學公司 心臟肌節抑制劑
KR20240030592A (ko) * 2022-08-31 2024-03-07 주식회사 아이엔테라퓨틱스 인비보 세포외 신경다발절 기록법을 이용한 전기생리학적 약효평가법
WO2025011450A1 (fr) * 2023-07-07 2025-01-16 Novartis Ag Bloqueurs des canaux sodiques

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US4326525A (en) 1980-10-14 1982-04-27 Alza Corporation Osmotic device that improves delivery properties of agent in situ
US5877193A (en) 1996-07-19 1999-03-02 Hoffmann-La Roche Inc. Use of N-(4-aryl-thiazol-2-yl)-sulfonamides
DE69809222T2 (de) 1997-05-07 2003-08-14 Galen (Chemicals) Ltd., Dublin Vorrichtungen zur intravaginalen verabreichung von testosteron und testosteron-vorläuferverbindungen
AU2201500A (en) 1999-01-13 2000-08-01 Warner-Lambert Company Benzenesulfonamide derivatives and their use as mek inhibitors
DK1202724T3 (da) 1999-07-16 2004-01-26 Warner Lambert Co Fremgangsmåde til behandling af kronisk smerte under anvendelse af mek-inhibitorer
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
FR2836917B1 (fr) 2002-03-11 2006-02-24 Lipha Derives nitroso de la diphenylamine, compositions pharmaceutiques les contenant en tant que medicaments utilisables dans le traitement des pathologies caracterisees par une situation de stress oxydatif
AU2003243921B2 (en) 2002-06-27 2009-05-07 Novo Nordisk A/S Aryl carbonyl derivatives as therapeutic agents
WO2004092123A2 (fr) 2003-04-10 2004-10-28 Microbia, Inc. Inhibiteurs d'invasion fongique
WO2005000309A2 (fr) 2003-06-27 2005-01-06 Ionix Pharmaceuticals Limited Composes chimiques
JP2009513523A (ja) 2003-07-08 2009-04-02 ノバルティス アクチエンゲゼルシャフト ベンゼンスルホニルアミノ化合物およびそれらを含む医薬組成物
TW200524888A (en) 2003-08-08 2005-08-01 Vertex Pharma Compositions useful as inhibitors of voltage-gated ion channels
HU227684B1 (en) 2003-08-29 2011-11-28 Sanofi Aventis Adamantane and azabicyclo-octane and nonane derivatives and their use as dpp-iv inhibitors
JP2008524244A (ja) 2004-12-17 2008-07-10 タケダ サン ディエゴ インコーポレイテッド 水酸化ステロイド脱水素酵素阻害剤
GB0510139D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B1
RU2008113210A (ru) 2005-10-06 2009-10-10 Санофи-Авентис (Fr) 4-окси-n-[1, 3, 4]-тиадиазол-2-илбензолсульфонамиды, способы их получения и их применение в качестве фармацевтических средств
NZ593074A (en) 2005-12-21 2012-04-27 Vertex Pharma sulfonamide-pyrrolidone derivatives as Modulators of Ion Channels
KR101117931B1 (ko) 2006-08-15 2012-04-12 에프. 호프만-라 로슈 아게 페닐, 피리딘 및 퀴놀린 유도체
ES2383370T3 (es) 2006-10-19 2012-06-20 Signal Pharmaceuticals Llc Compuestos de heteroarilo, sus composiciones y uso de los mismos como inhibidores de proteína quinasa
CA2694748A1 (fr) 2007-07-13 2009-01-22 Icagen, Inc. Inhibiteurs de canaux sodiques
EP2173743A2 (fr) 2007-07-13 2010-04-14 Icagen, Inc. Inhibiteurs des canaux sodiques
WO2009013171A2 (fr) 2007-07-24 2009-01-29 F. Hoffmann-La Roche Ag Composés antiviraux hétérocycliques
US7935779B2 (en) 2008-03-07 2011-05-03 Great Eastern Resins Industrial Co., Ltd. Synthesis of polyimides (PI) from poly-carbodiimides and dianhydrides by sequential self-repetitive reaction (SSRR)
CA2727340A1 (fr) 2008-06-25 2009-12-30 Daiichi Sankyo Company, Limited Compose d'acide carboxylique
CN102099356A (zh) 2008-07-01 2011-06-15 沃泰克斯药物股份有限公司 用作离子通道调节剂的杂环衍生物
GB0815947D0 (en) 2008-09-02 2008-10-08 Univ Dundee Compounds
WO2010029300A1 (fr) 2008-09-12 2010-03-18 Biolipox Ab Composés bis-aromatiques pour utilisation dans le traitement de l’inflammation
HUE025013T2 (hu) 2009-01-12 2016-04-28 Pfizer Ltd Szulfonamid-származékok
CA2804593C (fr) 2010-07-09 2015-11-24 Pfizer Limited Derives de biphenyloxybenzensulphonamide utiles en tant qu'inhibiteurs du canal sodique
JP5749341B2 (ja) 2010-08-20 2015-07-15 ハチソン メディファーマ リミテッド ピロロピリミジン化合物およびその使用
AU2012296529A1 (en) 2011-08-17 2014-02-20 Amgen Inc. Heteroaryl sodium channel inhibitors
MX2014005068A (es) 2011-10-28 2014-07-30 Merck Sharp & Dohme Compuestos de benzoxazolinona con actividad selectiva en canales de sodio activados por voltaje.
ES2586213T3 (es) 2011-10-31 2016-10-13 Xenon Pharmaceuticals Inc. Compuestos de bencenosulfonamida y su uso como agentes terapéuticos
JP6014155B2 (ja) 2011-10-31 2016-10-25 ゼノン・ファーマシューティカルズ・インコーポレイテッドＸｅｎｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． ビアリールエーテルスルホンアミドおよび治療剤としてのそれらの使用
US8889741B2 (en) 2012-02-09 2014-11-18 Daiichi Sankyo Company, Limited Cycloalkane derivatives
US9346798B2 (en) 2012-02-13 2016-05-24 Amgen Inc. Dihydrobenzoxazine and tetrahydroquinoxaline sodium channel inhibitors
WO2014061970A1 (fr) 2012-10-15 2014-04-24 Daewoong Pharmaceutical Co., Ltd. Bloqueurs de canal sodique, leur procédé de préparation et leur utilisation
US9388179B2 (en) 2012-10-26 2016-07-12 Merck Sharp & Dohme Corp. N-substituted indazole sulfonamide compounds with selective activity in voltage-gated sodium channels
US9624208B2 (en) 2012-10-26 2017-04-18 Merck Sharp & Dohme Corp. Benzoxazolinone compounds with selective activity in voltage-gated sodium channels
TW201443025A (zh) 2013-04-19 2014-11-16 Pfizer Ltd 化學化合物
TW201512171A (zh) 2013-04-19 2015-04-01 Pfizer Ltd 化學化合物
US9776995B2 (en) 2013-06-12 2017-10-03 Amgen Inc. Bicyclic sulfonamide compounds as sodium channel inhibitors
GB201310542D0 (en) 2013-06-13 2013-07-31 Antabio Sas Compounds
WO2015035278A1 (fr) 2013-09-09 2015-03-12 Bristol-Myers Squibb Company Modulateurs de rorγ
CN105611923B (zh) 2013-09-10 2019-08-23 卓莫赛尔公司 用于治疗疼痛和糖尿病的钠通道调节剂
WO2015077905A1 (fr) 2013-11-29 2015-06-04 Merck Sharp & Dohme Corp. Composés de benzènesulfonamide à substitution bicycloamine ayant une activité sélective dans les canaux sodiques sensibles à la tension
AU2014370407B2 (en) 2013-12-23 2018-03-29 Purdue Pharma L.P. Indazoles and use thereof
CN106795149B (zh) 2015-05-05 2019-09-24 上海海雁医药科技有限公司 双环取代的苯磺酰胺衍生物、其制法与医药上的用途
TW201726637A (zh) 2015-12-18 2017-08-01 默沙東藥廠 對電位閘控鈉通道具選擇活性之羥基烷基胺－及羥基環烷基胺－取代之二胺－芳基磺胺化合物
WO2017106409A1 (fr) 2015-12-18 2017-06-22 Merck Sharp & Dohme Corp. Composés d'arylsulfonamide à liaisons diamino-alkylamino ayant une activité sélective vis-à-vis des canaux sodiques voltage-dépendants
US10844016B2 (en) 2016-05-03 2020-11-24 Bayer Pharma Aktiengesellschaft Aromatic sulfonamide derivatives
KR102366077B1 (ko) 2016-05-20 2022-02-21 제논 파마슈티칼스 인크. 벤젠술폰아미드 화합물 및 치료제로서의 그의 용도
EP3541373B1 (fr) 2016-11-17 2023-11-01 Merck Sharp & Dohme LLC Composés d'arylsulfonamide à liaisons diamino-alkylamino présentant une activité sélective dans les canaux sodiques sensibles à la tension
KR20190086772A (ko) 2016-12-09 2019-07-23 제논 파마슈티칼스 인크. 벤젠술폰아미드 화합물 및 치료제로서의 그의 용도
US10710994B2 (en) 2018-03-19 2020-07-14 Genentech, Inc. Oxadiazole transient receptor potential channel inhibitors
BR112020024729A2 (pt) 2018-06-13 2021-03-23 Xenon Pharmaceuticals, Inc. compostos de benzenossulfonamida e seu uso como agentes terapêuticos
CA3104913A1 (fr) 2018-08-31 2020-03-05 Xenon Pharmaceuticals Inc. Composes de sulfonamide substitues par heteroaryle et leur utilisation en tant qu'inhibiteurs de canaux sodiques
IL279810B2 (en) 2018-08-31 2025-03-01 Xenon Pharmaceuticals Inc Heteroaryl-modified sulfonamide compounds and their use as medicinal agents
CN112867539B (zh) 2018-08-31 2024-08-06 赛特凯恩蒂克公司 心脏肌小节抑制剂

Also Published As

Publication number Publication date
MX2021001380A (es) 2021-05-27
AU2019331005A1 (en) 2021-02-18
CR20210099A (es) 2021-06-24
WO2020047323A1 (fr) 2020-03-05
US20200157089A1 (en) 2020-05-21
KR20210054510A (ko) 2021-05-13
CA3110853A1 (fr) 2020-03-05
IL279810B1 (en) 2024-11-01
ECSP21013035A (es) 2021-03-31
SG11202100109TA (en) 2021-02-25
NI202100013A (es) 2021-06-22
PH12021550381A1 (en) 2021-12-13
IL279810A (en) 2021-03-01
JOP20200337A1 (ar) 2020-12-24
EP3844150A1 (fr) 2021-07-07
AU2019331005B2 (en) 2024-03-28
MY207670A (en) 2025-03-11
US10981905B2 (en) 2021-04-20
JP2021535134A (ja) 2021-12-16
DOP2021000031A (es) 2021-03-31
EA202190395A1 (ru) 2021-06-15
BR112021000209A2 (pt) 2021-08-24
PE20211066A1 (es) 2021-06-09
US11639351B2 (en) 2023-05-02
TW202115018A (zh) 2021-04-16
CN112638879B (zh) 2024-06-18
JP7450606B2 (ja) 2024-03-15
US20220348570A1 (en) 2022-11-03
ZA202100593B (en) 2023-10-25
CN112638879A (zh) 2021-04-09
CO2021001433A2 (es) 2021-05-10
IL279810B2 (en) 2025-03-01
CL2021000443A1 (es) 2021-07-02

Similar Documents

Publication Publication Date Title
MA48583A (fr) Composés de benzènesulfonamide et leur utilisation en tant qu'agents thérapeutiques
MA52888A (fr) Composés de benzènesulfonamide et leur utilisation en tant qu'agents thérapeutiques
MA53488A (fr) Composés de sulfonamide substitués par hétéroaryle et leur utilisation en tant qu'inhibiteurs de canaux sodiques
MA51224A (fr) Composés de sulfonamide et leur utilisation
MA48765A (fr) Cyanopyrrolidines substituées par sulfonamide ayant une activité en tant qu'inhibiteurs de dub
EP3768854A4 (fr) Modulation de l'expression de hsd17b13
MA53221A (fr) Nouveaux composés de sulfonamide urée
EP3814567A4 (fr) Appareil d'entretien de vêtements
MA45377A (fr) Composés hétérocycliques en tant qu'agents antibacteriens
EP3861343A4 (fr) Nanoconstructions fluorescentes ultralégères en tant qu'amplificateurs universels
EP3860449A4 (fr) Agencement d'électrodes
MA51232A (fr) Indane-amines utiles en tant qu'antagonistes de pd-l1
EP3768250A4 (fr) Formulations pour la pulvérisation d'épinéphrine
MA45375A (fr) Composés hétérocycliques utilisés en tant qu'agents antibacteriens
EP4000451A4 (fr) Masque cosmétique pour les yeux
IL279810A (en) Heteroaryl-converted sulfonamide compounds and their use as medicinal agents
EP3250035A4 (fr) Composés et leur utilisation en tant qu'inhibiteurs de bace1
EP3883576A4 (fr) Composés amino-triazolopyrimidine et amino-triazolopyrazine substitués utilisés en tant qu'antagonistes de récepteur de l'adénosine, compositions pharmaceutiques et leur utilisation
HUE071358T2 (hu) Benzolszulfonamid vegyületek és terápiás szerként való alkalmazásuk
MA49017A (fr) Modulateurs du récepteur 7 de la 5-hydroxytryptamine et utilisation de ces derniers en tant qu'agents thérapeutiques
MA56183A (fr) Pyrazolo-pyridines hétéroaromatiques substituées et leur utilisation en tant que modulateurs du récepteur glun2b
EP3887402A4 (fr) Plaquettes utilisées comme agents d'administration
MA53479A (fr) Composés hétérocycliques en tant q'inibiteurs de vanin
EP3334719A4 (fr) Benzimidazoles substitués, préparation et utilisation de ceux-ci en tant qu'agents pharmaceutiques
EP3728194A4 (fr) Composés de quinoléine sulfonamide et leur utilisation en tant qu'agents antibactériens