MA53370B1 - Procédé et intermédiaires pour la préparation de bilastine - Google Patents

Procédé et intermédiaires pour la préparation de bilastine

Info

Publication number
MA53370B1
MA53370B1 MA53370A MA53370A MA53370B1 MA 53370 B1 MA53370 B1 MA 53370B1 MA 53370 A MA53370 A MA 53370A MA 53370 A MA53370 A MA 53370A MA 53370 B1 MA53370 B1 MA 53370B1
Authority
MA
Morocco
Prior art keywords
bilastine
preparation
intermediates
iii
compound
Prior art date
Application number
MA53370A
Other languages
English (en)
Other versions
MA53370A (fr
Inventor
Herrero Gonzalo Hernández
Domínguez Neftalí García
Poladura Pablo Morán
García Tania González
Cerdeiras Paloma Tato
González Álvaro Ganza
Original Assignee
Faes Farma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Faes Farma Sa filed Critical Faes Farma Sa
Publication of MA53370A publication Critical patent/MA53370A/fr
Publication of MA53370B1 publication Critical patent/MA53370B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/39—Preparation of carboxylic acid esters by oxidation of groups which are precursors for the acid moiety of the ester
    • C07C67/42—Preparation of carboxylic acid esters by oxidation of groups which are precursors for the acid moiety of the ester by oxidation of secondary alcohols or ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne un procédé de préparation d'un composé (iii), x étant un groupe partant ; et r1 étant un alkyle en c1-c6 ; qui comprend un réarrangement oxydatif d'un composé de formule (ii) ou d'un solvate de celui-ci, les composés de formule (iii) sont des intermédiaires clés dans la synthèse de la bilastine.
MA53370A 2018-07-24 2019-07-23 Procédé et intermédiaires pour la préparation de bilastine MA53370B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18382556.1A EP3599235A1 (fr) 2018-07-24 2018-07-24 Procédé et intermédiaires pour la préparation de bilastine
PCT/EP2019/069772 WO2020020873A1 (fr) 2018-07-24 2019-07-23 Procédé et intermédiaires pour la préparation de bilastine

Publications (2)

Publication Number Publication Date
MA53370A MA53370A (fr) 2021-06-02
MA53370B1 true MA53370B1 (fr) 2021-12-31

Family

ID=63103892

Family Applications (1)

Application Number Title Priority Date Filing Date
MA53370A MA53370B1 (fr) 2018-07-24 2019-07-23 Procédé et intermédiaires pour la préparation de bilastine

Country Status (28)

Country Link
US (1) US11370742B2 (fr)
EP (2) EP3599235A1 (fr)
JP (1) JP7145312B2 (fr)
KR (1) KR20210038905A (fr)
CN (1) CN112469709A (fr)
AU (1) AU2019311251B2 (fr)
BR (1) BR112021001179A2 (fr)
CA (1) CA3107879A1 (fr)
CL (1) CL2021000171A1 (fr)
CO (1) CO2021000940A2 (fr)
CY (1) CY1124909T1 (fr)
EA (1) EA202190346A1 (fr)
EC (1) ECSP21008461A (fr)
ES (1) ES2901786T3 (fr)
HR (1) HRP20211994T1 (fr)
HU (1) HUE056822T2 (fr)
LT (1) LT3826997T (fr)
MA (1) MA53370B1 (fr)
MX (1) MX2021000924A (fr)
MY (1) MY206164A (fr)
PE (1) PE20211243A1 (fr)
PH (1) PH12021550144A1 (fr)
PL (1) PL3826997T3 (fr)
PT (1) PT3826997T (fr)
SG (1) SG11202100576WA (fr)
SI (1) SI3826997T1 (fr)
WO (1) WO2020020873A1 (fr)
ZA (1) ZA202101214B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112110893A (zh) * 2020-10-28 2020-12-22 山东齐环医药科技有限公司 一种比拉斯汀的制备方法
WO2022214921A1 (fr) * 2021-04-10 2022-10-13 Ocimum Labs Private Limited Procédé amélioré pour la préparation d'intermédiaires utilisés dans la préparation d'un agent antihistaminique
WO2023037184A2 (fr) * 2021-08-19 2023-03-16 Biophore India Pharmaceuticals Pvt. Ltd Nouveau procédé de préparation de bilastine et ses intermédiaires
WO2024116135A1 (fr) * 2022-12-01 2024-06-06 Piramal Pharma Limited Procédé de préparation de bilastine
CN117024313B (zh) * 2023-08-09 2024-08-30 重庆恩联生物科技有限公司 一种比拉斯汀中间体2-甲基-2-{4-[2-甲基-4-磺酰氧基-乙基]苯基}丙酸甲酯的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52108943A (en) * 1976-03-10 1977-09-12 Teikoku Hormone Mfg Co Ltd Alkyl phenyl ketone derivative
WO2009050116A2 (fr) * 2007-10-17 2009-04-23 Basf Se Photoinitiateurs favorisant l'adhérence de revêtements durcis aux uv sur des surfaces métalliques
KR101123903B1 (ko) * 2008-02-12 2012-03-23 주식회사유한양행 2-메틸-2'-페닐프로피온산 유도체의 제조 방법 및 이에 사용되는 신규한 중간체 화합물
CN102675101B (zh) 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CN103159674A (zh) 2013-04-03 2013-06-19 苏州安诺生物医药技术有限公司 2-苯烷酰胺类化合物及其制备方法、药物组合物和用途
CN104151160A (zh) 2013-05-15 2014-11-19 重庆华邦制药有限公司 用酯类化合物合成2-甲基丙酸酯衍生物的方法
WO2014188453A2 (fr) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Nouveau procédé de préparation de l'acide 2-[4-(2-{4-[1-(2-éthoxyéthyl)-1h-benzimidazol-2-yl]-1-pipéridinyl}éthyl) phényl]-2-méthylpropanoïque
CN104326909A (zh) 2014-09-22 2015-02-04 暨南大学 一种制备α,α-二甲基-4-(2-卤乙基)苯乙酸酯及合成比拉斯汀的方法

Also Published As

Publication number Publication date
EA202190346A1 (ru) 2021-05-20
ES2901786T3 (es) 2022-03-23
CY1124909T1 (el) 2023-01-05
PE20211243A1 (es) 2021-07-13
PL3826997T3 (pl) 2022-05-30
AU2019311251B2 (en) 2021-10-21
US11370742B2 (en) 2022-06-28
SG11202100576WA (en) 2021-02-25
CN112469709A (zh) 2021-03-09
US20210300856A1 (en) 2021-09-30
WO2020020873A1 (fr) 2020-01-30
BR112021001179A2 (pt) 2021-04-27
MY206164A (en) 2024-12-03
PH12021550144A1 (en) 2021-09-13
KR20210038905A (ko) 2021-04-08
EP3599235A1 (fr) 2020-01-29
JP2021531300A (ja) 2021-11-18
AU2019311251A1 (en) 2021-03-04
HRP20211994T1 (hr) 2022-04-01
PT3826997T (pt) 2022-01-21
CL2021000171A1 (es) 2021-07-09
LT3826997T (lt) 2021-12-27
MA53370A (fr) 2021-06-02
CO2021000940A2 (es) 2021-02-17
CA3107879A1 (fr) 2020-01-30
ECSP21008461A (es) 2021-03-31
ZA202101214B (en) 2022-09-28
HUE056822T2 (hu) 2022-03-28
EP3826997B1 (fr) 2021-11-10
JP7145312B2 (ja) 2022-09-30
EP3826997A1 (fr) 2021-06-02
SI3826997T1 (sl) 2022-01-31
MX2021000924A (es) 2021-03-31

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