PE20040164A1 - Mimeticos de glucocorticoides, procedimientos para su preparacion y composiciones farmaceuticas - Google Patents

Mimeticos de glucocorticoides, procedimientos para su preparacion y composiciones farmaceuticas

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Publication number
PE20040164A1
PE20040164A1 PE2003000290A PE2003000290A PE20040164A1 PE 20040164 A1 PE20040164 A1 PE 20040164A1 PE 2003000290 A PE2003000290 A PE 2003000290A PE 2003000290 A PE2003000290 A PE 2003000290A PE 20040164 A1 PE20040164 A1 PE 20040164A1
Authority
PE
Peru
Prior art keywords
alkyl
trifluoro
fluoro
mimetics
preparation
Prior art date
Application number
PE2003000290A
Other languages
English (en)
Inventor
Younes Bekkali
Rajashekhar Betageri
Thomas A Gilmore
Christian H J J Harcken
Thomas M Kirrane
Daniel Kuzmich
John R Proudfoot
Doris Riether
Hidenori Takahashi
David S Thomson
Ji Wang
Renee Zindell
Hossein Razavi
Mario G Cardozo
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of PE20040164A1 publication Critical patent/PE20040164A1/es

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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I ENTRE OTROS DONDE R1 ES UN GRUPO ARILO O HETEROARILO SUSTITUIDO CON ALQUILO C1-C5, ALQUENILO C2-C5, ALQUINILO C2-C5, ENTRE OTROS; R2 Y R3 SON HIDROGENO, ALQUILO C1-C5 O FORMAN UN ANILLO CICLOALQUILO C3-C8; R4 ES ALQUILO C1-C5, ALQUENILO C2-C5, ALQUINILO C2-C5, ENTRE OTROS; R5 ES HETEROARILO. SON COMPUESTOS PREFERIDOS:1,1,1-TRIFLUORO-4-(5-FLUORO-2-METOXIFENIL)-2-(4,6-DIMETILPIRIDIN-2-ILMETIL)-4-METILPENTAN-2-OL,1,1,1-TRIFLUORO-4-(5-FLUORO-2-METOXIFENIL)-2-(PIRIDIN-2-ILMETIL)-4-METILPENTAN-2-OL,1,1,1-TRIFLUORO-4-(5-FLUORO-2-METOXIFENIL)-4-METIL-2-(6-METILPIRIDIN-2-ILMETIL)PENTAN-2-OL,1,1,1-TRIFLUORO-4-(5-FLUORO-2-METOXIFENIL)-4-METIL-2-(4-METILPIRIDIN-2-ILMETIL)PENTAN-2-OL, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION Y COMPUESTOS INTERMEDIOS. LA INVENCION SE REFIERE A MIMETICOS DE GLUCOCORTICOIDES O LIGANDOS UTILES PARA EL TRATAMIENTO DE DIABETES, OSBESIDAD, ENFERMEDADES CARDIOVASCULARES
PE2003000290A 2002-03-26 2003-03-24 Mimeticos de glucocorticoides, procedimientos para su preparacion y composiciones farmaceuticas PE20040164A1 (es)

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