MA53859A - Procédé de transfert de gaz de membrane dans une culture de bioréacteur à haute densité - Google Patents

Procédé de transfert de gaz de membrane dans une culture de bioréacteur à haute densité

Info

Publication number
MA53859A
MA53859A MA053859A MA53859A MA53859A MA 53859 A MA53859 A MA 53859A MA 053859 A MA053859 A MA 053859A MA 53859 A MA53859 A MA 53859A MA 53859 A MA53859 A MA 53859A
Authority
MA
Morocco
Prior art keywords
gas transfer
membrane gas
bioreactor culture
density bioreactor
density
Prior art date
Application number
MA053859A
Other languages
English (en)
Inventor
jonathan Coffman
Scott Godfrey
Lisa Sawicki
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MA53859A publication Critical patent/MA53859A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/26—Conditioning fluids entering or exiting the reaction vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/24—Gas permeable parts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/16—Hollow fibers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/02—Means for regulation, monitoring, measurement or control, e.g. flow regulation of foam
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12—Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Sustainable Development (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
MA053859A 2018-10-10 2019-10-08 Procédé de transfert de gaz de membrane dans une culture de bioréacteur à haute densité MA53859A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862743767P 2018-10-10 2018-10-10

Publications (1)

Publication Number Publication Date
MA53859A true MA53859A (fr) 2022-01-19

Family

ID=68345046

Family Applications (1)

Application Number Title Priority Date Filing Date
MA053859A MA53859A (fr) 2018-10-10 2019-10-08 Procédé de transfert de gaz de membrane dans une culture de bioréacteur à haute densité

Country Status (6)

Country Link
US (2) US12415980B2 (fr)
EP (1) EP3864127A1 (fr)
KR (1) KR20210074341A (fr)
CN (1) CN113166695A (fr)
MA (1) MA53859A (fr)
WO (1) WO2020076776A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11629332B2 (en) 2017-03-31 2023-04-18 Terumo Bct, Inc. Cell expansion
WO2020076776A1 (fr) 2018-10-10 2020-04-16 Boehringer Ingelheim International Gmbh Procédé de transfert de gaz de membrane dans une culture de bioréacteur à haute densité
CN111454841A (zh) * 2020-05-26 2020-07-28 上海艾众生物科技有限公司 用于生物反应器的通气装置
CN111484937A (zh) * 2020-05-26 2020-08-04 上海艾众生物科技有限公司 用于生物反应器的培养基外循环更新装置
CA3183646A1 (fr) * 2020-07-06 2022-01-13 Merck Patent Gmbh Dispositif et procede pour la preparation de milieux de culture cellulaire et la realisation d'une culture cellulaire
CN112210504B (zh) * 2020-10-15 2021-05-18 新疆天润生物科技股份有限公司 一种马克思克鲁维酵母菌菌株的培养方法
CN113388515A (zh) * 2021-05-21 2021-09-14 瑞太生物科技(沈阳)有限公司 一种用于外泌体生产制备的系统及其制备外泌体的方法
JP7358664B1 (ja) 2022-08-08 2023-10-10 日機装株式会社 培養システム
EP4324905A1 (fr) * 2022-08-19 2024-02-21 Sartorius Stedim Biotech GmbH Système de bioréacteur avec installation de fumigation
KR20250132459A (ko) * 2022-10-31 2025-09-04 아벡, 아이엔씨. 회전 혼합을 이용한 세포 배양 생물반응기
JPWO2024106441A1 (fr) * 2022-11-15 2024-05-23
CN116041103B (zh) * 2023-02-01 2025-04-11 郑州大学 一种易于微生物发酵的有机肥料生产加工设备
US20240360399A1 (en) * 2023-04-26 2024-10-31 Terumo Bct, Inc. Methods To Remove Solutes Without Suspension Cell Loss
CN119001024A (zh) * 2024-08-22 2024-11-22 楚天科技股份有限公司 一种生物反应器中传质系数的测定方法
CN120555192A (zh) * 2025-08-01 2025-08-29 苏州英赛斯智能科技有限公司 生物反应装置及生物培养方法

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
JPS5028515B2 (fr) 1971-09-30 1975-09-16
US4515893A (en) 1979-04-26 1985-05-07 Ortho Pharmaceutical Corporation Hybrid cell line for producing complement-fixing monoclonal antibody to human T cells
DK187280A (da) 1980-04-30 1981-10-31 Novo Industri As Ruhedsreducerende middel til et fuldvaskemiddel fuldvaskemiddel og fuldvaskemetode
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
JPS58116678A (ja) * 1981-12-28 1983-07-11 Ajinomoto Co Inc 浮遊性動物細胞の培養法およびその装置
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
JPS60234580A (ja) * 1984-05-09 1985-11-21 Hitachi Ltd 動物細胞培養方法
US5672347A (en) 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
JPS63230079A (ja) * 1987-03-18 1988-09-26 Toyobo Co Ltd 動物細胞大量培養用通気装置
US5091313A (en) 1988-08-05 1992-02-25 Tanox Biosystems, Inc. Antigenic epitopes of IgE present on B cell but not basophil surface
US5720937A (en) 1988-01-12 1998-02-24 Genentech, Inc. In vivo tumor detection assay
WO1989012463A1 (fr) 1988-06-21 1989-12-28 Genentech, Inc. Procede et preparation therapeutique pour le traitement de l'infarctus du myocarde
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US4897359A (en) * 1989-03-27 1990-01-30 Bio-Response, Inc. Apparatus for oxygenating culture medium
JPH03164169A (ja) * 1989-08-04 1991-07-16 Mitsubishi Rayon Co Ltd 細胞培養方法
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
JPH0427386A (ja) 1990-05-24 1992-01-30 Kao Corp プロテアーゼ耐性セルラーゼ、これを産生する微生物及び該セルラーゼの製造法
ES2193136T3 (es) 1991-08-14 2003-11-01 Genentech Inc Variantes de inmunoglubina para receptores especificos de fc epsilon.
DK0656789T3 (da) 1992-08-21 1998-08-24 Genentech Inc Fremgangsmåde til behandling af en LFA-1-medieretforstyrrelse.
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
EP1005870B1 (fr) 1992-11-13 2009-01-21 Biogen Idec Inc. Application thérapeutique d'anticorps chimériques et radio-marqués contre l'antigène à différentiation restreinte des lymphocytes B humains pour le traitement du lymphome des cellules B
DE69405251T2 (de) 1993-12-10 1998-02-05 Genentech Inc Methoden zur diagnose von allergie und prüfung anti-allergischer therapeutika
MX9602818A (es) 1994-01-18 1997-06-28 Genentech Inc Un metodo de tratamiento de infeccion parasitaria usando antagonistas ige.
WO1995023865A1 (fr) 1994-03-03 1995-09-08 Genentech, Inc. Anticorps monoclonaux anti-il-8 pour le traitement des troubles
US5534615A (en) 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
IL117645A (en) 1995-03-30 2005-08-31 Genentech Inc Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
EP0831880A4 (fr) 1995-06-07 2004-12-01 Imclone Systems Inc Anticorps et fragments d'anticorps inhibant la croissance des tumeurs
JP4864175B2 (ja) 1996-01-23 2012-02-01 ジェネンテック， インコーポレイテッド 発作に関する抗―ｃｄ１８抗体
DE19725602C2 (de) 1996-06-18 2003-08-21 Ming-Yi Liau Verfahren und Vorrichtung zum Züchten von Zellen
US7147851B1 (en) 1996-08-15 2006-12-12 Millennium Pharmaceuticals, Inc. Humanized immunoglobulin reactive with α4β7 integrin
DK0941344T3 (da) 1996-11-27 2004-09-27 Genentech Inc Humaniserede anti-CD11a-antistoffer
KR100870353B1 (ko) 1997-04-07 2008-11-25 제넨테크, 인크. 항-ｖｅｇｆ 항체
ATE516354T1 (de) 1997-05-15 2011-07-15 Genentech Inc Apo-2-rezeptor
US5998184A (en) * 1997-10-08 1999-12-07 Unisyn Technologies, Inc. Basket-type bioreactor
US6001585A (en) * 1997-11-14 1999-12-14 Cellex Biosciences, Inc. Micro hollow fiber bioreactor
US8026096B1 (en) * 1998-10-08 2011-09-27 Protein Sciences Corporation In vivo active erythropoietin produced in insect cells
US6946129B1 (en) 1999-06-08 2005-09-20 Seattle Genetics, Inc. Recombinant anti-CD40 antibody and uses thereof
JP4028237B2 (ja) 1999-10-29 2007-12-26 ジェネンテック・インコーポレーテッド 抗前立腺幹細胞抗原（ｐｓｃａ）抗体組成物及び使用方法
WO2003025158A1 (fr) * 2001-09-14 2003-03-27 Medcell Biologics, Inc. Bioreacteur enrichi en oxygene et procede destine a cultiver des cellules
US20040096943A1 (en) * 2002-01-28 2004-05-20 Uwe Marx Method and device for cultivating of cells at high densities and for obtaining of products from these cells
CN101096639B (zh) 2007-05-16 2011-08-10 宁波 多组纤维管均匀分布的多功能中空纤维膜管生物反应器
US20080305540A1 (en) * 2007-06-08 2008-12-11 Robert Hickey Membrane supported bioreactor for conversion of syngas components to liquid products
CN101549181B (zh) 2009-05-07 2011-11-02 浙江大学 纳米纤维网片叠加式生物反应器
CN101831382A (zh) * 2010-04-09 2010-09-15 中国科学院广州能源研究所 以难溶气体为发酵原料的无泡供气-固液分离一体式膜生物膜反应器
GB201019932D0 (en) 2010-11-24 2011-01-05 Imp Innovations Ltd Dimensional hollow fibre bioreactor systems for the maintenance, expansion, differentiation and harvesting of human stem cells and their progeny
CN202576435U (zh) 2012-05-08 2012-12-05 广州齐志生物工程设备有限公司 生物反应器的通气装置
CN203280815U (zh) 2013-05-15 2013-11-13 浙江中医药大学 一种无泡供氧式生物人工肝细胞培养装置
JP2014234580A (ja) * 2013-06-04 2014-12-15 ユアサグローブ株式会社 手袋
KR20160088331A (ko) * 2013-11-06 2016-07-25 엘앤드제이 바이오사이언스 인코포레이티드 연속적으로 조절되는 중공사 생물반응기
US9813410B2 (en) 2014-06-26 2017-11-07 Rakuten, Inc. Information processing apparatus, information processing method, and information processing program
WO2017066725A1 (fr) * 2015-10-16 2017-04-20 California Institute Of Technology Procédés et compositions d'oxydation du méthane
CN106540345A (zh) 2016-12-13 2017-03-29 广州奥柏仕医疗器械有限公司 一种四组中空纤维动态培养生物人工肝反应器
CN106754259A (zh) * 2017-02-14 2017-05-31 中国科学院过程工程研究所 一种发酵合成气生产醇类的系统及其处理方法
WO2020076776A1 (fr) 2018-10-10 2020-04-16 Boehringer Ingelheim International Gmbh Procédé de transfert de gaz de membrane dans une culture de bioréacteur à haute densité
US20230323264A1 (en) * 2022-04-07 2023-10-12 Mirror Biologics, Inc. Artificial lymph node bioreactor
JP2025116678A (ja) * 2024-01-29 2025-08-08 株式会社ホタルクス 照準器、ランプ、閃光灯、閃光装置及びランプの方位調整方法

Also Published As

Publication number Publication date
EP3864127A1 (fr) 2021-08-18
WO2020076776A1 (fr) 2020-04-16
US12415980B2 (en) 2025-09-16
KR20210074341A (ko) 2021-06-21
CN113166695A (zh) 2021-07-23
US20250368939A1 (en) 2025-12-04
US20210380923A1 (en) 2021-12-09

Similar Documents

Publication Publication Date Title
MA53859A (fr) Procédé de transfert de gaz de membrane dans une culture de bioréacteur à haute densité
DK3460042T3 (da) Celledyrkningsmedium til dyrkning af et organoid, dyrkningsfremgnagsmåde og organoid
IL261455B (en) Method of purifying antifungal compounds and exopolysaccharides from a microbial cell culture
EP3733835A4 (fr) Matériau de charpente pour cultures de cellules souches et procédé de culture de cellules souches l'utilisant
DK3528621T3 (da) System og metode til flydende dyrkning af akvakultur med lukket opbevaring
EP3438248A4 (fr) Milieu de culture de cellules souches pluripotentes naïves et procédé de culture de cellules souches pluripotentes
IL280465A (en) Methods for gene modification of hematopoietic cells
DK2672807T3 (da) Fremgangsmåde og bioreaktor til dyrkning af mikroorganismer
DK2766468T3 (da) Fremgangsmåde til kontrolleret drift af en bioteknologisk indretning og bioreaktorsystemer
EP3375863A4 (fr) Procédé de culture cellulaire utilisant un milieu contenant un fragment de laminine
EP3395939A4 (fr) Cuve de tri, de culture et de croissance cellulaires ; et procédé de tri, de culture et de croissance cellulaires
GB2602727B (en) Method of culture
EP3896154A4 (fr) Cellule primaire de tumeur solide de cancer colorectal et procédé de culture de cellules tumorales primaires de fluide ascitique de cancer colorectal, et réactif de mise en correspondance
EP3376871A4 (fr) Composition et procédé de réduction de la pénalité de rendement associée à la culture répétée du maïs
EP3994246A4 (fr) Procédé de culture de cellules adhérentes dans un bioréacteur multiparallèle
DK3843793T3 (da) System og fremgangsmåde til reduktion af mikroorganismer
EP4056886A4 (fr) Procédé de remplacement de gaz
DK3507355T3 (da) Fotobioreaktor og fremgangsmåde til dyrkning af mikroalger
DE112019005820A5 (de) Brennstoffzellensystem und Verfahren zum Temperieren eines Brennstoffzellensystems
EP4005382A4 (fr) Fluide de perfusion et procédé de perfusion
EP3924460A4 (fr) Système d'inoculation de sol à base de microalgues et procédés d'utilisation
EP4002989A4 (fr) Procédé et bâtiment destinés à la culture de plantes
EP3485726A4 (fr) Procédé de culture pour racines de légumineuses cultivées à teneur accrue en coumestrol
EP3508567A4 (fr) Procédé de culture de microalgues photosynthétiques
EP4006134A4 (fr) Procédé de culture et récipient de culture