MA54200B1 - Procédé industriel pour la préparation d'estétrol de pureté élevée - Google Patents

Procédé industriel pour la préparation d'estétrol de pureté élevée

Info

Publication number
MA54200B1
MA54200B1 MA54200A MA54200A MA54200B1 MA 54200 B1 MA54200 B1 MA 54200B1 MA 54200 A MA54200 A MA 54200A MA 54200 A MA54200 A MA 54200A MA 54200 B1 MA54200 B1 MA 54200B1
Authority
MA
Morocco
Prior art keywords
estetrol
preparation
high purity
industrial process
formula
Prior art date
Application number
MA54200A
Other languages
English (en)
Other versions
MA54200A (fr
Inventor
Róbert Lovas
Sándor Mahó
Ildikó Bacsa
Beatrix Mayer
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Publication of MA54200A publication Critical patent/MA54200A/fr
Publication of MA54200B1 publication Critical patent/MA54200B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0074—Esters
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne la préparation d'estétrol de formule (i), des dérivés de ceux-ci protégés aux positions 3,15a, 16a, 17ß de formule générale (iii), et des dérivés 3-hydroxy de ceux-ci protégés aux positions 15a, 16a, 17ß de formule générale (iv), et des intermédiaires des formules générales (iii) et (iv) appliqués dans le procédé. Un autre aspect de l'invention concerne l'utilisation d'estétrol de formule (i) obtenu par le procédé de l'invention pour la préparation d'une composition pharmaceutique.
MA54200A 2019-09-03 2020-09-02 Procédé industriel pour la préparation d'estétrol de pureté élevée MA54200B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU1900315A HU231240B1 (hu) 2019-09-03 2019-09-03 Ipari eljárás nagytisztaságú ösztetrol hatóanyag előállítására
PCT/IB2020/058148 WO2021044302A1 (fr) 2019-09-03 2020-09-02 Procédé industriel pour la préparation d'estétrol de pureté élevée

Publications (2)

Publication Number Publication Date
MA54200A MA54200A (fr) 2022-04-27
MA54200B1 true MA54200B1 (fr) 2023-02-28

Family

ID=89992977

Family Applications (1)

Application Number Title Priority Date Filing Date
MA54200A MA54200B1 (fr) 2019-09-03 2020-09-02 Procédé industriel pour la préparation d'estétrol de pureté élevée

Country Status (33)

Country Link
US (1) US11633406B2 (fr)
EP (1) EP3877395B1 (fr)
JP (1) JP7265087B2 (fr)
KR (1) KR102871606B1 (fr)
CN (1) CN114302889B (fr)
AU (1) AU2020343497B2 (fr)
CA (1) CA3147815C (fr)
CL (1) CL2022000492A1 (fr)
CO (1) CO2022003769A2 (fr)
CU (1) CU24692B1 (fr)
DK (1) DK3877395T3 (fr)
EC (1) ECSP22022403A (fr)
ES (1) ES2855923T3 (fr)
FI (1) FI3877395T3 (fr)
GE (1) GEP20247626B (fr)
HR (1) HRP20230230T1 (fr)
HU (2) HU231240B1 (fr)
IL (1) IL290973B2 (fr)
JO (1) JOP20220041A1 (fr)
LT (1) LT3877395T (fr)
MA (1) MA54200B1 (fr)
MD (1) MD3877395T2 (fr)
MX (1) MX2022002603A (fr)
MY (1) MY206905A (fr)
NZ (1) NZ786568A (fr)
PE (1) PE20221418A1 (fr)
PH (1) PH12022550388A1 (fr)
PL (1) PL3877395T3 (fr)
PT (1) PT3877395T (fr)
RS (1) RS63966B1 (fr)
SI (1) SI3877395T1 (fr)
WO (1) WO2021044302A1 (fr)
ZA (1) ZA202203557B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2603868B (en) * 2019-09-27 2023-10-11 Ind Chimica Srl Process for preparing (15ALPHA,16ALPHA,17BETA)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-tetrol monohydrate (estetrol monohydrate) and intermediates of said process
DE112021008305T5 (de) * 2021-10-01 2024-07-25 Industriale Chimica S.R.L. VERFAHREN ZUR HERSTELLUNG VON (15α,16α,17β)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-TETROL (ESTETROL) UND ESTETROL-MONOHYDRAT
AU2023428138A1 (en) * 2023-02-02 2025-09-04 Industriale Chimica S.R.L. PROCESS FOR PREPARING (15α,16α,17β)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-TETROL (ESTETROL) MONOHYDRATE
CN117088928B (zh) * 2023-08-16 2025-09-09 湖北共同甾体药物研究院有限公司 用于制备高纯度雌四醇的工艺
CN119569803B (zh) * 2023-09-05 2025-09-16 秦皇岛紫竹药业有限公司 一种制备高纯度雌四醇的方法
HUP2400151A1 (hu) 2024-02-28 2025-09-28 Richter Gedeon Nyrt Ösztetrol-monohidrát kristályosítási eljárás

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1260225A1 (fr) 2001-05-18 2002-11-27 Pantarhei Bioscience B.V. Compositions pharmaceutiques pour le traitement hormonal substitutif
PT1390040E (pt) 2001-05-18 2007-04-30 Pantarhei Bioscience Bv Composição farmacêutica para ser utilizado na terapia hormonal de substituição.
ES2337129T3 (es) 2001-05-23 2010-04-21 Pantarhei Bioscience B.V. Sistema de administracion de medicamento comprendiendo un estrogeno tetrahidroxilado para el uso en la anticoncepcion hormonal.
EP1390042B1 (fr) 2001-05-23 2007-11-28 Pantarhei Bioscience B.V. Systeme d'administration de medicament comprenant un oestrogene tetrahydroxyle destine a une contraception hormonale
US8026228B2 (en) 2001-11-15 2011-09-27 Pantarhei Bioscience B.V. Estrogenic compounds in combination with progestogenic compounds in hormone-replacement therapy
CN100352445C (zh) 2002-06-11 2007-12-05 潘塔希生物科学股份有限公司 一种皮肤护理组合物及其用途
PT1511496E (pt) 2002-06-11 2007-01-31 Pantarhei Bioscience Bv Método para tratamento ou prevenção de doenças mediadas pelo sistema imunitário e formulação farmacológica para utilização nas mesmas
SI1526856T1 (sl) 2002-07-12 2008-04-30 Pantarhei Bioscience Bv Farmacevtski sestavek, ki obsega estetrolne derivate za uporabo pri zdravljenju raka
SI1556058T1 (sl) 2002-10-23 2008-02-29 Pantarhei Bioscience Bv Farmacevtski sestavki, ki obsegajo estetrolne derivate, za uporabo pri zdravljenju raka
AU2003279624A1 (en) * 2002-11-08 2004-06-07 Pantarhei Bioscience B.V. Synthesis of estetrol via estrone derived steroids
WO2007081206A1 (fr) 2006-01-09 2007-07-19 Pantarhei Bioscience B.V. Procédé de traitement d'un trouble vasculaire aigu
ATE473746T1 (de) 2007-01-08 2010-07-15 Pantarhei Bioscience Bv Verfahren zur behandlung oder prävention von unfruchtbarkeit bei weiblichen säugern und pharmazeutisches kit zur anwendung dieses verfahrens
EP2383279A1 (fr) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Procédé de préparation d'estetrol
PL2741824T3 (pl) 2011-08-11 2018-03-30 Estetra S.P.R.L. Zastosowanie estetrolu jako środka antykoncepcji awaryjnej
RS55231B1 (sr) 2011-10-07 2017-02-28 Estetra Sprl Postupak proizvodnje estetrola
EP2653163A1 (fr) 2012-04-19 2013-10-23 Université de Liège Constituants estrogènes pour l'utilisation dans le traitement de troubles neurologiques
WO2013034780A2 (fr) 2012-12-20 2013-03-14 Crystal Pharma, S.A.U. Procédé de préparation de l'estétrol et de composés analogues
EP3046928B1 (fr) * 2013-09-18 2017-02-08 Crystal Pharma, S.A.U. Procédé de préparation d'estetrol
JP6447931B2 (ja) 2013-12-12 2019-01-09 ドネスタ バイオサイエンス ビー．ブイ．Ｄｏｎｅｓｔａ Ｂｉｏｓｃｉｅｎｃｅ Ｂ．Ｖ． エステトロール成分を含有する口腔内崩壊固体単位剤形
LT3310345T (lt) 2015-06-18 2021-06-25 Estetra Sprl Burnoje disperguojama tabletė, turinti estetrolio
LT3310346T (lt) 2015-06-18 2021-06-10 Estetra Sprl Burnoje disperguojama tabletė, turinti estetrolio
DK3701944T3 (da) 2015-06-18 2022-03-14 Estetra Srl Oro-dispergerbar doseringsenhed indeholdende en estetrolkomponent
KR102712911B1 (ko) 2016-08-05 2024-10-04 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 월경통 및 생리통의 관리방법
CA3041016C (fr) 2016-10-28 2023-09-05 Estetra Sprl Methode de prise en charge de la dysmenorrhee et des douleurs menstruelles
PL3661520T3 (pl) 2017-08-01 2022-03-28 Fund Sa Terapia adiuwantowa do stosowania w leczeniu raka prostaty
SG11202007163WA (en) 2018-02-07 2020-08-28 Estetra Sprl Contraceptive composition with reduced cardiovascular effects
GB2603868B (en) 2019-09-27 2023-10-11 Ind Chimica Srl Process for preparing (15ALPHA,16ALPHA,17BETA)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-tetrol monohydrate (estetrol monohydrate) and intermediates of said process

Also Published As

Publication number Publication date
JP7265087B2 (ja) 2023-04-25
CA3147815A1 (fr) 2021-03-11
PH12022550388A1 (en) 2024-01-29
CU20220013A7 (es) 2022-10-11
KR20220071206A (ko) 2022-05-31
US20220296609A1 (en) 2022-09-22
GEP20247626B (en) 2024-05-27
MA54200A (fr) 2022-04-27
ZA202203557B (en) 2022-11-30
JOP20220041A1 (ar) 2023-01-30
CL2022000492A1 (es) 2023-03-10
LT3877395T (lt) 2023-02-27
FI3877395T3 (fi) 2023-03-18
CN114302889B (zh) 2023-08-29
NZ786568A (en) 2026-01-30
CU24692B1 (es) 2024-01-10
PL3877395T3 (pl) 2023-05-08
MX2022002603A (es) 2022-03-25
BR112022003254A2 (pt) 2022-05-17
ES2855923T1 (es) 2021-09-24
CN114302889A (zh) 2022-04-08
JP2022546016A (ja) 2022-11-02
SI3877395T1 (sl) 2023-03-31
PE20221418A1 (es) 2022-09-20
ECSP22022403A (es) 2022-04-29
PT3877395T (pt) 2023-02-02
IL290973A (en) 2022-05-01
RS63966B1 (sr) 2023-03-31
EP3877395A1 (fr) 2021-09-15
HUE061427T2 (hu) 2023-07-28
HU231240B1 (hu) 2022-04-28
HRP20230230T1 (hr) 2023-04-14
WO2021044302A1 (fr) 2021-03-11
US11633406B2 (en) 2023-04-25
MY206905A (en) 2025-01-15
KR102871606B1 (ko) 2025-10-16
IL290973B2 (en) 2023-11-01
CO2022003769A2 (es) 2022-04-19
MD3877395T2 (ro) 2023-05-31
AU2020343497B2 (en) 2023-02-02
IL290973B1 (en) 2023-07-01
CA3147815C (fr) 2023-03-28
EP3877395B1 (fr) 2022-12-07
ES2855923T3 (es) 2023-04-28
AU2020343497A1 (en) 2022-04-14
HUP1900315A1 (hu) 2021-03-29
DK3877395T3 (da) 2023-03-06

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