ECSP21052184A - Inhibidores de apol1 y sus métodos de uso - Google Patents

Inhibidores de apol1 y sus métodos de uso

Info

Publication number
ECSP21052184A
ECSP21052184A ECSENADI202152184A ECDI202152184A ECSP21052184A EC SP21052184 A ECSP21052184 A EC SP21052184A EC SENADI202152184 A ECSENADI202152184 A EC SENADI202152184A EC DI202152184 A ECDI202152184 A EC DI202152184A EC SP21052184 A ECSP21052184 A EC SP21052184A
Authority
EC
Ecuador
Prior art keywords
apol1
inhibitors
use methods
methods
ndkd
Prior art date
Application number
ECSENADI202152184A
Other languages
English (en)
Inventor
Jon H Come
Francois Denis
Kan-Nian Hu
Warren A Dorsch
Ales Medek
Leslie A Dakin
Martine Hamel
Brian Ledford
Tiansheng Wang
Yi Shi
Peter Rose
Faith Witkos
Kevin Gagnon
Suganthini S Nanthakumar
Elaine B Krueger
Olivier Nicolas
Jingrong Cao
Timothy J Senter
Muna Shrestha
Anne Fortier
Michael Brodney
Camil Sayegh
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of ECSP21052184A publication Critical patent/ECSP21052184A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

La descripción proporciona al menos una entidad seleccionada de compuestos de la fórmula (I), formas en estado sólido de ellos, composiciones que los comprenden y métodos que los usan, incluyendo el uso en el tratamiento de glomeruloesclerosis segmentaria focal (FSGS) y/o enfermedad renal no diabética (NDKD).
ECSENADI202152184A 2018-12-17 2021-07-15 Inhibidores de apol1 y sus métodos de uso ECSP21052184A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862780667P 2018-12-17 2018-12-17

Publications (1)

Publication Number Publication Date
ECSP21052184A true ECSP21052184A (es) 2021-08-31

Family

ID=69182627

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202152184A ECSP21052184A (es) 2018-12-17 2021-07-15 Inhibidores de apol1 y sus métodos de uso

Country Status (29)

Country Link
US (3) US11618746B2 (es)
EP (1) EP3897833B1 (es)
JP (1) JP7573528B2 (es)
KR (2) KR20260020195A (es)
CN (1) CN113453760B (es)
AR (1) AR116913A1 (es)
AU (1) AU2019405477B2 (es)
CA (1) CA3121910A1 (es)
CL (1) CL2021001561A1 (es)
CO (1) CO2021009053A2 (es)
CR (1) CR20210383A (es)
DK (1) DK3897833T3 (es)
DO (1) DOP2021000116A (es)
EC (1) ECSP21052184A (es)
FI (1) FI3897833T3 (es)
IL (2) IL283592B2 (es)
JO (3) JOP20210131A1 (es)
LT (1) LT3897833T (es)
MA (1) MA54538B1 (es)
MX (1) MX2021007152A (es)
PE (1) PE20212302A1 (es)
PT (1) PT3897833T (es)
SA (1) SA521422270B1 (es)
SG (1) SG11202105769XA (es)
SM (1) SMT202600169T1 (es)
TW (1) TWI848031B (es)
UA (1) UA128375C2 (es)
UY (1) UY38514A (es)
WO (1) WO2020131807A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL283592B2 (en) 2018-12-17 2025-08-01 Vertex Pharma Inhibitors of apol1 and methods of using same
EP4097083A1 (en) * 2020-01-29 2022-12-07 Vertex Pharmaceuticals Incorporated Inhibitors of apol1 and methods of using same
US20210246121A1 (en) * 2020-02-04 2021-08-12 Vertex Pharmaceuticals Incorporated Solid forms of apol1 inhibitor and methods of using same
CN115209894B (zh) * 2020-03-06 2025-05-02 弗特克斯药品有限公司 治疗apol-1依赖性局灶节段性肾小球硬化的方法
CA3185144A1 (en) * 2020-06-12 2021-12-16 Vertex Pharmaceuticals Incorporated Inhibitors of apol1 and use of the same
CN116157393A (zh) 2020-06-12 2023-05-23 弗特克斯药品有限公司 Apol1的抑制剂及其用途
EP4165036A1 (en) * 2020-06-12 2023-04-19 Vertex Pharmaceuticals Incorporated Solid forms of apol1 inhibitor and using the same
UY39395A (es) * 2020-08-26 2022-03-31 Vertex Pharma Inhibidores de apol1 y métodos para usar los mismos
WO2022178315A1 (en) 2021-02-19 2022-08-25 Maze Therapeutics, Inc. Apol1 inhibitors and methods of use
KR20240051990A (ko) * 2021-08-26 2024-04-22 버텍스 파마슈티칼스 인코포레이티드 스피로트리시클릭 apol1 억제제의 고형분 형태 및 이의 사용 방법
US12612379B2 (en) 2021-11-30 2026-04-28 Vertex Pharmaceuticals Incorporated Inhibitors of APOL1 and methods of using same
JP2024544060A (ja) * 2021-11-30 2024-11-27 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｐｏｌ１のスピロ環式阻害剤およびこれを使用する方法
KR20240149461A (ko) * 2022-01-18 2024-10-14 메이즈 테라퓨틱스, 인코퍼레이티드 Apol1 저해제 및 사용 방법
CA3251050A1 (en) * 2022-02-08 2023-08-17 Vertex Pharmaceuticals Incorporated 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES USED AS APOL1 INHIBITORS AND THEIR METHODS OF USE
WO2023194895A1 (en) 2022-04-06 2023-10-12 Glaxosmithkline Intellectual Property Development Limited Pyrrol derivatives as inhibitors of apolipoprotein l-1
EP4573077A1 (en) * 2022-08-19 2025-06-25 Maze Therapeutics, Inc. Apol1 inhibitors and methods of use
WO2025006262A1 (en) * 2023-06-29 2025-01-02 Omniab, Inc. Tetracyclic compounds containing a fused indole for treating apol1-mediated chronic kidney disease
GB202401326D0 (en) * 2024-02-01 2024-03-20 Podium Bio Ltd Novel compounds
KR20250122547A (ko) 2024-02-05 2025-08-14 서주사이언티픽 주식회사 AIoT 기반 방사성 동위원소 관리 시스템
WO2026012338A1 (zh) * 2024-07-09 2026-01-15 上海旭成医药科技有限公司 一种APOLs抑制剂

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CN115209894B (zh) 2020-03-06 2025-05-02 弗特克斯药品有限公司 治疗apol-1依赖性局灶节段性肾小球硬化的方法
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EP4165036A1 (en) 2020-06-12 2023-04-19 Vertex Pharmaceuticals Incorporated Solid forms of apol1 inhibitor and using the same
CN116157393A (zh) 2020-06-12 2023-05-23 弗特克斯药品有限公司 Apol1的抑制剂及其用途
UY39395A (es) 2020-08-26 2022-03-31 Vertex Pharma Inhibidores de apol1 y métodos para usar los mismos
KR20240051990A (ko) 2021-08-26 2024-04-22 버텍스 파마슈티칼스 인코포레이티드 스피로트리시클릭 apol1 억제제의 고형분 형태 및 이의 사용 방법
US12612379B2 (en) 2021-11-30 2026-04-28 Vertex Pharmaceuticals Incorporated Inhibitors of APOL1 and methods of using same
JP2024544060A (ja) 2021-11-30 2024-11-27 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｐｏｌ１のスピロ環式阻害剤およびこれを使用する方法
WO2023154310A1 (en) 2022-02-08 2023-08-17 Vertex Pharmaceuticals Incorporated 2-methyl-4-phenylpiperidin-4-ol derivatives as inhibitors of apol1 and methods of using same
JP2025505644A (ja) 2022-02-08 2025-02-28 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｐｏｌ１の阻害剤としての４’，５’－ジヒドロスピロ［ピペリジン－４，７’－チエノ［２，３－ｃ］ピラン］誘導体、及びそれを使用する方法
CA3251050A1 (en) 2022-02-08 2023-08-17 Vertex Pharmaceuticals Incorporated 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES USED AS APOL1 INHIBITORS AND THEIR METHODS OF USE
CA3251155A1 (en) 2022-02-08 2023-08-17 Vertex Pharmaceuticals Incorporated Spiropiperidine derivatives used as APOL1 inhibitors and their methods of use

Also Published As

Publication number Publication date
IL283592A (en) 2021-07-29
TWI848031B (zh) 2024-07-11
UA128375C2 (uk) 2024-06-26
JP2022515369A (ja) 2022-02-18
CN113453760A (zh) 2021-09-28
SG11202105769XA (en) 2021-07-29
EP3897833A1 (en) 2021-10-27
KR20210116483A (ko) 2021-09-27
CR20210383A (es) 2021-09-22
MA54538B1 (fr) 2026-04-30
AU2019405477B2 (en) 2025-04-03
US20230271945A1 (en) 2023-08-31
CA3121910A1 (en) 2020-06-25
US11618746B2 (en) 2023-04-04
JP7573528B2 (ja) 2024-10-25
KR20260020195A (ko) 2026-02-10
AR116913A1 (es) 2021-06-23
IL283592B1 (en) 2025-04-01
CL2021001561A1 (es) 2021-11-26
CN113453760B (zh) 2024-05-24
BR112021011564A2 (pt) 2021-08-31
US20250042878A1 (en) 2025-02-06
SMT202600169T1 (it) 2026-05-12
CO2021009053A2 (es) 2021-08-09
TW202039471A (zh) 2020-11-01
US20200377479A1 (en) 2020-12-03
JOP20210131A1 (ar) 2023-01-30
UY38514A (es) 2020-07-31
PE20212302A1 (es) 2021-12-10
SA521422270B1 (ar) 2024-02-18
KR102912203B1 (ko) 2026-01-16
US12060346B2 (en) 2024-08-13
FI3897833T3 (fi) 2026-04-07
AU2019405477A1 (en) 2021-06-24
JOP20210129A1 (ar) 2023-01-30
DK3897833T3 (da) 2026-03-30
IL319575A (en) 2025-05-01
LT3897833T (lt) 2026-04-27
DOP2021000116A (es) 2021-09-30
MA54538A (fr) 2021-10-27
MX2021007152A (es) 2021-11-03
JOP20210130A1 (ar) 2023-01-30
WO2020131807A1 (en) 2020-06-25
PT3897833T (pt) 2026-04-22
EP3897833B1 (en) 2026-02-04
IL283592B2 (en) 2025-08-01

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