MA55199B1 - (n-)acétyl-l-leucine pour le traitement des lésions cérébrales traumatiques - Google Patents

(n-)acétyl-l-leucine pour le traitement des lésions cérébrales traumatiques

Info

Publication number
MA55199B1
MA55199B1 MA55199A MA55199A MA55199B1 MA 55199 B1 MA55199 B1 MA 55199B1 MA 55199 A MA55199 A MA 55199A MA 55199 A MA55199 A MA 55199A MA 55199 B1 MA55199 B1 MA 55199B1
Authority
MA
Morocco
Prior art keywords
leucine
pharmaceutically acceptable
acceptable salt
acetyl
brain injury
Prior art date
Application number
MA55199A
Other languages
English (en)
Other versions
MA55199A (fr
Inventor
Mallory Factor
Taylor FIELDS
Original Assignee
Intrabio Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intrabio Ltd filed Critical Intrabio Ltd
Publication of MA55199A publication Critical patent/MA55199A/fr
Publication of MA55199B1 publication Critical patent/MA55199B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des procédés de traitement de maladies, de troubles, d'états ou de syndromes, par exemple d'une lésion cérébrale traumatique, chez un patient en ayant besoin par l'administration d'une quantité thérapeutiquement efficace de DL-leucine, ou d'un sel pharmaceutiquement acceptable de celle-ci, de L-leucine, ou d'un sel pharmaceutiquement acceptable de celle-ci, de D-leucine, ou d'un sel pharmaceutiquement acceptable de celle-ci, d'un ester d'éthyle de L-leucine, ou d'un sel pharmaceutiquement acceptable de celui-ci, d'acétyl-DL-leucine, ou d'un sel pharmaceutiquement acceptable de celle-ci, d'acétyl-D-leucine, ou d'un sel pharmaceutiquement acceptable de celle-ci, ou d'acétyl-L-leucine, ou d'un sel pharmaceutiquement acceptable de celle-ci.
MA55199A 2019-03-02 2020-03-02 (n-)acétyl-l-leucine pour le traitement des lésions cérébrales traumatiques MA55199B1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201962812987P 2019-03-02 2019-03-02
US201962842296P 2019-05-02 2019-05-02
US201962888894P 2019-08-19 2019-08-19
US201962895144P 2019-09-03 2019-09-03
PCT/IB2020/051767 WO2020178721A1 (fr) 2019-03-02 2020-03-02 Leucine, acétyl leucine et analogues apparentés pour le traitement d'une maladie
EP20712029.6A EP3934637B1 (fr) 2019-03-02 2020-03-02 (n-)acétyl-l-leucine pour le traitement des lésions cérébrales traumatiques

Publications (2)

Publication Number Publication Date
MA55199A MA55199A (fr) 2022-01-12
MA55199B1 true MA55199B1 (fr) 2024-08-30

Family

ID=69845470

Family Applications (1)

Application Number Title Priority Date Filing Date
MA55199A MA55199B1 (fr) 2019-03-02 2020-03-02 (n-)acétyl-l-leucine pour le traitement des lésions cérébrales traumatiques

Country Status (25)

Country Link
US (1) US20220142959A1 (fr)
EP (2) EP4464378A3 (fr)
JP (2) JP7555346B2 (fr)
KR (1) KR20250171484A (fr)
CN (2) CN114040757B (fr)
AU (2) AU2020231189B2 (fr)
BR (1) BR112021017203A2 (fr)
CA (1) CA3131948A1 (fr)
DK (1) DK3934637T3 (fr)
ES (1) ES2990183T3 (fr)
FI (1) FI3934637T3 (fr)
HR (1) HRP20241150T1 (fr)
HU (1) HUE068527T2 (fr)
IL (2) IL285870B2 (fr)
LT (1) LT3934637T (fr)
MA (1) MA55199B1 (fr)
MD (1) MD3934637T2 (fr)
MX (2) MX2021010568A (fr)
PL (1) PL3934637T3 (fr)
PT (1) PT3934637T (fr)
RS (1) RS65849B1 (fr)
SG (1) SG11202109512SA (fr)
SI (1) SI3934637T1 (fr)
SM (1) SMT202400334T1 (fr)
WO (1) WO2020178721A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201709459D0 (en) 2017-06-14 2017-07-26 Intrabio Ltd Treatment for migraine
KR20250022899A (ko) 2018-12-06 2025-02-17 인트라바이오 리미티드 아세틸-류신의 중수소화된 유사체
US20250025442A1 (en) * 2020-12-10 2025-01-23 Texas Tech University System BCAA-Lowering Compounds for Prevention and/or Treatment of Alzheimer's Disease and Related Disorders
WO2022264037A1 (fr) * 2021-06-14 2022-12-22 Intrabio Ltd. Dérivés d'acides aminés à chaîne ramifiée pour traiter une maladie
WO2024243004A2 (fr) * 2023-05-19 2024-11-28 The Children's Hospital Of Philadelphia Compositions et procédés de traitement d'une lésion cérébrale traumatique
US12403111B2 (en) 2024-02-02 2025-09-02 SynGAP Research Fund Compositions and methods for treating neurodevelopmental disorders
WO2025175092A1 (fr) * 2024-02-14 2025-08-21 Intrabio Inc. Acétylleucine pour le traitement de troubles liés à syngap1
WO2025264957A2 (fr) * 2024-06-20 2025-12-26 Intrabio Inc. Acétyl leucine pour le traitement de troubles neurodéveloppementaux

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060063827A1 (en) * 2004-09-23 2006-03-23 Yu Ruey J Systemic administration of therapeutic amino acids and N-acetylamino acids
FR2905600B1 (fr) * 2006-09-13 2010-01-15 Pf Medicament Traitement des vertiges par l'acetyl-l-leucine.
TN2010000251A1 (fr) * 2010-06-03 2011-11-11 Rekik Raouf N-acetyl-dl-leucine medicament neuro et retino protecteur
UA115648C2 (uk) 2010-06-25 2017-12-11 Шае Хюмен Дженетік Терапіс, Інк. Доставка терапевтичних агентів до цнс
US20140080885A1 (en) * 2012-09-13 2014-03-20 University Of South Florida (A Florida Non-Profit Corporation) Methods of treating traumatic brain injury
HUE069219T2 (hu) * 2016-04-19 2025-02-28 Intrabio Ltd Acetil-leucin vagy gyógyszerészetileg elfogadható sója javított mozgásképességért
TN2016000259A1 (en) * 2016-06-27 2017-10-06 Rekik Raouf Salbutamol (albuterol) eye protective medicament.
HUE052837T2 (hu) 2016-08-11 2021-05-28 Intrabio Ltd Lizoszóma-tárolási betegségre irányuló gyógyászati készítmények és alkalmazásaik
BR112019002730A2 (pt) * 2016-08-11 2019-05-14 Intrabio Ltd acetil-leucina, ou um sal farmaceuticamente aceitável da mesma, para uso em um método de tratamento de uma doença neurodegenetativa
EP3684350A1 (fr) 2017-08-14 2020-07-29 Axcella Health Inc. Acides aminés à chaîne ramifiée pour le traitement d'une lésion neuronale

Also Published As

Publication number Publication date
EP3934637B1 (fr) 2024-07-31
AU2025204995A1 (en) 2025-07-17
IL285870B1 (en) 2025-08-01
HRP20241150T1 (hr) 2024-11-22
JP2022522819A (ja) 2022-04-20
SG11202109512SA (en) 2021-09-29
EP3934637A1 (fr) 2022-01-12
RS65849B1 (sr) 2024-09-30
US20220142959A1 (en) 2022-05-12
MD3934637T2 (ro) 2024-12-31
AU2020231189B2 (en) 2025-07-24
MX2021010568A (es) 2021-11-12
MX2024015063A (es) 2025-01-09
ES2990183T3 (es) 2024-11-29
KR20210135272A (ko) 2021-11-12
PT3934637T (pt) 2024-08-30
CN114040757A (zh) 2022-02-11
IL321899A (en) 2025-09-01
AU2020231189A1 (en) 2021-09-30
JP2024170602A (ja) 2024-12-10
IL285870B2 (en) 2025-12-01
FI3934637T3 (fi) 2024-09-02
CA3131948A1 (fr) 2020-09-10
PL3934637T3 (pl) 2024-10-14
SMT202400334T1 (it) 2024-09-16
IL285870A (en) 2021-10-31
DK3934637T3 (da) 2024-09-02
KR20250171484A (ko) 2025-12-08
MA55199A (fr) 2022-01-12
CN114040757B (zh) 2024-09-20
SI3934637T1 (sl) 2024-10-30
JP7555346B2 (ja) 2024-09-24
EP4464378A3 (fr) 2025-04-09
LT3934637T (lt) 2024-08-26
CN119097618A (zh) 2024-12-10
HUE068527T2 (hu) 2025-01-28
BR112021017203A2 (pt) 2021-12-14
EP4464378A2 (fr) 2024-11-20
WO2020178721A1 (fr) 2020-09-10

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