MA55402A - Dérivés de 7-benzyl-4-(2-méthylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, leurs sels et leur utilisation en thérapie - Google Patents

Dérivés de 7-benzyl-4-(2-méthylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, leurs sels et leur utilisation en thérapie

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Publication number
MA55402A
MA55402A MA055402A MA55402A MA55402A MA 55402 A MA55402 A MA 55402A MA 055402 A MA055402 A MA 055402A MA 55402 A MA55402 A MA 55402A MA 55402 A MA55402 A MA 55402A
Authority
MA
Morocco
Prior art keywords
hexahydroimidazo
pyrido
methylbenzyl
pyrimidin
benzyl
Prior art date
Application number
MA055402A
Other languages
English (en)
Other versions
MA55402B1 (fr
Inventor
Joshua E Allen
Bhaskara Rao Nallaganchu
Gary L Olson
Richard S Pottorf
Martin Stogniew
Yanjun Sun
Original Assignee
Oncoceutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncoceutics Inc filed Critical Oncoceutics Inc
Publication of MA55402A publication Critical patent/MA55402A/fr
Publication of MA55402B1 publication Critical patent/MA55402B1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
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    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
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    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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  • Physical Education & Sports Medicine (AREA)
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MA55402A 2015-01-30 2016-01-29 Dérivés de 7-benzyl-4-(2-méthylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, leurs sels et leur utilisation en thérapie MA55402B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562109737P 2015-01-30 2015-01-30
US201562148844P 2015-04-17 2015-04-17
US201562233757P 2015-09-28 2015-09-28
EP20198062.0A EP3805222B1 (fr) 2015-01-30 2016-01-29 Dérivés de 7-benzyl-4-(2-méthylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, leurs sels et leur utilisation en thérapie

Publications (2)

Publication Number Publication Date
MA55402A true MA55402A (fr) 2022-02-02
MA55402B1 MA55402B1 (fr) 2025-02-28

Family

ID=56544438

Family Applications (2)

Application Number Title Priority Date Filing Date
MA41434A MA41434B1 (fr) 2015-01-30 2016-01-29 7-benzyl-4-(4-(trifluorométhyl)benzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4h)-one, ses sels et leur utilisation en thérapie
MA55402A MA55402B1 (fr) 2015-01-30 2016-01-29 Dérivés de 7-benzyl-4-(2-méthylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, leurs sels et leur utilisation en thérapie

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA41434A MA41434B1 (fr) 2015-01-30 2016-01-29 7-benzyl-4-(4-(trifluorométhyl)benzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4h)-one, ses sels et leur utilisation en thérapie

Country Status (27)

Country Link
US (6) US9845324B2 (fr)
EP (4) EP3250208B1 (fr)
JP (4) JP6802172B2 (fr)
KR (3) KR20250134216A (fr)
CN (2) CN113149985B (fr)
AU (4) AU2016211243B2 (fr)
BR (1) BR112017016487B1 (fr)
CA (3) CA2975476C (fr)
CY (1) CY1123616T1 (fr)
DK (2) DK3805222T3 (fr)
EA (1) EA037552B1 (fr)
ES (2) ES3009132T3 (fr)
FI (1) FI3805222T3 (fr)
HR (2) HRP20201949T1 (fr)
HU (2) HUE070309T2 (fr)
IL (5) IL288525B (fr)
LT (2) LT3805222T (fr)
MA (2) MA41434B1 (fr)
MD (2) MD3250208T2 (fr)
MX (3) MX2021001096A (fr)
PL (2) PL3250208T3 (fr)
PT (2) PT3250208T (fr)
RS (2) RS61243B1 (fr)
SG (2) SG10201803508WA (fr)
SI (2) SI3250208T1 (fr)
SM (2) SMT202000696T1 (fr)
WO (1) WO2016123571A1 (fr)

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CN113149985B (zh) 2015-01-30 2025-01-28 昂克希尔迪克斯有限公司 六氢咪唑并吡啶并嘧啶酮、其类似物和盐、及其治疗用途
CN104860948B (zh) 2015-05-15 2017-09-26 南京盖特医药技术有限公司 咪唑并嘧啶酮类化合物及其制备方法和应用
RS66519B1 (sr) * 2016-01-29 2025-03-31 Oncoceutics Inc Modulacija g protein-spregnutog receptora (gpcr) pomoću imipridona
JP6847120B2 (ja) 2016-03-01 2021-03-24 コーセプト セラピューティクス， インコーポレイテッド チェックポイントインヒビターを強化するためのグルココルチコイドレセプターモジュレーターの使用
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
US11091483B2 (en) * 2016-08-12 2021-08-17 Madera Therapeutics, LLC Protein kinase regulators
US10172862B2 (en) * 2017-01-30 2019-01-08 Oncoceutics, Inc. Imipridones for gliomas
WO2018169994A1 (fr) * 2017-03-13 2018-09-20 City Of Hope Modification de l'arnm m6a dans le traitement du cancer
WO2019197024A1 (fr) * 2018-04-11 2019-10-17 Chemestmed Ltd. Procédé de modulation de la méthylation de l'arn
WO2020196738A1 (fr) 2019-03-26 2020-10-01 富士フイルム株式会社 Composition pharmaceutique inhibant la production d'une protéine du virus de l'hépatite b, composition pharmaceutique pour le traitement de l'hépatite b et procédé de criblage
KR20220133275A (ko) * 2020-01-29 2022-10-04 코어셉트 쎄라퓨틱스 인코포레이티드 선택적 글루코코르티코이드 수용체 조절제 (sgrm) 및 항체 체크포인트 억제제를 사용한 부신피질 암종의 치료
EP4192467A1 (fr) * 2020-08-06 2023-06-14 Eötvös Loránd Tudományegyetem Synthèse de nouveaux dérivés d'imipridone et leur évaluation concernant leur activité anticancéreuse
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