MA41434A - 7-benzyl-4-(4-(trifluorométhyl)benzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4h)-one, ses sels et leur utilisation en thérapie - Google Patents

7-benzyl-4-(4-(trifluorométhyl)benzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4h)-one, ses sels et leur utilisation en thérapie

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Publication number
MA41434A
MA41434A MA041434A MA41434A MA41434A MA 41434 A MA41434 A MA 41434A MA 041434 A MA041434 A MA 041434A MA 41434 A MA41434 A MA 41434A MA 41434 A MA41434 A MA 41434A
Authority
MA
Morocco
Prior art keywords
benzyl
salts
hexahydroimidazo
pyrido
pyrimidin
Prior art date
Application number
MA041434A
Other languages
English (en)
Other versions
MA41434B1 (fr
Inventor
Joshua E Allen
Bhaskara Rao Nallaganchu
Gary L Olson
Richard S Pottorf
Martin Stogniew
Yanjun Sun
Original Assignee
Oncoceutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncoceutics Inc filed Critical Oncoceutics Inc
Publication of MA41434A publication Critical patent/MA41434A/fr
Publication of MA41434B1 publication Critical patent/MA41434B1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
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    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract

La présente invention concerne des méthodes de traitement dans lesquelles on utilise un composé (1) ou ses analogues, et leurs sels pharmaceutiquement acceptables. L'invention concerne également des composés de formule (10) telle que définie dans la description, et des sels pharmaceutiquement acceptables de ceux-ci, ainsi que des compositions pharmaceutiques les comprenant. L'invention concerne également des méthodes de traitement, contre le cancer par exemple, qui consistent à administrer les composés et leurs sels à un sujet nécessitant un tel traitement.
MA41434A 2015-01-30 2016-01-29 7-benzyl-4-(4-(trifluorométhyl)benzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4h)-one, ses sels et leur utilisation en thérapie MA41434B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562109737P 2015-01-30 2015-01-30
US201562148844P 2015-04-17 2015-04-17
US201562233757P 2015-09-28 2015-09-28
PCT/US2016/015817 WO2016123571A1 (fr) 2015-01-30 2016-01-29 7-benzyl-4-(2-méthylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, analogues et sels de ce composé et leur utilisation en thérapie

Publications (2)

Publication Number Publication Date
MA41434A true MA41434A (fr) 2017-12-06
MA41434B1 MA41434B1 (fr) 2021-03-31

Family

ID=56544438

Family Applications (2)

Application Number Title Priority Date Filing Date
MA55402A MA55402B1 (fr) 2015-01-30 2016-01-29 Dérivés de 7-benzyl-4-(2-méthylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, leurs sels et leur utilisation en thérapie
MA41434A MA41434B1 (fr) 2015-01-30 2016-01-29 7-benzyl-4-(4-(trifluorométhyl)benzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4h)-one, ses sels et leur utilisation en thérapie

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA55402A MA55402B1 (fr) 2015-01-30 2016-01-29 Dérivés de 7-benzyl-4-(2-méthylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, leurs sels et leur utilisation en thérapie

Country Status (27)

Country Link
US (6) US9845324B2 (fr)
EP (4) EP4512483A3 (fr)
JP (4) JP6802172B2 (fr)
KR (3) KR102618971B1 (fr)
CN (2) CN113149985B (fr)
AU (5) AU2016211243B2 (fr)
BR (1) BR112017016487B1 (fr)
CA (3) CA2975476C (fr)
CY (1) CY1123616T1 (fr)
DK (2) DK3805222T3 (fr)
EA (1) EA037552B1 (fr)
ES (2) ES3009132T3 (fr)
FI (1) FI3805222T3 (fr)
HR (2) HRP20201949T1 (fr)
HU (2) HUE070309T2 (fr)
IL (5) IL312936A (fr)
LT (2) LT3250208T (fr)
MA (2) MA55402B1 (fr)
MD (2) MD3250208T2 (fr)
MX (3) MX379425B (fr)
PL (2) PL3250208T3 (fr)
PT (2) PT3250208T (fr)
RS (2) RS61243B1 (fr)
SG (2) SG11201706062TA (fr)
SI (2) SI3250208T1 (fr)
SM (2) SMT202500087T1 (fr)
WO (1) WO2016123571A1 (fr)

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CN104860948B (zh) 2015-05-15 2017-09-26 南京盖特医药技术有限公司 咪唑并嘧啶酮类化合物及其制备方法和应用
WO2017132661A2 (fr) * 2016-01-29 2017-08-03 Oncoceutics, Inc. Modulation des récepteurs couplés aux protéines g (rcpg) par les imipridones
AU2017228329B2 (en) 2016-03-01 2021-03-11 Corcept Therapeutics, Inc. The use of glucocorticoid receptor modulators to potentiate checkpoint inhibitors
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
US11091483B2 (en) * 2016-08-12 2021-08-17 Madera Therapeutics, LLC Protein kinase regulators
US10172862B2 (en) * 2017-01-30 2019-01-08 Oncoceutics, Inc. Imipridones for gliomas
WO2018169994A1 (fr) * 2017-03-13 2018-09-20 City Of Hope Modification de l'arnm m6a dans le traitement du cancer
EP3589745A1 (fr) * 2018-04-11 2020-01-08 Chemestmed Ltd. Procédé de modulation de la méthylation de l'arn
EP3949992A4 (fr) 2019-03-26 2022-09-14 FUJIFILM Corporation Composition pharmaceutique inhibant la production d'une protéine du virus de l'hépatite b, composition pharmaceutique pour le traitement de l'hépatite b et procédé de criblage
US12636293B2 (en) 2019-04-04 2026-05-26 Cmtx Biotech Inc. Methods of treating charcot-marie-tooth disease
AU2021214938B2 (en) 2020-01-29 2024-02-08 Corcept Therapeutics Incorporated Treatment of adrenocortical carcinoma with selective glucocorticoid receptor modulators (SGRMs) and antibody checkpoint inhibitors
BR112023002082A2 (pt) * 2020-08-06 2023-05-09 Eoetvoes Lorand Tudomanyegyetem Síntese de derivados de imipridona e sua avaliação para sua atividade anticancerígena
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