MA55556A - Composés ciblant prmt5 - Google Patents

Composés ciblant prmt5

Info

Publication number
MA55556A
MA55556A MA055556A MA55556A MA55556A MA 55556 A MA55556 A MA 55556A MA 055556 A MA055556 A MA 055556A MA 55556 A MA55556 A MA 55556A MA 55556 A MA55556 A MA 55556A
Authority
MA
Morocco
Prior art keywords
compounds targeting
prmt5
targeting prmt5
compounds
targeting
Prior art date
Application number
MA055556A
Other languages
English (en)
Inventor
Leonid Beigelman
Yannick Debing
Jerome Deval
David Mcgowan
Pierre Jean-Marie Bernard Raboisson
Koen Vandyck
Original Assignee
Aligos Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aligos Therapeutics Inc filed Critical Aligos Therapeutics Inc
Publication of MA55556A publication Critical patent/MA55556A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MA055556A 2019-04-02 2020-03-31 Composés ciblant prmt5 MA55556A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962828282P 2019-04-02 2019-04-02
US201962877411P 2019-07-23 2019-07-23
US201962946649P 2019-12-11 2019-12-11

Publications (1)

Publication Number Publication Date
MA55556A true MA55556A (fr) 2022-02-09

Family

ID=72661994

Family Applications (1)

Application Number Title Priority Date Filing Date
MA055556A MA55556A (fr) 2019-04-02 2020-03-31 Composés ciblant prmt5

Country Status (15)

Country Link
US (2) US11198699B2 (fr)
EP (1) EP3947388A4 (fr)
JP (1) JP2022522534A (fr)
KR (1) KR20210145787A (fr)
CN (1) CN114072407A (fr)
AU (1) AU2020256166A1 (fr)
BR (1) BR112021019465A8 (fr)
CA (1) CA3134613A1 (fr)
IL (1) IL286849A (fr)
MA (1) MA55556A (fr)
MX (1) MX2021011606A (fr)
PH (1) PH12021552482A1 (fr)
SG (1) SG11202110742TA (fr)
TW (1) TW202102509A (fr)
WO (1) WO2020205867A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11077101B1 (en) 2018-07-18 2021-08-03 Tango Therapeutics, Inc. Compounds and methods of use
US12173026B2 (en) 2018-08-07 2024-12-24 Merck Sharp & Dohme Llc PRMT5 inhibitors
US12552826B2 (en) 2018-08-07 2026-02-17 Merck Sharp & Dohme Llc PRMT5 inhibitors
EP3833668B1 (fr) * 2018-08-07 2025-03-19 Merck Sharp & Dohme LLC Inhibiteurs de prmt5
US11981701B2 (en) 2018-08-07 2024-05-14 Merck Sharp & Dohme Llc PRMT5 inhibitors
MA55556A (fr) * 2019-04-02 2022-02-09 Aligos Therapeutics Inc Composés ciblant prmt5
EP4048674A2 (fr) * 2019-10-21 2022-08-31 Accent Therapeutics, Inc. Modulateurs de mettl3
KR20220086628A (ko) * 2019-10-22 2022-06-23 루핀 리미티드 Prmt5 저해제의 약학적 조합물
US12403137B2 (en) 2019-10-28 2025-09-02 Tango Therapeutics, Inc. Compounds and methods of use
EP4069698A1 (fr) 2019-12-03 2022-10-12 Lupin Limited Analogues nucléosidiques substitués en tant qu'inhibiteurs de prmt5
BR112022012015A2 (pt) 2019-12-17 2022-08-30 Merck Sharp & Dohme Llc Inibidores de prmt5
US12441730B2 (en) 2019-12-17 2025-10-14 Merck Sharp & Dohme Llc PRMT5 inhibitors
US20220112194A1 (en) * 2020-04-01 2022-04-14 Aligos Therapeutics, Inc. Compounds targeting prmt5
WO2022026892A1 (fr) 2020-07-31 2022-02-03 Tango Therapeutics, Inc. Dérivés de pipéridin-1-yl-n-pyrydine-3-yl-2-oxo-acétamide utiles pour le traitement de cancers déficients en mtap et/ou accumulant mta
CN117157297A (zh) * 2021-07-20 2023-12-01 上海齐鲁制药研究中心有限公司 Prmt5抑制剂
CN116655638B (zh) * 2022-05-12 2024-01-26 上海齐鲁制药研究中心有限公司 氘代prmt5抑制剂

Family Cites Families (191)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR927003044A (ko) 1990-01-11 1992-12-17 크리스토퍼 케이. 미라벨리 Rna 활성과 유전자 발현을 검출하고 조절하는 조성물 및 그 방법
ATE140213T1 (de) 1990-03-08 1996-07-15 Fujisawa Pharmaceutical Co N-monosubstituierte cyclopentenylamine, ein verfahren zu ihrer herstellung, und ihre verwendung als medikament
MX9302312A (es) 1992-04-21 1994-06-30 Ligand Pharm Inc Compuestos agonistas y antagonistas receptores de la progesterona, no esteroides y composiciones farmaceuticas que los contienen.
GB9307694D0 (en) 1993-04-14 1993-06-02 Smithkine Beecham Corp Novel compounds
GB2291872A (en) 1994-08-02 1996-02-07 Zeneca Ltd Alkyl cyclopentane-carboxylate fungicides
US5681940A (en) 1994-11-02 1997-10-28 Icn Pharmaceuticals Sugar modified nucleosides and oligonucleotides
AU692977B2 (en) 1994-11-07 1998-06-18 Pfizer Inc. Certain substituted benzylamine derivatives; a new class of neuropeptide Y1 specific ligands
US5900415A (en) 1994-11-07 1999-05-04 Pfizer Inc. Certain substituted benzylamine derivatives; a new class of neuropeptide Y1 specific ligands
DE19501482A1 (de) 1995-01-19 1996-07-25 Bayer Ag 2,9-disubstituierte Purin-6-one
US5514505A (en) 1995-05-15 1996-05-07 Xerox Corporation Method for obtaining improved image contrast in migration imaging members
WO1998003493A1 (fr) 1996-07-23 1998-01-29 Neurogen Corporation Derives benzylamine substitues et nouvelle classe de ligands specifiques des neuropeptides y1
ES2197354T3 (es) 1996-07-23 2004-01-01 Neurogen Corporation Derivados de bencilamina sustituidos con amido y amino; una nueva clase de ligandos especificos del neuropeptido y1.
ATE230403T1 (de) 1996-07-23 2003-01-15 Neurogen Corp Einige amido- und ammo- substituierte benzylaminderivate: eine neue klasse von neuropeptid y1 spezifische ligande
BR9714349A (pt) 1996-10-16 2000-11-14 Icn Pharmaceuticals L-nucleosìdeos purina, seus análogos e utilizacões dos mesmos
WO1999032489A1 (fr) 1997-12-23 1999-07-01 Alcon Laboratories, Inc. Agents muscariniques et leur utilisation pour traiter le glaucome, la myopie, et d'autres dysfonctionnements
AU2206499A (en) 1997-12-23 1999-07-12 Alcon Laboratories, Inc. Muscarinic agents and use thereof to treat glaucoma, myopia, and various other conditions
WO1999032486A1 (fr) 1997-12-23 1999-07-01 Alcon Laboratories, Inc. Agents muscariniques et leur utilisation pour traiter le glaucome, la myopie, et d'autres dysfonctionnements
AU2307999A (en) 1997-12-23 1999-07-12 Alcon Laboratories, Inc. Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions
AU2206599A (en) 1997-12-23 1999-07-12 Alcon Laboratories, Inc. Oximino-piperidine, -pyrrolidine and -azepine derivatives, their preparation andtheir use as muscarinic receptor (ant-)agonists
WO1999032479A1 (fr) 1997-12-23 1999-07-01 Alcon Laboratories, Inc. Derives de phtalamidepiperidine, de phtalamidepyrrolidine, et de phtalamide-azepine, leur preparation, et leur utilisation comme agonistes(antagonistes) des recepteurs muscariniques
US6518305B1 (en) 1998-04-23 2003-02-11 Abbott Laboratories Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
JP2002521312A (ja) 1998-04-23 2002-07-16 アボット・ラボラトリーズ ノイラミニダーゼの阻害剤
CN1302300A (zh) 1998-05-21 2001-07-04 盐野义制药株式会社 吡咯并[1,2－b]哒嗪sPLA2抑制剂
US6268372B1 (en) 1998-09-11 2001-07-31 Cell Pathways, Inc. Method for inhibiting neoplastic cells and related conditions by exposure to 2,9-disubstituted purin-6-ones
MXPA02001340A (es) 1999-08-05 2004-07-16 Prescient Neuropharma Inc Compuestos novedosos 1,4-benzodiazepina y derivados de los mismos.
US6787545B1 (en) 1999-08-23 2004-09-07 Shiongi & Co., Ltd. Pyrrolotriazine derivatives having spla2-inhibitory activities
AU769578B2 (en) 1999-08-27 2004-01-29 Icn Pharmaceuticals, Inc. Pyrrolo(2,3-d)pyrimidine nucleoside analogs
US6831069B2 (en) * 1999-08-27 2004-12-14 Ribapharm Inc. Pyrrolo[2,3-d]pyrimidine nucleoside analogs
UA72612C2 (en) 2000-07-06 2005-03-15 Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells
US20030175950A1 (en) 2001-05-29 2003-09-18 Mcswiggen James A. RNA interference mediated inhibition of HIV gene expression using short interfering RNA
DE10142100A1 (de) 2001-08-30 2003-04-03 Epcos Ag Elektrolytlösung für Kondensatoren und ein Elektrolytkondensator mit der Elektrolytlösung sowie dessen Verwendung
WO2003039523A2 (fr) 2001-11-05 2003-05-15 Exiqon A/S Oligonucleotides modifies a l'aide de nouveaux analogues d'arn-l-alpha
WO2003072757A2 (fr) 2002-02-28 2003-09-04 Biota, Inc. Mimetiques nucleotidiques et leurs promedicaments
NZ535763A (en) 2002-04-18 2007-06-29 Schering Corp (1-4-piperidinyl) benzimidazole derivatives useful as histamine H3 antagonists
US7220735B2 (en) 2002-04-18 2007-05-22 Schering Corporation Benzimidazolone histamine H3 antagonists
WO2004032827A2 (fr) 2002-05-20 2004-04-22 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hepatite c
WO2004014312A2 (fr) 2002-08-08 2004-02-19 Sirna Therapeutics, Inc. Compositions a petit mere et leurs procedes d'utilisation
AU2003258050A1 (en) 2002-10-11 2004-05-04 Ligand Pharmaceuticals Incorporated 5-cycloalkenyl 5h-chromeno(3,4-f)quinoline derivatives as selective progesterone receptor modulator compounds
EP1565436B1 (fr) 2002-11-27 2012-04-25 Incyte Corporation Derives de la 3-aminopyrrolidine modulateurs des recepteurs de la chemoquine
WO2004081643A1 (fr) 2002-12-20 2004-09-23 Kaiser Aerospace & Electronics Corp. Reseau de lentilles a conversion de polarisation
BRPI0409198A (pt) 2003-04-04 2006-05-02 Novartis Ag derivados quinolin-2-ona para o tratamento de doenças de vias aéreas
JP4661029B2 (ja) 2003-05-22 2011-03-30 東ソー株式会社 光学活性マレイミド誘導体、光学活性ポリマレイミド誘導体、その製造方法、その光学活性ポリマレイミド誘導体からなる分離剤及びそれを用いた光学活性化合物の分離方法
WO2004106356A1 (fr) 2003-05-27 2004-12-09 Syddansk Universitet Derives de nucleotides fonctionnalises
NZ546055A (en) 2003-08-27 2010-05-28 Biota Scient Management Novel tricyclic nucleosides or nucleotides as therapeutic agents
EP1670755A4 (fr) 2003-10-08 2007-02-28 Harvard College Analogues de pyrovalerone et utilisations therapeutiques
JPWO2005037269A1 (ja) 2003-10-21 2006-12-28 住友製薬株式会社 新規ピペリジン誘導体
KR20080052683A (ko) 2003-12-18 2008-06-11 인사이트 코포레이션 케모킨 수용체의 조절제로서의3-사이클로알킬아미노피롤리딘 유도체
AU2004309420B2 (en) 2003-12-23 2008-10-30 Novartis Ag Bicyclic heterocyclic p-38 kinase inhibitors
EP1736467A4 (fr) 2004-04-06 2009-07-01 Dainippon Sumitomo Pharma Co Nouveau derive sulfonamide
AR048523A1 (es) 2004-04-07 2006-05-03 Kalypsys Inc Compuestos con estructura de aril sulfonamida y sulfonilo como moduladores de ppar y metodos para tratar trastornos metabolicos
CA2584502A1 (fr) 2004-06-24 2006-01-05 Incyte Corporation 2-methylpropanamides et leur utilisation comme produits pharmaceutiques
EP1616874A1 (fr) 2004-07-14 2006-01-18 Universiteit Gent Composés mono- et bicycliques à activité thérapeutique et compositions pharmaceutiques les comprenant
JP2006124326A (ja) 2004-10-28 2006-05-18 Sumitomo Chemical Co Ltd クロピドグレルの製造方法
JP2008528598A (ja) 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
PT1848718E (pt) 2005-02-04 2012-10-11 Millennium Pharm Inc Inibidores de enzimas de activação e1
JP2006241090A (ja) 2005-03-04 2006-09-14 Tosoh Corp 光学活性カルボン酸類の分離方法
CA2600886A1 (fr) 2005-03-08 2006-09-14 Biota Scientific Management Pty Ltd. Nucleosides bicycliques et nucleotides servant d'agents therapeutiques
EP1866298A2 (fr) 2005-03-31 2007-12-19 Takeda San Diego, Inc. Inhibiteurs de l'hydroxysteroide deshydrogenase
ATE450525T1 (de) 2005-06-20 2009-12-15 Schering Corp Kohlenstoffgebundene substituierte piperidine und derivate daraus als histamin-h3-antagonisten
TW200738676A (en) 2005-06-20 2007-10-16 Schering Corp Heteroatom-linked substituted piperidines and derivatives thereof useful as histamine H3 antagonists
DE102005059892A1 (de) 2005-12-15 2007-06-28 Bayer Cropscience Ag Alkylthio-spirocyclische Tetramsäuren
DE102005059891A1 (de) 2005-12-15 2007-06-28 Bayer Cropscience Ag 3'-Alkoxy-spirocyclopentyl substituierte Tetram- und Tetronsäuren
KR20080080131A (ko) 2005-12-20 2008-09-02 노파르티스 아게 Ｉａｐ-억제제와 탁산의 조합물
EP1965862A2 (fr) 2005-12-21 2008-09-10 Schering Corporation Combinaison d'un antagoniste/agoniste inverse de h3 et d'un moderateur de l'appetit
AU2007244978B2 (en) 2006-04-24 2013-05-30 Allergan, Inc. Abnormal Cannabidiols as agents for lowering intraocular pressure
US7612101B2 (en) 2006-04-24 2009-11-03 Allergan, Inc. Abnormal cannabidiols as agents for lowering intraocular pressure
EA201501088A1 (ru) 2006-08-08 2017-01-30 Миллениум Фармасьютикалз, Инк. Гетероарильные соединения, применяемые в качестве ингибиторов e1 активирующих ферментов
AU2007325280B2 (en) 2006-11-28 2011-03-10 Dana-Farber Cancer Institute, Inc. Combination of IAP inhibitors and FLT3 inhibitors
DE102006056740A1 (de) 2006-12-01 2008-06-05 Bayer Healthcare Ag Cyclisch substituierte 3,5-Dicyano-2-thiopyridine und ihre Verwendung
CN101195586A (zh) 2006-12-05 2008-06-11 中国科学院上海药物研究所 一类具有取代环戊烷结构的化合物、制备方法及其医学用途
US20130012485A1 (en) 2006-12-22 2013-01-10 Baeschlin Daniel Kaspar Organic compounds
WO2008138843A1 (fr) 2007-05-10 2008-11-20 Galapagos N.V. Imidazopyridines et triazolopyrimidines utiles pour le traitement de maladies dégénératives et inflammatoires des articulations
WO2009042013A1 (fr) 2007-08-02 2009-04-02 Millennium Pharmaceuticals, Inc. Procédé pour la synthèse d'inhibiteurs de l'enzyme d'activation e1
US8598165B2 (en) 2007-11-26 2013-12-03 University Of Kansas Morpholines as selective inhibitors of cytochrome P450 2A13
WO2009124103A2 (fr) 2008-04-02 2009-10-08 Schering Corporation Thérapies de combinaison comprenant des antagonistes de récepteur 1 activé par protéase (par1) associés à des antagonistes récepteur 4 activé par protéase (par4)
BRPI0910891A2 (pt) 2008-04-15 2015-09-29 Mallinckrodt Inc composições contendo compostos antivirais e métodos de usar os mesmo
CA2722704A1 (fr) 2008-04-28 2009-11-05 Zalicus Pharmaceuticals Ltd. Derives de cyclylamine utilises comme agents bloquant le canal calcique
US8163707B2 (en) 2008-09-15 2012-04-24 Enanta Pharmaceuticals, Inc. 4′-allene-substituted nucleoside derivatives
BRPI0919977A2 (pt) 2008-10-30 2015-08-25 Oncotherapy Science Inc Derivados de 7-hidróxi-benzoimidazol-4-il-metanona e inibidores de pbk contendo os mesmos
US8722082B2 (en) 2008-11-10 2014-05-13 Tekmira Pharmaceuticals Corporation Lipids and compositions for the delivery of therapeutics
JP2012509249A (ja) 2008-11-20 2012-04-19 オンコセラピー・サイエンス株式会社 ７−ヒドロキシ−ベンゾイミダゾール−４−イル−メタノン誘導体を含むグリコーゲン合成酵素キナーゼ−３ベータ阻害剤
EP2393815A4 (fr) 2009-02-06 2012-11-21 Rfs Pharma Llc Promédicaments à base de purine nucléoside monophosphate pour le traitement du cancer et des infections virales
JP2012521359A (ja) 2009-03-20 2012-09-13 アリオス バイオファーマ インク． 置換されたヌクレオシドアナログおよびヌクレオチドアナログ
EP2264169A1 (fr) 2009-06-15 2010-12-22 Qiagen GmbH SiNA modifié
WO2011005595A2 (fr) 2009-06-24 2011-01-13 Alios Biopharma, Inc. Analogues de 2-5a et leurs procédés d'utilisation
WO2011005860A2 (fr) 2009-07-07 2011-01-13 Alnylam Pharmaceuticals, Inc. Mimétiques de 5' phosphate
KR101049260B1 (ko) 2009-07-23 2011-07-13 주식회사 엘지화학 새로운 포스트 메탈로센형 전이금속 화합물
UA107360C2 (en) 2009-08-05 2014-12-25 Biogen Idec Inc Bicyclic aryl sphingosine 1-phosphate analogs
TW201118099A (en) 2009-08-12 2011-06-01 Boehringer Ingelheim Int New compounds for the treatment of CNS disorders
CA2772989A1 (fr) 2009-09-10 2011-03-17 Novartis Ag Sulfamides utilises comme inhibiteurs des proteines de la famille de bcl-2 dans le traitement du cancer
WO2011057204A2 (fr) 2009-11-06 2011-05-12 The Johns Hopkins University Toxicité neuronale médiée par lrrk2
WO2011061590A1 (fr) 2009-11-17 2011-05-26 Hetero Research Foundation Nouveaux dérivés carboxamides comme inhibiteurs du vih
WO2011066482A2 (fr) 2009-11-25 2011-06-03 Cytokine Pharmasciences, Inc. Synthèse chirale d'isoxazolines, composés d'isoxazoline et utilisations de ceux-ci
CN102812003B (zh) 2009-12-18 2015-01-21 欧洲筛选有限公司 吡咯烷羧酸衍生物、药物组合物以及在代谢紊乱中作为g-蛋白偶联受体43(gpr43)激动剂使用的方法
WO2011103441A1 (fr) 2010-02-18 2011-08-25 Schering Corporation Dérivés de pyridine et pyrimidine substitués et leur utilisation dans le traitement d'infections virales
WO2011133871A2 (fr) 2010-04-22 2011-10-27 Alnylam Pharmaceuticals, Inc. Dérivés d'extrémité 5'
CN102858807B (zh) 2010-04-23 2014-07-30 Lg化学株式会社 催化剂组合物以及使用该催化剂组合物制备烯烃聚合物的方法
JP2013147430A (ja) 2010-04-28 2013-08-01 Astellas Pharma Inc 夜間頻尿の予防又は治療剤
KR20110123657A (ko) 2010-05-07 2011-11-15 에스케이케미칼주식회사 피콜린아마이드 및 피리미딘-4-카복사미드 화합물, 이의 제조방법 및 이를 함유하는 약제학적 조성물
EP2576513A1 (fr) 2010-06-01 2013-04-10 Biotheryx Inc. Dérivés d'hydroxypyridone, compositions pharmaceutiques réalisées à partir de ces dérivés, et utilisations thérapeutiques correspondants pour traiter des maladies prolifératives
WO2012025857A1 (fr) 2010-08-23 2012-03-01 Hetero Research Foundation Dérivés de cycloalkyl méthoxybenzyl phényl pyrane en tant qu'inhibiteurs du cotransporteur de glucose sodium-dépendant (sglt2)
WO2012028331A1 (fr) 2010-09-03 2012-03-08 Grünenthal GmbH Dérivés de tétrahydropyrrolopyrazines substituées
NZ607996A (en) 2010-09-22 2014-07-25 Alios Biopharma Inc Substituted nucleotide analogs
WO2012040126A1 (fr) 2010-09-22 2012-03-29 Alios Biopharma, Inc. Analogues de nucléotides substitués
US8883791B2 (en) 2010-09-29 2014-11-11 Intervet Inc. N-heteroaryl compounds with cyclic bridging unit for the treatment of parasitic diseases
WO2012075381A1 (fr) 2010-12-03 2012-06-07 Epizyme, Inc. Composés purines et 7-déazapurines substituées en tant que modulateurs d'enzymes épigéniques
CN103391931A (zh) 2011-02-25 2013-11-13 辉瑞有限公司 治疗肝纤维化的方法
EP2508511A1 (fr) 2011-04-07 2012-10-10 Laboratoire Biodim Inhibiteurs de la réplication virale, leur procédé de préparation et leurs utilisations thérapeutiques
BR112014001075A2 (pt) 2011-07-19 2016-11-29 Univ Idaho sonda, seu uso, método in vitro para associar uma sonda com um alvo e kit
CN102924457A (zh) 2011-08-12 2013-02-13 上海恒瑞医药有限公司 三唑并嘧啶类衍生物、其制备方法及其用途
EP2758402B9 (fr) 2011-09-22 2016-09-14 Pfizer Inc Dérivés de pyrrolopyrimidine et de purine
CN103102345B (zh) 2011-11-14 2015-06-03 广东东阳光药业有限公司 氨基喹唑啉类衍生物及其盐和使用方法
WO2013096939A1 (fr) 2011-12-23 2013-06-27 Sri International Composés de liaison sélective
WO2013120040A1 (fr) 2012-02-10 2013-08-15 Children's Medical Center Corporation Inhibition d'une voie ciblée pour améliorer la structure, le fonctionnement et l'activité musculaires dans la dystrophie musculaire
WO2013151975A1 (fr) 2012-04-02 2013-10-10 Northeastern University Compositions et procédés d'inhibition de méthyltransférases
WO2013188881A1 (fr) 2012-06-15 2013-12-19 President And Fellows Of Harvard College Composés, compositions et méthodes de traitement ou de prévention de troubles neurodégénératifs
TW201408652A (zh) 2012-07-11 2014-03-01 Hoffmann La Roche 作爲ＲＯＲｃ調節劑之芳基磺內醯胺衍生物
WO2014026198A1 (fr) 2012-08-10 2014-02-13 Epizyme, Inc. Inhibiteurs de protéine méthyltransférase de dot1l et leurs procédés d'utilisation
CN104926808B (zh) 2012-08-24 2018-09-14 广东东阳光药业有限公司 二氢嘧啶类化合物及其在药物中的应用
HK1214270A1 (zh) 2012-10-29 2016-07-22 共晶制药股份有限公司 用於治療病毒感染和癌症的嘧啶核苷及其單磷酸酯前藥
KR20150092764A (ko) 2012-12-10 2015-08-13 에프. 호프만-라 로슈 아게 RORc 조절인자로서의 벤질 설폰아마이드 유도체
HK1220407A1 (zh) 2013-03-14 2017-05-05 Chdi Foundation, Inc. 组蛋白去乙酰酶抑制剂，其组合物及其使用方法
JP2016517434A (ja) 2013-03-14 2016-06-16 エピザイム，インコーポレイティド 癌を処置するための併用療法
EP3235817B1 (fr) 2013-03-15 2018-12-12 Cayman Chemical Company, Incorporated Composés de lactamine en tant qu'agonistes sélectifs du récepteur ep4 destinés à être utilisés dans le traitement des maladies et affections transmises par l'ep4
US9227978B2 (en) 2013-03-15 2016-01-05 Araxes Pharma Llc Covalent inhibitors of Kras G12C
CA2904393A1 (fr) 2013-03-15 2014-09-25 Araxes Pharma Llc Inhibiteurs covalents de k-ras g12c
WO2015077360A2 (fr) 2013-11-20 2015-05-28 Idenix Pharmaceuticals, Inc. Analogues nucléosidiques renfermant un cyclopentane ou un cyclopentène pour le traitement de l'hépatite c
TWI608080B (zh) 2014-01-29 2017-12-11 達興材料股份有限公司 液晶化合物、液晶組成物以及液晶顯示元件
EA033866B1 (ru) * 2014-02-06 2019-12-03 Рибосайенс Ллк 4'-дифторметилзамещенные производные нуклеозидов в качестве ингибиторов репликации рнк вируса гриппа
CN106458991A (zh) 2014-05-23 2017-02-22 豪夫迈·罗氏有限公司 苯磺酰胺衍生物和它们作为 rorc 调节剂的用途
CN104059674B (zh) 2014-06-06 2016-01-20 北京八亿时空液晶科技股份有限公司 一种含有二氟甲氧基桥键的液晶化合物及其应用
CN104087312B (zh) 2014-06-17 2016-07-06 北京八亿时空液晶科技股份有限公司 一种液晶组合物及其应用
MA40031A (fr) * 2014-06-24 2015-12-30 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
AR101214A1 (es) 2014-07-22 2016-11-30 Bayer Cropscience Ag Ciano-cicloalquilpenta-2,4-dienos, ciano-cicloalquilpent-2-en-4-inas, ciano-heterociclilpenta-2,4-dienos y ciano-heterociclilpent-2-en-4-inas sustituidos como principios activos contra el estrés abiótico de plantas
MX2017001103A (es) 2014-07-31 2017-04-27 Merck Patent Gmbh Derivados de indolizina que son aplicables a enfermedades neurodegenerativas.
WO2016024185A1 (fr) 2014-08-12 2016-02-18 Pfizer Inc. Dérivés de pyrrolo[2,3-d]pyrimidine utiles pour inhiber la janus kinase
EP3193884A4 (fr) 2014-09-17 2018-06-20 Epizyme, Inc. Polythérapie pour le traitement du cancer
JO3556B1 (ar) 2014-09-18 2020-07-05 Araxes Pharma Llc علاجات مدمجة لمعالجة السرطان
WO2016049565A1 (fr) 2014-09-25 2016-03-31 Araxes Pharma Llc Compositions et procédés pour inhiber la ras
JP2017528498A (ja) 2014-09-25 2017-09-28 アラクセス ファーマ エルエルシー Ｋｒａｓ ｇ１２ｃ変異体タンパク質のインヒビター
AU2015320511B2 (en) * 2014-09-26 2020-11-12 Riboscience Llc 4'-vinyl substituted nucleoside derivatives as inhibitors of Respiratory Syncytial Virus RNA replication
WO2016066582A1 (fr) 2014-10-28 2016-05-06 Bci Pharma Inhibiteurs de la nucléoside kinase
US10421696B2 (en) 2014-12-18 2019-09-24 California Institute Of Technology Enantioselective synthesis of α-quaternary mannich adducts by palladium-catalyzed allylic alkylation
US10767112B2 (en) 2015-01-15 2020-09-08 The Trustees Of The Columbia University In The City Of New York Methods of producing metal sulfides, metal selenides, and metal sulfides/selenides having controlled architectures using kinetic control
WO2016145142A1 (fr) 2015-03-10 2016-09-15 Emory University Compositions thérapeutiques renfermant des nucléotides et des nucléosides et utilisations associées
FR3034767A1 (fr) 2015-04-07 2016-10-14 Centre Nat Rech Scient Reduction des fonctions carbonyles de glucides et derives de glucides en milieu aqueux par le dithionite de sodium
MX380290B (es) 2015-08-10 2025-03-12 Alzheon Inc Composiciones y métodos para el tratamiento y la prevención de trastornos neurodegenerativos.
TWI870767B (zh) 2015-08-26 2025-01-21 比利時商健生藥品公司 使用作為prmt5抑制劑之新穎經6-6雙環芳香環取代之核苷類似物
US9926277B2 (en) 2015-10-02 2018-03-27 Biotheryx, Inc. Pyridone compounds, pharmaceutical compositions thereof, and their therapeutic use for treating proliferative diseases
US11433047B2 (en) 2015-10-09 2022-09-06 Neurotheryx Canada Ltd. Pharmaceutical compositions comprising one or more pyrone compounds, and their use for treating inflammatory and neurodegenerative diseases
WO2017066791A1 (fr) 2015-10-16 2017-04-20 Modernatx, Inc. Analogues de coiffe d'arnm à substitution sucre
SI3362461T1 (sl) 2015-10-16 2022-05-31 Modernatx, Inc. Analogi kape MRNA z modificirano fosfatno povezavo
WO2017066782A1 (fr) 2015-10-16 2017-04-20 Modernatx, Inc. Analogues de coiffes d'arnm hydrophobes
WO2017066797A1 (fr) 2015-10-16 2017-04-20 Modernatx, Inc. Analogues de coiffes d'arnm trinucléotidiques
WO2017066789A1 (fr) 2015-10-16 2017-04-20 Modernatx, Inc. Analogues de coiffe d'arnm avec sucre modifié
WO2017066793A1 (fr) 2015-10-16 2017-04-20 Modernatx, Inc. Analogues de coiffes arnm et procédés de coiffage d'arnm
WO2017099969A1 (fr) 2015-12-10 2017-06-15 Merck Sharp & Dohme Corp. Modulateurs allostériques positifs du récepteur muscarinique m1 tétrahydroquinoxaline
WO2017117433A1 (fr) 2015-12-31 2017-07-06 Braskem America, Inc. Système de catalyseur de type non-phtalate et son utilisation dans la polymérisation des oléfines
AU2017230658B2 (en) 2016-03-10 2021-03-04 Janssen Pharmaceutica Nv Substituted nucleoside analogues for use as PRMT5 inhibitors
CA2969295A1 (fr) 2016-06-06 2017-12-06 Pfizer Inc. Derives de carbonucleosides substitues et leur utilisation comme inhibiteur de prmt5
CN109071392B (zh) 2016-06-08 2020-10-02 四川海思科制药有限公司 苯环衍生物及其制备方法和在医药上的应用
WO2018022761A1 (fr) 2016-07-27 2018-02-01 Blueprint Medicines Corporation Cyclopentane-amides substitués pour le traitement des troubles liés au ret
CN107674013B (zh) 2016-08-02 2022-05-24 上海迪诺医药科技有限公司 多环化合物、其制备方法、药物组合物及应用
CN107674029A (zh) 2016-08-02 2018-02-09 上海迪诺医药科技有限公司 多环化合物、其药物组合物及应用
CN107793409B (zh) 2016-09-05 2022-09-27 广东东阳光药业有限公司 二氢嘧啶类化合物及其在药物中的应用
WO2018065353A1 (fr) 2016-10-03 2018-04-12 Umicore Ag & Co. Kg Article catalyseur et procédé de réduction d'ammoniac et d'oxydes d'azote
WO2018065365A1 (fr) * 2016-10-03 2018-04-12 Janssen Pharmaceutica Nv Nouveaux analogues de carbanucléoside substitués par un système cyclique, monocyclique et bicyclique destinés à être utilisés en tant qu'inhibiteurs de prmt5
JP2018070512A (ja) 2016-10-31 2018-05-10 住友化学株式会社 有害節足動物防除組成物
WO2018081863A1 (fr) 2016-11-04 2018-05-11 University Of Wollongong Dérivés à substitution en position 6 de l'hexaméthylène amiloride en tant qu'inhibiteurs de upa et leurs utilisations
WO2018085818A1 (fr) * 2016-11-07 2018-05-11 Prelude Therapeutics, Incorporated Inhibiteurs sélectifs de la protéine arginine méthyltransférase 5 (prmt5)
CN108276463A (zh) 2017-01-06 2018-07-13 米文君 一类新的化合物及其用途
WO2018152501A1 (fr) 2017-02-20 2018-08-23 Prelude Therapeutics, Incorporated Inhibiteurs sélectifs de la protéine arginine méthyltransférase 5 (prmt5)
US11220524B2 (en) 2017-02-20 2022-01-11 Prelude Therapeutics Incorporated Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
TN2019000212A1 (en) 2017-02-27 2021-01-07 Janssen Pharmaceutica Nv Use of biomarkers in identifying cancer patients that will be responsive to treatment with a prmt5 inhibitor
WO2018160824A1 (fr) 2017-03-01 2018-09-07 Prelude Therapeutics, Incorporated Inhibiteurs sélectifs de la protéine arginine méthyltransférase 5 (prmt5)
WO2018162607A1 (fr) 2017-03-07 2018-09-13 F. Hoffmann-La Roche Ag Oxadiazole en tant qu'inhibiteurs de canaux potentiels de récepteur transitoire
WO2018213258A1 (fr) 2017-05-15 2018-11-22 Millennium Pharmaceuticals, Inc. Traitement de tumeurs déficientes en merlin à l'aide d'inhibiteurs de nae
CN110997653B (zh) 2017-06-09 2023-06-06 百时美施贵宝公司 芳基杂环哌啶酮甲酰肽2受体和甲酰肽1受体激动剂
JP2021505583A (ja) 2017-12-05 2021-02-18 エンジェクス ファーマシューティカル インコーポレイテッド Ｐｍｒｔ５阻害剤としての複素環式化合物
SMT202200396T1 (it) 2017-12-13 2022-11-18 Lupin Ltd Composti eterociclici biciclici sostituiti come inibitori di prmt5
KR20190076339A (ko) 2017-12-22 2019-07-02 한미약품 주식회사 신규한 2,6-나프티리딘 2-옥시드 유도체 화합물 및 이의 용도
EP3765006A4 (fr) 2018-03-13 2022-02-23 Merck Sharp & Dohme Corp. Inhibiteurs d'arginase et procédés d'utilisation
CN110386954B (zh) 2018-04-16 2020-08-21 中国科学院化学研究所 含不对称稠环吡啶亚胺基配合物及其制备方法与应用
IL304348B2 (en) 2018-04-30 2024-08-01 Oric Pharmaceuticals Inc CD73 inhibitors
US11981701B2 (en) 2018-08-07 2024-05-14 Merck Sharp & Dohme Llc PRMT5 inhibitors
EP3833668B1 (fr) 2018-08-07 2025-03-19 Merck Sharp & Dohme LLC Inhibiteurs de prmt5
US12552826B2 (en) 2018-08-07 2026-02-17 Merck Sharp & Dohme Llc PRMT5 inhibitors
US12173026B2 (en) * 2018-08-07 2024-12-24 Merck Sharp & Dohme Llc PRMT5 inhibitors
ES2946657T3 (es) 2018-09-18 2023-07-24 Bristol Myers Squibb Co Acidos ciclopentílicos como antagonistas de LPA
MA55556A (fr) * 2019-04-02 2022-02-09 Aligos Therapeutics Inc Composés ciblant prmt5
CN110423265A (zh) 2019-04-03 2019-11-08 中国药科大学 一种环肽类trf2抑制剂的制备方法和用途

Also Published As

Publication number Publication date
WO2020205867A1 (fr) 2020-10-08
CA3134613A1 (fr) 2020-10-08
AU2020256166A1 (en) 2021-10-14
MX2021011606A (es) 2021-12-10
PH12021552482A1 (en) 2022-07-18
SG11202110742TA (en) 2021-10-28
CN114072407A (zh) 2022-02-18
BR112021019465A2 (pt) 2022-02-15
TW202102509A (zh) 2021-01-16
US20220048922A1 (en) 2022-02-17
US20200317686A1 (en) 2020-10-08
IL286849A (en) 2021-10-31
US11198699B2 (en) 2021-12-14
JP2022522534A (ja) 2022-04-19
BR112021019465A8 (pt) 2022-06-07
EP3947388A1 (fr) 2022-02-09
KR20210145787A (ko) 2021-12-02
EP3947388A4 (fr) 2022-12-21

Similar Documents

Publication Publication Date Title
MA55556A (fr) Composés ciblant prmt5
EP3941898C0 (fr) Composés fongicides
EP3836923A4 (fr) Composés pyrrolo-dipyridine
EP4054724A4 (fr) Composés bifonctionnels
MA52948A (fr) Composés
MA52489A (fr) Nouveaux composés
EP3956033A4 (fr) Composés bicycliques
MA51669A (fr) Composés
PT3980417T (pt) Inibidores de prmt5
MA55131A (fr) Nouveaux composés hétérocycliques
MA51530A (fr) Composés cycliques fondus
MA53287A (fr) Inhibiteurs de prmt5
EP3802467A4 (fr) Composés spirocycliques
EP3720430A4 (fr) Composés benzocarbonyle
EP3781156A4 (fr) Composés spirocycliques
MA53003A (fr) Composés
EP3691623A4 (fr) Composés de benzosulfonyle
EP3740487A4 (fr) Composés benzamide
EP4077282A4 (fr) Inhibiteurs de prmt5
EP4077318A4 (fr) Composés
EP4190864A4 (fr) Composés
EP3924358A4 (fr) Composés macrocycliques
EP3728289A4 (fr) Composés optimisés
MA52946A (fr) Composés
EP3908319A4 (fr) Composés inhibiteurs de métalloenzyme