MA55131A - Nouveaux composés hétérocycliques - Google Patents

Nouveaux composés hétérocycliques

Info

Publication number
MA55131A
MA55131A MA055131A MA55131A MA55131A MA 55131 A MA55131 A MA 55131A MA 055131 A MA055131 A MA 055131A MA 55131 A MA55131 A MA 55131A MA 55131 A MA55131 A MA 55131A
Authority
MA
Morocco
Prior art keywords
heterocyclic compounds
new heterocyclic
new
compounds
heterocyclic
Prior art date
Application number
MA055131A
Other languages
English (en)
Other versions
MA55131B1 (fr
Inventor
Uwe Grether
Zbinden Katrin Groebke
Benoit Hornsperger
Carsten Kroll
Bernd Kuhn
Marius Daniel Rinaldo Lutz
Fionn O`Hara
Hans Richter
Didier Rombach
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA55131A publication Critical patent/MA55131A/fr
Publication of MA55131B1 publication Critical patent/MA55131B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
MA55131A 2018-11-22 2019-11-20 Nouveaux composés hétérocycliques MA55131B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18207725 2018-11-22
PCT/EP2019/081870 WO2020104494A1 (fr) 2018-11-22 2019-11-20 Nouveaux composés hétérocycliques

Publications (2)

Publication Number Publication Date
MA55131A true MA55131A (fr) 2022-03-02
MA55131B1 MA55131B1 (fr) 2023-10-31

Family

ID=64453331

Family Applications (1)

Application Number Title Priority Date Filing Date
MA55131A MA55131B1 (fr) 2018-11-22 2019-11-20 Nouveaux composés hétérocycliques

Country Status (31)

Country Link
US (1) US12577257B2 (fr)
EP (1) EP3883936B1 (fr)
JP (1) JP7444882B2 (fr)
KR (1) KR102913813B1 (fr)
CN (1) CN113166170A (fr)
AR (1) AR117139A1 (fr)
AU (1) AU2019383500B2 (fr)
BR (1) BR112021009348A2 (fr)
CA (1) CA3119506A1 (fr)
CL (1) CL2021001330A1 (fr)
CO (1) CO2021007056A2 (fr)
CR (1) CR20210247A (fr)
DK (1) DK3883936T3 (fr)
ES (1) ES2955037T3 (fr)
FI (1) FI3883936T3 (fr)
HR (1) HRP20231083T1 (fr)
HU (1) HUE062913T2 (fr)
IL (1) IL283333B2 (fr)
LT (1) LT3883936T (fr)
MA (1) MA55131B1 (fr)
MX (1) MX2021005714A (fr)
PE (1) PE20211870A1 (fr)
PH (1) PH12021551167A1 (fr)
PL (1) PL3883936T3 (fr)
PT (1) PT3883936T (fr)
RS (1) RS64579B1 (fr)
SG (1) SG11202104206SA (fr)
SI (1) SI3883936T1 (fr)
TW (1) TWI825227B (fr)
UA (1) UA128505C2 (fr)
WO (1) WO2020104494A1 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR114136A1 (es) 2017-10-10 2020-07-29 Hoffmann La Roche Compuestos heterocíclicos
EP3717477B1 (fr) 2017-11-28 2022-07-20 F. Hoffmann-La Roche AG Nouveaux composés hétérocycliques
EP3737680A1 (fr) 2018-01-08 2020-11-18 F. Hoffmann-La Roche AG Octahydropyrido[1,2-alpha]pyrazines en tant qu'inhibiteurs de magl
MY210507A (en) 2018-08-13 2025-09-28 Hoffmann La Roche New heterocyclic compounds as monoacylglycerol lipase inhibitors
WO2020104494A1 (fr) 2018-11-22 2020-05-28 F. Hoffmann-La Roche Ag Nouveaux composés hétérocycliques
CN114072405A (zh) 2019-07-03 2022-02-18 豪夫迈·罗氏有限公司 杂环单酰基甘油脂肪酶(magl)抑制剂
KR20220034104A (ko) 2019-07-09 2022-03-17 에프. 호프만-라 로슈 아게 신규 헤테로고리 화합물
US20210094971A1 (en) * 2019-09-09 2021-04-01 Hoffmann-La Roche Inc. Heterocyclic compounds
PH12022550339A1 (en) 2019-09-12 2023-03-13 Hoffmann La Roche 4,4a,5,7,8,8a-hexapyrido[4,3-b][1,4]oxazin-3-one compounds as magl inhibitors
PE20231372A1 (es) 2020-09-03 2023-09-07 Hoffmann La Roche Compuestos heterociclicos
US20240101552A1 (en) * 2020-09-18 2024-03-28 Shanghai Pharmaceuticals Holding Co., Ltd. Carbonyl heterocyclic compound and application thereof
KR20230142745A (ko) 2021-01-29 2023-10-11 세딜라 테라퓨틱스, 인크. Cdk2 억제제 및 그의 사용 방법
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AR128333A1 (es) * 2022-01-25 2024-04-17 Hoffmann La Roche Nuevos compuestos heterociclicos
WO2023247670A1 (fr) * 2022-06-24 2023-12-28 F. Hoffmann-La Roche Ag Nouveaux composés carbonyles-cycliques hétérocycliques utilisés en tant qu'inhibiteurs de magl
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EP4590673A1 (fr) * 2022-09-20 2025-07-30 F. Hoffmann-La Roche AG Sondes fluorescentes pour magl
CA3264503A1 (fr) * 2022-10-24 2024-05-02 F. Hoffmann-La Roche Ag Composés hétérocycliques en tant qu'inhibiteurs de monoacylglycérol lipase (magl)
WO2024168426A1 (fr) 2023-02-13 2024-08-22 Apogee Pharmaceuticals, Inc. Petites molécules utilisées en tant qu'inhibiteurs de monoacylglycérol lipase (magl), compositions et utilisation associées
EP4784588A1 (fr) 2023-09-28 2026-08-05 F. Hoffmann-La Roche AG Nouveaux composés hétérocycliques
WO2025153656A1 (fr) 2024-01-19 2025-07-24 F. Hoffmann-La Roche Ag Inhibiteurs hétérocycliques de monoacylglycérol lipase (magl)

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KR20220034104A (ko) 2019-07-09 2022-03-17 에프. 호프만-라 로슈 아게 신규 헤테로고리 화합물
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PH12022550339A1 (en) 2019-09-12 2023-03-13 Hoffmann La Roche 4,4a,5,7,8,8a-hexapyrido[4,3-b][1,4]oxazin-3-one compounds as magl inhibitors
WO2021048241A1 (fr) * 2019-09-12 2021-03-18 F. Hoffmann-La Roche Ag Composés radiomarqués
MX2022003023A (es) 2019-09-23 2022-04-07 Hoffmann La Roche Compuestos heterociclicos.
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WO2021058443A1 (fr) 2019-09-24 2021-04-01 F. Hoffmann-La Roche Ag Sondes fluorescentes pour la monoacylglycérol lipase (magl)
CA3152213A1 (fr) 2019-09-24 2021-04-01 F. Hoffmann-La Roche Ag Nouveaux inhibiteurs heterocycliques de la monoacylglycerol lipase (magl)
WO2022043284A1 (fr) 2020-08-26 2022-03-03 F. Hoffmann-La Roche Ag Composés hétérocycliques utiles en tant qu'inhibiteurs de magl
PE20231372A1 (es) 2020-09-03 2023-09-07 Hoffmann La Roche Compuestos heterociclicos
AU2022260537A1 (en) 2021-04-23 2023-09-21 F. Hoffmann-La Roche Ag Heterocyclic compounds

Also Published As

Publication number Publication date
AU2019383500A1 (en) 2021-05-27
JP2022507919A (ja) 2022-01-18
FI3883936T3 (fi) 2023-09-05
JP7444882B2 (ja) 2024-03-06
WO2020104494A1 (fr) 2020-05-28
CO2021007056A2 (es) 2021-06-10
LT3883936T (lt) 2023-09-25
PT3883936T (pt) 2023-09-04
RS64579B1 (sr) 2023-10-31
TWI825227B (zh) 2023-12-11
EP3883936A1 (fr) 2021-09-29
PH12021551167A1 (en) 2021-10-25
PE20211870A1 (es) 2021-09-21
CA3119506A1 (fr) 2020-05-28
IL283333B1 (en) 2024-04-01
TW202039513A (zh) 2020-11-01
EP3883936B1 (fr) 2023-07-12
BR112021009348A2 (pt) 2021-08-10
AR117139A1 (es) 2021-07-14
CR20210247A (es) 2021-06-08
MA55131B1 (fr) 2023-10-31
IL283333B2 (en) 2024-08-01
HUE062913T2 (hu) 2023-12-28
MX2021005714A (es) 2021-07-21
ES2955037T3 (es) 2023-11-28
SG11202104206SA (en) 2021-06-29
IL283333A (en) 2021-07-29
HRP20231083T1 (hr) 2023-12-22
KR20210094540A (ko) 2021-07-29
KR102913813B1 (ko) 2026-01-16
NZ775640A (en) 2024-10-25
CN113166170A (zh) 2021-07-23
AU2019383500B2 (en) 2025-09-18
PL3883936T3 (pl) 2023-11-20
SI3883936T1 (sl) 2023-10-30
US20210387999A1 (en) 2021-12-16
US12577257B2 (en) 2026-03-17
DK3883936T3 (da) 2023-09-18
UA128505C2 (uk) 2024-07-31
CL2021001330A1 (es) 2021-10-29

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