MA55131A - Nouveaux composés hétérocycliques - Google Patents

Nouveaux composés hétérocycliques

Info

Publication number
MA55131A
MA55131A MA055131A MA55131A MA55131A MA 55131 A MA55131 A MA 55131A MA 055131 A MA055131 A MA 055131A MA 55131 A MA55131 A MA 55131A MA 55131 A MA55131 A MA 55131A
Authority
MA
Morocco
Prior art keywords
heterocyclic compounds
new heterocyclic
new
compounds
heterocyclic
Prior art date
Application number
MA055131A
Other languages
English (en)
Other versions
MA55131B1 (fr
Inventor
Uwe Grether
Zbinden Katrin Groebke
Benoit Hornsperger
Carsten Kroll
Bernd Kuhn
Marius Daniel Rinaldo Lutz
Fionn O`Hara
Hans Richter
Didier Rombach
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA55131A publication Critical patent/MA55131A/fr
Publication of MA55131B1 publication Critical patent/MA55131B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53831,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
MA55131A 2018-11-22 2019-11-20 Nouveaux composés hétérocycliques MA55131B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18207725 2018-11-22
PCT/EP2019/081870 WO2020104494A1 (fr) 2018-11-22 2019-11-20 Nouveaux composés hétérocycliques

Publications (2)

Publication Number Publication Date
MA55131A true MA55131A (fr) 2022-03-02
MA55131B1 MA55131B1 (fr) 2023-10-31

Family

ID=64453331

Family Applications (1)

Application Number Title Priority Date Filing Date
MA55131A MA55131B1 (fr) 2018-11-22 2019-11-20 Nouveaux composés hétérocycliques

Country Status (31)

Country Link
US (1) US12577257B2 (fr)
EP (1) EP3883936B1 (fr)
JP (1) JP7444882B2 (fr)
KR (1) KR102913813B1 (fr)
CN (1) CN113166170A (fr)
AR (1) AR117139A1 (fr)
AU (1) AU2019383500B2 (fr)
BR (1) BR112021009348A2 (fr)
CA (1) CA3119506A1 (fr)
CL (1) CL2021001330A1 (fr)
CO (1) CO2021007056A2 (fr)
CR (1) CR20210247A (fr)
DK (1) DK3883936T3 (fr)
ES (1) ES2955037T3 (fr)
FI (1) FI3883936T3 (fr)
HR (1) HRP20231083T1 (fr)
HU (1) HUE062913T2 (fr)
IL (1) IL283333B2 (fr)
LT (1) LT3883936T (fr)
MA (1) MA55131B1 (fr)
MX (1) MX2021005714A (fr)
PE (1) PE20211870A1 (fr)
PH (1) PH12021551167A1 (fr)
PL (1) PL3883936T3 (fr)
PT (1) PT3883936T (fr)
RS (1) RS64579B1 (fr)
SG (1) SG11202104206SA (fr)
SI (1) SI3883936T1 (fr)
TW (1) TWI825227B (fr)
UA (1) UA128505C2 (fr)
WO (1) WO2020104494A1 (fr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR114136A1 (es) 2017-10-10 2020-07-29 Hoffmann La Roche Compuestos heterocíclicos
WO2019105915A1 (fr) 2017-11-28 2019-06-06 F. Hoffmann-La Roche Ag Nouveaux composés hétérocycliques
WO2019134985A1 (fr) 2018-01-08 2019-07-11 F. Hoffmann-La Roche Ag Octahydropyrido[1,2-alpha]pyrazines en tant qu'inhibiteurs de magl
PE20211089A1 (es) 2018-08-13 2021-06-14 Hoffmann La Roche Nuevos compuestos heterociclicos como inhibidores de la monoacilglicerol lipasa
WO2020104494A1 (fr) 2018-11-22 2020-05-28 F. Hoffmann-La Roche Ag Nouveaux composés hétérocycliques
US20210094971A1 (en) * 2019-09-09 2021-04-01 Hoffmann-La Roche Inc. Heterocyclic compounds
CN114269755A (zh) * 2019-09-12 2022-04-01 豪夫迈·罗氏有限公司 作为magl抑制剂的4,4a,5,7,8,8a-六吡啶并[4,3-b][1,4]噁嗪-3-酮化合物
CA3190277A1 (fr) 2020-09-03 2022-03-10 Joerg Benz Composes heterocycliques
US20240101552A1 (en) * 2020-09-18 2024-03-28 Shanghai Pharmaceuticals Holding Co., Ltd. Carbonyl heterocyclic compound and application thereof
BR112023015210A2 (pt) 2021-01-29 2023-11-07 Cedilla Therapeutics Inc Inibidores de cdk2 e métodos de uso dos mesmos
CN117295726A (zh) * 2021-04-23 2023-12-26 豪夫迈·罗氏有限公司 杂环化合物
CA3225439A1 (fr) 2021-06-26 2022-12-29 Cedilla Therapeutics, Inc. Inhibiteurs de cdk2 et leurs procedes d'utilisation
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CN120379996A (zh) * 2022-08-11 2025-07-25 瑞敏德股份有限公司 用于治疗神经退行性障碍的(氮杂)螺庚烷衍生物
CN119894887A (zh) * 2022-09-20 2025-04-25 豪夫迈·罗氏有限公司 用于magl的荧光探针
JP2025536386A (ja) * 2022-10-24 2025-11-05 エフ. ホフマン-ラ ロシュ アーゲー モノアシルグリセロールリパーゼ(magl)の阻害剤としての複素環式化合物
EP4665718A1 (fr) 2023-02-13 2025-12-24 Apogee Pharmaceuticals, Inc. Petites molécules utilisées en tant qu'inhibiteurs de monoacylglycérol lipase (magl), compositions et utilisation associées
CN121843953A (zh) 2023-09-28 2026-04-10 豪夫迈·罗氏有限公司 新颖杂环化合物
TW202539671A (zh) 2024-01-19 2025-10-16 瑞士商赫孚孟拉羅股份公司 新穎雜環化合物

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JP7785755B2 (ja) 2020-08-26 2025-12-15 エフ. ホフマン-ラ ロシュ アーゲー Magl阻害剤として有用な複素環化合物
CA3190277A1 (fr) 2020-09-03 2022-03-10 Joerg Benz Composes heterocycliques
CN117295726A (zh) 2021-04-23 2023-12-26 豪夫迈·罗氏有限公司 杂环化合物

Also Published As

Publication number Publication date
PE20211870A1 (es) 2021-09-21
CL2021001330A1 (es) 2021-10-29
RS64579B1 (sr) 2023-10-31
WO2020104494A1 (fr) 2020-05-28
NZ775640A (en) 2024-10-25
MA55131B1 (fr) 2023-10-31
UA128505C2 (uk) 2024-07-31
MX2021005714A (es) 2021-07-21
LT3883936T (lt) 2023-09-25
ES2955037T3 (es) 2023-11-28
CO2021007056A2 (es) 2021-06-10
SG11202104206SA (en) 2021-06-29
US20210387999A1 (en) 2021-12-16
HUE062913T2 (hu) 2023-12-28
HRP20231083T1 (hr) 2023-12-22
KR20210094540A (ko) 2021-07-29
PL3883936T3 (pl) 2023-11-20
CA3119506A1 (fr) 2020-05-28
AU2019383500B2 (en) 2025-09-18
JP2022507919A (ja) 2022-01-18
DK3883936T3 (da) 2023-09-18
IL283333B1 (en) 2024-04-01
KR102913813B1 (ko) 2026-01-16
IL283333A (en) 2021-07-29
PH12021551167A1 (en) 2021-10-25
CR20210247A (es) 2021-06-08
SI3883936T1 (sl) 2023-10-30
JP7444882B2 (ja) 2024-03-06
TW202039513A (zh) 2020-11-01
PT3883936T (pt) 2023-09-04
AR117139A1 (es) 2021-07-14
FI3883936T3 (fi) 2023-09-05
EP3883936B1 (fr) 2023-07-12
IL283333B2 (en) 2024-08-01
TWI825227B (zh) 2023-12-11
BR112021009348A2 (pt) 2021-08-10
EP3883936A1 (fr) 2021-09-29
CN113166170A (zh) 2021-07-23
US12577257B2 (en) 2026-03-17
AU2019383500A1 (en) 2021-05-27

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