MA56098B1 - Immunomodulateurs hétérocycliques autant qu'inhibiteurs de pdl1 - Google Patents

Immunomodulateurs hétérocycliques autant qu'inhibiteurs de pdl1

Info

Publication number
MA56098B1
MA56098B1 MA56098A MA56098A MA56098B1 MA 56098 B1 MA56098 B1 MA 56098B1 MA 56098 A MA56098 A MA 56098A MA 56098 A MA56098 A MA 56098A MA 56098 B1 MA56098 B1 MA 56098B1
Authority
MA
Morocco
Prior art keywords
immunomodulators
heterocyclic
well
pdl1 inhibitors
inhibitors
Prior art date
Application number
MA56098A
Other languages
English (en)
Other versions
MA56098A (fr
Inventor
Edgar Jacoby
Gowan David Craig Mc
Original Assignee
Janssen Sciences Ireland Unlimited Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Unlimited Co filed Critical Janssen Sciences Ireland Unlimited Co
Publication of MA56098A publication Critical patent/MA56098A/fr
Publication of MA56098B1 publication Critical patent/MA56098B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne des inhibiteurs de pd-l1 contenant de la pyridinone, des compositions pharmaceutiques comprenant ces composés, des procédés chimiques pour préparer ces composés, et leur utilisation dans le traitement de maladies infectieuses et du cancer. Formule (i).
MA56098A 2019-06-07 2020-06-05 Immunomodulateurs hétérocycliques autant qu'inhibiteurs de pdl1 MA56098B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19179072 2019-06-07
PCT/EP2020/065646 WO2020245372A1 (fr) 2019-06-07 2020-06-05 Immunomodulateurs hétérocycliques utilisés comme inhibiteur de point de contrôle pdl1

Publications (2)

Publication Number Publication Date
MA56098A MA56098A (fr) 2022-04-13
MA56098B1 true MA56098B1 (fr) 2023-10-31

Family

ID=66793871

Family Applications (1)

Application Number Title Priority Date Filing Date
MA56098A MA56098B1 (fr) 2019-06-07 2020-06-05 Immunomodulateurs hétérocycliques autant qu'inhibiteurs de pdl1

Country Status (18)

Country Link
US (1) US20220259186A1 (fr)
EP (1) EP3980413B1 (fr)
JP (1) JP7768770B2 (fr)
KR (1) KR102939670B1 (fr)
CN (1) CN113966329B (fr)
AU (1) AU2020286962B2 (fr)
BR (1) BR112021023780A2 (fr)
CA (1) CA3138494A1 (fr)
ES (1) ES2956866T3 (fr)
HR (1) HRP20230873T1 (fr)
HU (1) HUE063236T2 (fr)
MA (1) MA56098B1 (fr)
MD (1) MD3980413T2 (fr)
MX (1) MX2021015048A (fr)
PL (1) PL3980413T3 (fr)
RS (1) RS64681B1 (fr)
SM (1) SMT202300280T1 (fr)
WO (1) WO2020245372A1 (fr)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4815773B2 (ja) * 2003-09-17 2011-11-16 住友化学株式会社 シンナモイル化合物及びその用途
JP6417419B2 (ja) * 2013-09-04 2018-11-07 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 免疫調節剤として有用な化合物
US9850225B2 (en) * 2014-04-14 2017-12-26 Bristol-Myers Squibb Company Compounds useful as immunomodulators
WO2018005374A1 (fr) * 2016-06-27 2018-01-04 Chemocentryx, Inc. Composés immunomodulateurs
CN109689640B (zh) * 2016-07-08 2022-01-04 百时美施贵宝公司 可用作免疫调节剂的化合物
KR20190133714A (ko) * 2017-03-27 2019-12-03 브리스톨-마이어스 스큅 컴퍼니 면역조정제로서 유용한 치환된 이소퀴놀린 유도체

Also Published As

Publication number Publication date
WO2020245372A1 (fr) 2020-12-10
MX2021015048A (es) 2022-01-18
JP7768770B2 (ja) 2025-11-12
US20220259186A1 (en) 2022-08-18
CN113966329B (zh) 2024-08-13
HRP20230873T1 (hr) 2024-02-16
AU2020286962B2 (en) 2025-10-16
SMT202300280T1 (it) 2023-11-13
CA3138494A1 (fr) 2020-12-10
KR20220017942A (ko) 2022-02-14
JP2022535879A (ja) 2022-08-10
EP3980413C0 (fr) 2023-07-19
BR112021023780A2 (pt) 2022-01-11
KR102939670B1 (ko) 2026-03-13
RS64681B1 (sr) 2023-11-30
EP3980413B1 (fr) 2023-07-19
MA56098A (fr) 2022-04-13
PL3980413T3 (pl) 2023-12-27
CN113966329A (zh) 2022-01-21
MD3980413T2 (ro) 2023-12-31
HUE063236T2 (hu) 2024-01-28
AU2020286962A1 (en) 2022-02-03
EP3980413A1 (fr) 2022-04-13
ES2956866T3 (es) 2023-12-29

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