MA56445A - Dérivé de tétrahydroisoquinoléine substitué utilisé comme modulateur allostérique positif de d1 - Google Patents

Dérivé de tétrahydroisoquinoléine substitué utilisé comme modulateur allostérique positif de d1

Info

Publication number
MA56445A
MA56445A MA056445A MA56445A MA56445A MA 56445 A MA56445 A MA 56445A MA 056445 A MA056445 A MA 056445A MA 56445 A MA56445 A MA 56445A MA 56445 A MA56445 A MA 56445A
Authority
MA
Morocco
Prior art keywords
positive allosteric
derivative used
allosteric modulator
tetrahydroisoquinoline derivative
substituted tetrahydroisoquinoline
Prior art date
Application number
MA056445A
Other languages
English (en)
Inventor
Anne Valade
Original Assignee
UCB Biopharma SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB Biopharma SRL filed Critical UCB Biopharma SRL
Publication of MA56445A publication Critical patent/MA56445A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MA056445A 2019-07-01 2020-06-29 Dérivé de tétrahydroisoquinoléine substitué utilisé comme modulateur allostérique positif de d1 MA56445A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP19183641 2019-07-01

Publications (1)

Publication Number Publication Date
MA56445A true MA56445A (fr) 2022-05-11

Family

ID=67137842

Family Applications (1)

Application Number Title Priority Date Filing Date
MA056445A MA56445A (fr) 2019-07-01 2020-06-29 Dérivé de tétrahydroisoquinoléine substitué utilisé comme modulateur allostérique positif de d1

Country Status (24)

Country Link
US (1) US12358890B2 (fr)
EP (1) EP3993795B1 (fr)
JP (1) JP7618597B2 (fr)
KR (1) KR102949226B1 (fr)
CN (1) CN114008032B (fr)
AR (1) AR119317A1 (fr)
AU (1) AU2020299705B2 (fr)
BR (1) BR112021022379A2 (fr)
CA (1) CA3139622A1 (fr)
CL (1) CL2021002949A1 (fr)
CO (1) CO2021017740A2 (fr)
EC (1) ECSP22007557A (fr)
IL (1) IL289317B2 (fr)
MA (1) MA56445A (fr)
MX (1) MX2021015872A (fr)
MY (1) MY210362A (fr)
PE (1) PE20220373A1 (fr)
PH (1) PH12021552819A1 (fr)
SA (1) SA521431274B1 (fr)
SG (1) SG11202112539XA (fr)
TW (1) TWI842923B (fr)
UA (1) UA130613C2 (fr)
WO (1) WO2021001286A1 (fr)
ZA (1) ZA202109194B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116601146A (zh) 2020-10-07 2023-08-15 伊莱利利公司 作为多巴胺d1受体正变构调节剂的苯基-3,4-二氢异喹啉-2(1h)-基-乙-1-酮衍生物
US20240165101A1 (en) * 2021-03-09 2024-05-23 Eli Lilly And Company Use of mevidalen and other d1 positive allosteric modulators for slowing of parkinson's disease progression

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101668746A (zh) 2007-03-01 2010-03-10 詹森药业有限公司 作为组胺h3受体调节剂的四氢异喹啉化合物
KR101284796B1 (ko) 2011-10-05 2013-07-10 (주)포인트엔지니어링 캔 패지키 타입의 광 디바이스 제조 방법 및 이에 의해 제조된 광 디바이스
MX344308B (es) 2011-11-03 2016-12-13 Merck Sharp & Dohme Derivados de quinolina carboxamida y quinolina carbonitrilo como moduladores alostericos negativos de mglur2, composiciones y su uso.
JO3316B1 (ar) 2013-05-30 2019-03-13 Lilly Co Eli مركبات 3، 4-داي هيدرو أيزو كوينولين -2(1h)-يل
DK3204359T3 (da) 2014-10-08 2020-09-14 UCB Biopharma SRL Tetrahydroisoquinolinderivater
CA3018352A1 (fr) 2016-04-13 2017-10-19 Ucb Biopharma Sprl Derives de tetrahydroisoquinoleine
CN110382484B (zh) * 2017-03-16 2022-12-06 豪夫迈·罗氏有限公司 新的作为atx抑制剂的二环化合物
TWI725408B (zh) 2018-04-20 2021-04-21 美商美國禮來大藥廠 多巴胺d1受體正向異位調節劑

Also Published As

Publication number Publication date
CN114008032B (zh) 2023-11-10
AR119317A1 (es) 2021-12-09
US12358890B2 (en) 2025-07-15
IL289317B1 (en) 2025-05-01
KR20220029687A (ko) 2022-03-08
KR102949226B1 (ko) 2026-04-06
JP7618597B2 (ja) 2025-01-21
WO2021001286A1 (fr) 2021-01-07
BR112021022379A2 (pt) 2022-03-08
ZA202109194B (en) 2023-11-29
SA521431274B1 (ar) 2024-01-09
PH12021552819A1 (en) 2022-09-28
AU2020299705A1 (en) 2021-12-09
AU2020299705B2 (en) 2026-03-19
IL289317B2 (en) 2025-09-01
SG11202112539XA (en) 2021-12-30
CO2021017740A2 (es) 2022-01-17
CN114008032A (zh) 2022-02-01
US20220251064A1 (en) 2022-08-11
TWI842923B (zh) 2024-05-21
TW202115009A (zh) 2021-04-16
MX2021015872A (es) 2022-02-03
ECSP22007557A (es) 2022-02-25
MY210362A (en) 2025-09-13
PE20220373A1 (es) 2022-03-16
UA130613C2 (uk) 2026-04-01
EP3993795A1 (fr) 2022-05-11
EP3993795B1 (fr) 2026-04-22
CL2021002949A1 (es) 2022-07-15
CA3139622A1 (fr) 2021-01-07
JP2022537994A (ja) 2022-08-31
IL289317A (en) 2022-02-01

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