MA56466A - Anticorps anti-epha4 - Google Patents

Anticorps anti-epha4

Info

Publication number
MA56466A
MA56466A MA056466A MA56466A MA56466A MA 56466 A MA56466 A MA 56466A MA 056466 A MA056466 A MA 056466A MA 56466 A MA56466 A MA 56466A MA 56466 A MA56466 A MA 56466A
Authority
MA
Morocco
Prior art keywords
epha4 antibodies
epha4
antibodies
Prior art date
Application number
MA056466A
Other languages
English (en)
Inventor
Maki Deguchi
Toshio Imai
Eiji Inoue
Tomomi Kawakatsu
Aki Nakatani
Akio Yamada
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of MA56466A publication Critical patent/MA56466A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
MA056466A 2019-07-01 2020-06-29 Anticorps anti-epha4 MA56466A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2019122982 2019-07-01

Publications (1)

Publication Number Publication Date
MA56466A true MA56466A (fr) 2022-05-11

Family

ID=74066003

Family Applications (1)

Application Number Title Priority Date Filing Date
MA056466A MA56466A (fr) 2019-07-01 2020-06-29 Anticorps anti-epha4

Country Status (23)

Country Link
US (2) US10947313B2 (fr)
EP (1) EP3995582A4 (fr)
JP (2) JP6979147B2 (fr)
KR (1) KR20220027825A (fr)
CN (2) CN117398459A (fr)
AR (1) AR119303A1 (fr)
AU (1) AU2020300205B2 (fr)
BR (1) BR112021025161A2 (fr)
CA (1) CA3139398A1 (fr)
CL (1) CL2021003326A1 (fr)
CO (1) CO2021016588A2 (fr)
IL (1) IL287828A (fr)
JO (1) JOP20210333A1 (fr)
MA (1) MA56466A (fr)
MX (1) MX2021015298A (fr)
MY (1) MY207780A (fr)
PE (1) PE20220570A1 (fr)
PH (1) PH12021553090A1 (fr)
SG (1) SG11202112433VA (fr)
TW (3) TWI866304B (fr)
UA (1) UA129772C2 (fr)
WO (1) WO2021002312A1 (fr)
ZA (1) ZA202108836B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7368856B2 (ja) 2017-07-25 2023-10-25 トゥルーバインディング，インコーポレイテッド Ｔｉｍ－３とそのリガンドとの相互作用の遮断によるがん治療
CN120058944A (zh) 2019-01-30 2025-05-30 真和制药有限公司 抗gal3抗体及其用途
WO2021002312A1 (fr) 2019-07-01 2021-01-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 ANTICORPS ANTI-EphA4
JP2023528797A (ja) 2020-05-26 2023-07-06 トゥルーバインディング，インコーポレイテッド ガレクチン－３を遮断することにより炎症性疾患を処置する方法
KR20230124547A (ko) * 2020-12-24 2023-08-25 에자이 알앤드디 매니지먼트 가부시키가이샤 근위축성 측삭 경화증에 대한 치료적 약학 조성물
CN118234864A (zh) * 2021-11-11 2024-06-21 卫材R&D管理有限公司 抗EphA4抗体
WO2025151607A1 (fr) * 2024-01-10 2025-07-17 Santa Ana Bio, Inc. Méthodes et compositions pour le traitement de maladies auto-immunes, allergiques et inflammatoires

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1094731A (en) 1911-06-06 1914-04-28 Lucien Linden Oxidizing process.
CA1339413C (fr) 1988-06-24 1997-09-02 Junichi Miyazaki Vecteur pour l'expression d'un gene exogene, renfermant un promoteur de gene .beta.-actine de poule
JP2824433B2 (ja) 1988-12-09 1998-11-11 財団法人化学及血清療法研究所 新規なハイブリッドプロモーターおよびこれを組み込んだ外来遺伝子発現用ベクター
JP3680114B2 (ja) 1993-09-17 2005-08-10 敏一 中村 脳神経障害治療剤
US5902732A (en) 1995-10-04 1999-05-11 Cytoscan Sciences Llc Drug screening process measuring changes in cell volume
WO1998045708A1 (fr) 1997-04-08 1998-10-15 Sugen, Inc. Etude et traitement des maladies liees a des fonctions cellulaires specifiques de proteines tyrosines kinases receptrices
US20020068361A1 (en) 1997-04-08 2002-06-06 Douglas Clary Methods of evaluating specific cellular functions of receptor protein tyrosine kinases in a ligand independent manner
US5876946A (en) 1997-06-03 1999-03-02 Pharmacopeia, Inc. High-throughput assay
US20060241074A1 (en) 2001-08-14 2006-10-26 The General Hospital Corporation Methods for treatment of pain
AU2002324700A1 (en) 2001-08-14 2003-03-03 Bayer Ag Nucleic acid and amino acid sequences involved in pain
US20070026409A1 (en) 2001-08-14 2007-02-01 The General Hospital Corporation Nucleic acid and amino acid sequences involved in pain
JP2003169699A (ja) 2001-12-10 2003-06-17 Japan Science & Technology Corp 特異的γプロテアーゼ阻害剤のスクリーニング方法
JP2004000060A (ja) 2002-05-31 2004-01-08 Otsuka Pharmaceut Co Ltd アミロイドβ産生に影響を与える化合物のスクリーニング方法
EP1553963A4 (fr) 2002-09-24 2006-05-03 Burnham Inst Nouveaux agents modulant l'activite du recepteur eph
HRP20050461A2 (en) 2002-11-26 2005-08-31 Pharmacia & Upjohn Company Llc Soluble notch-based substrates for gamma secretase and methods and compositions for using same
EP1638514A4 (fr) 2003-06-06 2009-11-18 Medimmune Inc Utilisation du epha4 et de ses modulateurs, pour le diagnostic, le traitement et la prevention du cancer
WO2005045028A1 (fr) 2003-11-10 2005-05-19 Osaka Industrial Promotion Organization Procede d'analyse acellulaire du clivage de notch et procede d'identification de medicaments par criblage
TW200538739A (en) 2004-02-27 2005-12-01 Oncotherapy Science Inc EphA4 as therapeutic target of PRC and PDACa
CA2579352A1 (fr) 2004-09-08 2006-03-16 The University Of Queensland Traitement de la gliose, et prevention ou reduction de la formation de cicatrices gliales, de l'inflammation ou de l'inhibition de la croissance axonale dans le systeme nerveux enmodulant le recepteur eph
EP1662259A1 (fr) 2004-11-25 2006-05-31 Cellzome Ag Utilisation des inhibiteurs du récepteur Eph pour le traitement des maladies neurodégénératives
GB0427023D0 (en) 2004-12-09 2005-01-12 Merck Sharp & Dohme Assay method
EP2004228A1 (fr) 2006-02-28 2008-12-24 Oncotherapy Science, Inc. Procédés de dégradation de cellules utilisant les fonctions effectrices d'anticorps anti-epha4
EP1947193A1 (fr) 2007-01-17 2008-07-23 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Procédé de criblage pour composés antidiabétiques
EP2166110B1 (fr) 2007-06-08 2012-02-22 Eisai R&D Management Co., Ltd. Procédé de criblage employant un nouveau substrat epha4 pour la gamma-secrétase
EP2183598A1 (fr) 2007-07-13 2010-05-12 Elan Pharmaceuticals Inc. Compositions et procédés permettant d'identifier la spécificité de substrat des inhibiteurs de la gamma secrétase
US20090191580A1 (en) 2007-07-19 2009-07-30 Eisai R & D Management Co., Ltd. METHOD OF SCREENING USING c-MET, A NOVEL SUBSTRATE FOR GAMMA-SECRETASE
US20100190184A1 (en) 2007-08-01 2010-07-29 Eisai R & D Management Co., Ltd. Screening method utilizing novel substrate c-ret for gamma-secretase
EP2031064A1 (fr) 2007-08-29 2009-03-04 Boehringer Ingelheim Pharma GmbH & Co. KG Procédé d'augmentation de titres de protéines
US20090163594A1 (en) 2007-10-31 2009-06-25 Elan Pharmaceuticals, Inc. Triple Assay System for Identifying Substrate Selectivity of Gamma Secretase Inhibitors
WO2009064006A1 (fr) 2007-11-15 2009-05-22 Eisai R & D Management Co., Ltd. PROCÉDÉ DE CRIBLAGE UTILISANT UN NOUVEAU SUBSTRAT EphA7 POUR LA γ-SECRÉTASE
US7892769B2 (en) 2007-11-30 2011-02-22 Eisai R&D Management Co., Ltd. Processing of EphA4 polypeptide by γ-secretase activity
US20100113415A1 (en) 2008-05-29 2010-05-06 Rajapakse Hemaka A Epha4 rtk inhibitors for treatment of neurological and neurodegenerative disorders and cancer
EP2260864A1 (fr) 2009-06-10 2010-12-15 University of Melbourne Applications thérapeutiques
JP2010285413A (ja) 2009-06-10 2010-12-24 Univ Of Melbourne 治療用途
JP6059017B2 (ja) 2010-12-17 2017-01-11 エーザイ・アール・アンド・ディー・マネジメント株式会社 ゼラチナーゼによるＥｐｈＡ４の切断反応を指標としたスクリーニング方法
WO2012147798A1 (fr) 2011-04-25 2012-11-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 Méthode de détection d'une maladie neurologique associée à un dysfonctionnement cognitif impliquant la mesure du domaine extracellulaire epha4
GB201107996D0 (en) 2011-05-13 2011-06-29 Vib Vzw EphA4 is a diease modifier in motor neuron disease
ES2848857T3 (es) 2014-07-31 2021-08-12 Us Gov Health & Human Services Anticuerpos monoclonales humanos contra EphA4 y su uso
CA2989993A1 (fr) * 2015-09-08 2017-03-16 Eisai R&D Management Co., Ltd. Anticorps anti-epha4
WO2021002312A1 (fr) 2019-07-01 2021-01-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 ANTICORPS ANTI-EphA4

Also Published As

Publication number Publication date
NZ783106A (en) 2025-08-29
KR20220027825A (ko) 2022-03-08
JP6979147B2 (ja) 2021-12-08
ZA202108836B (en) 2023-04-26
JP2022031271A (ja) 2022-02-18
PE20220570A1 (es) 2022-04-20
TWI866304B (zh) 2024-12-11
EP3995582A1 (fr) 2022-05-11
US11136400B2 (en) 2021-10-05
TW202115116A (zh) 2021-04-16
US20210002378A1 (en) 2021-01-07
WO2021002312A1 (fr) 2021-01-07
AU2020300205A1 (en) 2022-01-20
AU2020300205B2 (en) 2026-03-19
TWI808882B (zh) 2023-07-11
MY207780A (en) 2025-03-18
CO2021016588A2 (es) 2022-04-08
US10947313B2 (en) 2021-03-16
TWI779307B (zh) 2022-10-01
JPWO2021002312A1 (ja) 2021-09-13
TW202248216A (zh) 2022-12-16
PH12021553090A1 (en) 2022-07-25
JP7072114B2 (ja) 2022-05-19
BR112021025161A2 (pt) 2022-01-25
CN117398459A (zh) 2024-01-16
EP3995582A4 (fr) 2023-01-18
US20210171644A1 (en) 2021-06-10
IL287828A (en) 2022-01-01
AR119303A1 (es) 2021-12-09
TW202342101A (zh) 2023-11-01
JOP20210333A1 (ar) 2023-01-30
SG11202112433VA (en) 2021-12-30
CN113906050B (zh) 2023-11-21
CN113906050A (zh) 2022-01-07
MX2021015298A (es) 2022-01-18
UA129772C2 (uk) 2025-07-30
CA3139398A1 (fr) 2021-01-07
CL2021003326A1 (es) 2022-07-22

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