MA56466A - Anticorps anti-epha4 - Google Patents

Anticorps anti-epha4

Info

Publication number
MA56466A
MA56466A MA056466A MA56466A MA56466A MA 56466 A MA56466 A MA 56466A MA 056466 A MA056466 A MA 056466A MA 56466 A MA56466 A MA 56466A MA 56466 A MA56466 A MA 56466A
Authority
MA
Morocco
Prior art keywords
epha4 antibodies
epha4
antibodies
Prior art date
Application number
MA056466A
Other languages
English (en)
Inventor
Maki Deguchi
Toshio Imai
Eiji Inoue
Tomomi Kawakatsu
Aki Nakatani
Akio Yamada
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of MA56466A publication Critical patent/MA56466A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
MA056466A 2019-07-01 2020-06-29 Anticorps anti-epha4 MA56466A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2019122982 2019-07-01

Publications (1)

Publication Number Publication Date
MA56466A true MA56466A (fr) 2022-05-11

Family

ID=74066003

Family Applications (1)

Application Number Title Priority Date Filing Date
MA056466A MA56466A (fr) 2019-07-01 2020-06-29 Anticorps anti-epha4

Country Status (23)

Country Link
US (2) US10947313B2 (fr)
EP (1) EP3995582B1 (fr)
JP (2) JP6979147B2 (fr)
KR (1) KR102953475B1 (fr)
CN (2) CN113906050B (fr)
AR (1) AR119303A1 (fr)
AU (1) AU2020300205B2 (fr)
BR (1) BR112021025161A2 (fr)
CA (1) CA3139398A1 (fr)
CL (1) CL2021003326A1 (fr)
CO (1) CO2021016588A2 (fr)
IL (1) IL287828A (fr)
JO (1) JOP20210333A1 (fr)
MA (1) MA56466A (fr)
MX (1) MX2021015298A (fr)
MY (1) MY207780A (fr)
PE (1) PE20220570A1 (fr)
PH (1) PH12021553090A1 (fr)
SG (1) SG11202112433VA (fr)
TW (3) TWI808882B (fr)
UA (1) UA129772C2 (fr)
WO (1) WO2021002312A1 (fr)
ZA (1) ZA202108836B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3658172A4 (fr) 2017-07-25 2021-05-05 TrueBinding, Inc. Traitement du cancer par blocage de l'interaction de tim-3 et de son ligand
CN113711036B (zh) 2019-01-30 2025-03-18 真和制药有限公司 抗gal3抗体及其用途
EP3995582B1 (fr) 2019-07-01 2026-04-22 Eisai R&D Management Co., Ltd. Anticorps anti-epha4
CN116157151A (zh) 2020-05-26 2023-05-23 真和制药有限公司 通过阻断半乳凝素-3治疗炎性疾病的方法
US20240010735A1 (en) * 2020-12-24 2024-01-11 Eisai R&D Management Co., Ltd. Therapeutic pharmaceutical composition for amyotrophic lateral sclerosis
AU2022388189A1 (en) * 2021-11-11 2024-05-02 Eisai R&D Management Co., Ltd. Anti-epha4 antibody
WO2025151607A1 (fr) * 2024-01-10 2025-07-17 Santa Ana Bio, Inc. Méthodes et compositions pour le traitement de maladies auto-immunes, allergiques et inflammatoires

Family Cites Families (41)

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US1094731A (en) 1911-06-06 1914-04-28 Lucien Linden Oxidizing process.
JP2824433B2 (ja) 1988-12-09 1998-11-11 財団法人化学及血清療法研究所 新規なハイブリッドプロモーターおよびこれを組み込んだ外来遺伝子発現用ベクター
CA1339413C (fr) 1988-06-24 1997-09-02 Junichi Miyazaki Vecteur pour l'expression d'un gene exogene, renfermant un promoteur de gene .beta.-actine de poule
JP3680114B2 (ja) 1993-09-17 2005-08-10 敏一 中村 脳神経障害治療剤
US5902732A (en) 1995-10-04 1999-05-11 Cytoscan Sciences Llc Drug screening process measuring changes in cell volume
US20020068361A1 (en) 1997-04-08 2002-06-06 Douglas Clary Methods of evaluating specific cellular functions of receptor protein tyrosine kinases in a ligand independent manner
WO1998045708A1 (fr) 1997-04-08 1998-10-15 Sugen, Inc. Etude et traitement des maladies liees a des fonctions cellulaires specifiques de proteines tyrosines kinases receptrices
US5876946A (en) 1997-06-03 1999-03-02 Pharmacopeia, Inc. High-throughput assay
US20060241074A1 (en) 2001-08-14 2006-10-26 The General Hospital Corporation Methods for treatment of pain
US20070026409A1 (en) 2001-08-14 2007-02-01 The General Hospital Corporation Nucleic acid and amino acid sequences involved in pain
EP1478772A2 (fr) 2001-08-14 2004-11-24 The General Hospital Corporation Sequences d'acides nucleiques et d'acides amines intervenant dans la douleur
JP2003169699A (ja) 2001-12-10 2003-06-17 Japan Science & Technology Corp 特異的γプロテアーゼ阻害剤のスクリーニング方法
JP2004000060A (ja) 2002-05-31 2004-01-08 Otsuka Pharmaceut Co Ltd アミロイドβ産生に影響を与える化合物のスクリーニング方法
WO2004028551A1 (fr) 2002-09-24 2004-04-08 The Burnham Institute Nouveaux agents modulant l'activite du recepteur eph
HRP20050461A2 (en) 2002-11-26 2005-08-31 Pharmacia & Upjohn Company Llc Soluble notch-based substrates for gamma secretase and methods and compositions for using same
WO2005048917A2 (fr) 2003-06-06 2005-06-02 Medimmune, Inc. Utilisation du epha4 et de ses modulateurs, pour le diagnostic, le traitement et la prevention du cancer
EP1693449A4 (fr) 2003-11-10 2007-07-25 Osaka Ind Promotion Org Procede d'analyse acellulaire du clivage de notch et procede d'identification de medicaments par criblage
JP2007525203A (ja) 2004-02-27 2007-09-06 オンコセラピー・サイエンス株式会社 PRCおよびPDACaの治療標的としてのEphA4
WO2006026820A1 (fr) 2004-09-08 2006-03-16 The University Of Queensland Methode de traitement et agents utiles pour celle-ci
EP1662259A1 (fr) 2004-11-25 2006-05-31 Cellzome Ag Utilisation des inhibiteurs du récepteur Eph pour le traitement des maladies neurodégénératives
GB0427023D0 (en) 2004-12-09 2005-01-12 Merck Sharp & Dohme Assay method
EP2004228A1 (fr) 2006-02-28 2008-12-24 Oncotherapy Science, Inc. Procédés de dégradation de cellules utilisant les fonctions effectrices d'anticorps anti-epha4
EP1947193A1 (fr) 2007-01-17 2008-07-23 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Procédé de criblage pour composés antidiabétiques
WO2008150010A1 (fr) 2007-06-08 2008-12-11 Eisai R & D Management Co., Ltd. PROCÉDÉ DE CRIBLAGE EMPLOYANT UN NOUVEAU SUBSTRAT EphA4 POUR LA Ϝ-SECRÉTASE
US20090023158A1 (en) 2007-07-13 2009-01-22 Elan Pharmaceuticals, Inc. Compositions and Methods for Identifying Substrate Specificity of Inhibitors of Gamma Secretase
EP2177623A4 (fr) 2007-07-19 2010-12-29 Eisai R&D Man Co Ltd Procede de criblage utilisant c-met, un nouveau substrat pour la gamma-secretase
EP2192181A4 (fr) 2007-08-01 2010-12-08 Eisai R&D Man Co Ltd Procédé de criblage utilisant le nouveau substrat c-ret pour la gamma-sécrétase
EP2031064A1 (fr) 2007-08-29 2009-03-04 Boehringer Ingelheim Pharma GmbH & Co. KG Procédé d'augmentation de titres de protéines
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JP5580598B2 (ja) 2007-11-15 2014-08-27 エーザイ・アール・アンド・ディー・マネジメント株式会社 γ−セクレターゼの新規基質EphA7を利用したスクリーニング方法
EP2223999B1 (fr) 2007-11-30 2017-10-18 Eisai R&D Management Co., Ltd. Polypeptide epha4 ayant une nouvelle activité et son utilisation
US20100113415A1 (en) 2008-05-29 2010-05-06 Rajapakse Hemaka A Epha4 rtk inhibitors for treatment of neurological and neurodegenerative disorders and cancer
JP2010285413A (ja) 2009-06-10 2010-12-24 Univ Of Melbourne 治療用途
EP2260864A1 (fr) 2009-06-10 2010-12-15 University of Melbourne Applications thérapeutiques
EP2653552B1 (fr) 2010-12-17 2016-10-19 Eisai R&D Management Co., Ltd. PROCÉDÉ DE CRIBLAGE INDEXÉ SUR UNE RÉACTION DE CLIVAGE DE L'EphA4 PAR LA GÉLATINASE
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WO2015007222A1 (fr) * 2013-07-17 2015-01-22 The Hong Kong University Of Science And Technology Inhibiteurs d'epha4 en tant qu'agents neuroprotecteurs
WO2016019280A1 (fr) 2014-07-31 2016-02-04 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Anticorps monoclonaux humains dirigés contre l'epha4 et leur utilisation
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Also Published As

Publication number Publication date
JP6979147B2 (ja) 2021-12-08
AU2020300205B2 (en) 2026-03-19
NZ783106A (en) 2025-08-29
ZA202108836B (en) 2023-04-26
MX2021015298A (es) 2022-01-18
US10947313B2 (en) 2021-03-16
WO2021002312A1 (fr) 2021-01-07
IL287828A (en) 2022-01-01
AU2020300205A1 (en) 2022-01-20
PH12021553090A1 (en) 2022-07-25
CN117398459A (zh) 2024-01-16
CN113906050A (zh) 2022-01-07
TWI808882B (zh) 2023-07-11
US11136400B2 (en) 2021-10-05
EP3995582A4 (fr) 2023-01-18
CL2021003326A1 (es) 2022-07-22
KR102953475B1 (ko) 2026-04-16
TW202342101A (zh) 2023-11-01
TW202248216A (zh) 2022-12-16
BR112021025161A2 (pt) 2022-01-25
TWI866304B (zh) 2024-12-11
SG11202112433VA (en) 2021-12-30
EP3995582B1 (fr) 2026-04-22
US20210002378A1 (en) 2021-01-07
MY207780A (en) 2025-03-18
KR20220027825A (ko) 2022-03-08
JOP20210333A1 (ar) 2021-12-14
CO2021016588A2 (es) 2022-04-08
AR119303A1 (es) 2021-12-09
CN113906050B (zh) 2023-11-21
US20210171644A1 (en) 2021-06-10
TW202115116A (zh) 2021-04-16
TWI779307B (zh) 2022-10-01
JP7072114B2 (ja) 2022-05-19
PE20220570A1 (es) 2022-04-20
CA3139398A1 (fr) 2021-01-07
EP3995582A1 (fr) 2022-05-11
JPWO2021002312A1 (ja) 2021-09-13
JP2022031271A (ja) 2022-02-18
UA129772C2 (uk) 2025-07-30

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