MA53434A - Anticorps anti-tigit - Google Patents

Anticorps anti-tigit

Info

Publication number
MA53434A
MA53434A MA053434A MA53434A MA53434A MA 53434 A MA53434 A MA 53434A MA 053434 A MA053434 A MA 053434A MA 53434 A MA53434 A MA 53434A MA 53434 A MA53434 A MA 53434A
Authority
MA
Morocco
Prior art keywords
tigit antibodies
tigit
antibodies
Prior art date
Application number
MA053434A
Other languages
English (en)
Inventor
Courtney Beers
Shyra Gardai
Scott Peterson
Julia C Piasecki
Bianka Prinz
Original Assignee
Seagen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seagen Inc filed Critical Seagen Inc
Publication of MA53434A publication Critical patent/MA53434A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA053434A 2018-08-23 2019-08-22 Anticorps anti-tigit MA53434A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862722063P 2018-08-23 2018-08-23
US201862734130P 2018-09-20 2018-09-20
US201962822674P 2019-03-22 2019-03-22

Publications (1)

Publication Number Publication Date
MA53434A true MA53434A (fr) 2021-12-01

Family

ID=67841280

Family Applications (1)

Application Number Title Priority Date Filing Date
MA053434A MA53434A (fr) 2018-08-23 2019-08-22 Anticorps anti-tigit

Country Status (14)

Country Link
US (2) US11401339B2 (fr)
EP (1) EP3841123A2 (fr)
JP (2) JP2021534196A (fr)
KR (1) KR20210057053A (fr)
CN (1) CN112638944A (fr)
AU (1) AU2019324170A1 (fr)
BR (1) BR112021003156A2 (fr)
CA (1) CA3107596A1 (fr)
IL (1) IL280780A (fr)
MA (1) MA53434A (fr)
MX (1) MX2021002002A (fr)
SG (1) SG11202101429YA (fr)
TW (1) TW202023625A (fr)
WO (1) WO2020041541A2 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3458485B1 (fr) 2016-05-19 2021-12-29 The General Hospital Corporation Interleukine-2 liée à son récepteur il-2rbêta, plate-forme pour améliorer l'activité des cellules tueuses naturelles et des lymphocytes t régulateurs
US20200318200A1 (en) 2019-04-02 2020-10-08 The Brigham And Women's Hospital, Inc. Methods for Identifying Progression of a Primary Melanoma
WO2021113831A1 (fr) 2019-12-05 2021-06-10 Compugen Ltd. Anticorps anti-pvrig et anti-tigit pour élimination de tumeurs à base de cellules nk améliorées
CA3176248A1 (fr) 2020-04-10 2021-10-14 Seagen Inc. Lieurs de variants de charge
CR20220611A (es) 2020-06-02 2023-06-07 Arcus Biosciences Inc Anticuerpos anti-tigit
IL298946A (en) 2020-06-18 2023-02-01 Genentech Inc Treatment with anti-tigit antibodies and pd-1 axis binding antagonists
CN111718415B (zh) * 2020-07-03 2021-02-23 上海洛启生物医药技术有限公司 一种抗tigit纳米抗体及其应用
TW202216778A (zh) 2020-07-15 2022-05-01 美商安進公司 Ｔｉｇｉｔ及ｃｄ１１２ｒ阻斷
US20230265187A1 (en) * 2020-08-05 2023-08-24 Crystal Bioscience Inc. Anti-tigit antibody and methods of use thereof
CN111763660A (zh) * 2020-08-07 2020-10-13 南京大学 一种重组溶瘤痘苗病毒及其制备方法和应用
KR20230158005A (ko) 2021-03-18 2023-11-17 씨젠 인크. 생물학적 활성 화합물의 내재화된 접합체로부터의 선택적 약물 방출
IL307556A (en) 2021-04-09 2023-12-01 Seagen Inc Cancer treatment methods using antibodies against TIGIT
WO2022226100A1 (fr) 2021-04-20 2022-10-27 Seagen Inc. Modulation de la cytotoxicité cellulaire dépendante des anticorps
TW202304965A (zh) 2021-05-04 2023-02-01 美商艾吉納斯公司 抗ｔｉｇｉｔ抗體、抗ｃｄ９６抗體及其使用方法
AU2022270207A1 (en) * 2021-05-04 2023-09-28 Agenus Inc. Anti-tigit antibodies and methods of use thereof
CA3221398A1 (fr) 2021-05-28 2022-12-01 Seagen Inc. Conjugues d'anticorps d'anthracycline
JP2024527049A (ja) 2021-07-28 2024-07-19 ジェネンテック， インコーポレイテッド がんを治療するための方法及び組成物
WO2023056403A1 (fr) 2021-09-30 2023-04-06 Genentech, Inc. Méthodes de traitement de cancers hématologiques au moyen d'anticorps anti-tigit, d'anticorps anti-cd38 et d'antagonistes de liaison à l'axe pd-1
PE20242179A1 (es) 2022-03-17 2024-11-07 Seagen Inc Conjugados de camptotecina
US20250179176A1 (en) 2022-05-02 2025-06-05 Arcus Biosciences, Inc. Anti-tigit antibodies and uses of the same
IL317449A (en) 2022-06-07 2025-02-01 Genentech Inc Method for determining the efficacy of a lung cancer treatment comprising an anti-PD-L1 antagonist and an anti-TIGIT antibody-antagonist
KR102769148B1 (ko) * 2022-06-10 2025-02-20 메디맵바이오 주식회사 항-tigit 항체, 인터류킨-15, 및 인터류킨-15 수용체 알파 스시 도메인을 포함하는 융합 단백질 및 이의 용도
EP4634227A1 (fr) 2022-12-13 2025-10-22 Seagen Inc. Conjugués anticorps-médicament modifiés par la cystéine spécifiques d'un site
WO2024191807A1 (fr) 2023-03-10 2024-09-19 Seagen Inc. Méthodes de traitement du cancer à l'aide d'anticorps anti-tigit
WO2025090774A1 (fr) 2023-10-24 2025-05-01 Seagen Inc. Composés chimiothérapeutiques et procédés d'utilisation
WO2026013616A1 (fr) 2024-07-10 2026-01-15 Takeda Pharmaceutical Company Limited Compositions et méthodes pour traiter le cancer

Family Cites Families (188)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
JPH0742304B2 (ja) 1986-12-05 1995-05-10 財団法人微生物化学研究会 新規なアンスラサイクリン誘導体およびその製造法
AU600575B2 (en) 1987-03-18 1990-08-16 Sb2, Inc. Altered antibodies
DE3712350A1 (de) 1987-04-11 1988-10-20 Behringwerke Ag Semisynthetische rhodomycine, verfahren zu ihrer herstellung und ihre verwendung als zytostatika
EP0335369A3 (fr) 1988-03-29 1990-03-28 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Dérivés des anthracyclines et procédé de leur préparation
US5047335A (en) 1988-12-21 1991-09-10 The Regents Of The University Of Calif. Process for controlling intracellular glycosylation of proteins
ES2096590T3 (es) 1989-06-29 1997-03-16 Medarex Inc Reactivos biespecificos para la terapia del sida.
WO1991019725A2 (fr) 1990-06-11 1991-12-26 Biochem Pharma Inc. Analogues heterocycliques d'anthracycline et d'anthracyclinone
AU8295491A (en) 1990-06-29 1992-01-23 Biosource Technologies Incorporated Melanin production by transformed microorganisms
MY106399A (en) 1990-07-24 1995-05-30 Pfizer Cephalosporins and homologeus, preparation and pharmaceutical composition
US5192880A (en) 1990-11-13 1993-03-09 Nec Corporation High-speed emitter coupled logic circuit with large current driving capability
KR100211417B1 (ko) 1990-11-30 1999-10-01 유충식 L-탈로피라노시드 유도체 및 그의 제조방법
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
NZ241606A (en) 1991-02-28 1994-08-26 Iaf Biochem Int Heteroanthracycline antitumor analogs, preparation and pharmaceutical compositions thereof; intermediates therefor
JP3025056B2 (ja) 1991-03-12 2000-03-27 財団法人微生物化学研究会 ２，６−ジデオキシ−２−フルオロ−ｌ−タロピラノース誘導体の製造法
US5278299A (en) 1991-03-18 1994-01-11 Scripps Clinic And Research Foundation Method and composition for synthesizing sialylated glycosyl compounds
JPH04290891A (ja) 1991-03-19 1992-10-15 Yasumitsu Tamura 新規なアンスラサイクリン系化合物
DE4111971C1 (fr) 1991-04-12 1992-03-12 Wolf-Dieter Dr. 7803 Gundelfingen De Fessner
US5552534A (en) 1991-08-22 1996-09-03 The Trustees Of The University Of Pennsylvania Non-Peptide peptidomimetics
FI941572L (fi) 1991-10-07 1994-05-27 Oncologix Inc Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
SK42594A3 (en) 1991-10-15 1994-10-05 Scripps Research Inst Method of production of fucosylated carbohydrates
WO1993008829A1 (fr) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions induisant la destruction de cellules infectees par l'hiv
AU3144193A (en) 1991-11-21 1993-06-15 Board Of Trustees Of The Leland Stanford Junior University Controlling degradation of glycoprotein oligosaccharides by extracellular glycosisases
DE69333807T2 (de) 1992-02-06 2006-02-02 Chiron Corp., Emeryville Marker für krebs und biosynthetisches bindeprotein dafür
US5278311A (en) 1992-06-05 1994-01-11 E. R. Squibb & Sons, Inc. Nonionic radiographic contrast agents
US5736523A (en) 1992-11-09 1998-04-07 Biochem Pharma Inc. Antineoplastic heteronapthoquinones
DK76193D0 (da) 1993-06-25 1993-06-25 Astra Ab Kulhydratderivater
CA2126391C (fr) 1993-09-13 2002-01-08 Nobuko Yamamoto Determination d'acides nucleiques par pcr, mesure du nombre de cellules microbiennes, de genes ou d'exemplaires de genes par pcr et trousse de mesure employee a cette fin
GB9418260D0 (en) 1994-09-09 1994-10-26 Erba Carlo Spa Anthracycline derivatives
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
JPH08286368A (ja) 1995-04-14 1996-11-01 Toyo Ink Mfg Co Ltd 着色画像形成材料およびそれを用いた着色画像形成媒体と着色画像形成方法
US6245347B1 (en) 1995-07-28 2001-06-12 Zars, Inc. Methods and apparatus for improved administration of pharmaceutically active compounds
DE69601908T2 (de) 1995-09-08 1999-07-29 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Tokio/Tokyo Fluorenthaltende Anthracyclinderivate mit Mono- oder Di-0-aminoalkanoylaten Hydroxylgruppen in dem Zuckerrest
DE19541260A1 (de) 1995-11-06 1997-05-07 Lohmann Therapie Syst Lts Therapeutische Zubereitung zur transdermalen Applikation von Wirkstoffen durch die Haut
US5834597A (en) 1996-05-20 1998-11-10 Protein Design Labs, Inc. Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same
US6512010B1 (en) 1996-07-15 2003-01-28 Alza Corporation Formulations for the administration of fluoxetine
PL182601B1 (pl) 1996-07-17 2002-02-28 Waldpharm Sp Z Oo Sposób otrzymywania antybiotyków antracyklinowych
DE19640969A1 (de) 1996-10-04 1998-04-16 Bayer Ag 20-0-verknüpfte Glycokonjugate von Camptothecin
US5770407A (en) 1996-12-10 1998-06-23 The Scripps Research Institute Process for preparing nucleotide inhibitors of glycosyltransferases
FR2764304B1 (fr) 1997-06-06 1999-07-16 Rhone Poulenc Rorer Sa Nouvelle classe d'agents transfectants cationiques des acides nucleiques
JPH1135593A (ja) 1997-07-18 1999-02-09 Daikin Ind Ltd ２−フルオロフコシル−ｎ−アロイルグルコサミン誘導体及びその中間物、並びにそれらの製造方法
US6248864B1 (en) 1997-12-31 2001-06-19 Adherex Technologies, Inc. Compounds and methods and modulating tissue permeability
ES2434961T5 (es) 1998-04-20 2018-01-18 Roche Glycart Ag Ingeniería de glicosilación de anticuerpos para mejorar la citotoxicidad celular dependiente del anticuerpo
US6312717B1 (en) 1998-07-07 2001-11-06 Bristol-Myers Squibb Company Method for treatment of anxiety and depression
SE9802864D0 (sv) 1998-08-27 1998-08-27 Pharmacia & Upjohn Ab Transdermally administered tolterodine as antimuscarinic agent for the treatment of overactive bladder
MXPA01007845A (es) 1999-02-05 2004-06-22 Samsung Electronics Co Ltd Metodo para la recuperacion de la textura de imagenes y aparato para el mismo.
EP1176195B1 (fr) 1999-04-09 2013-05-22 Kyowa Hakko Kirin Co., Ltd. Methode de regulation de l'activite d'une molecule immunologiquement fonctionnelle
US6544548B1 (en) 1999-09-13 2003-04-08 Keraplast Technologies, Ltd. Keratin-based powders and hydrogel for pharmaceutical applications
US20080050809A1 (en) 1999-09-28 2008-02-28 Alejandro Abuin Novel human kinases and polynucleotides encoding the same
US20040219521A1 (en) 2000-01-21 2004-11-04 Tang Y. Tom Novel nucleic acids and polypeptides
FR2807767B1 (fr) 2000-04-12 2005-01-14 Lab Francais Du Fractionnement Anticorps monoclonaux anti-d
US6589549B2 (en) 2000-04-27 2003-07-08 Macromed, Incorporated Bioactive agent delivering system comprised of microparticles within a biodegradable to improve release profiles
US6670330B1 (en) 2000-05-01 2003-12-30 Theodore J. Lampidis Cancer chemotherapy with 2-deoxy-D-glucose
US6696081B2 (en) 2000-06-09 2004-02-24 Duke University Carbohydrate based lipid compositions and supramolecular structures comprising same
EP1296992B1 (fr) 2000-06-26 2008-04-23 Basf Se Phosphacyclohexanes et leur utilisation dans l'hydroformylation d'olefines
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
RU2321630C2 (ru) 2001-08-03 2008-04-10 Гликарт Биотекнолоджи АГ Гликозилированные антитела (варианты), обладающие повышенной антителозависимой клеточной цитотоксичностью
CA2469941A1 (fr) 2001-12-10 2003-07-03 Nuvelo, Inc. Nouveaux acides nucleiques et polypeptides
WO2003068943A2 (fr) 2002-02-13 2003-08-21 Incyte Corporation Proteines secretees
WO2003072035A2 (fr) 2002-02-22 2003-09-04 Genentech, Inc. Compositions et methodes de traitement de maladies relatives au systeme immunitaire
US7193069B2 (en) 2002-03-22 2007-03-20 Research Association For Biotechnology Full-length cDNA
AUPS247502A0 (en) 2002-05-22 2002-06-13 Griffith University An antimicrobial agent
EP1578373A4 (fr) 2002-09-11 2007-10-24 Genentech Inc Nouvelles compositions et methodes pour le traitement de maladies associees au systeme immunitaire
DE60335552D1 (de) 2002-09-11 2011-02-10 Genentech Inc Neue zusammensetzung und verfahren zur behandlung von immunerkrankungen
CA2501239A1 (fr) 2002-10-07 2004-04-22 Encore Pharmaceuticals, Inc. Esters de r-enantiomeres d'anti-inflammatoires non-steroidiens et leur utilisation
ATE472338T1 (de) 2003-02-20 2010-07-15 Seattle Genetics Inc Anti-cd70 antikörper-arzneimittelkonjugate und ihre verwendung zur behandlung von krebs
WO2004091499A2 (fr) 2003-04-09 2004-10-28 Neose Technologies, Inc. Formation intracellulaire de conjugues de peptides
CN1835962A (zh) 2003-06-03 2006-09-20 加利福尼亚大学董事会 利用乙酰化二糖治疗疾病的组合物与方法
FR2858235B1 (fr) 2003-07-31 2006-02-17 Lab Francais Du Fractionnement Utilisation d'anticorps optimises en adcc pour traiter les patients faibles repondeurs
US20070274928A1 (en) 2003-11-17 2007-11-29 Sergey Selifonov Novel Cyclic Oxygenated Compounds Having Cooling, Fragrance, and Flavor Properties, and Uses Thereof
WO2005061523A1 (fr) 2003-12-23 2005-07-07 Progen Industries Limited Composes mimetiques du glycosaminoglycane (gag)
PL369253A1 (pl) 2004-07-23 2006-02-06 Zakład Badawczo-Produkcyjny SYNTEX Sp.z o.o. Sposób otrzymywania złożonych 2-deoksy-2-jodopiranozydów o wysokiej czystości, szczególnie Annamycyny o czystości farmaceutycznej
MX2007000998A (es) 2004-07-30 2007-07-11 Rinat Neuroscience Corp Anticuerpos dirigidos peptido beta-amiloide y procedimientos que usan los mismos.
JP2008516938A (ja) 2004-10-15 2008-05-22 アストラゼネカ アクチボラグ 置換アデニンとその使用
US7632497B2 (en) 2004-11-10 2009-12-15 Macrogenics, Inc. Engineering Fc Antibody regions to confer effector function
ES2609429T3 (es) 2005-05-12 2017-04-20 Zymogenetics, Inc. Composiciones y métodos para modular respuestas inmunitarias
CA2609269C (fr) 2005-05-26 2014-08-05 Seattle Genetics, Inc. Anticorps anti-cd40 humanises et procedes d'utilisation
WO2007073478A2 (fr) 2005-12-19 2007-06-28 Genizon Biosciences Inc. Carte genetique du gene humain associe a la maladie de crohn
WO2007100728A2 (fr) 2006-02-24 2007-09-07 University Of Miami Dérivés du mannose pour tuer des cellules tumorales
WO2007101148A2 (fr) 2006-02-24 2007-09-07 Board Of Regents, The University Of Texas System Composés à base d'hexose pour traiter le cancer
US20100075377A1 (en) 2006-04-13 2010-03-25 West James W Tetramerizing polypeptides and methods of use
AU2007240491A1 (en) 2006-04-13 2007-11-01 Zymogenetics, Inc. Tetramerizing polypeptides and methods of use
US9149489B2 (en) 2006-04-27 2015-10-06 Board Of Regents, University Of Texas System Inhibitors of glycolysis useful in the treatment of brain tumors
WO2008021290A2 (fr) 2006-08-09 2008-02-21 Homestead Clinical Corporation Protéines spécifiques d'organes et procédés d'utilisation
DE102006053637B4 (de) 2006-11-14 2011-06-30 Sanofi-Aventis Deutschland GmbH, 65929 Neue mit Fluor substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE102006053635B4 (de) 2006-11-14 2011-06-30 Sanofi-Aventis Deutschland GmbH, 65929 Neue mit Benzylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DK2099823T4 (da) 2006-12-01 2022-05-09 Seagen Inc Målbindingsmiddelvarianter og anvendelser deraf
WO2008131024A1 (fr) 2007-04-17 2008-10-30 Board Of Regents, The University Of Texas System Composés d'iodo-hexose utiles pour traiter un cancer
GB0714514D0 (en) * 2007-07-26 2007-09-05 Univ City Computer system
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
JP5933894B2 (ja) 2007-09-14 2016-06-15 アディマブ， エルエルシー 合理的に設計された、合成抗体ライブラリおよびその使用
JP5496897B2 (ja) 2007-10-04 2014-05-21 ザイモジェネティクス， インコーポレイテッド Ｂ７ファミリーメンバーのｚＢ７Ｈ６ならびに関連する組成物および方法
US8293720B2 (en) 2007-12-20 2012-10-23 Dogwood Pharmaceuticals, Inc. Substituted 4-{3-[6-amino-9-(3, 4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists
CN104356177A (zh) 2008-02-12 2015-02-18 陶氏益农公司 杀虫组合物
JP5260093B2 (ja) 2008-03-10 2013-08-14 クラレノリタケデンタル株式会社 重合性単量体、重合性組成物及び歯科用材料
EP3231804B1 (fr) 2008-03-21 2021-03-03 The General Hospital Corporation Composés et compositions pour la détection et le traitement de la maladie d'alzheimer et des troubles apparentés
CN101555262A (zh) 2008-04-08 2009-10-14 中国科学院生态环境研究中心 六水合三氯化铁(FeCl3·6H2O)选择性脱除糖类化合物异头碳酰基的方法
HUE036780T2 (hu) 2008-04-09 2018-07-30 Genentech Inc Új kompozíciók és eljárások immunológiai vonatkozású betegségek kezelésére
ES2458541T5 (en) 2008-05-02 2025-08-04 Seagen Inc Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
EP2303282A4 (fr) 2008-05-23 2013-02-13 Univ Miami Traitement utilisant une application continue à faible dose d analogues de sucre
DK2396338T3 (da) 2009-02-11 2014-06-30 Dow Agrosciences Llc Pesticidsammensætninger
AU2010225456B2 (en) 2009-03-18 2016-03-17 Carina Biotech Pty Ltd Biomarkers and uses thereof
EP2411529A4 (fr) 2009-03-27 2012-09-19 Zacharon Pharmaceuticals Inc Modulateurs de la biosynthèse des glycanes n-liés
AU2010240569A1 (en) 2009-04-20 2011-10-20 Pfizer Inc. Control of protein glycosylation and compositions and methods relating thereto
WO2011019419A1 (fr) 2009-08-11 2011-02-17 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University Ciblage de tumeurs médié par un hydrate de carbone
WO2011100131A2 (fr) 2010-01-28 2011-08-18 Alnylam Pharmacuticals, Inc. Monomères et oligonucléotides comprenant un ou plusieurs adduits de cycloaddition
WO2011137528A1 (fr) 2010-05-06 2011-11-10 Simon Fraser University Méthodes et composés d'inhibition des glycosyltransférases
MX2012013899A (es) 2010-06-09 2013-03-20 Zymogenetics Inc Proteinas de fusion vstm3 dimericas y composiciones y metodos relacionados.
KR102810907B1 (ko) 2010-07-16 2025-05-21 아디맵 엘엘씨 항체 라이브러리
KR101950520B1 (ko) 2010-08-05 2019-02-20 시애틀 지네틱스, 인크. 푸코스 유사체를 사용한 생체 내에서의 단백질 푸코실화 억제 방법
EP2603596B1 (fr) 2010-08-12 2020-10-07 Novozymes, Inc. Compositions contenant un polypeptide à activité cellulolytique renforcée et une solution aqueuse et leurs utilisations
TWI410431B (zh) 2010-12-22 2013-10-01 Ind Tech Res Inst 齊敦果酸衍生物在製備預防或治療ｃ型肝炎之藥物的用途
US8923278B2 (en) 2011-01-10 2014-12-30 Vtech Telecommunications Limited Peer-to-peer, internet protocol telephone system with system-wide configuration data
US20120276108A1 (en) 2011-01-11 2012-11-01 Intertech Bio Monosaccharide-based compounds for the treatment of proliferative and inflammatory dermatological diseases
US9493452B2 (en) 2011-03-24 2016-11-15 Southern Methodist University Compounds and derivatives of 2H-pyrido (3,2-b)(1, 4) oxazin 3)4H)-ones as raf kinase and LRRK2 inhibitors
JP5990262B2 (ja) 2011-05-31 2016-09-07 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ヒドリド−トリシアノ−ボラートアニオンを含む化合物
EP2731955B1 (fr) 2011-07-15 2017-01-11 Merck Patent GmbH Composés contenant les anions alkyle, cyano, borate ou alkyle, cyano, fluoroborate
WO2013068874A1 (fr) 2011-11-11 2013-05-16 Pfizer Inc. Conjugués anticorps-médicament
CA3215250A1 (fr) 2012-03-13 2013-09-19 Salk Institute For Biological Studies Ciblage cellulaire selectif a l'aide d'adenovirus et de dimeres chimiques
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
EP2834259A4 (fr) 2012-04-02 2016-08-24 Moderna Therapeutics Inc Polynucléotides modifiés
EP2854850B1 (fr) 2012-05-25 2021-05-26 Sloan Kettering Institute For Cancer Research Compositions pour le traitement ou la prévention du syndrome gastro-intestinal et de la maladie causée par des radiations
JP2015520192A (ja) 2012-06-06 2015-07-16 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｈｉｐｐｏ経路を調節する結合剤およびその使用
WO2014089113A1 (fr) 2012-12-03 2014-06-12 Bristol-Myers Squibb Company Amélioration de l'activité anticancéreuse de protéines de fusion de fc immuno-modulatrices
KR20150090919A (ko) 2012-12-04 2015-08-06 온코메드 파마슈티칼스, 인크. 결합제를 사용한 면역요법
CN104250302B (zh) 2013-06-26 2017-11-14 上海君实生物医药科技股份有限公司 抗pd‑1抗体及其应用
AU2014290069B2 (en) 2013-07-16 2019-01-03 Genentech, Inc. Methods of treating cancer using PD-1 axis binding antagonists and TIGIT inhibitors
US10077305B2 (en) 2013-09-10 2018-09-18 Medimmune Limited Antibodies against PD-1 and uses thereof
WO2015061668A1 (fr) 2013-10-25 2015-04-30 Dana-Farber Cancer Institute, Inc. Anticorps monoclonaux anti-pd-l1 et fragments de ceux-ci
WO2015073682A1 (fr) 2013-11-13 2015-05-21 Oregon Health And Science University Procédés de détection de cellules présentant une infection latente par le vih
RS63295B1 (sr) * 2013-12-24 2022-06-30 Janssen Pharmaceutica Nv Anti-vista antitela i fragmenti
US20170107300A1 (en) 2014-03-21 2017-04-20 The Brigham And Women's Hospital, Inc. Methods and compositions for treatment of immune-related diseases or disorders and/or therapy monitoring
JP2017522311A (ja) 2014-07-16 2017-08-10 ジェネンテック， インコーポレイテッド Ｔｉｇｉｔ阻害剤及び抗癌剤を使用する癌の治療方法
MY198017A (en) 2014-08-19 2023-07-26 Merck Sharp & Dohme Anti-tigit antibodies
PL3212230T3 (pl) 2014-10-29 2021-07-26 Seagen Inc. Dawkowanie i podawanie niefukozylowanych przeciwciał anty-CD40
WO2016073906A2 (fr) 2014-11-06 2016-05-12 Scholar Rock, Inc. Immunoessais liés à des facteurs de croissance transformants
KR20170072343A (ko) 2014-11-06 2017-06-26 제넨테크, 인크. Ox40 결합 효능제 및 tigit 억제제를 포함하는 병용 요법
AU2015343048A1 (en) 2014-11-06 2017-05-18 Children's Research Institute, Children's National Medical Center Immunotherapeutics for cancer and autoimmune diseases
ES2905615T3 (es) 2014-11-20 2022-04-11 Promega Corp Sistemas y métodos para evaluar moduladores de puntos de control inmunitario
TWI595006B (zh) 2014-12-09 2017-08-11 禮納特神經系統科學公司 抗ｐｄ－１抗體類和使用彼等之方法
CA3175979A1 (fr) 2014-12-22 2016-06-30 Pd-1 Acquisition Group, Llc Anticorps anti-pd-1
AR103268A1 (es) 2014-12-23 2017-04-26 Bristol Myers Squibb Co Anticuerpos contra tigit
JP2018502123A (ja) 2015-01-20 2018-01-25 イミューンエクサイト， インコーポレイテッド 癌免疫療法のための組成物及び方法
US10227408B2 (en) 2015-02-19 2019-03-12 Compugen Ltd. Anti-PVRIG antibodies and methods of use
EP3259597B1 (fr) 2015-02-19 2022-04-06 Compugen Ltd. Polypeptides pvrig et méthodes de traitement
WO2016166139A1 (fr) 2015-04-14 2016-10-20 Eberhard Karls Universität Tübingen Protéines de fusion bispécifiques pour augmenter les réponses immunitaires de lymphocytes contre des cellules tumorales
EP3283508B1 (fr) 2015-04-17 2021-03-17 Alpine Immune Sciences, Inc. Protéines immunomodulatrices à affinités accordables
US11022615B2 (en) 2015-05-04 2021-06-01 University Of Florida Research Foundation, Inc. Regulatory T-cells, method for their isolation and uses
TWI715587B (zh) 2015-05-28 2021-01-11 美商安可美德藥物股份有限公司 Ｔｉｇｉｔ結合劑和彼之用途
WO2016196389A1 (fr) 2015-05-29 2016-12-08 Bristol-Myers Squibb Company Traitement du néphrocarcinome
AU2016270996A1 (en) 2015-06-03 2017-11-23 Dana-Farber Cancer Institute, Inc. Methods to induce conversion of regulatory T cells into effector T cells for cancer immunotherapy
JO3620B1 (ar) 2015-08-05 2020-08-27 Amgen Res Munich Gmbh مثبطات نقطة فحص مناعية للاستخدام في علاج سرطانات محمولة عبر الدم
WO2017030823A2 (fr) 2015-08-14 2017-02-23 Merck Sharp & Dohme Corp. Anticorps anti-tigit
WO2017040666A2 (fr) 2015-08-31 2017-03-09 Oncomed Pharmaceuticals, Inc. Polythérapie pour le traitement d'une maladie
WO2017040660A1 (fr) 2015-08-31 2017-03-09 Oncomed Pharmaceuticals, Inc. Polythérapie pour le traitement d'une maladie
WO2017037707A1 (fr) 2015-09-02 2017-03-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Anticorps spécifiques contre le domaine d'immunoglobuline de lymphocyte t et itim (tigit)
CA2997551A1 (fr) 2015-09-04 2017-03-09 Memorial Sloan Kettering Cancer Center Compositions a base de cellules immunitaires et leurs procedes d'utilisation
AU2016323069A1 (en) 2015-09-14 2018-04-12 Alpine Immune Sciences, Inc. Tunable variant immunoglobulin superfamily domains and engineered cell therapy
AU2016322934A1 (en) 2015-09-14 2018-04-12 Compass Therapeutics Llc Compositions and methods for treating cancer via antagonism of the CD155/TIGIT pathway and TGF-beta
KR20250021613A (ko) 2015-09-25 2025-02-13 제넨테크, 인크. 항-tigit 항체 및 이의 이용 방법
KR20180068990A (ko) 2015-10-01 2018-06-22 포텐자 테라퓨틱스, 인코포레이티드 항-tigit 항체-결합 단백질 및 이의 사용 방법
US10183060B2 (en) 2015-10-01 2019-01-22 Heat Biologics, Inc. Compositions and methods for adjoining type I and type II extracellular domains as heterologous chimeric proteins
SMT202200118T1 (it) 2015-11-03 2022-05-12 Janssen Biotech Inc Anticorpi che legano specificamente pd-1 e loro usi
AU2016362993A1 (en) 2015-12-04 2018-07-12 Seagen Inc. Cancer treatment using 2-deoxy-2-fluoro-L-fucose in combination with a checkpoint inhibitor
JP7123794B2 (ja) 2015-12-09 2022-08-23 メモリアル スローン ケタリング キャンサー センター 免疫細胞組成物及びそれを使用する方法
CN109071666B (zh) 2016-03-01 2022-06-28 耶路撒冷希伯来大学伊森姆研究发展有限公司 人脊髓灰质炎病毒受体(pvr)特异性抗体
US10537633B2 (en) 2016-03-04 2020-01-21 Jn Biosciences Llc Antibodies to TIGIT
WO2017180587A2 (fr) 2016-04-11 2017-10-19 Obsidian Therapeutics, Inc. Systèmes de biocircuits régulés
US11078282B2 (en) 2016-04-15 2021-08-03 Alpine Immune Sciences, Inc. CD80 variant immunomodulatory proteins and uses thereof
SG11201808457PA (en) 2016-04-15 2018-10-30 Alpine Immune Sciences Inc Icos ligand variant immunomodulatory proteins and uses thereof
US11078247B2 (en) 2016-05-04 2021-08-03 Curevac Ag RNA encoding a therapeutic protein
US11400116B2 (en) 2016-05-06 2022-08-02 The Regents Of The University Of California Systems and methods for targeting cancer cells
CA3023980A1 (fr) 2016-05-16 2017-11-23 Checkmab S.R.L. Marqueurs a deregulation selective presents dans des lymphocytes t regulateurs infiltrant la tumeur
TWI640536B (zh) 2016-06-20 2018-11-11 克馬伯有限公司 抗體
CN110088127A (zh) 2016-07-28 2019-08-02 高山免疫科学股份有限公司 Cd155变体免疫调节蛋白及其用途
US11834490B2 (en) 2016-07-28 2023-12-05 Alpine Immune Sciences, Inc. CD112 variant immunomodulatory proteins and uses thereof
CN112274637A (zh) 2016-08-17 2021-01-29 康姆普根有限公司 抗tigit抗体、抗pvrig抗体及其组合
CA3034691A1 (fr) 2016-08-30 2018-03-08 Memorial Sloan Kettering Cancer Center Compositions de cellules immunitaires et procedes d'utilisation pour le traitement d'infections virales et d'autres infections
WO2018041120A1 (fr) 2016-08-31 2018-03-08 Beijing Biocytogen Co., Ltd Animal non humain génétiquement modifié avec un tigit humain ou chimérique
IL300982B2 (en) 2016-09-10 2024-08-01 Yeda Res & Dev Reducing systemic regulatory t cell levels or activity fortreatment of " disease and injury of the cns
EP3293271A1 (fr) 2016-09-12 2018-03-14 The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin Marqueur et cible en tant que variable de diagnostic et cible pour therapie de cancer metastatique
US20190225701A1 (en) 2016-09-26 2019-07-25 The Brigham And Women's Hospital, Inc. Regulators of b cell-mediated immunosuppression
US10759855B2 (en) * 2016-12-02 2020-09-01 Rigel Pharmaceuticals, Inc. Antigen binding molecules to TIGIT
MX2019010206A (es) 2017-02-28 2019-12-11 Seattle Genetics Inc Anticuerpos anti inmunorreceptor de linfocitos t con dominios de motivo de inactivación basado en tirosina de inmunorreceptor e inmunoglobulina (tigit).
JOP20190203A1 (ar) 2017-03-30 2019-09-03 Potenza Therapeutics Inc بروتينات رابطة لمولد ضد مضادة لـ tigit وطرق استخدامها

Also Published As

Publication number Publication date
IL280780A (en) 2021-04-29
US20230050440A1 (en) 2023-02-16
EP3841123A2 (fr) 2021-06-30
WO2020041541A2 (fr) 2020-02-27
SG11202101429YA (en) 2021-03-30
JP2021534196A (ja) 2021-12-09
TW202023625A (zh) 2020-07-01
CN112638944A (zh) 2021-04-09
US20200062859A1 (en) 2020-02-27
KR20210057053A (ko) 2021-05-20
WO2020041541A3 (fr) 2020-03-26
MX2021002002A (es) 2021-05-31
JP2023182854A (ja) 2023-12-26
BR112021003156A2 (pt) 2021-05-11
US11401339B2 (en) 2022-08-02
CA3107596A1 (fr) 2020-02-27
WO2020041541A9 (fr) 2020-08-06
AU2019324170A1 (en) 2021-02-18

Similar Documents

Publication Publication Date Title
MA52884A (fr) Anticorps anti-il-11
MA53434A (fr) Anticorps anti-tigit
EP3903817A4 (fr) Nouvel anticorps anti-ccr8
EP3784699A4 (fr) Anticorps anti-tl1a optimisés
EP3883970A4 (fr) Anticorps anti-b7-h3
MA52742A (fr) Anticorps bispécifiques dll3-cd3
EP3589313A4 (fr) Anticorps anti-tigit
MA49034A (fr) Anticorps anti-lag3
MA47268A (fr) Anticorps anti-gpc3
MA52212A (fr) Anticorps multivalent
EP3498840A4 (fr) Anticorps anti-lag-3
EP3423089A4 (fr) Anticorps anti-tigit
EP3684806A4 (fr) Nouveaux anticorps anti-cd3epsilon
EP3492591A4 (fr) Anticorps anti-b7-h4
EP3617231A4 (fr) Anticorps anti-gpc-1
MA52152A (fr) Anticorps
EP3526247A4 (fr) Anticorps anti-il1-rap
EP3752536A4 (fr) Anticorps anti-her2
EP3831851A4 (fr) Anticorps anti-btla
MA51134A (fr) Anticorps anti-alpha-synucléine
EP3399992A4 (fr) Anticorps autoréticulants
EP3484919A4 (fr) Anticorps anti-bêta-amyloïde
EP3995582A4 (fr) Anticorps anti-epha4
MA51135A (fr) Anticorps anti-alpha-synucléine
EP3746120A4 (fr) Anticorps anti-pd-1