MA56508A - Inhibiteur d'egfr pour le traitement du cancer - Google Patents

Inhibiteur d'egfr pour le traitement du cancer

Info

Publication number
MA56508A
MA56508A MA056508A MA56508A MA56508A MA 56508 A MA56508 A MA 56508A MA 056508 A MA056508 A MA 056508A MA 56508 A MA56508 A MA 56508A MA 56508 A MA56508 A MA 56508A
Authority
MA
Morocco
Prior art keywords
cancer
treatment
egfr inhibitor
egfr
inhibitor
Prior art date
Application number
MA056508A
Other languages
English (en)
Other versions
MA56508B1 (fr
Inventor
Cosimo Dolente
Annick Goergler
David Hewings
Georg Jaeschke
Bernd Kuhn
Yvonne Alice Nagel
Sander Ulrike Obst
Antonio Ricci
Daniel Rueher
Sandra Steiner
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA56508A publication Critical patent/MA56508A/fr
Publication of MA56508B1 publication Critical patent/MA56508B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MA56508A 2019-06-21 2020-06-19 Inhibiteur de l'egfr pour le traitement du cancer MA56508B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19181754 2019-06-21
PCT/EP2020/067076 WO2020254562A1 (fr) 2019-06-21 2020-06-19 Inhibiteur d'egfr pour le traitement du cancer

Publications (2)

Publication Number Publication Date
MA56508A true MA56508A (fr) 2022-04-27
MA56508B1 MA56508B1 (fr) 2023-11-30

Family

ID=67139601

Family Applications (1)

Application Number Title Priority Date Filing Date
MA56508A MA56508B1 (fr) 2019-06-21 2020-06-19 Inhibiteur de l'egfr pour le traitement du cancer

Country Status (31)

Country Link
US (5) US12344613B2 (fr)
EP (4) EP3986898B1 (fr)
JP (4) JP7550800B2 (fr)
KR (1) KR102913816B1 (fr)
CN (4) CN113993872B (fr)
AR (4) AR119209A1 (fr)
AU (1) AU2020295703B2 (fr)
BR (1) BR112021025445B1 (fr)
CA (1) CA3140485A1 (fr)
CL (1) CL2021003408A1 (fr)
CO (1) CO2021017173A2 (fr)
CR (1) CR20210624A (fr)
DK (1) DK3986897T3 (fr)
ES (1) ES2961187T3 (fr)
FI (1) FI3986897T3 (fr)
HR (1) HRP20231276T1 (fr)
HU (1) HUE063676T2 (fr)
IL (1) IL288522B2 (fr)
LT (1) LT3986897T (fr)
MA (1) MA56508B1 (fr)
MX (1) MX2021015464A (fr)
MY (1) MY209340A (fr)
PE (1) PE20220576A1 (fr)
PH (1) PH12021553190A1 (fr)
PL (1) PL3986897T3 (fr)
PT (1) PT3986897T (fr)
RS (1) RS64720B1 (fr)
SI (1) SI3986897T1 (fr)
TW (4) TW202115074A (fr)
UA (1) UA129328C2 (fr)
WO (4) WO2020254568A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA56507A (fr) * 2019-06-21 2022-04-27 Hoffmann La Roche Nouveaux inhibiteurs d'egfr
IL288522B2 (en) * 2019-06-21 2025-02-01 Hoffmann La Roche EGFR inhibitor for cancer treatment
AU2020383423A1 (en) 2019-11-11 2022-06-23 Dana-Farber Cancer Institute, Inc. Allosteric EGFR inhibitors and methods of use thereof
EP4255906A1 (fr) * 2020-12-01 2023-10-11 F. Hoffmann-La Roche AG Nouveaux dérivés d'indazole
EP4255907A1 (fr) 2020-12-01 2023-10-11 F. Hoffmann-La Roche AG Nouveaux dérivés d'indazole
CA3174207A1 (fr) * 2021-05-26 2022-12-01 Christopher G. Nasveschuck Degradateurs du recepteur du facteur de croissance epidermique (egfr) pour traiter le cancer metastase dans le cerveau ou le systeme nerveux central
JP2025515833A (ja) * 2022-05-13 2025-05-20 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 新規インダゾール誘導体
US20260007678A1 (en) * 2022-05-13 2026-01-08 Hoffmann-La Roche Inc. Combination of allosteric and orthosteric egfr inhibitors for the treatment of cancer
AU2024241633A1 (en) 2023-03-30 2025-11-06 Revolution Medicines, Inc. Compositions for inducing ras gtp hydrolysis and uses thereof
TW202508595A (zh) 2023-05-04 2025-03-01 美商銳新醫藥公司 用於ｒａｓ相關疾病或病症之組合療法
US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
AU2024360465A1 (en) 2023-10-12 2026-04-09 Revolution Medicines, Inc. Macrocyclic ras inhibitors
WO2025171296A1 (fr) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Inhibiteurs de ras
TW202547461A (zh) 2024-05-17 2025-12-16 美商銳新醫藥公司 Ｒａｓ抑制劑
WO2025255438A1 (fr) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Procédés de traitement d'une maladie ou d'un trouble lié à la protéine ras
WO2025265060A1 (fr) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Compositions thérapeutiques et procédés de gestion d'effets liés au traitement
WO2026006747A1 (fr) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Inhibiteurs de ras
WO2026015790A1 (fr) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Méthodes de traitement d'une maladie ou d'un trouble lié à ras
WO2026015801A1 (fr) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Méthodes de traitement d'une maladie ou d'un trouble liés à ras
WO2026015796A1 (fr) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Méthodes de traitement d'une maladie ou d'un trouble lié à ras
WO2026015825A1 (fr) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Utilisation d'un inhibiteur de ras pour traiter le cancer du pancréas
WO2026050446A1 (fr) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Inhibiteurs de ras
WO2026072904A2 (fr) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions et méthodes de traitement du cancer du poumon

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0508715D0 (en) * 2005-04-29 2005-06-08 Astrazeneca Ab Chemical compounds
CN101273033A (zh) * 2005-09-20 2008-09-24 阿斯利康(瑞典)有限公司 作为治疗癌症的erbb受体酪氨酸激酶抑制剂的4-（1h-吲哚-5-基-氨基）-喹唑啉化合物
US20110212078A1 (en) 2008-06-25 2011-09-01 Reddy Panduranga Adulla P Synthesis and use of heterocyclic antibacterial agents
US8420661B2 (en) 2010-04-13 2013-04-16 Hoffmann-La Roche Inc. Arylethynyl derivatives
EP2964638B1 (fr) 2013-03-06 2017-08-09 Astrazeneca AB Inhibiteurs quinazoline de l'activation des formes mutantes du récepteur de croissance épidermique (egfr)
WO2015095807A1 (fr) * 2013-12-20 2015-06-25 Biomed Valley Discoveries, Inc. Traitements du cancer au moyen de combinaisons d'inhibiteurs de l'egfr et de l'erk
CN105777756B (zh) * 2014-07-02 2019-03-01 广东东阳光药业有限公司 杂芳化合物及其在药物中的应用
CN107108613B (zh) * 2014-11-10 2020-02-25 基因泰克公司 布罗莫结构域抑制剂及其用途
BR112017024481B1 (pt) 2015-05-14 2020-11-17 The Wistar Institute Of Anatomy And Biology composto inibidor de ebna1, composição farmacêutica compreendendo dito composto e usos terapêuticos do mesmo
JP6845165B2 (ja) 2015-06-30 2021-03-17 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド Ｅｇｆｒ阻害剤およびその使用方法
TW201834651A (zh) 2016-12-22 2018-10-01 瑞士商赫孚孟拉羅股份公司 化合物
WO2018220149A1 (fr) * 2017-06-02 2018-12-06 F. Hoffmann-La Roche Ag Composés
UA126452C2 (uk) 2017-06-02 2022-10-05 Ф. Хоффманн-Ля Рош Аг Похідні ізоіндолу
WO2019046668A1 (fr) * 2017-08-31 2019-03-07 Kezar Life Sciences Thiazoles à substitution amide utilisés en tant qu'inhibiteurs de la sécrétine protéique
PE20211388A1 (es) 2018-06-29 2021-07-27 Hoffmann La Roche Compuestos
IL288522B2 (en) 2019-06-21 2025-02-01 Hoffmann La Roche EGFR inhibitor for cancer treatment
JP7561777B2 (ja) 2019-06-21 2024-10-04 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 新規ｅｇｆｒ阻害剤
MA56507A (fr) 2019-06-21 2022-04-27 Hoffmann La Roche Nouveaux inhibiteurs d'egfr
AR120799A1 (es) 2019-12-20 2022-03-16 Hoffmann La Roche 2-[4-cloro-6-[2-[4-[[4-(hidroximetil)-1-piperidil]metil]fenil]etinil]-1-oxoisoindolin-2-il]-2-(6,7-dihidro-5h-pirrolo[1,2-c]imidazol-1-il)-n-tiazol-2-il-acetamida como inhibidor de egfr
AR120800A1 (es) 2019-12-20 2022-03-16 Hoffmann La Roche Derivados de 6,7-dihidro-5h-pirrolo[1,2-c]imidazol como inhibidores de egfr
EP4255907A1 (fr) 2020-12-01 2023-10-11 F. Hoffmann-La Roche AG Nouveaux dérivés d'indazole
EP4255906A1 (fr) 2020-12-01 2023-10-11 F. Hoffmann-La Roche AG Nouveaux dérivés d'indazole
CA3197659A1 (fr) 2020-12-01 2022-06-09 F. Hoffman-La Roche Ag Nouveaux derives d'indazole acetylene
US20260007678A1 (en) 2022-05-13 2026-01-08 Hoffmann-La Roche Inc. Combination of allosteric and orthosteric egfr inhibitors for the treatment of cancer
JP2025515833A (ja) 2022-05-13 2025-05-20 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 新規インダゾール誘導体

Also Published As

Publication number Publication date
JP2022537191A (ja) 2022-08-24
WO2020254565A1 (fr) 2020-12-24
AR119206A1 (es) 2021-12-01
JP7550800B2 (ja) 2024-09-13
EP3986896B1 (fr) 2023-03-15
US20220315593A1 (en) 2022-10-06
TW202115071A (zh) 2021-04-16
AR119209A1 (es) 2021-12-01
AU2020295703B2 (en) 2026-02-12
US20250289824A1 (en) 2025-09-18
CL2021003408A1 (es) 2022-10-14
KR20220024105A (ko) 2022-03-03
WO2020254572A1 (fr) 2020-12-24
CN113993872B (zh) 2024-09-24
AR119208A1 (es) 2021-12-01
US20220135571A1 (en) 2022-05-05
AU2020295703A1 (en) 2022-01-06
EP3986895B1 (fr) 2023-03-15
HRP20231276T1 (hr) 2024-02-02
EP3986895A1 (fr) 2022-04-27
SI3986897T1 (sl) 2023-12-29
JP2022538055A (ja) 2022-08-31
BR112021025445A2 (pt) 2022-02-01
CN114008049B (zh) 2024-07-05
CN113993873A (zh) 2022-01-28
CN113966335B (zh) 2024-08-02
TW202115053A (zh) 2021-04-16
US12344613B2 (en) 2025-07-01
IL288522B1 (en) 2024-10-01
PH12021553190A1 (en) 2022-11-07
DK3986897T3 (da) 2023-10-30
CR20210624A (es) 2022-02-14
UA129328C2 (uk) 2025-03-19
WO2020254562A1 (fr) 2020-12-24
CN113966335A (zh) 2022-01-21
WO2020254568A1 (fr) 2020-12-24
TW202115074A (zh) 2021-04-16
CN114008049A (zh) 2022-02-01
LT3986897T (lt) 2023-11-10
CA3140485A1 (fr) 2020-12-24
ES2961187T3 (es) 2024-03-08
JP7550798B2 (ja) 2024-09-13
JP2022538403A (ja) 2022-09-02
EP3986897A1 (fr) 2022-04-27
CO2021017173A2 (es) 2022-01-17
JP7550799B2 (ja) 2024-09-13
IL288522B2 (en) 2025-02-01
US12479849B2 (en) 2025-11-25
RS64720B1 (sr) 2023-11-30
PL3986897T3 (pl) 2024-01-22
CN113993872A (zh) 2022-01-28
JP2022537769A (ja) 2022-08-29
FI3986897T3 (fi) 2023-10-20
TWI869416B (zh) 2025-01-11
EP3986898B1 (fr) 2023-03-15
PE20220576A1 (es) 2022-04-20
TW202115072A (zh) 2021-04-16
EP3986898A1 (fr) 2022-04-27
MX2021015464A (es) 2022-01-24
AR119210A1 (es) 2021-12-01
EP3986897B1 (fr) 2023-08-30
US20220315592A1 (en) 2022-10-06
JP7530391B2 (ja) 2024-08-07
US20230054473A1 (en) 2023-02-23
MA56508B1 (fr) 2023-11-30
MY209340A (en) 2025-07-03
HUE063676T2 (hu) 2024-01-28
CN113993873B (zh) 2024-08-02
PT3986897T (pt) 2023-10-23
BR112021025445B1 (pt) 2024-02-27
KR102913816B1 (ko) 2026-01-16
EP3986896A1 (fr) 2022-04-27
IL288522A (en) 2022-01-01

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