MA56748B1 - Formes à l'état solide de (s)-2-(((s)-6,8-difluoro-1,2,3,4-tétrahydronaphthalén-2-yl)amino)-n-(1-(2-méthyl-1-(néopentylamino)propan-2-yl)-1h-imidazol-4-yl)pentanamide et utilisations assosiées - Google Patents

Formes à l'état solide de (s)-2-(((s)-6,8-difluoro-1,2,3,4-tétrahydronaphthalén-2-yl)amino)-n-(1-(2-méthyl-1-(néopentylamino)propan-2-yl)-1h-imidazol-4-yl)pentanamide et utilisations assosiées

Info

Publication number
MA56748B1
MA56748B1 MA56748A MA56748A MA56748B1 MA 56748 B1 MA56748 B1 MA 56748B1 MA 56748 A MA56748 A MA 56748A MA 56748 A MA56748 A MA 56748A MA 56748 B1 MA56748 B1 MA 56748B1
Authority
MA
Morocco
Prior art keywords
solid forms
diflooro
neopentylamino
pentanamide
tetrahydronaphthalen
Prior art date
Application number
MA56748A
Other languages
English (en)
Inventor
Elaine Greer
Stephen Anderson
Mark MALONEY
Shu Yu
Ekaterina Albert
Emily Rigsbee
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Priority claimed from PCT/US2019/045948 external-priority patent/WO2021029854A1/fr
Publication of MA56748B1 publication Critical patent/MA56748B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne : a) des formes à l'état solide de sels de bromhydrate du composé 1; b) des compositions pharmaceutiques comprenant une ou plusieurs formes à l'état solide de sels de bromhydrate du composé 1, et, éventuellement, un excipient pharmaceutiquement acceptable; c) des méthodes de traitement de tumeurs ou de cancers par administration d'une ou de plusieurs formes à l'état solide de sels de bromhydrate du composé 1 à un sujet en ayant besoin; et d) des procédés de préparation des formes à l'état solide du composé 1.
MA56748A 2019-08-09 2019-08-09 Formes à l'état solide de (s)-2-(((s)-6,8-difluoro-1,2,3,4-tétrahydronaphthalén-2-yl)amino)-n-(1-(2-méthyl-1-(néopentylamino)propan-2-yl)-1h-imidazol-4-yl)pentanamide et utilisations assosiées MA56748B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US2019/045948 WO2021029854A1 (fr) 2019-08-09 2019-08-09 Formes à l'état solide de (s)-2-(((s)-6,8-difluoro-1,2,3,4-tétrahydronaphthalén-2-yl)amino)-n-(1-(2-méthyl-1-(néopentylamino)propan-2-yl)-1h-imidazol-4-yl)pentanamide et utilisations assosiées
US16/537,394 US10590087B1 (en) 2019-08-09 2019-08-09 Solid state forms of (S)-2-(((S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide and uses thereof
EP19758589.6A EP4010322B1 (fr) 2019-08-09 2019-08-09 Formes à l'état solide de (s)-2-(((s)-6,8-difluoro-1,2,3,4-tétrahydronaphthalén-2-yl)amino)-n-(1-(2-méthyl-1-(néopentylamino)propan-2-yl)-1h-imidazol-4-yl)pentanamide et utilisations assosiées

Publications (1)

Publication Number Publication Date
MA56748B1 true MA56748B1 (fr) 2025-12-31

Family

ID=69778968

Family Applications (1)

Application Number Title Priority Date Filing Date
MA56748A MA56748B1 (fr) 2019-08-09 2019-08-09 Formes à l'état solide de (s)-2-(((s)-6,8-difluoro-1,2,3,4-tétrahydronaphthalén-2-yl)amino)-n-(1-(2-méthyl-1-(néopentylamino)propan-2-yl)-1h-imidazol-4-yl)pentanamide et utilisations assosiées

Country Status (13)

Country Link
US (11) US10590087B1 (fr)
JP (1) JP2024149803A (fr)
KR (1) KR20250030524A (fr)
ES (1) ES3055762T3 (fr)
FI (1) FI4010322T3 (fr)
FR (1) FR26C1013I1 (fr)
LT (1) LTPA2026516I1 (fr)
MA (1) MA56748B1 (fr)
MX (1) MX2025004371A (fr)
PL (1) PL4010322T3 (fr)
SI (1) SI4010322T1 (fr)
TW (1) TWI867022B (fr)
ZA (1) ZA202202325B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL4010322T3 (pl) * 2019-08-09 2026-02-16 Pfizer Inc. Stałe postacie (s)-2-(((s)-6,8-difluoro-1,2,3,4-tetrahydronaftalen-2-ylo)amino)-n-(1-(2-metylo-1-(neopentyloamino)propan-2-ylo)-1h-imidazol-4-ilo)pentanamidu i ich zastosowanie
US20230049311A1 (en) * 2019-08-09 2023-02-16 Springworks Therapeutics, Inc. Methods of treating desmoid tumors with (s)-2-(((s)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-n-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1h-imidazol-4-yl)pentanamide
US11884634B2 (en) * 2019-08-09 2024-01-30 Pfizer Inc. Compositions of solid forms of (S)-2-(((S)-6,8-difluoro-1,2,3,4- tetrahydronaphthalen-2-yl)amino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide
AU2021244215A1 (en) 2020-03-26 2022-10-13 Seagen Inc. Methods of treating multiple myeloma
IL300405A (en) 2020-08-20 2023-04-01 Univ Leland Stanford Junior Methods for treating respiratory diseases characterized by excessive secretion of mucus
TWI905452B (zh) 2021-09-01 2025-11-21 美商斯普林渥克斯治療有限公司 尼羅司他（ｎｉｒｏｇａｃｅｓｔａｔ）之合成
US11504354B1 (en) 2021-09-08 2022-11-22 SpringWorks Therapeutics Inc.. Chlorinated tetralin compounds and pharmaceutical compositions
WO2023081830A2 (fr) * 2021-11-05 2023-05-11 Springworks Therapeutics, Inc. Compositions et traitements à base de nirogacestat
WO2023150559A2 (fr) * 2022-02-01 2023-08-10 Springworks Therapeutics, Inc. Traitement du cancer de l'ovaire avec du nirogacestat
WO2023174390A1 (fr) * 2022-03-17 2023-09-21 苏州科睿思制药有限公司 Forme cristalline de dihydrobromure de nirogacestat, son procédé de préparation et son utilisation
US12036207B2 (en) 2022-05-20 2024-07-16 Springworks Therapeutics, Inc. Treatments with nirogacestat
US12138246B2 (en) 2022-05-20 2024-11-12 Springworks Therapeutics, Inc. Treatments with nirogacestat
US11951096B2 (en) 2022-05-20 2024-04-09 Springworks Therapeutics, Inc. Treatments with nirogacestat
CN119486713A (zh) * 2022-05-20 2025-02-18 斯普林渥克斯治疗有限公司 尼罗加司他治疗
EP4678635A1 (fr) * 2023-03-09 2026-01-14 Crystal Pharmaceutical (Suzhou) Co., Ltd. Forme cristalline de dihydrobromate de nirogacestat, son procédé de préparation et son utilisation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO5160260A1 (es) 1999-02-19 2002-05-30 Lilly Co Eli Secretagogos de la hormona del crecimiento derivados de imi- dazol 1,4- substituido
GT200100147A (es) 2000-07-31 2002-06-25 Derivados de imidazol
ATE399155T1 (de) 2004-03-23 2008-07-15 Pfizer Prod Inc Imidazolverbindungen zur behandlung von neurodegenerativen erkrankungen
US10211310B2 (en) 2012-06-12 2019-02-19 Novellus Systems, Inc. Remote plasma based deposition of SiOC class of films
WO2015092614A1 (fr) 2013-12-20 2015-06-25 Pfizer Inc. Altérations d'activation de notch dans le cancer du sein
KR20180030545A (ko) * 2015-06-22 2018-03-23 다이닛본 스미토모 세이야꾸 가부시끼가이샤 바이사이클릭 헤테로사이클릭 아미드 유도체
WO2018045273A2 (fr) 2016-09-02 2018-03-08 The Brigham And Women's Hospital, Inc. Compositions et méthodes pour le traitement de néoplasies
WO2019053727A1 (fr) 2017-09-18 2019-03-21 Ramot At Tel-Aviv University Ltd. Redifférenciation de cellules développées in vitro à partir de cellules bêta d'îlots pancréatiques humains adultes par des inhibiteurs à petites molécules de la voie de signalisation
WO2020131998A1 (fr) * 2018-12-18 2020-06-25 The University Of North Carolina At Chapel Hill Inhibiteurs de notch pour le traitement de malformations vasculaires
PL4010322T3 (pl) 2019-08-09 2026-02-16 Pfizer Inc. Stałe postacie (s)-2-(((s)-6,8-difluoro-1,2,3,4-tetrahydronaftalen-2-ylo)amino)-n-(1-(2-metylo-1-(neopentyloamino)propan-2-ylo)-1h-imidazol-4-ilo)pentanamidu i ich zastosowanie
US20230049311A1 (en) 2019-08-09 2023-02-16 Springworks Therapeutics, Inc. Methods of treating desmoid tumors with (s)-2-(((s)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-n-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1h-imidazol-4-yl)pentanamide

Also Published As

Publication number Publication date
US11820748B2 (en) 2023-11-21
US10590087B1 (en) 2020-03-17
US10710966B1 (en) 2020-07-14
JP2024149803A (ja) 2024-10-18
US12116347B2 (en) 2024-10-15
PL4010322T3 (pl) 2026-02-16
US11905255B1 (en) 2024-02-20
US20230167069A1 (en) 2023-06-01
LTPA2026516I1 (fr) 2026-05-11
US20230406827A1 (en) 2023-12-21
US20210269407A1 (en) 2021-09-02
TWI867022B (zh) 2024-12-21
US11845732B2 (en) 2023-12-19
US11884635B2 (en) 2024-01-30
TW202525782A (zh) 2025-07-01
TW202120482A (zh) 2021-06-01
US20210040045A1 (en) 2021-02-11
ZA202202325B (en) 2024-06-26
KR20250030524A (ko) 2025-03-05
MX2025004371A (es) 2025-05-02
US20260078096A1 (en) 2026-03-19
US11566006B2 (en) 2023-01-31
US20240051924A1 (en) 2024-02-15
ES3055762T3 (en) 2026-02-16
US20230382872A1 (en) 2023-11-30
SI4010322T1 (sl) 2026-02-27
FI4010322T3 (fi) 2025-12-16
US12297177B2 (en) 2025-05-13
US20230202987A1 (en) 2023-06-29
FR26C1013I1 (fr) 2026-04-24
US10941118B2 (en) 2021-03-09
US20240150299A1 (en) 2024-05-09

Similar Documents

Publication Publication Date Title
ZA202202325B (en) Solid state forms of (s)-2-(((s)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-n-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1h-imidazol-4-yl)pentanamide and uses thereof
MX2023007192A (es) Inhibidores de prmt5.
MX2023009222A (es) Inhibidores tricíclicos-amido-bicíclicos de prmt5.
MA58498B1 (fr) Agonistes hétérocycliques de glp-1
MA55145B1 (fr) Polythérapie incluant un inhibiteur de kras g12c et un ou plusieurs principes pharmaceutiquement actifs supplémentaires pour le traitement de cancers
MX2024011056A (es) Compuesto heterociclico para inducir la degradacion de la proteina kras mutante g12d.
MX2025000772A (es) Compuesto heterociclico que actua sobre la proteina kras mutante g12d
MA34903B1 (fr) Derives de type azaindazole ou diazaindazole utilises comme medicaments
MA41496B1 (fr) Compositions pharmaceutiques comprenant n-(3,5-dimethoxyphenyl)-n'-(1-methylethyl)-n-[3-(1-methyl-1h-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine
MA40111A1 (fr) Dérivés du tétrahydronaphtalène inhibant la protéine mcl-1
CO2022002731A2 (es) Formas en estado sólido de (s)-2-(((s)-6,8-diflúor-1,2,3,4-tetrahidronaftalen-2-il)amino)-n-(1-(2-metil-1-(neopentilamino)propan-2-il)-1h-imidazol-4-il)pentanamida y usos de la misma
MA56883B1 (fr) Dérivés de 2-hydroxycycloalcane-1-carbamoyle
JOP20220104A1 (ar) نظام تجريع لعوامل مضادة لـ dll3
MA53927B1 (fr) Composition pharmaceutique pour une administration par voie orale comprenant un dérivé d'aminopyrimidine ou son sel
MA49673B1 (fr) Combinaison comprenant du palbociclib et 6-(2,4-dichlorophényl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulène-2-acide carboxylique et sa utilisation pour le traitement du cancer
JP2021038257A (ja) 組み合せ抗細菌組成物および短期抗細菌レジメン
WO2021168483A3 (fr) Traitement d'infections à coronavirus humain à l'aide d'inhibiteurs de traitement de glycoprotéine alpha-glucosidase
JOP20220227A1 (ar) مركبات بيرولو بيريميدين أمينات كمثبطات للمُتَمِّمِة
JOP20240237A1 (ar) مركبات أريل غير متجانسة لمعالجة الألم
MX2023013225A (es) Inhibidores de la cinasa 4 similar a polo.
TN2022000092A1 (en) Oral complement factor d inhibitors
MX2022004264A (es) Inhibidores del factor d del complemento para administracion oral.
MA53010B1 (fr) Formulations d'un inhibiteur de axl/mer
MA53427B1 (fr) Inhibiteurs de l'arginase et leurs méthodes d'utilisation
FR3047665B1 (fr) Celastrol et ses derives dans le traitement des tumeurs et pathologies pre-cancereuses cutanees