DK105489D0 - Polypeptid - Google Patents

Polypeptid

Info

Publication number
DK105489D0
DK105489D0 DK105489A DK105489A DK105489D0 DK 105489 D0 DK105489 D0 DK 105489D0 DK 105489 A DK105489 A DK 105489A DK 105489 A DK105489 A DK 105489A DK 105489 D0 DK105489 D0 DK 105489D0
Authority
DK
Denmark
Prior art keywords
polypeptide
terminal end
heterologous protein
presentation
leader
Prior art date
Application number
DK105489A
Other languages
English (en)
Inventor
Kjeld Norris
Fanny Norris
Soeren Bjoern
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26065137&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK105489(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Priority to DK105489A priority Critical patent/DK105489D0/da
Publication of DK105489D0 publication Critical patent/DK105489D0/da
Priority claimed from DK494189A external-priority patent/DK494189D0/da
Priority to ZA901476A priority patent/ZA901476B/xx
Priority to AT90904258T priority patent/ATE110414T1/de
Priority to JP2504527A priority patent/JP2609367B2/ja
Priority to CA002050336A priority patent/CA2050336C/en
Priority to KR1019910701029A priority patent/KR970005928B1/ko
Priority to NZ232742A priority patent/NZ232742A/xx
Priority to DK90904258.2T priority patent/DK0461165T3/da
Priority to SU5010019/13A priority patent/RU2194758C2/ru
Priority to PCT/DK1990/000058 priority patent/WO1990010075A1/en
Priority to ES90904258T priority patent/ES2062514T5/es
Priority to AU52612/90A priority patent/AU624694B2/en
Priority to UA5010019A priority patent/UA27706C2/uk
Priority to DE69011853T priority patent/DE69011853T3/de
Priority to HU902376A priority patent/HU215538B/hu
Priority to EP90904258A priority patent/EP0461165B2/en
Priority to DD90338353A priority patent/DD296965A5/de
Priority to PL90284146A priority patent/PL163532B1/pl
Priority to IL9360990A priority patent/IL93609A/en
Priority to IE74990A priority patent/IE66469B1/en
Priority to CS901039A priority patent/CZ285239B6/cs
Priority to FI914125A priority patent/FI104985B/fi
Priority to NO913427A priority patent/NO304236B1/no
Priority to US08/196,887 priority patent/US5395922A/en
Priority to US08/397,595 priority patent/US5510249A/en
Priority to US08/397,597 priority patent/US5514585A/en
Priority to HU95P/P00592P priority patent/HU211600A9/hu
Priority to NO974899A priority patent/NO974899D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/033—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the internal surface of the plasma membrane, e.g. containing a myristoylation motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • Processing Of Solid Wastes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Particle Accelerators (AREA)
DK105489A 1989-01-06 1989-03-03 Polypeptid DK105489D0 (da)

Priority Applications (28)

Application Number Priority Date Filing Date Title
DK105489A DK105489D0 (da) 1989-03-03 1989-03-03 Polypeptid
ZA901476A ZA901476B (en) 1989-03-03 1990-02-27 A yeast processing system
DE69011853T DE69011853T3 (de) 1989-03-03 1990-03-01 System zur bearbeitung von hefe, welches eine zur bearbeitungsstelle benachbarte negativ geladene aminosäure beeinhaltet.
HU902376A HU215538B (hu) 1989-03-03 1990-03-01 Eljárás heterológ proteinek előállítására új élesztő kifejező rendszerrel
PCT/DK1990/000058 WO1990010075A1 (en) 1989-03-03 1990-03-01 Yeast processing system comprising a negatively charged amino acid adjacent to the processing site
UA5010019A UA27706C2 (uk) 1989-03-03 1990-03-01 Спосіб одержання гетерологічного поліпептиду
EP90904258A EP0461165B2 (en) 1989-03-03 1990-03-01 Yeast processing system comprising a negatively charged amino acid adjacent to the processing site
CA002050336A CA2050336C (en) 1989-03-03 1990-03-01 Yeast processing system comprising a negatively charged amino acid adjacent to the processing site
KR1019910701029A KR970005928B1 (ko) 1989-03-03 1990-03-01 프라세싱 부위에 인접한 음전하를 띤 아미노산을 함유하는 이스트 프라세싱 시스템
NZ232742A NZ232742A (en) 1989-03-03 1990-03-01 Yeast heterologous protein production method, vectors, dna constructs and proteins so produced and aprotinin (1-58) so produced
DK90904258.2T DK0461165T3 (da) 1989-03-03 1990-03-01 Gærspaltningssystem
SU5010019/13A RU2194758C2 (ru) 1989-03-03 1990-03-01 СПОСОБ ПОЛУЧЕНИЯ ГЕТЕРОЛОГИЧНОГО ПОЛИПЕПТИДА В ДРОЖЖАХ Saccharomyces cerevisiae
JP2504527A JP2609367B2 (ja) 1989-03-03 1990-03-01 プロセッシング部位に隣接する負に帯電したアミノ酸からなる酵母プロセッシングシステム
ES90904258T ES2062514T5 (es) 1989-03-03 1990-03-01 Sistema de procesamiento de levadura que comprende un aminoacido cargado negativamente adyacente al sitio de procesamiento.
AU52612/90A AU624694B2 (en) 1989-03-03 1990-03-01 Yeast processing system comprising a negatively charged amino acid adjacent to the processing site
AT90904258T ATE110414T1 (de) 1989-03-03 1990-03-01 System zur bearbeitung von hefe, welches eine zur bearbeitungsstelle benachbarte negativ geladene aminosäure beeinhaltet.
CS901039A CZ285239B6 (cs) 1989-03-03 1990-03-02 Polypeptid, konstrukce DNA, rekombinantní expresní vektor a způsob výroby heterologního polypeptidu a kmen kvasinek k tomuto účelu
IE74990A IE66469B1 (en) 1989-03-03 1990-03-02 Yeast processing system comprising a negatively charged amino acid adjacent to the processing site
DD90338353A DD296965A5 (de) 1989-03-03 1990-03-02 Hefeverarbeitungssystem
IL9360990A IL93609A (en) 1989-03-03 1990-03-02 A polypeptide containing a yeast and amino acid processing site with a negative charge adjacent to it for yeast expression and a process to form a polypeptide or protein using the above polypeptide
PL90284146A PL163532B1 (pl) 1989-03-03 1990-03-02 Sposób wytwarzania heterologicznych bialek lub polipeptydów PL PL PL PL PL PL PL
FI914125A FI104985B (fi) 1989-03-03 1991-09-02 Hiivan muokkausjärjestelmä, joka käsittää muokkauskohdan vieressä negatiivisesti varautuneen aminohapon
NO913427A NO304236B1 (no) 1989-03-03 1991-09-02 Polypeptid omfattende en sammensmelting av et signalpeptid, et lederpeptid og et heterologt protein eller polypeptid, DNA-konstruksjoner omfattende en DNA-sekvens som koder for polypeptidet samt gjµrstamme og vektor som kan uttrykke det
US08/196,887 US5395922A (en) 1989-03-03 1994-02-15 Yeast processing system
US08/397,595 US5510249A (en) 1989-01-06 1995-03-02 Yeast processing system
US08/397,597 US5514585A (en) 1989-01-06 1995-03-02 Yeast processing system
HU95P/P00592P HU211600A9 (en) 1989-03-03 1995-06-29 Yeast expressing system
NO974899A NO974899D0 (no) 1989-03-03 1997-10-23 Analogifremgangsmåte for fremstilling av en terapeutisk aktiv aprotinin-analog

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK105489A DK105489D0 (da) 1989-03-03 1989-03-03 Polypeptid
DK494189A DK494189D0 (da) 1989-10-06 1989-10-06 Polypeptid
PCT/DK1990/000058 WO1990010075A1 (en) 1989-03-03 1990-03-01 Yeast processing system comprising a negatively charged amino acid adjacent to the processing site

Publications (1)

Publication Number Publication Date
DK105489D0 true DK105489D0 (da) 1989-03-03

Family

ID=26065137

Family Applications (2)

Application Number Title Priority Date Filing Date
DK105489A DK105489D0 (da) 1989-01-06 1989-03-03 Polypeptid
DK90904258.2T DK0461165T3 (da) 1989-03-03 1990-03-01 Gærspaltningssystem

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK90904258.2T DK0461165T3 (da) 1989-03-03 1990-03-01 Gærspaltningssystem

Country Status (23)

Country Link
US (3) US5395922A (da)
EP (1) EP0461165B2 (da)
JP (1) JP2609367B2 (da)
KR (1) KR970005928B1 (da)
AT (1) ATE110414T1 (da)
AU (1) AU624694B2 (da)
CA (1) CA2050336C (da)
CZ (1) CZ285239B6 (da)
DD (1) DD296965A5 (da)
DE (1) DE69011853T3 (da)
DK (2) DK105489D0 (da)
ES (1) ES2062514T5 (da)
FI (1) FI104985B (da)
HU (2) HU215538B (da)
IE (1) IE66469B1 (da)
IL (1) IL93609A (da)
NO (2) NO304236B1 (da)
NZ (1) NZ232742A (da)
PL (1) PL163532B1 (da)
RU (1) RU2194758C2 (da)
UA (1) UA27706C2 (da)
WO (1) WO1990010075A1 (da)
ZA (1) ZA901476B (da)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591603A (en) * 1987-08-28 1997-01-07 Novo Nordisk A/S Process for preparing aprotinin and aprotinin analogs in yeast cells
DK105489D0 (da) * 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
CA2057908A1 (en) * 1989-05-19 1990-11-20 John E. Cronan, Jr. Fusion proteins having an in vivo post-translational modification site and methods of manufacture and purification
GB9015825D0 (en) * 1990-07-18 1990-09-05 Ciba Geigy Ag In vitro processing of fusion proteins
DK300090D0 (da) * 1990-12-19 1990-12-19 Novo Nordisk As Fremgangsmaade til fremstilling af leadersekvenser
GB9106185D0 (en) * 1991-03-22 1991-05-08 Wellcome Found Biological control agents
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
FI92601C (fi) * 1992-03-11 1994-12-12 Marja Makarow Menetelmä hyötyproteiinien erittämiseksi hiivoista
US5521086A (en) * 1993-09-16 1996-05-28 Cephalon, Inc. Secretion sequence for the production of a heterologous protein in yeast
DE4417353A1 (de) * 1994-05-18 1996-01-25 Bayer Ag Verfahren zur Herstellung von rekombinantem Aprotinin und rekombinanten Aprotinin Varianten mit der natürlichen N-terminlaen Sequenz
IL114160A (en) * 1994-06-17 2006-12-31 Novo Nordisk As Dna constructs encoding heterologous proteins and processes for the heterologous protein production in yeast
US6500645B1 (en) 1994-06-17 2002-12-31 Novo Nordisk A/S N-terminally extended proteins expressed in yeast
US5861267A (en) * 1995-05-01 1999-01-19 Vertex Pharmaceuticals Incorporated Methods, nucleotide sequences and host cells for assaying exogenous and endogenous protease activity
ZA9610456B (en) * 1995-12-20 1997-06-20 Novo Nordisk As N-terminally extended proteins expressed in yeast
US5851800A (en) * 1996-05-14 1998-12-22 Pharmacia & Upjohn Ab Process for producing a protein
DE19629982A1 (de) 1996-07-25 1998-01-29 Bayer Ag Aprotinin-Varianten mit verbesserten Eigenschaften
WO1998026080A1 (en) 1996-12-13 1998-06-18 Chiron Corporation Method for expression of heterologous proteins in yeast
ES2258797T3 (es) * 1996-12-20 2006-09-01 Novo Nordisk A/S Proteinas con extension n-terminal expresadas en la levadura.
JP2001527387A (ja) * 1997-01-24 2001-12-25 ノボ ノルディスク アクティーゼルスカブ 合成リーダーペプチド配列
US6046000A (en) * 1997-11-07 2000-04-04 Millennium Biotherapeutics, Inc. Method for identifying genes encoding signal sequences
WO1999037793A1 (en) 1998-01-23 1999-07-29 Novo Nordisk A/S Process for making desired polypeptides in yeast
CA2392844A1 (en) 1999-12-29 2001-07-12 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
US20050100991A1 (en) * 2001-04-12 2005-05-12 Human Genome Sciences, Inc. Albumin fusion proteins
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PT1463751E (pt) 2001-12-21 2013-08-26 Human Genome Sciences Inc Proteínas de fusão de albumina
EP1463752A4 (en) * 2001-12-21 2005-07-13 Human Genome Sciences Inc ALBUM INFUSION PROTEINS
DE60335497D1 (de) 2002-09-13 2011-02-03 Cornell Res Foundation Inc Ergillus-phytasen
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EP1687428A1 (en) 2003-11-14 2006-08-09 Novo Nordisk A/S Processes for making acylated insulin
JP5697831B2 (ja) 2003-12-03 2015-04-08 ノヴォ ノルディスク アー／エス 単鎖インシュリン
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JP5202338B2 (ja) 2006-02-27 2013-06-05 ノボ・ノルデイスク・エー／エス 新規インシュリン誘導体
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US8518668B2 (en) 2006-09-27 2013-08-27 Novo Nordisk A/S Method for making maturated insulin polypeptides in a fungal cell
US8153395B2 (en) 2006-11-22 2012-04-10 Novo Nordisk A/S Method of making activated carboxypeptidases
US20100216691A1 (en) 2007-07-16 2010-08-26 Novo Nordisk A/S Protease Stabilized, Pegylated Insulin Analogues
CN101778862B (zh) 2007-08-13 2014-12-17 诺沃-诺迪斯克有限公司 快速作用的胰岛素类似物
ES2548304T3 (es) 2007-08-15 2015-10-15 Novo Nordisk A/S Análogos de la insulina que contienen una fracción acilo y alquilenglicol
EP2178910B1 (en) 2007-08-15 2014-10-08 Novo Nordisk A/S Insulins with an acyl moiety comprising repeating units of alkylene glycol containing amino acids
US8501449B2 (en) * 2007-12-04 2013-08-06 Proteon Therapeutics, Inc. Recombinant elastase proteins and methods of manufacturing and use thereof
WO2009115469A1 (en) 2008-03-18 2009-09-24 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
US9242011B2 (en) 2008-04-01 2016-01-26 Novo Nordisk A/S Insulin albumin conjugates
WO2011089170A2 (en) 2010-01-22 2011-07-28 Novo Nordisk A/S Process for preparing fgf-21 with low degree of o-glycosylation
KR101702342B1 (ko) * 2009-03-12 2017-02-03 빅텍 프라이빗 리미티드 폴리뉴클레오타이드 및 폴리펩타이드 서열 및 이의 방법
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ATE110414T1 (de) 1994-09-15
HU902376D0 (en) 1991-11-28
DD296965A5 (de) 1991-12-19
CA2050336C (en) 2000-01-18
UA27706C2 (uk) 2000-10-16
NO913427L (no) 1991-11-01
PL163532B1 (pl) 1994-04-29
DE69011853T2 (de) 1994-12-15
JP2609367B2 (ja) 1997-05-14
WO1990010075A1 (en) 1990-09-07
HU215538B (hu) 1999-01-28
ES2062514T3 (es) 1994-12-16
NO974899L (no) 1997-10-23
EP0461165B1 (en) 1994-08-24
US5395922A (en) 1995-03-07
FI104985B (fi) 2000-05-15
NZ232742A (en) 1991-10-25
ZA901476B (en) 1990-11-28
DE69011853T3 (de) 1998-06-25
AU624694B2 (en) 1992-06-18
JPH04504846A (ja) 1992-08-27
NO913427D0 (no) 1991-09-02
CZ285239B6 (cs) 1999-06-16
KR970005928B1 (ko) 1997-04-22
RU2194758C2 (ru) 2002-12-20
AU5261290A (en) 1990-09-26
NO304236B1 (no) 1998-11-16
ES2062514T5 (es) 1998-06-01
HUT58370A (en) 1992-02-28
IE66469B1 (en) 1995-12-27
KR920701452A (ko) 1992-08-11
US5510249A (en) 1996-04-23
EP0461165B2 (en) 1998-03-25
US5514585A (en) 1996-05-07
EP0461165A1 (en) 1991-12-18
IE900749L (en) 1990-09-03
CA2050336A1 (en) 1990-09-04
DK0461165T3 (da) 1994-11-21
NO974899D0 (no) 1997-10-23
HU211600A9 (en) 1995-12-28
IL93609A0 (en) 1990-12-23
FI914125A0 (fi) 1991-09-02
IL93609A (en) 2001-11-25
DE69011853D1 (de) 1994-09-29
CZ103990A3 (cs) 1999-03-17

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