MC1392A1 - Phenyl-quinolizidines - Google Patents

Phenyl-quinolizidines

Info

Publication number
MC1392A1
MC1392A1 MC811510A MC1510A MC1392A1 MC 1392 A1 MC1392 A1 MC 1392A1 MC 811510 A MC811510 A MC 811510A MC 1510 A MC1510 A MC 1510A MC 1392 A1 MC1392 A1 MC 1392A1
Authority
MC
Monaco
Prior art keywords
beta
racemate
quinolizine
process according
octahydro
Prior art date
Application number
MC811510A
Other languages
English (en)
French (fr)
Inventor
Emilio Kyburz
Rene Imhof
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MC1392A1 publication Critical patent/MC1392A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MC811510A 1980-04-11 1981-04-07 Phenyl-quinolizidines MC1392A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH278480 1980-04-11
CH70181 1981-02-03

Publications (1)

Publication Number Publication Date
MC1392A1 true MC1392A1 (fr) 1982-04-27

Family

ID=25685419

Family Applications (1)

Application Number Title Priority Date Filing Date
MC811510A MC1392A1 (fr) 1980-04-11 1981-04-07 Phenyl-quinolizidines

Country Status (18)

Country Link
US (2) US4391978A (cs)
EP (1) EP0037990B1 (cs)
AU (1) AU540599B2 (cs)
CA (1) CA1142933A (cs)
CS (1) CS222696B2 (cs)
DE (1) DE3167549D1 (cs)
DK (1) DK116181A (cs)
ES (1) ES8207175A1 (cs)
FI (1) FI67700C (cs)
HU (1) HU185633B (cs)
IE (1) IE51108B1 (cs)
IL (1) IL62592A (cs)
MC (1) MC1392A1 (cs)
NO (1) NO153258C (cs)
NZ (1) NZ196682A (cs)
PH (1) PH19199A (cs)
PT (1) PT72840B (cs)
ZW (1) ZW5581A1 (cs)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK116181A (da) * 1980-04-11 1981-10-12 Hoffmann La Roche Fremgangsmaade til fremstilling af quinolizidinderivater
EP0094744A1 (en) * 1982-04-23 1983-11-23 Beecham Group Plc Azabicyclobenzamides, their preparation and their pharmaceutical compositions
US4716172A (en) * 1986-04-10 1987-12-29 Mcneilab, Inc. 4-substituted octahydroquinolizine analgesic compounds and octahydroquinolizinium intermediates
US6770658B2 (en) 1998-09-09 2004-08-03 Inflazyme Pharmaceuticals Ltd. Substituted γ-phenyl-Δ-lactams and uses related thereto
EP1851216A2 (en) * 2004-11-30 2007-11-07 F.Hoffmann-La Roche Ag Substituted benzoquinolizines as dpp-iv inhibitors for the treatment of diabetes
WO2019134985A1 (en) * 2018-01-08 2019-07-11 F. Hoffmann-La Roche Ag Octahydropyrido[1,2-alpha]pyrazines as magl inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3394141A (en) * 1965-11-12 1968-07-23 Fabio Sparatore Z-benzyaminobenzimidazoles
US3852452A (en) * 1970-02-10 1974-12-03 Ayerst Mckenna & Harrison Benzocycloheptaisoquinoline derivatives as cns depressants
US3692791A (en) * 1970-05-18 1972-09-19 American Home Prod SUBSTITUTED 2-t-BUTYL-OCTAHYDRO-2H-QUINOLIZINES
US3948923A (en) * 1972-03-06 1976-04-06 Bayer Aktiengesellschaft Pentahydroqunolizine derivatives
US3997547A (en) * 1975-07-14 1976-12-14 Morton-Norwich Products, Inc. Phenylimino-2H-quinolizines
GB1593146A (en) * 1976-11-05 1981-07-15 Beecham Group Ltd Octahydro-quinolizinyl benzamide derivatives
NZ191763A (en) * 1978-10-13 1984-05-31 Hoffmann La Roche 7-beta-phenyl-quinolidines, intermediates and pharmaceutical compositions
DK116181A (da) * 1980-04-11 1981-10-12 Hoffmann La Roche Fremgangsmaade til fremstilling af quinolizidinderivater
US4339582A (en) * 1981-08-18 1982-07-13 Miles Laboratories, Inc. Quinolizidine-propionanilide compounds

Also Published As

Publication number Publication date
NO811263L (no) 1981-10-12
EP0037990B1 (de) 1984-12-05
NO153258C (no) 1986-02-12
PH19199A (en) 1986-01-31
CA1142933A (en) 1983-03-15
IE810822L (en) 1981-10-11
CS222696B2 (en) 1983-07-29
EP0037990A1 (de) 1981-10-21
ES501232A0 (es) 1982-09-16
US4684731A (en) 1987-08-04
FI67700B (fi) 1985-01-31
PT72840A (en) 1981-05-01
FI811102L (fi) 1981-10-12
AU540599B2 (en) 1984-11-29
IL62592A (en) 1984-12-31
DK116181A (da) 1981-10-12
IE51108B1 (en) 1986-10-01
PT72840B (en) 1983-01-10
DE3167549D1 (en) 1985-01-17
NO153258B (no) 1985-11-04
HU185633B (en) 1985-03-28
IL62592A0 (en) 1981-06-29
FI67700C (fi) 1985-05-10
AU6910781A (en) 1981-10-15
ZW5581A1 (en) 1981-11-18
ES8207175A1 (es) 1982-09-16
NZ196682A (en) 1984-03-30
US4391978A (en) 1983-07-05

Similar Documents

Publication Publication Date Title
EP0506532B1 (fr) Nouveaux dérivés de l'indole, procédé de préparation et médicaments les contenant
FR2687402A1 (fr) Nouveaux azaindoles, procedes de preparation et medicaments les contenant.
EP0172096A1 (fr) Dérivés d'acylaminométhyl-3 imidazo[1,2-a]pyridines, leur préparation et leur application en thérapeutique
FR2698873A1 (fr) Benzocycloheptènes, benzoxépines et benzothiépines activateurs des canaux potassiques, procédé de préparation, composition pharmaceutique les contenant.
CA2542727A1 (fr) Derives de n-[phenyl(pyrrolidin-2-yl)methyl]benzamide, et n-[[azepan-2-yl)phenylmethyl]benzamide, leur preparation et leur application en therapeutique
FR2531707A1 (fr) Trifluoromethylphenyltetrahydropyridines substituees a activite anorexigene, un procede de preparation et compositions pharmaceutiques
BE898278A (fr) Benzoxazines antipsychotiques.
FR2515179A1 (fr) Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique
FR2493315A1 (fr) Derive de piperazine, procede pour sa preparation et composition analgesique en contenant
FR2549061A1 (fr) Derives du spirosuccinimide utilisables comme medicaments
MC1392A1 (fr) Phenyl-quinolizidines
CA1231950A (fr) Procede d'obtention de nouveaux derives substitues du 2,5-diamino 1,4-diazole et des compositions pharmaceutiques en renfermant
LU85059A1 (fr) Composes amines heterocycliques et procedes pour leur preparation
MC1289A1 (fr) Phenyl quinolizidines
FR2466461A1 (fr) Composes heterocycliques, procedes pour leur preparation et compositions pharmaceutiques les contenant
FR2643634A1 (fr) Nouveaux derives benzoxazolinoniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
CH634321A5 (en) trans-5-Aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles, process for their preparation and pharmaceutical composition containing them
JPS648621B2 (cs)
KR100437561B1 (ko) 신규헤테로고리화합물
CA2045849A1 (fr) Derives d'oxazolo pyridines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
KR830001838B1 (ko) 페닐-퀴놀리지딘의 제조방법
EP1187824B1 (fr) Derives de [(2-substitue-5-[3-thienyl)-benzyl]-[2-([2-isopropoxy-5-fluoro]-phenoxy)-ethyl]-amine, leur procede de preparation et leur utilisation a titre de medicaments
FR2565586A1 (fr) Derives de la naphtoxazine, leur preparation, leur application comme medicaments et compositions pharmaceutiques les contenant
FR2477544A1 (fr) Nouveaux derives de la chloro-3 quinoleine, procedes pour leur preparation, et leur utilisation comme medicaments
FR2649981A1 (fr) Derives de dihydropyrimidothiazine, leur procede de preparation et compositions pharmaceutiques les contenant

Legal Events

Date Code Title Description
YP Annual fee paid