MC1742A1 - Procede pour preparer un derive de 3'-azido-3'desoxythymigline et procede pour preparer une formulation pharmaceutique le contenant - Google Patents

Procede pour preparer un derive de 3'-azido-3'desoxythymigline et procede pour preparer une formulation pharmaceutique le contenant

Info

Publication number
MC1742A1
MC1742A1 MC861828A MC1828A MC1742A1 MC 1742 A1 MC1742 A1 MC 1742A1 MC 861828 A MC861828 A MC 861828A MC 1828 A MC1828 A MC 1828A MC 1742 A1 MC1742 A1 MC 1742A1
Authority
MC
Monaco
Prior art keywords
azido
deoxy
thymidine
pharmaceutically acceptable
application
Prior art date
Application number
MC861828A
Other languages
English (en)
French (fr)
Inventor
Janet-Lister Rideout
David-Walter Barry
Sandra-Nusinoff Lehrman
Clair Martha-Heider St
Philip Allan Furman
George-Andrew Freeman
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27516579&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MC1742(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB858506869A external-priority patent/GB8506869D0/en
Priority claimed from GB858511774A external-priority patent/GB8511774D0/en
Priority claimed from US06/776,899 external-priority patent/US4724232A/en
Priority claimed from GB858523881A external-priority patent/GB8523881D0/en
Priority claimed from GB868603450A external-priority patent/GB8603450D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of MC1742A1 publication Critical patent/MC1742A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
MC861828A 1985-03-16 1986-03-14 Procede pour preparer un derive de 3'-azido-3'desoxythymigline et procede pour preparer une formulation pharmaceutique le contenant MC1742A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB858506869A GB8506869D0 (en) 1985-03-16 1985-03-16 Antiviral compound
GB858511774A GB8511774D0 (en) 1985-05-09 1985-05-09 Antiviral compounds
US06/776,899 US4724232A (en) 1985-03-16 1985-09-17 Treatment of human viral infections
GB858523881A GB8523881D0 (en) 1985-09-27 1985-09-27 Antiviral compounds
GB868603450A GB8603450D0 (en) 1986-02-12 1986-02-12 Antiviral compounds

Publications (1)

Publication Number Publication Date
MC1742A1 true MC1742A1 (fr) 1987-02-26

Family

ID=27516579

Family Applications (1)

Application Number Title Priority Date Filing Date
MC861828A MC1742A1 (fr) 1985-03-16 1986-03-14 Procede pour preparer un derive de 3'-azido-3'desoxythymigline et procede pour preparer une formulation pharmaceutique le contenant

Country Status (21)

Country Link
EP (2) EP0196185B1 (cs)
JP (1) JPH0780898B2 (cs)
AP (1) AP11A (cs)
AT (4) ATE81978T1 (cs)
AU (1) AU572019B2 (cs)
CA (1) CA1238277A (cs)
CS (1) CS385191A3 (cs)
CY (2) CY1508A (cs)
DE (4) DE3650130T3 (cs)
DK (1) DK164392C (cs)
FI (1) FI85978C (cs)
GR (1) GR860712B (cs)
HK (2) HK85789A (cs)
IE (1) IE56503B1 (cs)
IL (1) IL78158A (cs)
MC (1) MC1742A1 (cs)
MY (1) MY102693A (cs)
NZ (1) NZ215486A (cs)
PH (1) PH24388A (cs)
PT (1) PT82199B (cs)
SG (1) SG62889G (cs)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0217580A3 (en) * 1985-09-17 1990-11-07 The Wellcome Foundation Limited Therapeutic nucleosides
US4916122A (en) * 1987-01-28 1990-04-10 University Of Georgia Research Foundation, Inc. 3'-Azido-2',3'-dideoxyuridine anti-retroviral composition
US4841039A (en) * 1986-05-01 1989-06-20 Emory University 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents
US5084445A (en) * 1986-05-01 1992-01-28 University Of Georgia Research Foundation, Inc. 3'-azido-2',3'-dideoxy-5-methylcytidine
US5077279A (en) * 1986-05-01 1991-12-31 University Of Georgia Research Foundation, Inc. 3'-azido-2',3'-dideoxy-5-methylcytidine anti-viral composition
US4880782A (en) * 1986-11-21 1989-11-14 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V. Method of treating viral infections in humans and compositions therefor
FI892451L (fi) * 1986-11-21 1989-05-19 Max Planck Gesellschaft Foerfarande med vilket virusinfektioner i maenniskor kan skoetas och kompositioner anvaenda daeri.
SE8605503D0 (sv) * 1986-12-19 1986-12-19 Astra Laekemedel Ab Novel medicinal use
US5190926A (en) * 1987-01-28 1993-03-02 University Of Georgia Research Foundation, Inc. 3'-azido-2',3'-dideoxypyrimidines and related compounds as antiviral agents
DK140588A (da) * 1987-03-16 1988-09-17 Wellcome Found Terapeutisk nucleosider
EP0282618A1 (en) * 1987-03-18 1988-09-21 Vereniging Het Nederlands Kanker Instituut 1-Deoxynojirimycin as an anti-HIV therapeutic
EP0286825A3 (en) * 1987-03-18 1989-04-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Use of 3'-fluro-3' deoxythymidine for the manufacture of a medicament for the treatment of virus infections
US4950652A (en) * 1987-03-23 1990-08-21 Hem Research, Inc. dsRNAs for combination therapy in the treatment of viral diseases
EP0292101A3 (en) * 1987-03-25 1990-01-31 The Wellcome Foundation Limited Process for the preparation of 3'-azido-3'-deoxythymidine and intermediates
GB8707421D0 (en) * 1987-03-27 1987-04-29 Wellcome Found Pharmaceutical formulations
IL86007A0 (en) * 1987-04-09 1988-09-30 Wellcome Found 6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them
US5185437A (en) * 1987-04-09 1993-02-09 Burroughs Wellcome Co. Therapeutic nucleosides
IL86009A (en) * 1987-04-10 1991-09-16 Us Health Liposome-encapsulated phosphorylated nucleosides for treatment of retroviral diseases
SE8701605D0 (sv) * 1987-04-16 1987-04-16 Astra Ab Novel medicinal compounds
US5215970A (en) * 1987-04-16 1993-06-01 Medivir Ab Nucleosides and nucleotide analogues, pharmaceutical composition and processes for the preparation of the compounds
ATE72122T1 (de) * 1987-04-24 1992-02-15 Wellcome Found Antivirale mischungen.
US4863927A (en) * 1987-05-11 1989-09-05 Merck & Co., Inc. 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils
YU110888A (en) * 1987-06-10 1989-08-31 Wellcome Found Process for obtaining timine derivatives
USRE33887E (en) * 1987-06-22 1992-04-14 Hoffmann-La Roche Inc. Anti-retroviral compounds
SU1548182A1 (ru) * 1987-12-29 1990-03-07 Институт молекулярной биологии АН СССР 5 @ -Фосфонаты 3 @ -азидо-2 @ ,3 @ -дидезоксинуклеозидов, вл ющиес специфическими ингибиторами вируса СПИД в культуре лимфоцитов человека Н9/ШВ
US5384396A (en) * 1988-02-23 1995-01-24 The University Of Georgia Research Foundation, Inc. Process for the deoxygenation of nucleosides
DE3824669C2 (de) * 1988-07-20 1999-05-06 Wondrak Ewald M Verwendung von Trinatrium-Phosphonoformat
US4987224A (en) * 1988-08-02 1991-01-22 University Of Georgia Research Foundation, Inc. Method of preparation of 2',3'-dideoxynucleosides
EP0355245A1 (fr) * 1988-08-26 1990-02-28 Michel Vandevelde Utilisation d'agents d'inhibition de la réverse-transcriptase des rétrovirus
HU205089B (en) * 1989-05-31 1992-03-30 Biogal Gyogyszergyar Process for producing new thymine derivatives and pharmaceutical compositions comprising same
SE508601C2 (sv) * 1989-11-09 1998-10-19 Asta Medica Ag Läkemedel, vilka som aktiv substans innehåller karboxylsyror innehållande svavel samt deras användning för bekämpning av retrovirus
US5585367A (en) * 1990-04-19 1996-12-17 Previsan S.A. Method of treating humans and animals infected with viruses of the retrovirus group
ES2060373T3 (es) * 1990-04-19 1994-11-16 Previsan Sa Derivados azoicos, compuestos farmaceuticos y desinfectantes que los contienen y su utilizacion contra el sida.
US6812233B1 (en) 1991-03-06 2004-11-02 Emory University Therapeutic nucleosides
GB9104740D0 (en) * 1991-03-06 1991-04-17 Wellcome Found Antiviral nucleoside combination
US5593993A (en) * 1991-08-02 1997-01-14 Medivir Ab Method for inhibition of HIV related viruses
IL102548A (en) * 1991-08-02 1998-08-16 Medivir Ab Thiourea derivatives for use in the preparation of medicaments for the inhibition of hiv and the treatment of aids and some such novel compounds
ATE184787T1 (de) * 1992-05-13 1999-10-15 Wellcome Found Therapeutische kombinationen
US6177435B1 (en) 1992-05-13 2001-01-23 Glaxo Wellcome Inc. Therapeutic combinations
GR920100326A (el) * 1992-07-21 1994-03-31 Medivir Ag Ενώσεις και μέ?οδοι αναστολής του HIV και των σχετικών ιών.
DE4336640A1 (de) * 1993-10-22 1995-04-27 Deutsches Rheuma Forschungszen Neue Metallchelate, Verfahren zu deren Herstellung sowie deren Verwendung als antivirale Arzneimittel
CA2270600A1 (en) 1999-05-03 2000-11-03 Infectio Recherche Inc. Method and formulations for the treatment of diseases, particularly those caused by human immunodeficiency virus and leishmania
NZ533057A (en) 2001-10-26 2005-11-25 Angeletti P Ist Richerche Bio N-substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase
EP2316468A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
EP1579862A1 (en) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
EP3021832B9 (en) 2013-07-19 2023-03-15 Boehringer Ingelheim Vetmedica GmbH Preserved etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition
WO2022008025A1 (en) * 2020-07-05 2022-01-13 Since & Technology Development Fund Authority 2-hydroxyiminopyrimidine nucleosides and derivitives and antiviral uses thereto

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1285935C (en) * 1985-03-16 1991-07-09 Janet Lister Rideout Therapeutic nucleosides

Also Published As

Publication number Publication date
CY1508A (en) 1990-08-03
MY102693A (en) 1992-09-30
DE3650130D1 (de) 1994-12-08
AU572019B2 (en) 1988-04-28
DE196185T1 (de) 1987-04-30
ATA68386A (de) 1989-08-15
AP8600027A0 (en) 1986-02-01
HK85789A (en) 1989-11-03
AT390000B (de) 1990-02-26
FI85978C (fi) 1992-06-25
DE3687069T2 (de) 1993-03-25
PT82199B (pt) 1990-11-07
AP11A (en) 1987-12-22
FI861069L (fi) 1986-09-17
GR860712B (en) 1986-07-16
EP0291633A1 (en) 1988-11-23
FI861069A0 (fi) 1986-03-14
CY1889A (en) 1996-11-22
EP0196185B1 (en) 1989-07-12
DE3608606A1 (de) 1986-09-18
EP0196185A3 (en) 1988-01-13
CS385191A3 (en) 1992-05-13
DK164392B (da) 1992-06-22
ATE113603T1 (de) 1994-11-15
IL78158A (en) 1988-04-29
PT82199A (en) 1986-04-01
JPS63290895A (ja) 1988-11-28
AU5475886A (en) 1986-09-18
DK118086D0 (da) 1986-03-14
JPH0780898B2 (ja) 1995-08-30
DK164392C (da) 1992-11-09
DE3650130T2 (de) 1995-03-16
IE56503B1 (en) 1991-08-14
IL78158A0 (en) 1986-07-31
DE3687069D1 (de) 1992-12-10
SG62889G (en) 1990-01-26
FI85978B (fi) 1992-03-13
DE3650130T3 (de) 2003-07-24
EP0196185A2 (en) 1986-10-01
EP0291633B1 (en) 1992-11-04
DK118086A (da) 1986-09-17
NZ215486A (en) 1988-09-29
ATE81978T1 (de) 1992-11-15
CA1238277A (en) 1988-06-21
ATE44464T1 (de) 1989-07-15
IE860677L (en) 1986-09-16
HK164395A (en) 1995-10-27
PH24388A (en) 1990-06-13

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