MC2028A1 - Procede de preparation de thiazepine-4(5h)-ones optiquement actives,intermediaires de synthese,et procede de preparation de ces intermediaires - Google Patents

Procede de preparation de thiazepine-4(5h)-ones optiquement actives,intermediaires de synthese,et procede de preparation de ces intermediaires

Info

Publication number
MC2028A1
MC2028A1 MC892051A MC2051A MC2028A1 MC 2028 A1 MC2028 A1 MC 2028A1 MC 892051 A MC892051 A MC 892051A MC 2051 A MC2051 A MC 2051A MC 2028 A1 MC2028 A1 MC 2028A1
Authority
MC
Monaco
Prior art keywords
formula
compound
general formula
alkoxy
phenylcyclohexyl
Prior art date
Application number
MC892051A
Other languages
English (en)
French (fr)
Inventor
Llewellyn Coffen David
Balkrishna Madan Pradeep
Schwartz Alan
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MC2028A1 publication Critical patent/MC2028A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
MC892051A 1988-05-24 1989-05-23 Procede de preparation de thiazepine-4(5h)-ones optiquement actives,intermediaires de synthese,et procede de preparation de ces intermediaires MC2028A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19793488A 1988-05-24 1988-05-24

Publications (1)

Publication Number Publication Date
MC2028A1 true MC2028A1 (fr) 1990-04-25

Family

ID=22731334

Family Applications (1)

Application Number Title Priority Date Filing Date
MC892051A MC2028A1 (fr) 1988-05-24 1989-05-23 Procede de preparation de thiazepine-4(5h)-ones optiquement actives,intermediaires de synthese,et procede de preparation de ces intermediaires

Country Status (14)

Country Link
EP (1) EP0343474A3 (da)
JP (1) JPH0217170A (da)
KR (1) KR900018002A (da)
CN (1) CN1038639A (da)
AU (1) AU3509989A (da)
DK (1) DK250689A (da)
FI (1) FI892506A7 (da)
HU (1) HU204027B (da)
IL (1) IL90366A0 (da)
MC (1) MC2028A1 (da)
NO (1) NO892068L (da)
PT (1) PT90636A (da)
YU (1) YU105689A (da)
ZA (1) ZA893392B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902684A (en) * 1988-06-20 1990-02-20 E. R. Squibb & Sons, Inc. Benzazepine and benzothiazepine derivatives
IT1230057B (it) * 1989-04-13 1991-09-27 Zambon Spa Processo di risoluzione di intermedi utili per la preparazione di 1,5-benzotiazepine
ATE116643T1 (de) * 1989-04-28 1995-01-15 Tanabe Seiyaku Co Verfahren zur herstellung von 1,5- benzothiazepinderivaten.
JPH0798813B2 (ja) * 1989-04-28 1995-10-25 田辺製薬株式会社 １，５―ベンゾチアゼピン誘導体の製法
US5128469A (en) * 1989-04-28 1992-07-07 Tanabe Seiyaku Co., Ltd. Process for preparing 1,5-benzothiazepine derivatives
IT1234387B (it) * 1989-07-12 1992-05-18 Zambon Spa Processo di purificazione di intermedi utili nella preparazione del diltiazem
ZA906810B (en) * 1989-08-31 1991-10-30 Marion Merrell Dow Inc Heterogeneous synthesis of azepinones from esters
US5250680A (en) * 1989-08-31 1993-10-05 Merrell Dow Pharmaceuticals Inc. Heterogeneous synthesis of azepinones from esters
JPH085869B2 (ja) * 1990-03-08 1996-01-24 田辺製薬株式会社 １，５−ベンゾチアゼピン誘導体の製法
US5055575A (en) * 1990-04-12 1991-10-08 Tanabe Seiyaku Co., Ltd. Process for preparing 1,5-benzothiazepine derivatives
JP2601224Y2 (ja) * 1992-03-06 1999-11-15 株式会社キャットアイ 脈拍計
SG50796A1 (en) * 1996-02-23 1998-07-20 Tanabe Seiyaku Co Process for preparing 1,5-benzothiazepine derivative
KR19990041269A (ko) 1997-11-21 1999-06-15 이병훈 건강시계
JP3961505B2 (ja) * 2004-04-13 2007-08-22 松下電器産業株式会社 電圧検出回路、電源装置及び半導体装置
CN103304514B (zh) * 2013-06-28 2014-09-17 天津梅花医药有限公司 一种稳定性好的盐酸地尔硫卓化合物及药物组合物
CN111138243B (zh) * 2019-12-27 2022-06-24 郑州手性药物研究院有限公司 (1s,2r)-2-苯基环己醇的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61145160A (ja) * 1984-12-20 1986-07-02 Nippon Chemiphar Co Ltd 光学活性なプロピオン酸誘導体の製造法
JPS61268663A (ja) * 1985-05-22 1986-11-28 Fuji Kagaku Kogyo Kk 光学活性な２−ヒドロキシ−３，３−ジ置換プロピオン酸の製造方法
US4652561A (en) * 1986-02-26 1987-03-24 Hoffmann-La Roche Inc. Naphtho[1,2-b]-1,4-thiazepinones

Also Published As

Publication number Publication date
CN1038639A (zh) 1990-01-10
FI892506A0 (fi) 1989-05-23
IL90366A0 (en) 1989-12-15
ZA893392B (en) 1990-01-31
EP0343474A3 (en) 1991-01-23
FI892506A7 (fi) 1989-11-25
YU105689A (en) 1990-12-31
JPH0217170A (ja) 1990-01-22
AU3509989A (en) 1989-11-30
HU204027B (en) 1991-11-28
KR900018002A (ko) 1990-12-20
HUT50758A (en) 1990-03-28
NO892068L (no) 1989-11-27
PT90636A (pt) 1989-11-30
DK250689A (da) 1989-11-25
DK250689D0 (da) 1989-05-23
EP0343474A2 (en) 1989-11-29
NO892068D0 (no) 1989-05-23

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