MD1716C2 - Utilizare a melatoninei pentru tratamentul pacienţilor dependenţi de benzodiazepine - Google Patents

Utilizare a melatoninei pentru tratamentul pacienţilor dependenţi de benzodiazepine Download PDF

Info

Publication number: MD1716C2
Authority: MD; Moldova
Prior art keywords: benzodiazepine; melatonin; treatment; patient; patients dependent
Prior art date: 1995-02-01

Application number

MD97-0254A

Other languages

English (en)

Romanian (ro)

Russian (ru)

Other versions

MD970254A (en

MD1716B2 (en

Inventor

Nava Zisapel

Original Assignee

Neurim Pharmaceuticals (1991) Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-02-01

Filing date

1996-01-29

Publication date

2002-02-28

1995-02-01 Priority claimed from US08/381,535 external-priority patent/US6469044B1/en

1996-01-29 Application filed by Neurim Pharmaceuticals (1991) Ltd. filed Critical Neurim Pharmaceuticals (1991) Ltd.

1999-05-31 Publication of MD970254A publication Critical patent/MD970254A/xx

2001-08-31 Publication of MD1716B2 publication Critical patent/MD1716B2/xx

2002-02-28 Publication of MD1716C2 publication Critical patent/MD1716C2/ro

Links

SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 title abstract 4
229940049706 benzodiazepine Drugs 0.000 title abstract 4
YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 title abstract 2
DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 title abstract 2
229960003987 melatonin Drugs 0.000 title abstract 2
230000001419 dependent effect Effects 0.000 title 1
229940079593 drug Drugs 0.000 abstract 3
239000003814 drug Substances 0.000 abstract 3
208000024891 symptom Diseases 0.000 abstract 2
206010013663 drug dependence Diseases 0.000 abstract 1
230000035945 sensitivity Effects 0.000 abstract 1
208000011117 substance-related disease Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Anesthesiology (AREA)
Toxicology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

MD97-0254A 1995-02-01 1996-01-29 Utilizare a melatoninei pentru tratamentul pacienţilor dependenţi de benzodiazepine MD1716C2 (ro)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/381,535 US6469044B1 (en)	1995-02-01	1995-02-01	Method for treating patients suffering from drug dependencies which lead to plasma melationin deficiencies
EP95303853A EP0724878B1 (en)	1995-02-01	1995-06-06	Use of melatonin for treating patients suffering from drug dependencies
PCT/IB1996/000082 WO1996023496A1 (en)	1995-02-01	1996-01-29	Use of melatonin for treating patients suffering from drug addiction

Publications (3)

Publication Number	Publication Date
MD970254A MD970254A (en)	1999-05-31
MD1716B2 MD1716B2 (en)	2001-08-31
MD1716C2 true MD1716C2 (ro)	2002-02-28

Family

ID=26140195

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MD97-0254A MD1716C2 (ro)	1995-02-01	1996-01-29	Utilizare a melatoninei pentru tratamentul pacienţilor dependenţi de benzodiazepine

Country Status (22)

Country	Link
JP (1)	JP4516159B2 (is)
CN (1)	CN1083263C (is)
AT (1)	AT408188B (is)
AU (1)	AU695366B2 (is)
BG (1)	BG62876B1 (is)
BR (1)	BR9607169A (is)
CZ (1)	CZ291349B6 (is)
DK (1)	DK176081B1 (is)
EE (1)	EE03384B1 (is)
FI (1)	FI119586B (is)
IS (1)	IS1980B (is)
LU (1)	LU90118B1 (is)
LV (1)	LV11940B (is)
MD (1)	MD1716C2 (is)
NO (1)	NO312814B1 (is)
NZ (1)	NZ298878A (is)
PL (1)	PL183148B1 (is)
SI (1)	SI9620022A (is)
SK (1)	SK284521B6 (is)
TR (1)	TR199700723T1 (is)
TW (1)	TW483757B (is)
WO (1)	WO1996023496A1 (is)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HK1052655A1 (zh)	2000-01-05	2003-09-26	纽里姆药品(1991)有限公司	用於治療對抗高血壓藥的抗藥性和相關病症的方法和製劑
IL149377A (en) *	2002-04-28	2012-10-31	Neurim Pharma 1991	Pharmaceutical formulation comprising melatonin for the potentiation of the effect of hypnotic compounds
US9119846B2 (en)	2003-04-29	2015-09-01	Neurim Pharmaceuticals (1991) Ltd.	Method and composition for enhancing cognition in alzheimer's patients
IL155666A (en)	2003-04-29	2013-12-31	Neurim Pharma 1991	Insomnia treatment
CA3085116C (en)	2012-01-26	2022-07-19	Vanda Pharmaceuticals Inc.	Treatment of circadian rhythm disorders
US11918557B2 (en)	2012-01-26	2024-03-05	Vanda Pharmaceuticals Inc.	Treatment of circadian rhythm disorders
KR102148990B1 (ko)	2012-12-18	2020-08-27	반다 파마슈티칼즈, 인코퍼레이티드.	일주기 리듬 장애의 치료
US10376487B2 (en)	2013-11-12	2019-08-13	Vanda Pharmaceuticals Inc.	Method of treatment
US11090285B2 (en)	2013-11-12	2021-08-17	Vanda Pharmaceuticals Inc	Treatment of circadian rhythm disorders
MX386987B (es) *	2016-10-31	2025-03-19	Neurim Pharma 1991	Mini-tabletas de melatonina y métodos de fabricación de las mismas.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0513702A2 (en) *	1991-05-13	1992-11-19	I.F.L.O. ISTITUTO FARMACOLOGICO LOMBARDO S.A.S. di Giorgio & Aldo Laguzzi & C.	Melatonin derivaties for use in the therapy of sleep disorders and in pre-anaesthetic medication
EP0518468A1 (en) *	1991-05-09	1992-12-16	Neurim Pharmaceuticals (1991) Limited	Melatonin containing compositions

1996
- 1996-01-29 WO PCT/IB1996/000082 patent/WO1996023496A1/en not_active Ceased
- 1996-01-29 AT AT0901396A patent/AT408188B/de not_active IP Right Cessation
- 1996-01-29 BR BR9607169A patent/BR9607169A/pt not_active Application Discontinuation
- 1996-01-29 SK SK1030-97A patent/SK284521B6/sk unknown
- 1996-01-29 MD MD97-0254A patent/MD1716C2/ro not_active IP Right Cessation
- 1996-01-29 PL PL96321630A patent/PL183148B1/pl unknown
- 1996-01-29 EE EE9700166A patent/EE03384B1/xx not_active IP Right Cessation
- 1996-01-29 NZ NZ298878A patent/NZ298878A/xx not_active IP Right Cessation
- 1996-01-29 TR TR97/00723T patent/TR199700723T1/xx unknown
- 1996-01-29 CN CN96191750A patent/CN1083263C/zh not_active Expired - Lifetime
- 1996-01-29 SI SI9620022A patent/SI9620022A/sl not_active IP Right Cessation
- 1996-01-29 AU AU44574/96A patent/AU695366B2/en not_active Expired
- 1996-01-29 JP JP52338596A patent/JP4516159B2/ja not_active Expired - Lifetime
- 1996-01-29 CZ CZ19972405A patent/CZ291349B6/cs not_active IP Right Cessation
- 1996-04-12 TW TW085104319A patent/TW483757B/zh not_active IP Right Cessation
1997
- 1997-07-24 LV LVP-97-144A patent/LV11940B/en unknown
- 1997-07-25 IS IS4532A patent/IS1980B/is unknown
- 1997-07-30 BG BG101803A patent/BG62876B1/bg unknown
- 1997-07-30 DK DK199700896A patent/DK176081B1/da not_active IP Right Cessation
- 1997-07-31 FI FI973185A patent/FI119586B/fi not_active IP Right Cessation
- 1997-07-31 NO NO19973531A patent/NO312814B1/no not_active IP Right Cessation
- 1997-08-01 LU LU90118A patent/LU90118B1/fr active

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0518468A1 (en) *	1991-05-09	1992-12-16	Neurim Pharmaceuticals (1991) Limited	Melatonin containing compositions
EP0513702A2 (en) *	1991-05-13	1992-11-19	I.F.L.O. ISTITUTO FARMACOLOGICO LOMBARDO S.A.S. di Giorgio & Aldo Laguzzi & C.	Melatonin derivaties for use in the therapy of sleep disorders and in pre-anaesthetic medication

Also Published As

Publication number	Publication date
FI973185A0 (fi)	1997-07-31
SK284521B6 (sk)	2005-05-05
AT408188B (de)	2001-09-25
AU695366B2 (en)	1998-08-13
PL183148B1 (pl)	2002-05-31
CZ291349B6 (cs)	2003-02-12
NO973531L (no)	1997-09-30
SI9620022A (sl)	1998-10-31
PL321630A1 (en)	1997-12-08
CN1172431A (zh)	1998-02-04
FI119586B (fi)	2009-01-15
BR9607169A (pt)	1997-11-11
MX9705856A (es)	1998-07-31
NZ298878A (en)	1999-05-28
TW483757B (en)	2002-04-21
BG62876B1 (bg)	2000-10-31
WO1996023496A1 (en)	1996-08-08
LV11940B (en)	1998-05-20
MD970254A (en)	1999-05-31
DK176081B1 (da)	2006-04-18
BG101803A (en)	1998-04-30
EE03384B1 (et)	2001-04-16
DK89697A (da)	1997-07-30
CZ240597A3 (cs)	1998-01-14
EE9700166A (et)	1998-02-16
JPH10513177A (ja)	1998-12-15
JP4516159B2 (ja)	2010-08-04
NO973531D0 (no)	1997-07-31
AU4457496A (en)	1996-08-21
LU90118B1 (fr)	1997-11-13
MD1716B2 (en)	2001-08-31
IS1980B (is)	2005-01-14
ATA901396A (de)	2001-02-15
CN1083263C (zh)	2002-04-24
SK103097A3 (en)	1998-01-14
IS4532A (is)	1997-07-25
NO312814B1 (no)	2002-07-08
TR199700723T1 (xx)	1998-02-21
FI973185L (fi)	1997-09-30
LV11940A (lv)	1998-01-20

Legal Events

Date	Code	Title
1999-06-15	PD99	Pending application
2007-08-31	KA4A	Patent for invention lapsed due to non-payment of fees (with right of restoration)
2008-03-31	MM4A	Patent for invention definitely lapsed due to non-payment of fees

Publication	Publication Date	Title
CY2007001I2 (el)	2009-11-04	Φαρμακευτικο σκευασμα για χρηση στη θεραπεια του διαβητη
ES2165910T3 (es)	2002-04-01	Administracion nasal y ocular de cetamina para el tratamiento del dolor y para la desintoxicacion.
KR960700059A (ko)	1996-01-19	파킨슨씨 병 및 파킨슨 중후군의 치료에 카르바마제핀 및 옥스카르바제핀의 이용(application of carbamazepine and oxcarbazepine in the treatment of parkinson's disease and parkinsonian syndromes)
ATE127804T1 (de)	1995-09-15	Pharmazeutische verbindungen.
PT1025845E (pt)	2003-03-31	Terapia com hidromorfona
NZ504026A (en)	2002-12-20	Methods for treating hypercoagulable states or acquired protein C deficiency using human-activated protein C
BRPI0009719B8 (pt)	2021-05-25	processo de tratamento
HUP9802091A2 (hu)	1998-12-28	Idegátültetés pluripotens neuroepiteliális sejtek alkalmazásával
DE69617729D1 (de)	2002-01-17	Verwendung von antimineralcorticoidverbindungen gegen das drogenentzugssyndrom
EE9700302A (et)	1998-06-15	Meetod maania ja bipolaarse häire raviks
TR200001040T2 (tr)	2001-01-22	Kaşıntıyı önleme etkisi için bileşiklerin yeni bir kullanımı
ATE202599T1 (de)	2001-07-15	Mit isoliertem empfindlichem x-syndrom verbundene dns-sequenzen
KR950701221A (ko)	1995-03-23	물질 남용 장해 치료제
HUP9802423A2 (hu)	1999-02-01	Hiperproliferatív megbetegedések kombinált gyógyászati kezelése
FI874166A7 (fi)	1988-03-25	2',3'-dideoksisytidin-2'-eenin käyttö retroviruksilla infektoituneiden potilaiden hoitoon.
BR0009380A (pt)	2001-12-26	Tratamento de câncer melhorado comtemozolomida
MD1716B2 (en)	2001-08-31	Use of melatonin for treatment of patients dependent on benzodiazepine
AU1463088A (en)	1988-10-20	Receptor of the small rhinovirus receptor group
NO990450L (no)	1999-01-29	Behandling av sinnslidelser
PT869785E (pt)	2002-12-31	4-hidroxicumarina-3-carboxamidas para o tratamento de diabetes mellitus nao insulinodependente
NO984651L (no)	1998-12-03	Anvendelse av benzonaftalenderivater for fremstilling av medikamenter for behandling av sykdommer i sentralnervesystemet
NZ307601A (en)	2000-04-28	Use of a pharmaceutically acceptable oxalate derivative in the manufacture of a medicament for the treatment of skin conditions
ATE207357T1 (de)	2001-11-15	Verwendung von cotinin zur linderung des tabakentzugssyndrom
NO960545D0 (no)	1996-02-12	Behandling av skadelige virkninger i forbindelse med administrering av ekstracellulært hemoglobin
KR960003718A (ko)	1996-02-23	말초신경병 및 중추신경변성병의 치료에 유용한 의약의 제조를 위한 이펜프로딜 및 그 부분입체이성질체의 이용