MD177C2 - Inhibitori ai purinnucleozidfosforilazei, procedeu de obţinere a lor - Google Patents
Inhibitori ai purinnucleozidfosforilazei, procedeu de obţinere a lorInfo
- Publication number
- MD177C2 MD177C2 MD94-0241A MD940241A MD177C2 MD 177 C2 MD177 C2 MD 177C2 MD 940241 A MD940241 A MD 940241A MD 177 C2 MD177 C2 MD 177C2
- Authority
- MD
- Moldova
- Prior art keywords
- alkyl
- obtaining
- nucleoside phosphorylase
- revealed
- arbitrary
- Prior art date
Links
- OQRXBXNATIHDQO-UHFFFAOYSA-N 6-chloropyridine-3,4-diamine Chemical compound NC1=CN=C(Cl)C=C1N OQRXBXNATIHDQO-UHFFFAOYSA-N 0.000 title 1
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 title 1
- 102100036286 Purine nucleoside phosphorylase Human genes 0.000 title 1
- 108010009099 nucleoside phosphorylase Proteins 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- DNCYBUMDUBHIJZ-UHFFFAOYSA-N 1h-pyrimidin-6-one Chemical compound O=C1C=CN=CN1 DNCYBUMDUBHIJZ-UHFFFAOYSA-N 0.000 abstract 1
- 101100134922 Gallus gallus COR5 gene Proteins 0.000 abstract 1
- CWRVKFFCRWGWCS-UHFFFAOYSA-N Pentrazole Chemical compound C1CCCCC2=NN=NN21 CWRVKFFCRWGWCS-UHFFFAOYSA-N 0.000 abstract 1
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000565 sulfonamide group Chemical group 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Inhibitori ai purinnucleozidfosforilazei(I)Se dezvăluie o substanţă, care conţine 2-amino-7-(R)-3H, 5H-pirolo[3,2-d]pirimidină-4-on, în care R reprezintă ciclohexenil, ciclohexil sau -CH2-R1, în care R1 reprezintă grupa heteroaliciclică, piridinilică sau aliciclică arbitrar substituită. Se dezvăluie, de asemenea, o substanţă cu formula (I), în care R1 reprezintă H, NH2 sau OCH3, R2 reprezintă grupa ciclică din 5-7 atomi de carbon arbitrar substituită, ce conţine arbitrar unul sau mai mulţi heteroatomi, R3 şi R4 reprezintă H sau C1-4 alchil, m reprezintă 0-4, n reprezintă 0-6, p reprezintă 0-1, X reprezintă CN, CSNH2, PO(OH)2, COOH, SO2NH2, NH2,OH, CNHNH2, tetrazol sau triazol, COR5, în care R5 reprezintă C1-4 alchil, CF3, NH2 sau OC1-4 alchil, şi Y reprezintă O sau NH.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/429,100 US4985433A (en) | 1989-10-31 | 1989-10-31 | 2-amino-7-(pyridinylmethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same |
| US07/429,097 US5008270A (en) | 1989-10-31 | 1989-10-31 | 2-amino-7-(heterocyclomethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same |
| US44279889A | 1989-11-29 | 1989-11-29 | |
| SU925011315A RU2097384C1 (ru) | 1989-10-31 | 1990-10-12 | Производные 2-амино-7-(chr2r3)-3н,5н-пирроло[3,2-d]-пиримидин-4-она, способы их получения и способ селективного ингибирования пролиферации т-лимфоцитов млекопитающего и не оказывающий воздействия на b-лимфоциты |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MD177C2 true MD177C2 (ro) | 1996-01-31 |
Family
ID=62103981
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0241A MD177C2 (ro) | 1989-10-31 | 1994-07-05 | Inhibitori ai purinnucleozidfosforilazei, procedeu de obţinere a lor |
| MD940241D MD177F1 (ro) | 1989-10-31 | 1994-07-05 | Inhibitori purinnucleozidfosforilazei procedeu de obtinere a lor |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD940241D MD177F1 (ro) | 1989-10-31 | 1994-07-05 | Inhibitori purinnucleozidfosforilazei procedeu de obtinere a lor |
Country Status (1)
| Country | Link |
|---|---|
| MD (2) | MD177C2 (ro) |
-
1994
- 1994-07-05 MD MD94-0241A patent/MD177C2/ro unknown
- 1994-07-05 MD MD940241D patent/MD177F1/ro unknown
Non-Patent Citations (4)
| Title |
|---|
| M. I Lim, R.S.Klein, and J.J.Fox,Tetrahedron Lett., 21, 1013, 1980; * |
| M.I., W.I.Ren, B.A.Otter, and R.S.Klein J. Org. Chem. 48, 780, 1983. * |
| M.I.Lim and R.S.Klein, Tetrahedron Lett. 22, 25, 1981; * |
| M.I.Lim, R.S.Klein, and J.J.Fox, J.Org.Chem. 44, 3826, 1979; * |
Also Published As
| Publication number | Publication date |
|---|---|
| MD177F1 (ro) | 1995-03-31 |
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