MD20160132A2 - Săruri de adiţie ale (S)-2-(1-(6-amino-5-cianopirimidin-4-ilamino)etil)-4-oxo-3-fenil-3,4-dihidropirolo[1,2-f][1,2,4]triazin-5-carbonitrilului - Google Patents

Săruri de adiţie ale (S)-2-(1-(6-amino-5-cianopirimidin-4-ilamino)etil)-4-oxo-3-fenil-3,4-dihidropirolo[1,2-f][1,2,4]triazin-5-carbonitrilului Download PDF

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MD20160132A2
MD20160132A2 MDA20160132A MD20160132A MD20160132A2 MD 20160132 A2 MD20160132 A2 MD 20160132A2 MD A20160132 A MDA20160132 A MD A20160132A MD 20160132 A MD20160132 A MD 20160132A MD 20160132 A2 MD20160132 A2 MD 20160132A2
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MD
Moldova
Prior art keywords
cyanopyrimidin
dihydropyrrolo
ylamino
carbonitrile
triazine
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MDA20160132A
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English (en)
Russian (ru)
Inventor
КАРРЕРА Франческ КАРРЕРА
ГАРСИЯ Хуан Баутист ПЕРЕС
Хуан Бернат Видаль
ИСКИЭРДО Франсиско САНЧЕС
КОМА Мария Карме СЕРРА
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Almirall S.A.
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Publication of MD20160132A2 publication Critical patent/MD20160132A2/ro

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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Prezenta invenţie se referă la noi săruri de adiţie cristaline, stabile şi acceptabile farmaceutic ale (S)-2-(1-(6-amino-5-cianopirimidin-4-ilamino)etil)-4-oxo-3-fenil-3,4-dihidropirolo[1,2-f][1,2,4]triazin-5-carbonitrilului cu derivaţi ai acidului sulfonic, în special cu acidul metansulfonic, naftalin-2-sulfonic şi para-toluensulfonic, şi la solvaţi acceptabili farmaceutic ai acestora. Invenţia se referă, de asemenea, la compoziţii farmaceutice care conţin aceste săruri, la procedee de utilizare a acestora pentru tratarea, prevenirea sau suprimarea bolilor şi tulburărilor, care pot fi ameliorate prin inhibarea fosfoinozitid-3-kinazei (PI3K).
MDA20160132A 2014-05-27 2015-05-21 Săruri de adiţie ale (S)-2-(1-(6-amino-5-cianopirimidin-4-ilamino)etil)-4-oxo-3-fenil-3,4-dihidropirolo[1,2-f][1,2,4]triazin-5-carbonitrilului MD20160132A2 (ro)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP14382192 2014-05-27
EP14382401 2014-10-17
EP14382400 2014-10-17
PCT/EP2015/061307 WO2015181052A1 (en) 2014-05-27 2015-05-21 Addition salts of (s)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-4-oxo-3-phenyl-3,4-dihydropyrrolo[1,2-f][1,2,4]triazine-5-carbonitrile

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MD20160132A2 true MD20160132A2 (ro) 2017-05-31

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MDA20160132A MD20160132A2 (ro) 2014-05-27 2015-05-21 Săruri de adiţie ale (S)-2-(1-(6-amino-5-cianopirimidin-4-ilamino)etil)-4-oxo-3-fenil-3,4-dihidropirolo[1,2-f][1,2,4]triazin-5-carbonitrilului
MDA20160137A MD20160137A2 (ro) 2014-05-27 2015-05-21 Utilizare medicală
MDA20160138A MD20160138A2 (ro) 2014-05-27 2015-05-21 Combinaţie

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MDA20160137A MD20160137A2 (ro) 2014-05-27 2015-05-21 Utilizare medicală
MDA20160138A MD20160138A2 (ro) 2014-05-27 2015-05-21 Combinaţie

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US (3) US20170158699A1 (ro)
EP (3) EP3148586A1 (ro)
JP (3) JP2017516798A (ro)
KR (3) KR20170007760A (ro)
CN (3) CN106456777A (ro)
AU (3) AU2015266190A1 (ro)
BR (1) BR112016024538A2 (ro)
CA (3) CA2941436A1 (ro)
CL (2) CL2016002971A1 (ro)
CR (3) CR20160536A (ro)
EA (3) EA201692437A1 (ro)
IL (3) IL247073A0 (ro)
MA (3) MA39828A (ro)
MD (3) MD20160132A2 (ro)
MX (3) MX2016014904A (ro)
PE (2) PE20170385A1 (ro)
PH (3) PH12016502256A1 (ro)
SG (3) SG11201606763VA (ro)
TW (3) TW201625258A (ro)
UY (3) UY36153A (ro)
WO (3) WO2015181052A1 (ro)

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