MA39827A - Sels d'addition de (s)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)éthyl)-4-oxo-3-phényl-3,4-dihydropyrrolo[1,2-f][1,2,4]triazine-5-carbonitrile - Google Patents

Sels d'addition de (s)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)éthyl)-4-oxo-3-phényl-3,4-dihydropyrrolo[1,2-f][1,2,4]triazine-5-carbonitrile

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Publication number
MA39827A
MA39827A MA039827A MA39827A MA39827A MA 39827 A MA39827 A MA 39827A MA 039827 A MA039827 A MA 039827A MA 39827 A MA39827 A MA 39827A MA 39827 A MA39827 A MA 39827A
Authority
MA
Morocco
Prior art keywords
cyanopyrimidin
dihydropyrrolo
ylamino
carbonitrile
triazine
Prior art date
Application number
MA039827A
Other languages
English (en)
Inventor
Carrera Francesc Carrera
Garcia Juan Bautista Perez
Izquierdo Francisco Sanchez
Coma Maria Carme Serra
Juan Bernat Vidal
Original Assignee
Almirall Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Sa filed Critical Almirall Sa
Publication of MA39827A publication Critical patent/MA39827A/fr

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
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    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
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    • C07C309/33—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems
    • C07C309/34—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems formed by two rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07B2200/13—Crystalline forms, e.g. polymorphs

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Abstract

Cette invention concerne de nouveaux sels d'addition pharmaceutiquement acceptables de (s)-2-(1-(6-amino-5-cyano-pyrimidin-4-ylamino)éthyl)-4-oxo-3-phényl-3,4-dihydropyrrolo[1,2-f] [1,2,4] triazine-5-carbonitrile avec des dérivés d'acide sulfonique, en particulier avec de l'acide méthanesulfonique, de l'acide naphtalène-2-sulfonique et de l'acide para-toluènesulfonique, leurs solvates pharmaceutiquement acceptables, et leur utilisation à titre d'inhibiteurs de phosphoinositide 3-kinase (pi3k).
MA039827A 2014-05-27 2015-05-21 Sels d'addition de (s)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)éthyl)-4-oxo-3-phényl-3,4-dihydropyrrolo[1,2-f][1,2,4]triazine-5-carbonitrile MA39827A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14382192 2014-05-27
EP14382401 2014-10-17
EP14382400 2014-10-17

Publications (1)

Publication Number Publication Date
MA39827A true MA39827A (fr) 2015-12-03

Family

ID=53269467

Family Applications (3)

Application Number Title Priority Date Filing Date
MA039828A MA39828A (fr) 2014-05-27 2015-05-21 Usage médical
MA039827A MA39827A (fr) 2014-05-27 2015-05-21 Sels d'addition de (s)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)éthyl)-4-oxo-3-phényl-3,4-dihydropyrrolo[1,2-f][1,2,4]triazine-5-carbonitrile
MA039829A MA39829A (fr) 2014-05-27 2015-05-21 Combinaison

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA039828A MA39828A (fr) 2014-05-27 2015-05-21 Usage médical

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA039829A MA39829A (fr) 2014-05-27 2015-05-21 Combinaison

Country Status (21)

Country Link
US (3) US20170158699A1 (fr)
EP (3) EP3148586A1 (fr)
JP (3) JP2017516798A (fr)
KR (3) KR20170007760A (fr)
CN (3) CN106456777A (fr)
AU (3) AU2015266190A1 (fr)
BR (1) BR112016024538A2 (fr)
CA (3) CA2941436A1 (fr)
CL (2) CL2016002971A1 (fr)
CR (3) CR20160536A (fr)
EA (3) EA201692437A1 (fr)
IL (3) IL247073A0 (fr)
MA (3) MA39828A (fr)
MD (3) MD20160132A2 (fr)
MX (3) MX2016014904A (fr)
PE (2) PE20170385A1 (fr)
PH (3) PH12016502256A1 (fr)
SG (3) SG11201606763VA (fr)
TW (3) TW201625258A (fr)
UY (3) UY36153A (fr)
WO (3) WO2015181052A1 (fr)

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BRPI0906473A8 (pt) 2008-01-04 2016-02-10 Intellikine Inc Certas entidades químicas, composições e métodos
EP3238722B1 (fr) 2011-01-10 2019-03-13 Infinity Pharmaceuticals, Inc. Formes solides d'isoquinolinones
MX389479B (es) 2011-09-02 2025-03-20 Incyte Holdings Corp Heterociclilaminas como inhibidores de fosfoinositida 3-cinasas (pi3k)
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
RU2702908C2 (ru) 2012-11-01 2019-10-14 Инфинити Фармасьютикалз, Инк. Лечение злокачественных опухолей с использованием модуляторов изоформ pi3-киназы
US10172789B2 (en) 2013-01-24 2019-01-08 Palvella Therapeutics Llc Compositions for transdermal delivery of mTOR inhibitors
WO2015160975A2 (fr) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Polythérapies
US10077277B2 (en) 2014-06-11 2018-09-18 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
SG10201912302VA (en) 2015-02-27 2020-02-27 Incyte Corp Salts of pi3k inhibitor and processes for their preparation
WO2017189805A1 (fr) 2016-04-27 2017-11-02 Abbvie Inc. Méthodes de traitement de maladies dans lesquelles l'activité de l'il-13 est préjudiciable à l'aide d'anticorps anti-il-13
KR102483630B1 (ko) 2016-05-18 2023-01-02 토르쿠르 아게 피부 병변의 치료
GB201608797D0 (en) * 2016-05-19 2016-07-06 Ucb Biopharma Sprl Therapeutic use
CN107456454A (zh) * 2016-06-06 2017-12-12 先声药业有限公司 一种预防或治疗炎性疾病的药物组合物
EP3474856B1 (fr) 2016-06-24 2022-09-14 Infinity Pharmaceuticals, Inc. Therapies combinées
WO2018129364A1 (fr) 2017-01-06 2018-07-12 Palvella Therapeutics Llc Compositions anhydres d'inhibiteurs de mtor et méthodes d'utilisation
GB201708856D0 (en) * 2017-06-02 2017-07-19 Ucb Biopharma Sprl Seletalisib crystalline forms
BR112020009855A8 (pt) * 2017-11-23 2023-01-10 Piqur Therapeutics Ag Tratamento de distúrbios de pele
EP3817743A4 (fr) 2018-07-02 2022-07-06 Palvella Therapeutics, Inc. Compositions anhydres d'inhibiteurs de mtor et méthodes d'utilisation
JP2022515256A (ja) 2018-12-25 2022-02-17 ソル － ゲル テクノロジーズ リミテッド Ｅｇｆｒ阻害剤を含む組成物による皮膚障害の治療
CN113440614A (zh) * 2020-03-26 2021-09-28 长沙晶易医药科技有限公司 一种用于治疗类风湿性关节炎的组合物及其应用
KR102733299B1 (ko) * 2021-11-05 2024-11-25 연세대학교 산학협력단 피부-특이적 T 세포(skin-specific T cell)의 억제제를 유효성분으로 포함하는 아토피피부염의 예방 또는 치료용 조성물
US20230190755A1 (en) * 2021-12-16 2023-06-22 Incyte Corporation Topical formulations of PI3K-delta inhibitors
TWI823476B (zh) * 2022-07-15 2023-11-21 中化合成生技股份有限公司 托法替尼檸檬酸鹽的製備方法

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CR20160536A (es) 2017-01-02
PH12016502256A1 (en) 2017-02-06
WO2015181053A1 (fr) 2015-12-03
CR20160538A (es) 2017-01-02
MA39828A (fr) 2015-12-03
MA39829A (fr) 2015-12-03
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AU2015266193A1 (en) 2016-09-15
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CN107074862A (zh) 2017-08-18
BR112016024538A2 (pt) 2017-08-15
CA2941429A1 (fr) 2015-12-03
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CR20160537A (es) 2017-03-17
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