MD4874C1 - Перхлорат 2,6-диацетилпиридин-бис(пиколиноилгидразон)-бис(аква)железа(III)-гидрат(1/2,5) со свойствами стимулятора синтеза липаз штаммом грибов Rhizopus arrhizus CNMN FD 03 - Google Patents
Перхлорат 2,6-диацетилпиридин-бис(пиколиноилгидразон)-бис(аква)железа(III)-гидрат(1/2,5) со свойствами стимулятора синтеза липаз штаммом грибов Rhizopus arrhizus CNMN FD 03 Download PDFInfo
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- MD4874C1 MD4874C1 MDA20220005A MD20220005A MD4874C1 MD 4874 C1 MD4874 C1 MD 4874C1 MD A20220005 A MDA20220005 A MD A20220005A MD 20220005 A MD20220005 A MD 20220005A MD 4874 C1 MD4874 C1 MD 4874C1
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- Moldova
- Prior art keywords
- bis
- diacetylpyridine
- picolinoylhydrazone
- cnmn
- iii
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title claims abstract description 40
- 230000015572 biosynthetic process Effects 0.000 title claims abstract description 26
- 239000004367 Lipase Substances 0.000 title claims abstract description 22
- 102000004882 Lipase Human genes 0.000 title claims abstract description 22
- 108090001060 Lipase Proteins 0.000 title claims abstract description 22
- 235000019421 lipase Nutrition 0.000 title claims abstract description 22
- VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 title claims abstract description 21
- 240000005384 Rhizopus oryzae Species 0.000 title claims abstract description 17
- 238000003786 synthesis reaction Methods 0.000 title claims abstract description 16
- 229910052742 iron Inorganic materials 0.000 title claims abstract description 5
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 title claims abstract description 5
- 235000013752 Rhizopus oryzae Nutrition 0.000 title claims description 12
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- 229910001914 chlorine tetroxide Inorganic materials 0.000 claims abstract description 17
- BEZVGIHGZPLGBL-UHFFFAOYSA-N 2,6-diacetylpyridine Chemical compound CC(=O)C1=CC=CC(C(C)=O)=N1 BEZVGIHGZPLGBL-UHFFFAOYSA-N 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 26
- 150000001875 compounds Chemical class 0.000 abstract description 21
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- 238000000034 method Methods 0.000 abstract description 9
- 102000004190 Enzymes Human genes 0.000 abstract description 7
- 108090000790 Enzymes Proteins 0.000 abstract description 7
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 abstract description 4
- 238000011161 development Methods 0.000 abstract description 3
- 230000001764 biostimulatory effect Effects 0.000 abstract description 2
- 239000002609 medium Substances 0.000 description 10
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- 239000013078 crystal Substances 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 150000001768 cations Chemical class 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- SZVJSHCCFOBDDC-UHFFFAOYSA-N ferrosoferric oxide Chemical compound O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 6
- 241000233866 Fungi Species 0.000 description 5
- 125000004429 atom Chemical group 0.000 description 5
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- 239000003446 ligand Substances 0.000 description 4
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- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 2
- 239000007836 KH2PO4 Substances 0.000 description 2
- KPUUSZPMGYMAAZ-UHFFFAOYSA-N N1=C(C=CC=C1)C(=O)NN=C(C)C1=CC=CC(=N1)C(C)=NNC(C1=NC=CC=C1)=O Chemical compound N1=C(C=CC=C1)C(=O)NN=C(C)C1=CC=CC(=N1)C(C)=NNC(C1=NC=CC=C1)=O KPUUSZPMGYMAAZ-UHFFFAOYSA-N 0.000 description 2
- 239000002262 Schiff base Substances 0.000 description 2
- 150000004753 Schiff bases Chemical class 0.000 description 2
- 239000000370 acceptor Substances 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
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- 235000020188 drinking water Nutrition 0.000 description 2
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- 239000001963 growth medium Substances 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 2
- 235000019796 monopotassium phosphate Nutrition 0.000 description 2
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- -1 ClO4 anions Chemical class 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004157 Hydrolases Human genes 0.000 description 1
- 108090000604 Hydrolases Proteins 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
- 241000235527 Rhizopus Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000001851 biosynthetic effect Effects 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 238000002447 crystallographic data Methods 0.000 description 1
- 238000012866 crystallographic experiment Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- LHOWRPZTCLUDOI-UHFFFAOYSA-K iron(3+);triperchlorate Chemical compound [Fe+3].[O-]Cl(=O)(=O)=O.[O-]Cl(=O)(=O)=O.[O-]Cl(=O)(=O)=O LHOWRPZTCLUDOI-UHFFFAOYSA-K 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 150000002736 metal compounds Chemical class 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 239000007777 multifunctional material Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- BAQLNPIEFOYKNB-UHFFFAOYSA-N pyridine-2-carbohydrazide Chemical compound NNC(=O)C1=CC=CC=N1 BAQLNPIEFOYKNB-UHFFFAOYSA-N 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 238000004467 single crystal X-ray diffraction Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000002424 x-ray crystallography Methods 0.000 description 1
- 229910009112 xH2O Inorganic materials 0.000 description 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyridine Compounds (AREA)
Abstract
Изобретение относится к координационной химии и биотехнологии, в частности к новомукоординационному соединению железа(III) с бис(пиколиноилгидразоном) 2,6-диацетилпиридина, проявляющему свойства биостимулятора синтеза внеклеточных липаз штаммом мицелиальных грибов Rhizopus arrhizus CNMN FD 03 и может быть использовано при разработке биотехнологий для получения липолитических ферментов.Согласно изобретению, заявляется координационное соединение перхлорат 2,6-диацетилпиридин-бис(пиколиноилгидразон)-бис(аква)железа(III)-гидрат(1/2,5),с формулой [Fe(H2L)(H2O)2](ClO4)3·2,5H2O, в которой H2L представляет собой бис(пиколиноилгидразон) 2,6-диацетилпиридина. Заявляемое соединение хорошо растворимо в воде, тем самым обеспечивая практическое применение в качестве стимулятора процесса синтеза внеклеточных липаз штаммом мицелиальных грибов Rhizopus arrhizus CNMN FD 03.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20220005A MD4874C1 (ru) | 2022-02-04 | 2022-02-04 | Перхлорат 2,6-диацетилпиридин-бис(пиколиноилгидразон)-бис(аква)железа(III)-гидрат(1/2,5) со свойствами стимулятора синтеза липаз штаммом грибов Rhizopus arrhizus CNMN FD 03 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20220005A MD4874C1 (ru) | 2022-02-04 | 2022-02-04 | Перхлорат 2,6-диацетилпиридин-бис(пиколиноилгидразон)-бис(аква)железа(III)-гидрат(1/2,5) со свойствами стимулятора синтеза липаз штаммом грибов Rhizopus arrhizus CNMN FD 03 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| MD20220005A2 MD20220005A2 (ru) | 2023-09-30 |
| MD4874B1 MD4874B1 (ru) | 2023-11-30 |
| MD4874C1 true MD4874C1 (ru) | 2024-06-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20220005A MD4874C1 (ru) | 2022-02-04 | 2022-02-04 | Перхлорат 2,6-диацетилпиридин-бис(пиколиноилгидразон)-бис(аква)железа(III)-гидрат(1/2,5) со свойствами стимулятора синтеза липаз штаммом грибов Rhizopus arrhizus CNMN FD 03 |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD4874C1 (ru) |
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- 2022-02-04 MD MDA20220005A patent/MD4874C1/ru active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| MD20220005A2 (ru) | 2023-09-30 |
| MD4874B1 (ru) | 2023-11-30 |
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