MD4831C8 - Тетра(изотиоцианат)кобальтат(II) трис(диметил пиридин-2,6-дикарбоксилат)стронция с свойствами стимулятора липолитической активности штамма грибов Rhizopus arrhizus CNMN FD 03 - Google Patents
Тетра(изотиоцианат)кобальтат(II) трис(диметил пиридин-2,6-дикарбоксилат)стронция с свойствами стимулятора липолитической активности штамма грибов Rhizopus arrhizus CNMN FD 03 Download PDFInfo
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- MD4831C8 MD4831C8 MDA20210037A MD20210037A MD4831C8 MD 4831 C8 MD4831 C8 MD 4831C8 MD A20210037 A MDA20210037 A MD A20210037A MD 20210037 A MD20210037 A MD 20210037A MD 4831 C8 MD4831 C8 MD 4831C8
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- cnmn
- compound
- dicarboxylate
- isothiocyanate
- tris
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- 240000005384 Rhizopus oryzae Species 0.000 title claims abstract description 19
- 235000013752 Rhizopus oryzae Nutrition 0.000 title claims abstract description 17
- 230000002366 lipolytic effect Effects 0.000 title claims abstract description 15
- 239000007983 Tris buffer Substances 0.000 title claims abstract description 11
- SNQQJEJPJMXYTR-UHFFFAOYSA-N dimethyl pyridine-2,6-dicarboxylate Chemical compound COC(=O)C1=CC=CC(C(=O)OC)=N1 SNQQJEJPJMXYTR-UHFFFAOYSA-N 0.000 title claims abstract description 11
- 150000002540 isothiocyanates Chemical class 0.000 title claims abstract description 11
- 229910052712 strontium Inorganic materials 0.000 title claims abstract description 9
- 230000002538 fungal effect Effects 0.000 title abstract 3
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 39
- KJNGJIPPQOFCSK-UHFFFAOYSA-N [H][Sr][H] Chemical compound [H][Sr][H] KJNGJIPPQOFCSK-UHFFFAOYSA-N 0.000 claims abstract description 8
- CABMTIJINOIHOD-UHFFFAOYSA-N 2-[4-methyl-5-oxo-4-(propan-2-yl)-4,5-dihydro-1H-imidazol-2-yl]quinoline-3-carboxylic acid Chemical compound N1C(=O)C(C(C)C)(C)N=C1C1=NC2=CC=CC=C2C=C1C(O)=O CABMTIJINOIHOD-UHFFFAOYSA-N 0.000 claims abstract description 3
- WJJMNDUMQPNECX-UHFFFAOYSA-N Dipicolinic acid Natural products OC(=O)C1=CC=CC(C(O)=O)=N1 WJJMNDUMQPNECX-UHFFFAOYSA-N 0.000 claims abstract description 3
- OJURWUUOVGOHJZ-UHFFFAOYSA-N methyl 2-[(2-acetyloxyphenyl)methyl-[2-[(2-acetyloxyphenyl)methyl-(2-methoxy-2-oxoethyl)amino]ethyl]amino]acetate Chemical compound C=1C=CC=C(OC(C)=O)C=1CN(CC(=O)OC)CCN(CC(=O)OC)CC1=CC=CC=C1OC(C)=O OJURWUUOVGOHJZ-UHFFFAOYSA-N 0.000 claims abstract description 3
- 241000233866 Fungi Species 0.000 claims description 4
- 230000004936 stimulating effect Effects 0.000 claims description 4
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 8
- 101710158368 Extracellular lipase Proteins 0.000 abstract 1
- 101710128940 Triacylglycerol lipase Proteins 0.000 abstract 1
- 150000003438 strontium compounds Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 description 29
- 102000004882 Lipase Human genes 0.000 description 24
- 108090001060 Lipase Proteins 0.000 description 24
- 239000004367 Lipase Substances 0.000 description 24
- 235000019421 lipase Nutrition 0.000 description 24
- 238000003786 synthesis reaction Methods 0.000 description 18
- 230000000694 effects Effects 0.000 description 12
- 102000004190 Enzymes Human genes 0.000 description 11
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- 239000002609 medium Substances 0.000 description 11
- 239000003446 ligand Substances 0.000 description 10
- 235000015097 nutrients Nutrition 0.000 description 8
- 150000001450 anions Chemical class 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 230000004071 biological effect Effects 0.000 description 6
- 239000011521 glass Substances 0.000 description 6
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N N-phenyl amine Natural products NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 150000001768 cations Chemical class 0.000 description 4
- XLJKHNWPARRRJB-UHFFFAOYSA-N cobalt(2+) Chemical class [Co+2] XLJKHNWPARRRJB-UHFFFAOYSA-N 0.000 description 4
- 235000013312 flour Nutrition 0.000 description 4
- 239000001963 growth medium Substances 0.000 description 4
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- 229910004074 SiF6 Inorganic materials 0.000 description 3
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- JAWGVVJVYSANRY-UHFFFAOYSA-N cobalt(3+) Chemical compound [Co+3] JAWGVVJVYSANRY-UHFFFAOYSA-N 0.000 description 3
- 239000013068 control sample Substances 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 239000011737 fluorine Substances 0.000 description 3
- 229910052731 fluorine Inorganic materials 0.000 description 3
- 229910021645 metal ion Inorganic materials 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- SCVJRXQHFJXZFZ-KVQBGUIXSA-N 2-amino-9-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purine-6-thione Chemical compound C1=2NC(N)=NC(=S)C=2N=CN1[C@H]1C[C@H](O)[C@@H](CO)O1 SCVJRXQHFJXZFZ-KVQBGUIXSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 2
- 238000002441 X-ray diffraction Methods 0.000 description 2
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- 238000009825 accumulation Methods 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 150000001661 cadmium Chemical class 0.000 description 2
- 229910052793 cadmium Inorganic materials 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
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- XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 2
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- CUNNCKOPAWXYDX-SFECMWDFSA-N (NZ)-N-[(2Z)-2-hydroxyiminocyclohexylidene]hydroxylamine Chemical compound O\N=C/1\CCCC\C\1=N\O CUNNCKOPAWXYDX-SFECMWDFSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- VRUWSINVIFQDEW-UHFFFAOYSA-L C(C(C)C)(=O)[O-].C(C(C)C)(=O)[O-].[Co+2].N(CCO)(CCO)CCO.N(CCO)(CCO)CCO Chemical compound C(C(C)C)(=O)[O-].C(C(C)C)(=O)[O-].[Co+2].N(CCO)(CCO)CCO.N(CCO)(CCO)CCO VRUWSINVIFQDEW-UHFFFAOYSA-L 0.000 description 1
- 229910020676 Co—N Inorganic materials 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical class [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 239000007836 KH2PO4 Substances 0.000 description 1
- 101100396546 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) tif-6 gene Proteins 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
- 241000235527 Rhizopus Species 0.000 description 1
- 235000005811 Viola adunca Nutrition 0.000 description 1
- 240000009038 Viola odorata Species 0.000 description 1
- 235000013487 Viola odorata Nutrition 0.000 description 1
- 235000002254 Viola papilionacea Nutrition 0.000 description 1
- GQHZBSPNWMRGMM-UHFFFAOYSA-N [Co].[Sr] Chemical compound [Co].[Sr] GQHZBSPNWMRGMM-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- SOIFLUNRINLCBN-UHFFFAOYSA-N ammonium thiocyanate Chemical compound [NH4+].[S-]C#N SOIFLUNRINLCBN-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000001851 biosynthetic effect Effects 0.000 description 1
- 229940065285 cadmium compound Drugs 0.000 description 1
- 150000001662 cadmium compounds Chemical class 0.000 description 1
- WLZRMCYVCSSEQC-UHFFFAOYSA-N cadmium(2+) Chemical compound [Cd+2] WLZRMCYVCSSEQC-UHFFFAOYSA-N 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- BFGKITSFLPAWGI-UHFFFAOYSA-N chromium(3+) Chemical compound [Cr+3] BFGKITSFLPAWGI-UHFFFAOYSA-N 0.000 description 1
- 150000004700 cobalt complex Chemical class 0.000 description 1
- FDBAIUSFRPWFTD-UHFFFAOYSA-L cobalt(2+) dithiocyanate trihydrate Chemical compound O.O.O.[Co++].[S-]C#N.[S-]C#N FDBAIUSFRPWFTD-UHFFFAOYSA-L 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000002447 crystallographic data Methods 0.000 description 1
- 239000012225 czapek media Substances 0.000 description 1
- JGUQDUKBUKFFRO-CIIODKQPSA-N dimethylglyoxime Chemical compound O/N=C(/C)\C(\C)=N\O JGUQDUKBUKFFRO-CIIODKQPSA-N 0.000 description 1
- -1 dioximates Chemical class 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- 229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
- 235000019797 dipotassium phosphate Nutrition 0.000 description 1
- 230000009881 electrostatic interaction Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 150000002222 fluorine compounds Chemical class 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
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- 150000002576 ketones Chemical class 0.000 description 1
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- 239000000463 material Substances 0.000 description 1
- 239000013028 medium composition Substances 0.000 description 1
- BQPIGGFYSBELGY-UHFFFAOYSA-N mercury(2+) Chemical compound [Hg+2] BQPIGGFYSBELGY-UHFFFAOYSA-N 0.000 description 1
- 150000002736 metal compounds Chemical class 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 150000002923 oximes Chemical class 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- GWHOGODUVLQCEB-UHFFFAOYSA-N pyridine-2,6-dicarbonyl chloride Chemical compound ClC(=O)C1=CC=CC(C(Cl)=O)=N1 GWHOGODUVLQCEB-UHFFFAOYSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000013074 reference sample Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229910001631 strontium chloride Inorganic materials 0.000 description 1
- AHBGXTDRMVNFER-UHFFFAOYSA-L strontium dichloride Chemical compound [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 description 1
- 229910001427 strontium ion Inorganic materials 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 235000015099 wheat brans Nutrition 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Landscapes
- Pyridine Compounds (AREA)
Abstract
Изобретение относится к координационной химии и микробиологии, в частности к новому соединению тетра(изотиоцианат)кобальтат(II) трис(диметил пиридин-2,6-дикарбоксилат)стронция, которое может быть использовано в качестве стимулятора липолитической активности штамма грибов Rhizopus arrhizus CNMN FD 03.Согласно изобретению, заявляется координационное соединение тетра(изотиоцианат)кобальтат(II) трис(диметил пиридин-2,6-дикарбоксилат)стронция с формулой [SrL3][Co(NCS)4], где L представляет собой сложный диметиловый эфир 2,6-пиридиндикарбоксиловой кислоты.Соединение стимулирует у штамма грибов Rhizopus arrhizus CNMN FD 03 продуцирование внеклеточных липаз на 12…47%, в зависимости от используемой концентрации.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20210037A MD4831C8 (ru) | 2021-06-23 | 2021-06-23 | Тетра(изотиоцианат)кобальтат(II) трис(диметил пиридин-2,6-дикарбоксилат)стронция с свойствами стимулятора липолитической активности штамма грибов Rhizopus arrhizus CNMN FD 03 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20210037A MD4831C8 (ru) | 2021-06-23 | 2021-06-23 | Тетра(изотиоцианат)кобальтат(II) трис(диметил пиридин-2,6-дикарбоксилат)стронция с свойствами стимулятора липолитической активности штамма грибов Rhizopus arrhizus CNMN FD 03 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| MD4831B1 MD4831B1 (ru) | 2022-11-30 |
| MD4831C1 MD4831C1 (ru) | 2023-06-30 |
| MD4831C8 true MD4831C8 (ru) | 2024-04-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20210037A MD4831C8 (ru) | 2021-06-23 | 2021-06-23 | Тетра(изотиоцианат)кобальтат(II) трис(диметил пиридин-2,6-дикарбоксилат)стронция с свойствами стимулятора липолитической активности штамма грибов Rhizopus arrhizus CNMN FD 03 |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD4831C8 (ru) |
-
2021
- 2021-06-23 MD MDA20210037A patent/MD4831C8/ru active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| MD4831B1 (ru) | 2022-11-30 |
| MD4831C1 (ru) | 2023-06-30 |
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Owner name: INSTITUTIA PUBLICA UNIVERSITATEA DE STAT DIN MOLDOVA, MD STR. A. MATEEVICI NR. 60, MD-2009, REPUBLICA MOLDOVAINSTITUTIA PUBLICA UNIVERSITATEA TEHNICA A MOLDOVEI, MD BD. STEFAN CEL MARE SI SFANT NR. 168, MD-2004, CHISINAU, REPUBLICA MOLDOVA Free format text: PREVIOUS NAME OF PROPRIETOR: INSTITUTUL DE CHIMIE, MEC, MD STR. ACADEMIEI NR. 3, MD-2028, REPUBLICA MOLDOVAINSTITUTUL DE MICROBIOLOGIE SI BIOTEHNOLOGIE, MD STR. ACADEMIEI NR. 1, MD-2028, CHISINAU, REPUBLICA MOLDOVAINSTITUTUL DE FIZICA APLICATA, MD STR. ACADEMIEI NR. 5, MD-2028, CHISINAU, REPUBLICA MOLDOVA |