ME01042B - Morfolinil koji sadrži benzimidazole kao inhibitore replikacije sincicijonog respiratornog virusa - Google Patents

Morfolinil koji sadrži benzimidazole kao inhibitore replikacije sincicijonog respiratornog virusa

Info

Publication number
ME01042B
ME01042B MEP-2008-207A MEP2008207A ME01042B ME 01042 B ME01042 B ME 01042B ME P2008207 A MEP2008207 A ME P2008207A ME 01042 B ME01042 B ME 01042B
Authority
ME
Montenegro
Prior art keywords
6alkyl
substituted
6alkyloxy
formula
hydrogen
Prior art date
Application number
MEP-2008-207A
Other languages
English (en)
Unknown language (me)
Inventor
Jean François BONFANTI
Koenraad Jozef Lodewijk Andries
Jerome Michel Claude Fortin
Philippe Muller
Frederic Marc Maurice Doublet
Christophe Meyer
Rudy Edmond Willebrords
Tom Valerius Josepha Gevers
Philip Maria Martha Bern Timmerman
Original Assignee
Janssen Sciences Ireland Uc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34704695&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME01042(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Sciences Ireland Uc filed Critical Janssen Sciences Ireland Uc
Publication of ME01042B publication Critical patent/ME01042B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MEP-2008-207A 2003-12-18 2004-12-20 Morfolinil koji sadrži benzimidazole kao inhibitore replikacije sincicijonog respiratornog virusa ME01042B (me)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP03104810 2003-12-18
US56718204P 2004-04-30 2004-04-30
EP04105312 2004-10-26
PCT/EP2004/053620 WO2005058871A1 (en) 2003-12-18 2004-12-20 Morpholinyl containing benzimidazoles as inhibitors of respiratory syncytial virus replication

Publications (1)

Publication Number Publication Date
ME01042B true ME01042B (me) 2012-10-20

Family

ID=34704695

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2008-207A ME01042B (me) 2003-12-18 2004-12-20 Morfolinil koji sadrži benzimidazole kao inhibitore replikacije sincicijonog respiratornog virusa

Country Status (32)

Country Link
US (2) US7449463B2 (de)
EP (1) EP1697345B1 (de)
JP (1) JP4951348B2 (de)
KR (1) KR100967406B1 (de)
CN (2) CN101412709B (de)
AP (1) AP2150A (de)
AR (1) AR046959A1 (de)
AT (1) ATE388950T1 (de)
AU (1) AU2004298460B2 (de)
BR (1) BRPI0417268B8 (de)
CA (1) CA2548668C (de)
CY (1) CY1108142T1 (de)
DE (1) DE602004012448T2 (de)
DK (1) DK1697345T3 (de)
EA (1) EA009876B1 (de)
EG (1) EG25799A (de)
ES (1) ES2303653T3 (de)
HR (1) HRP20080245T3 (de)
IL (1) IL175910A (de)
ME (1) ME01042B (de)
MX (1) MXPA06007112A (de)
MY (1) MY143573A (de)
NO (1) NO339314B1 (de)
NZ (1) NZ547479A (de)
PL (1) PL1697345T3 (de)
PT (1) PT1697345E (de)
RS (1) RS50584B (de)
SI (1) SI1697345T1 (de)
TW (1) TWI351401B (de)
UA (1) UA84718C2 (de)
WO (1) WO2005058871A1 (de)
ZA (1) ZA200605894B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR046959A1 (es) * 2003-12-18 2006-01-04 Tibotec Pharm Ltd Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
TWI370820B (en) 2005-04-27 2012-08-21 Takeda Pharmaceutical Fused heterocyclic compounds
MX2007016311A (es) * 2005-06-20 2008-03-07 Tibotec Pharm Ltd Bencimidazoles sustituidos con heterociclilaminoalquilo.
AU2006260969B2 (en) * 2005-06-20 2011-11-17 Janssen Sciences Ireland Uc 1- ( 2-amino-3- (substituted alkyl)-3H-benzimidazolylmethyl) -3-substituted-1,3-dihydro-benzoimidazol-2-ones with activity on respiratory syncytial virus
US20120148678A1 (en) 2010-12-08 2012-06-14 Advanced Technologies And Regenerative Medicine, Llc. Sustained release of poorly water soluble active compounds
KR102066297B1 (ko) 2011-10-14 2020-01-14 암비트 바이오사이언시즈 코포레이션 헤테로사이클릭 화합물 및 이의 유형 3 수용체 티로신 키나아제의 조절인자로서의 용도
UA119050C2 (uk) * 2013-11-11 2019-04-25 Ґілеад Саєнсиз, Інк. ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ
JO3637B1 (ar) * 2015-04-28 2020-08-27 Janssen Sciences Ireland Uc مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv
US10906899B2 (en) 2016-05-10 2021-02-02 Georgia State University Research Foundation, Inc. Bicyclic fused pyrazole derivatives for the treatment of RSV
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
AR111295A1 (es) 2017-03-20 2019-06-26 Forma Therapeutics Inc Composiciones de pirrolopirrol como activadores de piruvato quinasa (pkr)
TW201932470A (zh) 2017-11-29 2019-08-16 愛爾蘭商健生科學愛爾蘭無限公司 具有抗rsv活性之吡唑并嘧啶
CA3087926A1 (en) 2018-01-31 2019-08-08 Janssen Sciences Ireland Unlimited Company Cycloalkyl substituted pyrazolopyrimidines having activity against rsv
AU2019260109B2 (en) 2018-04-23 2023-07-13 Janssen Sciences Ireland Unlimited Company Heteroaromatic compounds having activity against RSV
WO2020061255A1 (en) 2018-09-19 2020-03-26 Forma Therapeutics, Inc. Activating pyruvate kinase r
US20200129485A1 (en) 2018-09-19 2020-04-30 Forma Therapeutics, Inc. Treating sickle cell disease with a pyruvate kinase r activating compound
GB201820751D0 (en) * 2018-12-19 2019-01-30 Bp Oil Int Methods for preparing intermediates
DK4004002T3 (da) 2019-07-22 2024-09-30 Lupin Ltd Makrocykliske forbindelser som sting-agonister samt fremgangsmåder og anvendelser dermed
MX2022003025A (es) 2019-09-19 2022-04-07 Forma Therapeutics Inc Activacion de la piruvato cinasa r.
CA3172249A1 (en) 2020-03-20 2021-09-23 Calcimedica, Inc. Methods and compositions for treating acute lung injury and acute respiratory distress syndrome
JP7791898B2 (ja) 2020-11-13 2025-12-24 カルシメディカ,インク. Cracチャネル阻害剤の合成の改善
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R
EP4384168A4 (de) * 2021-08-13 2025-07-09 Univ Georgia State Res Found Bicyclische kondensierte pyrazolderivate zur behandlung von atemwegsinfektionen einschliesslich rsv
CN119118850B (zh) * 2023-06-13 2025-12-12 中国科学院兰州化学物理研究所 一种吲哚类化合物结构重整制备胺基苯乙醇类化合物的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1418175A1 (de) * 1999-06-28 2004-05-12 Janssen Pharmaceutica N.V. Replikationsinhibitoren des respiratorischen Synzytialvirus
MXPA02000120A (es) * 1999-06-28 2002-07-02 Janssen Pharmaceutica Nv Inhibidores de la replicacion del virus sincitial respiratorio.
JP2003503403A (ja) * 1999-06-28 2003-01-28 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 呼吸合胞体ウイルス複製阻害剤
AR046959A1 (es) * 2003-12-18 2006-01-04 Tibotec Pharm Ltd Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
ATE435222T1 (de) * 2003-12-18 2009-07-15 Tibotec Pharm Ltd Aminobenzimidazole und benzimidazole als inhibitoren der replikation von respiratory syncytial virus

Also Published As

Publication number Publication date
WO2005058871A1 (en) 2005-06-30
HK1130799A1 (en) 2010-01-08
ES2303653T3 (es) 2008-08-16
CY1108142T1 (el) 2014-02-12
PL1697345T3 (pl) 2008-08-29
CA2548668C (en) 2011-09-20
CN101412709A (zh) 2009-04-22
TWI351401B (en) 2011-11-01
DK1697345T3 (da) 2008-06-23
EG25799A (en) 2012-08-06
AP2150A (en) 2010-09-04
AU2004298460B2 (en) 2009-03-19
DE602004012448D1 (de) 2008-04-24
EP1697345B1 (de) 2008-03-12
US20080280881A1 (en) 2008-11-13
JP4951348B2 (ja) 2012-06-13
NZ547479A (en) 2009-03-31
US7449463B2 (en) 2008-11-11
MXPA06007112A (es) 2006-08-23
MY143573A (en) 2011-05-31
EP1697345A1 (de) 2006-09-06
KR20070015507A (ko) 2007-02-05
NO339314B1 (no) 2016-11-28
BRPI0417268B8 (pt) 2021-05-25
SI1697345T1 (sl) 2008-08-31
US20070043022A1 (en) 2007-02-22
PT1697345E (pt) 2008-06-12
DE602004012448T2 (de) 2009-03-26
JP2007514720A (ja) 2007-06-07
BRPI0417268A (pt) 2007-03-13
KR100967406B1 (ko) 2010-07-01
IL175910A (en) 2013-08-29
CN101412709B (zh) 2015-03-25
EA200601178A1 (ru) 2006-10-27
CA2548668A1 (en) 2005-06-30
AR046959A1 (es) 2006-01-04
EA009876B1 (ru) 2008-04-28
AU2004298460A1 (en) 2005-06-30
ZA200605894B (en) 2008-01-08
UA84718C2 (ru) 2008-11-25
US8883837B2 (en) 2014-11-11
TW200531972A (en) 2005-10-01
AP2006003640A0 (en) 2006-06-30
NO20063322L (no) 2006-09-18
IL175910A0 (en) 2006-10-05
HRP20080245T3 (hr) 2008-07-31
RS50584B (sr) 2010-05-07
ATE388950T1 (de) 2008-03-15
CN1894237A (zh) 2007-01-10
BRPI0417268B1 (pt) 2018-10-23

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