ATE388950T1 - Morpholinylhaltige benzimidazole als inhibitoren der replikation von respiratory syncytial virus - Google Patents
Morpholinylhaltige benzimidazole als inhibitoren der replikation von respiratory syncytial virusInfo
- Publication number
- ATE388950T1 ATE388950T1 AT04817576T AT04817576T ATE388950T1 AT E388950 T1 ATE388950 T1 AT E388950T1 AT 04817576 T AT04817576 T AT 04817576T AT 04817576 T AT04817576 T AT 04817576T AT E388950 T1 ATE388950 T1 AT E388950T1
- Authority
- AT
- Austria
- Prior art keywords
- morpholinyl
- replication
- inhibitors
- respiratory syncytial
- syncytial virus
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03104810 | 2003-12-18 | ||
| US56718204P | 2004-04-30 | 2004-04-30 | |
| EP04105312 | 2004-10-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE388950T1 true ATE388950T1 (de) | 2008-03-15 |
Family
ID=34704695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04817576T ATE388950T1 (de) | 2003-12-18 | 2004-12-20 | Morpholinylhaltige benzimidazole als inhibitoren der replikation von respiratory syncytial virus |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US7449463B2 (de) |
| EP (1) | EP1697345B1 (de) |
| JP (1) | JP4951348B2 (de) |
| KR (1) | KR100967406B1 (de) |
| CN (2) | CN1894237A (de) |
| AP (1) | AP2150A (de) |
| AR (1) | AR046959A1 (de) |
| AT (1) | ATE388950T1 (de) |
| AU (1) | AU2004298460B2 (de) |
| BR (1) | BRPI0417268B8 (de) |
| CA (1) | CA2548668C (de) |
| CY (1) | CY1108142T1 (de) |
| DE (1) | DE602004012448T2 (de) |
| DK (1) | DK1697345T3 (de) |
| EA (1) | EA009876B1 (de) |
| EG (1) | EG25799A (de) |
| ES (1) | ES2303653T3 (de) |
| HR (1) | HRP20080245T3 (de) |
| IL (1) | IL175910A (de) |
| ME (1) | ME01042B (de) |
| MX (1) | MXPA06007112A (de) |
| MY (1) | MY143573A (de) |
| NO (1) | NO339314B1 (de) |
| NZ (1) | NZ547479A (de) |
| PL (1) | PL1697345T3 (de) |
| PT (1) | PT1697345E (de) |
| RS (1) | RS50584B (de) |
| SI (1) | SI1697345T1 (de) |
| TW (1) | TWI351401B (de) |
| UA (1) | UA84718C2 (de) |
| WO (1) | WO2005058871A1 (de) |
| ZA (1) | ZA200605894B (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR046959A1 (es) * | 2003-12-18 | 2006-01-04 | Tibotec Pharm Ltd | Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio |
| TWI370820B (en) | 2005-04-27 | 2012-08-21 | Takeda Pharmaceutical | Fused heterocyclic compounds |
| RU2419613C2 (ru) * | 2005-06-20 | 2011-05-27 | Тиботек Фармасьютикалз Лтд | Гетероциклиламиноалкилзамещенные бензимидазолы |
| AU2006260969B2 (en) * | 2005-06-20 | 2011-11-17 | Janssen Sciences Ireland Uc | 1- ( 2-amino-3- (substituted alkyl)-3H-benzimidazolylmethyl) -3-substituted-1,3-dihydro-benzoimidazol-2-ones with activity on respiratory syncytial virus |
| US20120148678A1 (en) | 2010-12-08 | 2012-06-14 | Advanced Technologies And Regenerative Medicine, Llc. | Sustained release of poorly water soluble active compounds |
| AU2012322095B2 (en) | 2011-10-14 | 2017-06-29 | Ambit Biosciences Corporation | Heterocyclic compounds and use thereof as modulators of type III receptor tyrosine kinases |
| UA119050C2 (uk) * | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
| JO3637B1 (ar) | 2015-04-28 | 2020-08-27 | Janssen Sciences Ireland Uc | مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv |
| WO2017196982A1 (en) * | 2016-05-10 | 2017-11-16 | Georgia State University Research Foundation, Inc. | Bicyclic fused pyrazole derivatives for the treatment of rsv |
| TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| LT3483164T (lt) | 2017-03-20 | 2020-05-11 | Forma Therapeutics, Inc. | Pirolpirolo kompozicijos kaip piruvato kinazės (pkr) aktyvatoriai |
| TW201932470A (zh) | 2017-11-29 | 2019-08-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | 具有抗ｒｓｖ活性之吡唑并嘧啶 |
| SG11202006141RA (en) | 2018-01-31 | 2020-07-29 | Janssen Sciences Ireland Unlimited Co | Cycloalkyl substituted pyrazolopyrimidines having activity against rsv |
| US11708369B2 (en) | 2018-04-23 | 2023-07-25 | Janssen Sciences Ireland Unlimited Company | Heteroaromatic compounds having activity against RSV |
| EP3852791B1 (de) | 2018-09-19 | 2024-07-03 | Novo Nordisk Health Care AG | Aktivierung von pyruvatkinase r |
| EP3853206B1 (de) | 2018-09-19 | 2024-04-10 | Novo Nordisk Health Care AG | Behandlung von sichelzellanämie mit einer pyruvatkinase-r-aktivierenden verbindung |
| GB201820751D0 (en) * | 2018-12-19 | 2019-01-30 | Bp Oil Int | Methods for preparing intermediates |
| CR20220029A (es) | 2019-07-22 | 2022-03-14 | Lupin Ltd | Compuestos macrocíclicos como agonistas de sting y métodos y usos de los mismos |
| HRP20251148T1 (hr) | 2019-09-19 | 2025-11-21 | Novo Nordisk Health Care Ag | Pripravci koji aktiviraju piruvat-kinazu r (pkr) |
| JP2023528537A (ja) | 2020-03-20 | 2023-07-04 | カルシメディカ，インク． | 急性肺傷害及び急性呼吸窮迫症候群を処置するための方法及び組成物 |
| CA3198798A1 (en) | 2020-11-13 | 2022-05-19 | Kenneth Stauderman | Improved synthesis of crac channel inhibitors |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
| WO2023018560A1 (en) * | 2021-08-13 | 2023-02-16 | Georgia State University Research Foundation, Inc. | Bicyclic fused pyrazole derivatives for the treatment of respiratory infections including rsv |
| CN119118850B (zh) * | 2023-06-13 | 2025-12-12 | 中国科学院兰州化学物理研究所 | 一种吲哚类化合物结构重整制备胺基苯乙醇类化合物的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL147327A0 (en) * | 1999-06-28 | 2002-08-14 | Janssen Pharmaceutica Nv | Respiratory syncytial virus replication inhibitors |
| ES2215670T3 (es) * | 1999-06-28 | 2004-10-16 | Janssen Pharmaceutica N.V. | Inhibidores de la replicacion del virus sincitial respiratorio. |
| SI1196408T1 (en) * | 1999-06-28 | 2005-02-28 | Janssen Pharmaceutica N.V. | Respiratory syncytial virus replication inhibitors |
| TWI356055B (en) * | 2003-12-18 | 2012-01-11 | Tibotec Pharm Ltd | Aminobenzimidazoles and benzimidazoles as inhibito |
| AR046959A1 (es) * | 2003-12-18 | 2006-01-04 | Tibotec Pharm Ltd | Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio |
-
2004
- 2004-12-17 AR ARP040104755A patent/AR046959A1/es active IP Right Grant
- 2004-12-20 AU AU2004298460A patent/AU2004298460B2/en not_active Ceased
- 2004-12-20 US US10/563,691 patent/US7449463B2/en not_active Expired - Lifetime
- 2004-12-20 ME MEP-2008-207A patent/ME01042B/me unknown
- 2004-12-20 MY MYPI20045259A patent/MY143573A/en unknown
- 2004-12-20 EP EP04817576A patent/EP1697345B1/de not_active Expired - Lifetime
- 2004-12-20 MX MXPA06007112A patent/MXPA06007112A/es active IP Right Grant
- 2004-12-20 WO PCT/EP2004/053620 patent/WO2005058871A1/en not_active Ceased
- 2004-12-20 UA UAA200606224A patent/UA84718C2/ru unknown
- 2004-12-20 JP JP2006544467A patent/JP4951348B2/ja not_active Expired - Fee Related
- 2004-12-20 NZ NZ547479A patent/NZ547479A/en not_active IP Right Cessation
- 2004-12-20 CN CNA2004800378255A patent/CN1894237A/zh active Pending
- 2004-12-20 SI SI200430732T patent/SI1697345T1/sl unknown
- 2004-12-20 HR HR20080245T patent/HRP20080245T3/xx unknown
- 2004-12-20 BR BRPI0417268A patent/BRPI0417268B8/pt not_active IP Right Cessation
- 2004-12-20 AP AP2006003640A patent/AP2150A/xx active
- 2004-12-20 DE DE602004012448T patent/DE602004012448T2/de not_active Expired - Lifetime
- 2004-12-20 DK DK04817576T patent/DK1697345T3/da active
- 2004-12-20 AT AT04817576T patent/ATE388950T1/de active
- 2004-12-20 KR KR1020067014047A patent/KR100967406B1/ko not_active Expired - Fee Related
- 2004-12-20 TW TW093139923A patent/TWI351401B/zh not_active IP Right Cessation
- 2004-12-20 CN CN200810166056.9A patent/CN101412709B/zh not_active Expired - Lifetime
- 2004-12-20 CA CA2548668A patent/CA2548668C/en not_active Expired - Lifetime
- 2004-12-20 PL PL04817576T patent/PL1697345T3/pl unknown
- 2004-12-20 PT PT04817576T patent/PT1697345E/pt unknown
- 2004-12-20 EA EA200601178A patent/EA009876B1/ru unknown
- 2004-12-20 RS RSP-2008/0266A patent/RS50584B/sr unknown
- 2004-12-20 ES ES04817576T patent/ES2303653T3/es not_active Expired - Lifetime
-
2006
- 2006-05-25 IL IL175910A patent/IL175910A/en active IP Right Grant
- 2006-06-14 EG EGNA2006000561 patent/EG25799A/xx active
- 2006-07-17 ZA ZA2006/05894A patent/ZA200605894B/en unknown
- 2006-07-18 NO NO20063322A patent/NO339314B1/no not_active IP Right Cessation
-
2008
- 2008-06-12 CY CY20081100633T patent/CY1108142T1/el unknown
- 2008-06-17 US US12/140,686 patent/US8883837B2/en active Active
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