ME02608B - Kombinacija, komplet i postupak snižavanja intraokularnog pritiska - Google Patents

Kombinacija, komplet i postupak snižavanja intraokularnog pritiska

Info

Publication number
ME02608B
ME02608B MEP-2017-11A MEP1117A ME02608B ME 02608 B ME02608 B ME 02608B ME P1117 A MEP1117 A ME P1117A ME 02608 B ME02608 B ME 02608B
Authority
ME
Montenegro
Prior art keywords
combination
compound
eye
subject
use according
Prior art date
Application number
MEP-2017-11A
Other languages
German (de)
English (en)
French (fr)
Inventor
Norman N Kim
William K Mcvicar
Thomas Mccauley
Rudolf A Baumgartner
Original Assignee
Inotek Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44258984&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME02608(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Inotek Pharmaceuticals Corp filed Critical Inotek Pharmaceuticals Corp
Publication of ME02608B publication Critical patent/ME02608B/me

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Prostheses (AREA)

Claims (10)

1.  Oftalmološka kombinacija koja obuhvata i) ((2R,3S,4R,5R)-5-(6-(ciklopentilamino)-9H-purin-9-il)-3,4-dihidroksitetrahidrofuran-2-il)metil nitrat,ili njegova farmaceutski prihvatljiva so, i ii) jedinjenje odabrano iz grupe koju čine latanoprost, travoprost, unoproston i bimatoprost, za upotrebu u snižavanju povišenog intraokularnog pritiska u oku nekog subjekta.
2.  Kombinacija za upotrebu prema zahtevu 1, u kojoj jedinjenje (ii) je latanoprost.
3. Kombinacija za upotrebu prema bilo kom od zahteva 1 do 2, u kojoj se jedinjenje (i) primenjuje na oko subjekta simultano, odvojeno ili sekvencijalno u odnosu na primenu jedinjenja (ii) na oko subjekta.
4.  Kombinacija za upotrebu prema zahtevu 1, u kojoj se jedna ili više kapi od oko 0,05 mg/ml do oko 7,0 mg/ml jedinjenja (i) nanose na oko subjekta sa oko 30 µg/ml do oko 50 µg/ml jedinjenja (ii) od 1 do 4 puta dnevno.
5.  Kombinacija za upotrebu prema zahtevu 4, u kojoj se oko 20-700 µg, ili 20-350 µg jedinjenja (i) nanosi na oko subjekta od 1 do 2 puta dnevno.
6.  Kombinacija za upotrebu prema bilo kom od zahteva 1 do 5, u kojoj se jedinjenje (i) i jedinjenje (ii) nanose topikalno na oko subjekta kao jedna ili više očnih kapi.
7.  Kombinacija za upotrebu prema bilo kom od zahteva 1 do 6 za upotrebu u tretiranju bolesti i stanja izazvanih povišenim intraokularnim pritiskom kod subjekta.
8.  Kombinacija za upotrebu prema zahtevu 7, u kojoj su bolesti i stanja izazvana povišenim intraokularnim pritiskom kod čoveka odabrana iz grupe koju čine očna hipertenzija, i primarni glaukom otvorenog ugla.
9.  Komplet koji obuhvata kombinaciju prema bilo kom od zahteva 1 do 8 za upotrebu u snižavanju povišenog intraokularnog pritiska u oku nekog subjekta.
10.  Kombinacija koja obuhvata i) ((2R,3S,4R,5R)-5-(6-(ciklopentilamino)-9H-purin-9-il)-3,4-dihidroksitetrahidrofuran-2-il)metil nitrat ili njegovu farmaceutski prihvatljivu so i ii) jedinjenje odabrano iz grupe koju čine latanoprost, travoprost, unoproston i bimatoprost za upotrebu kao lek.
MEP-2017-11A 2010-01-11 2011-01-11 Kombinacija, komplet i postupak snižavanja intraokularnog pritiska ME02608B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29380610P 2010-01-11 2010-01-11
PCT/US2011/020808 WO2011085361A1 (en) 2010-01-11 2011-01-11 Combination, kit and method of reducing intraocular pressure
EP11732309.7A EP2523669B1 (en) 2010-01-11 2011-01-11 Combination, kit and method of reducing intraocular pressure

Publications (1)

Publication Number Publication Date
ME02608B true ME02608B (me) 2017-06-20

Family

ID=44258984

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2017-11A ME02608B (me) 2010-01-11 2011-01-11 Kombinacija, komplet i postupak snižavanja intraokularnog pritiska

Country Status (29)

Country Link
US (3) US8877732B2 (me)
EP (1) EP2523669B1 (me)
JP (2) JP2013516495A (me)
KR (1) KR20120115344A (me)
CN (1) CN102711771B (me)
AU (1) AU2011203897B2 (me)
BR (1) BR112012017106A2 (me)
CA (1) CA2784908A1 (me)
CL (1) CL2012001912A1 (me)
CO (1) CO6571924A2 (me)
CY (1) CY1118510T1 (me)
DK (1) DK2523669T3 (me)
EA (1) EA025415B1 (me)
ES (1) ES2613698T3 (me)
HR (1) HRP20170007T1 (me)
HU (1) HUE030566T2 (me)
IL (1) IL220604A (me)
IN (1) IN2012DN06592A (me)
LT (1) LT2523669T (me)
ME (1) ME02608B (me)
MX (1) MX2012007661A (me)
PH (1) PH12012501320A1 (me)
PL (1) PL2523669T3 (me)
PT (1) PT2523669T (me)
RS (1) RS55615B1 (me)
SG (2) SG182285A1 (me)
SI (1) SI2523669T1 (me)
SM (2) SMT201700017T1 (me)
WO (1) WO2011085361A1 (me)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
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LT2523669T (lt) * 2010-01-11 2017-04-25 Inotek Pharmaceuticals Corporation Akispūdžio mažinimo būdas, derinys ir rinkinys
AU2011230580A1 (en) 2010-03-26 2012-10-11 Inotek Pharmaceuticals Corporation Method of reducing intraocular pressure in humans using N6 -cyclopentyladenosine (CPA), CPA derivatives or prodrugs thereof
PL2807178T3 (pl) * 2012-01-26 2017-12-29 Inotek Pharmaceuticals Corporation Bezwodne polimorfy azotanu (2R,3S,4R,5R)-5-(6-(cyklopentyloamino)-9H-puryn-9-ylo)-3,4-dihydroksytetrahydrofuran-2-ylo)metylu i sposoby ich wytwarzania
MX2015013240A (es) * 2013-03-15 2016-04-07 Inotek Pharmaceuticals Corp Método para proporcionar neuroprotección ocular.
WO2014152723A1 (en) * 2013-03-15 2014-09-25 Inotek Pharmaceuticals Corporation Ophthalmic formulations
JP6217866B2 (ja) 2014-10-24 2017-10-25 小野薬品工業株式会社 Ｋｃｎｑ２〜５チャネル活性化剤
CN107406479A (zh) * 2014-12-03 2017-11-28 伊诺泰克制药公司 预防、减轻或治疗黄斑变性的方法

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