ME02647B - Sistemi i metode za pokretanje raspršivača lijeka - Google Patents

Sistemi i metode za pokretanje raspršivača lijeka

Info

Publication number
ME02647B
ME02647B MEP-2016-290A MEP29016A ME02647B ME 02647 B ME02647 B ME 02647B ME P29016 A MEP29016 A ME P29016A ME 02647 B ME02647 B ME 02647B
Authority
ME
Montenegro
Prior art keywords
liquid
output
voltage
resonant frequency
negative bias
Prior art date
Application number
MEP-2016-290A
Other languages
German (de)
English (en)
French (fr)
Inventor
Benjamin Morris Gordon
Steven David Gardner
Matthew James Hayes
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Publication of ME02647B publication Critical patent/ME02647B/me

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0085—Inhalators using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/08—Bellows; Connecting tubes ; Water traps; Patient circuits
    • A61M16/0816—Joints or connectors
    • A61M16/0833—T- or Y-type connectors, e.g. Y-piece
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/14—Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0638—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers spray being produced by discharging the liquid or other fluent material through a plate comprising a plurality of orifices
    • B05B17/0646—Vibrating plates, i.e. plates being directly subjected to the vibrations, e.g. having a piezoelectric transducer attached thereto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0057—Pumps therefor
    • A61M16/0066—Blowers or centrifugal pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
    • A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
    • A61M2016/0024—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with an on-off output signal, e.g. from a switch
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Special Spraying Apparatus (AREA)
  • Electrostatic Spraying Apparatus (AREA)
  • Catching Or Destruction (AREA)
  • Medicinal Preparation (AREA)
  • Nozzles (AREA)
  • Apparatuses For Generation Of Mechanical Vibrations (AREA)

Claims (15)

1. Metod za pracanje vibracije elementa (110) rasprsivaca (100-a, 100-c, 151, 178, 260), koji ima zaptiven rezervoar za tecni lijek (120, 186) sa negativnim prednaponom,elektricnim signalom koji salje pokretac (152, 172, 210), metod koji se sastoji od: pokretanja, pomocu pokretaca (152, 172, 210), elementa (110) rasprsivaca (100-a, 100-c, 151, 178, 260) pomocu elektricnog signala, koji dovodi do vibriranja elementa (110) rasprsivaca (100-a, 100-c, 151, 178, 260) i rasprsivanja tecnosti uskladistene u rezervoar za tecnost sa negativnim prednaponom (120, 186), elektricnog signa Ia koji se sastoji od elektricne struje i elektricnog napona; naznacen time da se vrsi mjerenje pomocu detektora faznog pomaka (240) pokretaca (152, 172, 210), faznog pomaka izmedu napona i elektricne struje elektricnog signa Ia koji pokrece rasprsivac (100-a, 100-c, 151, 178, 260); zasnovanog bar djelimicno na faznom pomaku elektricnog signa Ia koji pokrece element (110) rasprsivaca (100-a, 100-c, 151, 178, 260) mjerenog detektorom faznog pomaka (240), koji pomocu sistema za pracenje rezonantne frekvencije (220) pokretaca (152, 172, 210) utvrduje rezonantnu frekvenciju elementa (110) rasprsivaca (100-a, 100-c, 151, 178, 260) podesavanje, pomocu pokretaca (152, 172, 210) frekvencije elektricnog signala rasprsivaca (100-a, 100-c, 151, 178, 260), u kome se odrzava skoro konstantan fazni pomak izmedu napona i struje elektricnog signala a rezonantna frekvencija elementa rasprsivaca se mijenja dok se tecnost rasprsuje a pritisak negativnog prednapona u zaptivenom rezervoaru lijeka (120), 186) mijenja; i zasnovan bar djelimicno na rezonantnoj frekvenciji rasprsivaca (100-a, 100-c, 151, 178, 260) odredenoj sistemom za pracenje rezonantne frekvencije (220) pokretaca (152, 172, 210), kojim se pomocu profila napona (250) pokretaca (152, 172, 210) utvduje magnituda elektricnog signa Ia pri tacno odredenoj rezonantnoj frekveniciji da bi se odrzavala uvijek ista velicina kapljice i doziranje rasprsivane tecnosti.
2. Metod prema patentnom zahtjevu 1, u kome rezervoar za tecnost sa negativnim prednaponom (120, 186) dovodi do mijenjanja rezonantne frekvencije elementa (110) rasprsivaca (100-a, 100-c, 151, 178, 260) dok se tecnost crpi iz rezervoara sa negativnim prednaponom (120, 186).
3. Metod prema patentnom zahtjevu 1, dalje sadrzi, zasnovan makar djelimicno na rezonantnoj frekvenciji rasprsivaca (100-a, 100-c, 151, 178, 260), koju odreduje pokretac (152, 172, 210), odredujujuci, pomocu pokretaca (152, 172, 210), pritisak negativnog prednapona u rezervoaru za tecnost sa negativnim prednaponom (120, 186} rasprsivaca (100-a, 100-c, 151, 178, 260}.
4. Metod prema patentnom zahtjevu 1, u kame se napon magnitude odreduje pomocu unesenog seta vrijednosti, a uneseni set vrijednosti se mijenja u zavisnosti od tecnosti u rezervoaru za tecnost sa negativnim prednaponom (120, 186).
5. Uredaj za pokretanje elementa (110} rasprsivaca (100-a, 100-c, 151, 178, 260} u skladu sa metodom prema bilo kom patentnom zahtjevu od 1 do 4, uredaj koji se sastoji od: pojacivaca (230), konfigurisanog da proizvodi izlazni signal, izlazni tal as koji se sastoji od izlazne frekvencije, izlazne struje i izlaznog napona, u kame izlazni talas pokrece element (110) rasprsivaca (100-a, 100-c, 151, 178, 260} pri izlaznoj frekvenciji; detektora faznog pomaka (240), konfigurisanog da odreduje promjenu faze izmedu izlazne struje i izlaznog napona izlaznog talasa; sistema za pracenje rezonantne frekvencije 8220), konfigurisanog da proizvodi talas promjenjive frekvencije koji se salje na pojacivac (230), u kame: talas kontroliseizlaznu frekvenciju, promjenjiva frekvencija se podesava na osnovu faznog pomaka izlaznog talasa odredenog detektorskim modulom faznog pomaka, i naponskog profila (250), konfigurisan da podesava izlazni napon izlaznog tala sa pomocu pojacivaca (230) zasnovanog na frekvenciji signala koji proizvodi sistem za pracenje rezonantne frekvencije (220).
6. Uredaj prema patentnom zahtjevu 5, u kame rasprsivac (100-a, 100-c, 151, 178, 260) ima rezervoar za tecnost sa negativnim prednaponom (120, 186) koji dovodi do mijenjanja rezonantne frekvencije elementa (110) rasprsivaca (100-a, 100-c, 151, 178, 260) dok se tecnost crpi iz rezervoara za tecnost sa negativnim prednaponom (120, 186).
7.Uredaj za pokretanje prema patentnom zahtjevu 5, u kame se izlazni napon pojacivaca (230) utvrduje pomocu unesenog seta vrijednosti a taj set vrijednosti se mijenja u zavisnosti od tecnosti iz rezervoara za tecnost sa negativnim prednaponom (120, 186}.
8. Uredaj za pokretanje prema patentnom zahtjevu 6, u kome je tecnost u rezervoaru za tecnost lijek sa negativnim prednaponom (120, 186).
9. Uredaj za pokretanje prema patentnom zahtjevu 5, u kome uredaj za pokretanje zajedno sa rasprsivacem (100-c) cini rucnu napravu.
10. Sistem za kontrolu vibracije elementa rasprsivaca za rasprsivanje tecnosti, sistem koji se sastoji od: rezervoara za tecnost (120, 186) koji je podesen da drzi tecnost koju treba rasprsivati; rasprsivac {100-a, 100-c, 151, 178, 260), koji se sastoji od jednog elementa {110) sa mnostvom otvora, u kome: je element {110) konfigurisan tako da vibrira da bi se rasprsivala tecnost koja se crpi iz rezervoara za tecnost {120, 186) u kome se element pokrece elektricnim izlaznim talasom; pritisak negativnog prednapona rezervoara za tecnost {120, 186) se mijanje dok se tecnost iz rezervoara crpi; i rezervoar za tecnost {120, 186) je zaptiven tako da vazduh iz okruzenja uglavnom ne dopire u rezervoar za tecnost {120, 186) dok se tecnost smjestena u rezervoar (120, 186) crpi; i pokretaca (152, 172, 210), naznacen time sto se pokretac 8152, 172, 210) sastoji od: pojacivaca {230) za proizvodnju elektricnog izlaznog talasa, detektora promjene faze (240), konfigurisanog tako da utvrduje kad dode do faznog pomaka izmedu struje izlaznog talasa i napona izlaznog talasa; sistema za pracenje rezonantne frekvencije (220), konfigurisanog tako da proizvodi tal as koji se salje do pojacivaca (230), talas koji podesava frekvenciju izlaznog talasa, u kome se frekvencija podesava na osnovu faznog pomaka determinisanog detektorom promjene faze (240) tako da pojacivac (230) salje izlazni talas sa skoro konstantnim faznim pomakom izmedu napona i struje izlaznog talasa a rezonantna frekvencija elementa {110) rasprsivaca {100-a, 100-c, 151, 178, 260) se mijenja dok se tecnost rasprsuje a pritisak negativnog prednapona u rezervoaru za lijek mijenja (120, 186); i naponski profil 8250), konfigurisan da vrsi podesavanje napona izlaznog talasa na osnovu frekvencije signala koji je proizveo sistem za pracenje rezonantne frekvencije (220).
11.Sistem prema patentnom zahtjevu 10, u kome je raprsivac {178) konfigurisan tako da je spojen sa ventilatorom.
12. Sistem prema patentnom zahtjevu 10, u kome je pokretac spojen sa rasprsivacem (100-c) u jednu rucnu napravu.
13. Sistem prema patentnom zahtjevu 10, u kome je pojacivac (230) konfigurisan tako da proizvodi izlazni talas pomocu talasa dobijenih od sistema za pracenje rezonantne frekvencije (220) i naponskog profila (250).
14. Sistem prema patentnom zahtjevu 10, u kome se izlazni napon pojacivaca (230) utvrduje pomocu unesenog seta vrijednosti, a taj uneseni set vrijednosti varira u zavisnosti od tecnosti uskladistene u rezervoar za tecnost (120, 186).
15. Sistem prema patentnom zahtjevu 14, u kome je tecnost lijek.
MEP-2016-290A 2009-07-17 2010-07-19 Sistemi i metode za pokretanje raspršivača lijeka ME02647B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22659109P 2009-07-17 2009-07-17
PCT/US2010/042473 WO2011009133A1 (en) 2009-07-17 2010-07-19 Systems and methods for driving sealed nebulizers
EP10800673.5A EP2453864B1 (en) 2009-07-17 2010-07-19 Systems and methods for driving sealed nebulizers

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ME02647B true ME02647B (me) 2017-06-20

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US (2) US9149588B2 (me)
EP (1) EP2453864B1 (me)
JP (1) JP5841942B2 (me)
KR (1) KR101740670B1 (me)
CN (1) CN102573745B (me)
AU (1) AU2010273957B2 (me)
BR (1) BR112012001074A2 (me)
CA (1) CA2768487A1 (me)
CY (1) CY1118401T1 (me)
DK (1) DK2453864T3 (me)
EA (1) EA022926B1 (me)
ES (1) ES2614917T3 (me)
HR (1) HRP20161699T1 (me)
HU (1) HUE032278T2 (me)
IL (1) IL217512A (me)
IN (1) IN2012DN00966A (me)
LT (1) LT2453864T (me)
ME (1) ME02647B (me)
MX (1) MX2012000751A (me)
PL (1) PL2453864T3 (me)
PT (1) PT2453864T (me)
RS (1) RS55481B1 (me)
SI (1) SI2453864T1 (me)
SM (2) SMT201700045T1 (me)
WO (1) WO2011009133A1 (me)

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AU2010273957A1 (en) 2012-02-23
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